Regenerative medicine is a translational field that combines tissue engineering and molecular biology to construct spare organs or help injured or defective tissues to regenerate or restore their normal functions.

• Transplants of fresh and cryopreserved autologous adipose tissue improve reintegrative phenomena in newly formed muscle tissue in the reconstruction of muscle volume loss: A histological evaluation
• Engineering polyphenol-based osteogenic system for bone and cartilage repair: Transplantation, tissue engineering, and organoid
• Cholinergic neuron-to-glioblastoma synapses in a human iPSC-derived co-culture model
• Insights From Amniotic and Umbilical Cord Mesenchymal Stem Cells in Wound Healing
• Adeno-associated virus-mediated inhibition of ROCK2 promotes synaptogenesis and neurogenesis in rats after ischemic stroke
• Mitochondrial dynamics dysfunction and neurodevelopmental disorders: From pathological mechanisms to clinical translation
• Phenethyl isothiocyanate modulates macrophage migration inhibitory factor and suppresses malignant phenotypes of glioblastoma cells
• Advanced Therapeutic Approaches Based on Small Extracellular Vehicles (sEVs) For the Regeneration of Spinal Cord Injuries

The goal of regenerative medicine is to restore function through therapy at levels such as the gene, cell, tissue, or organ. For many disorders, however, regenerative medicine approaches in isolation may not be optimally effective. Rehabilitation is a promising adjunct therapy given the beneficial impact that physical activity and other training modalities can offer. Accordingly, “regenerative rehabilitation” is an emerging concentration of study, with the specific goal of improving positive functional outcomes by enhancing tissue restoration following injury ¹⁾.

This is particularly important with specific organs such as heart, central nervous system, retina or limbs which possess very limited regenerative capacity. As such, regenerative medicine has received peculiar attention in the last decade. In this regard, Wnt signaling pathway has been subject to intensive research, since it plays many essential roles in the regulation of the progenitor cell fate, developmental decisions, proliferation during embryonic development, and adult tissue homeostasis.

Majidinia et al. briefly introduce Wnt signaling pathway and discuss how it integrally contributes to both stem and cancer stem cell maintenance. Finally, they summarize the current understanding of the role of Wnt/β-catenin signaling in the development and regeneration of heart, lung, liver, bone, and cartilage ²⁾.