From 1995 to 2014, 83 patients (45% females, median age 66) with spondylodiscitis were treated. Microbiological confirmation was obtained in 67.4%. Forty-four percent of patients presented with neurological defect. The most common affected level was thoracic (54.2%). The most frequent isolations were Mycobacterium tuberculosis (229%), Staphylococcus aureus (20.5%) and MRSA (7.2%). Eighty-one patients underwent surgery: simple laminectomy and/or biopsy (22.2%), debridement and posterior fixation (43.2%) and debridement and anterior fixation (34.5%). Improvement of pain or neurological defect was achieved in 86.7% of the patients; 7 patients stabilized and 2 worsened. Complications occurred in 35 patients, mainly pleural effusion (9), anaemia (7) and need for re-debridement (7). Median postoperative stay was 14days. After a median follow up of 8.5 months, 46 patients were considered completely cured, 10 presented sequelae, 22 patients were lost and 5 patients died. No readmissions occurred because of the infectious episode.

Although prolonged and specific antibiotic therapy remains the mainstay of treatment in spontaneous spondylodiscitis, surgery provides samples for microbiological confirmation and histopathologic study, allows debridement of the infectious foci and stabilizes the spine. In our experience, the use of internal metallic fixation material accelerates recovery and does not predispose to chronic infection ¹⁾.

4698 patients were operated for lumbar spine disorders:lumbar disc herniation, spinal canal stenosis. Of these patients, 47 (1%) were diagnosed with postoperative discitis. In December 2012 there were 24 cases of spondylodiscitis after lumbar disc herniation operated by inter-lamar approach and foraminotomy. The A group of 13 patients received antistaphylococcal empirical antibiotic treatment. The B group consisting of 11 patients received antibiotic therapy after germ isolation by open biopsy from discal intervertebral space (n=8)and from surgical wound secretion (n=3) and antibiotic susceptibility testing.

After 4 to 6 months of antibiotic treatment associated with immobilization in Boston corset the symptoms gradually improved in parallel with normalization of biological constants, ESR, CRP. Five patients of Group A did not respond to the given antibiotic treatment and required further debridement and germ isolation ²⁾.

A total of 17 cases of postoperative discitis treated from 2002 to 2009 were followed up and evaluated clinically, radiologically and by laboratory investigations. All the patients were treated initially conservatively with rest and antibiotic therapy after diagnosis and those who did not respond to conservative treatment of at least 4 weeks were treated surgically. The cases were followed up with serial C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), X-ray, computed tomography (CT) scan and magnetic resonance imaging (MRI) for at least 1 year.

The mean followup was 40.38 months (range 12-86 months). Four cases failed to respond to conservative therapy and were treated surgically. In three of these four cases, open debridement, transpedicular fixation and posterolateral fusion was performed, and in the fourth case percutaneous transpedicular fixation was done. In the former group, one case was diagnosed to be tubercular, in another case Staphylococcus aureus was cultured where as the third case culture was sterile. All operated patients showed evidence of interbody fusion at 1 year followup. ³⁾.

Seventeen patients with septic postoperative spondylodiscitis (POD) who were managed by early microsurgical removal of the infected necrotic tissue, application of a closed suction-irrigation system (for a mean of 6.7 days), and early mobilisation. The POD was diagnosed clinically by elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) values and radiographically by computerised tomography scanning or magnetic resonance imaging. According to the sensitivity studies of the obtained pathogens, systemic antibiotics were given, followed by early mobilisation of all patients in a light cast corset. Immediate pain relief was noted in all patients except one, who required a third operation that was followed by rapid clinical improvement. Bacteriological diagnosis was obtained in 88% of the patients. Excellent or good clinical long-term results were achieved in 82% of the patients, whereas 18% had poor results. Elevated ESR/CRP values returned to normal ranges within 6 to 44 days (mean 15 days) after reoperation. All but one patient tolerated early mobilisation (within 2 to 4 weeks) well without any complication. Early microsurgical removal of the necrotic and infected tissue and application of a closed suction-irrigation system supported by specific antibiotic therapy should be considered an effective means to treat POD, thereby avoiding a prolonged period of unpleasant immobilisation for the patient ⁴⁾.

13 cases of lumbar disc infection following surgical discectomy. Two groups of patients were identified. The six patients in group A reported that the initial symptoms of discitis had appeared a mean of 15 days after surgery; on average, antibiotic treatment was started 31 days following operation and continued for 62 days, and symptoms regressed after 3.9 months. Four patients showed moderate changes, while two had extensive osteolytic lesions of one or both vertebral bodies adjacent to the involved disc. In the 7 cases in group B, discitis was suspected a mean of 5 days and antibiotics were initiated a mean of 8 days following surgery; on average, symptoms regressed 1.8 months after operation. Only four patients showed vertebral radiographic changes and none had marked destructive lesions. In both groups erythrocyte sedimentation rate exceeded 70 mm/h in cases in which discitis was suspected. Tomograms and magnetic resonance studies were the most diagnostic imaging studies in the initial stages of the disease. All patients obtained satisfactory clinical results at the last follow-up. Careful observation of the early postoperative clinical course usually allows detection of disc space infection. Early and adequately prolonged antibiotic treatment may shorten the course of the disease and avoid extensive osteolytic vertebral lesions ⁵⁾.

111 cases of postoperative discitis during 1968-1986 were analyzed retrospectively. The diagnosis was confirmed by lumbar tomography. Low back pain appeared at an average of 16 days postoperatively. Laboratory findings were of minor value in the diagnosis since elevated ESR, white blood cell count, and body temperature were inconstant findings. Compared with a matched control group, there was a higher incidence of chronic low back pain and vocational handicap in the discitis patients. There was no difference in the consumption of analgetics, the subjective evaluation of the final outcome, spinal mobility or neurologic findings ⁶⁾.

In a retrospective analysis of 12 consecutive patients with POD followed for an average of 29 months (17-42 months), the CT scan was extremely sensitive in showing a pathogen was present. The CT scan was misread in over one-third of the cases. Gram-positive cocci were the only organisms cultured (10 of 13 cultures, 8 of 12 patients). The erythrocyte sedimentation rate (ESR) invariably fell predictably to normal within 90 days when patients were treated with IV antibiotics for more than 40 days. Most patients were clinically improved and subjectively better at follow-up examination. No correlation existed between the patient's subjective result and preexisting medical conditions, the type of antibiotic, or the length of treatment, the ESR, or the follow-up roentgenograms ⁷⁾.