Peroxisome proliferator-activated receptor gamma

Peroxisome proliferator- activated receptor gamma, also known as the glitazone reverse insulin resistance receptor, or NR1C3 is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPARγ gene.

see PPAR agonist

1: Liu L, Zhu Z, Li X, Zheng Y. DNA methylation-induced ablation of miR-133a accelerates cancer aggressiveness in glioma through upregulating peroxisome proliferator-activated receptor γ. SLAS Discov. 2022 Sep 5:S2472-5552(22)13691-9. doi: 10.1016/j.slasd.2022.08.004. Epub ahead of print. PMID: 36067936.

2: Ma XX, Meng XQ, Wang YL, Liu Y, Shi XR, Shao S, Duan SZ, Lu HX. Ncor1 Deficiency Promotes Osteoclastogenesis and Exacerbates Periodontitis. J Dent Res. 2022 Aug 18:220345221116927. doi: 10.1177/00220345221116927. Epub ahead of print. PMID: 35983582.

3: Li YF, Ren X, Zhang L, Wang YH, Chen T. Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals. Front Aging Neurosci. 2022 Aug 1;14:901117. doi: 10.3389/fnagi.2022.901117. PMID: 35978950; PMCID: PMC9376354.

4: Shao S, Lu TY, Zhang JS, Wang WJ, Zhang XH, Chen K, Jia F. Hypothermia Protects against Ischemic Stroke through Peroxisome-Proliferator-Activated- Receptor Gamma. Oxid Med Cell Longev. 2022 Jul 14;2022:6029445. doi: 10.1155/2022/6029445. PMID: 35873794; PMCID: PMC9303492.

5: Kang R, Gamdzyk M, Luo Y, Tang H, Huang L, Lenahan C, Doycheva D, Li D, Tang J, Tan S, Zhang JH. Three Days Delayed Recanalization Improved Neurological Function in pMCAO Rats by Increasing M2 Microglia-Possible Involvement of the IL-4R/STAT6/PPARγ Pathway. Transl Stroke Res. 2022 Jul 22. doi: 10.1007/s12975-022-01032-5. Epub ahead of print. PMID: 35867328.

6: Wei X, Zhou Y, Song J, Zhao J, Huang T, Zhang M, Zhao Y. Hyperglycemia Aggravates Blood-Brain Barrier Disruption Following Diffuse Axonal Injury by Increasing the Levels of Inflammatory Mediators through the PPARγ/Caveolin-1/TLR4 Pathway. Inflammation. 2022 Jul 20. doi: 10.1007/s10753-022-01716-y. Epub ahead of print. PMID: 35857154.

7: Kristiansen CK, Chen A, Høyland LE, Ziegler M, Sullivan GJ, Bindoff LA, Liang KX. Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations. Cell Cycle. 2022 Oct;21(20):2206-2221. doi: 10.1080/15384101.2022.2092185. Epub 2022 Jul 10. PMID: 35815665; PMCID: PMC9518993.

8: Schillemans T, Tragante V, Maitusong B, Gigante B, Cresci S, Laguzzi F, Vikström M, Richards M, Pilbrow A, Cameron V, Foco L, Doughty RN, Kuukasjärvi P, Allayee H, Hartiala JA, Tang WHW, Lyytikäinen LP, Nikus K, Laurikka JO, Srinivasan S, Mordi IR, Trompet S, Kraaijeveld A, van Setten J, Gijsberts CM, Maitland-van der Zee AH, Saely CH, Gong Y, Johnson JA, Cooper-DeHoff RM, Pepine CJ, Casu G, Leiherer A, Drexel H, Horne BD, van der Laan SW, Marziliano N, Hazen SL, Sinisalo J, Kähönen M, Lehtimäki T, Lang CC, Burkhardt R, Scholz M, Jukema JW, Eriksson N, Åkerblom A, James S, Held C, Hagström E, Spertus JA, Algra A, de Faire U, Åkesson A, Asselbergs FW, Patel RS, Leander K. Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual- Level Meta-Analysis. Front Physiol. 2022 Jun 23;13:909870. doi: 10.3389/fphys.2022.909870. PMID: 35812313; PMCID: PMC9260705.

9: Li X, Wang B, Yu N, Yang L, Nan C, Sun Z, Guo L, Zhao Z. Gabapentin Alleviates Brain Injury in Intracerebral Hemorrhage Through Suppressing Neuroinflammation and Apoptosis. Neurochem Res. 2022 Oct;47(10):3063-3075. doi: 10.1007/s11064-022-03657-2. Epub 2022 Jul 9. PMID: 35809188.

10: Wang K, Wang G, Zhou B. TSPO knockdown attenuates OGD/R-induced neuroinflammation and neural apoptosis by decreasing NLRP3 inflammasome activity through PPARγ pathway. Brain Res Bull. 2022 Sep;187:1-10. doi: 10.1016/j.brainresbull.2022.06.009. Epub 2022 Jun 20. PMID: 35738501.

11: Xu N, Li X, Weng J, Wei C, He Z, Doycheva DM, Lenahan C, Tang W, Zhou J, Liu Y, Xu Q, Liu Y, He X, Tang J, Zhang JH, Duan C. Adiponectin Ameliorates GMH- Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats. Front Immunol. 2022 Jun 3;13:873382. doi: 10.3389/fimmu.2022.873382. PMID: 35720361; PMCID: PMC9203698.

12: Tang T, Wang X, Qi E, Li S, Sun H. Ginkgetin Promotes M2 Polarization of Microglia and Exert Neuroprotection in Ischemic Stroke via Modulation of PPARγ Pathway. Neurochem Res. 2022 Oct;47(10):2963-2974. doi: 10.1007/s11064-022-03583-3. Epub 2022 May 20. PMID: 35593977.

13: Liu J, Li N, Zhu Z, Kiang KM, Ng ACK, Dong CM, Leung GK. Vitamin D Enhances Hematoma Clearance and Neurologic Recovery in Intracerebral Hemorrhage. Stroke. 2022 Jun;53(6):2058-2068. doi: 10.1161/STROKEAHA.121.037769. Epub 2022 May 6. PMID: 35514286.

14: Monternier PA, Singh J, Parasar P, Theurey P, DeWitt S, Jacques V, Klett E, Kaur N, Nagaraja TN, Moller DE, Hallakou-Bozec S. Therapeutic potential of deuterium-stabilized (R)-pioglitazone-PXL065-for X-linked adrenoleukodystrophy. J Inherit Metab Dis. 2022 Jul;45(4):832-847. doi: 10.1002/jimd.12510. Epub 2022 May 19. PMID: 35510808.

15: Liang H, Tang T, Huang H, Li T, Gao C, Han Y, Yuan B, Gao S, Wang H, Zhou ML. Peroxisome proliferator-activated receptor-γ ameliorates neuronal ferroptosis after traumatic brain injury in mice by inhibiting cyclooxygenase-2. Exp Neurol. 2022 Aug;354:114100. doi: 10.1016/j.expneurol.2022.114100. Epub 2022 Apr 29. PMID: 35490721.

16: Chen X, Wei G, Li D, Fan Y, Zeng Y, Qian Z, Jia Z, Tang Y, Shi Y, Wu H, Li X. Sirtuin 1 alleviates microglia-induced inflammation by modulating the PGC-1α/Nrf2 pathway after traumatic brain injury in male rats. Brain Res Bull. 2022 Jul;185:28-38. doi: 10.1016/j.brainresbull.2022.04.012. Epub 2022 Apr 27. PMID: 35487384.

17: Jin P, Qi D, Cui Y, Lenahan C, Deng S, Tao X. Activation of LRP6 with HLY78 Attenuates Oxidative Stress and Neuronal Apoptosis via GSK3β/Sirt1/PGC-1α Pathway after ICH. Oxid Med Cell Longev. 2022 Apr 4;2022:7542468. doi: 10.1155/2022/7542468. PMID: 35419167; PMCID: PMC9001077.

18: Meng X, Zhang Y, Li Z, Hu J, Zhang D, Cao W, Li M, Ma G, Wang S, Cui P, Cai Q, Huang G. A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates cognitive deficits by enhancing brain glucose uptake via the activation of Akt/GLUT4 signaling in db/db mice. Phytother Res. 2022 Apr;36(4):1770-1784. doi: 10.1002/ptr.7413. Epub 2022 Feb 22. PMID: 35192202.

19: Mou KJ, Shen KF, Li YL, Wu ZF, Duan W. Adenosine A_2A Receptor in Bone Marrow-Derived Cells Mediated Macrophages M2 Polarization via PPARγ-P65 Pathway in Chronic Hypoperfusion Situation. Front Aging Neurosci. 2022 Jan 3;13:792733. doi: 10.3389/fnagi.2021.792733. PMID: 35046793; PMCID: PMC8761901.

20: Wu X, Liu X, Yang L, Wang Y. Berberine Protects against Neurological Impairments and Blood-Brain Barrier Injury in Mouse Model of Intracerebral Hemorrhage. Neuroimmunomodulation. 2021 Dec 23:1-10. doi: 10.1159/000520747. Epub ahead of print. PMID: 34942622.

21: Meng H, Sun LK, Su J, Yan WY, Jin Y, Luo X, Jiang XR, Wang HL. Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis. Hum Cell. 2022 Jan;35(1):63-82. doi: 10.1007/s13577-021-00610-3. Epub 2021 Nov 22. PMID: 34807408.

22: Jiang Q, Wei D, He X, Gan C, Long X, Zhang H. Phillyrin Prevents Neuroinflammation-Induced Blood-Brain Barrier Damage Following Traumatic Brain Injury via Altering Microglial Polarization. Front Pharmacol. 2021 Oct 20;12:719823. doi: 10.3389/fphar.2021.719823. PMID: 34744713; PMCID: PMC8565465.

23: Xie S, Jiang X, Doycheva DM, Shi H, Jin P, Gao L, Liu R, Xiao J, Hu X, Tang J, Zhang L, Zhang JH. Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic-ischemic injury in rats. J Neuroinflammation. 2021 Oct 13;18(1):226. doi: 10.1186/s12974-021-02289-7. PMID: 34645465; PMCID: PMC8513331.

24: Kasamo Y, Kikuchi K, Yamakuchi M, Otsuka S, Takada S, Kambe Y, Ito T, Kawahara KI, Arita K, Yoshimoto K, Maruyama I. 1,5-Anhydro-D-fructose Protects against Rotenone-Induced Neuronal Damage In Vitro through Mitochondrial Biogenesis. Int J Mol Sci. 2021 Sep 14;22(18):9941. doi: 10.3390/ijms22189941. PMID: 34576111; PMCID: PMC8466044.

25: Lu KY, Primus Dass KT, Lin SZ, Tseng YH, Liu SP, Harn HJ. N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Dec;1866(12):159033. doi: 10.1016/j.bbalip.2021.159033. Epub 2021 Sep 3. PMID: 34487913.

26: Zhang Y, Wang M, Ji C, Chen Z, Yang H, Wang L, Yu Y, Qiao N, Ma Z, Ye Z, Shao X, Liu W, Wang Y, Gong W, Melnikov V, Hu L, Lee EJ, Ye H, Wang Y, Li Y, He M, Zhao Y, Zhang Z. Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary neuroendocrine tumor and liver. iScience. 2021 Aug 14;24(9):102983. doi: 10.1016/j.isci.2021.102983. PMID: 34485865; PMCID: PMC8403734.

27: Nguyen TTT, Shang E, Shu C, Kim S, Mela A, Humala N, Mahajan A, Yang HW, Akman HO, Quinzii CM, Zhang G, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma. Nat Commun. 2021 Sep 1;12(1):5203. doi: 10.1038/s41467-021-25501-x. PMID: 34471141; PMCID: PMC8410792.

28: Sharma A, Tobar-Tosse F, Chand Dakal T, Liu H, Biswas A, Menon A, Paruchuri A, Katsonis P, Lichtarge O, Gromiha MM, Ludwig M, Schmidt-Wolf IGH, Holz FG, Loeffler KU, Herwig-Carl MC. PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ-DNMT1 Interactions in the Genome. Cancers (Basel). 2021 Aug 7;13(16):3993. doi: 10.3390/cancers13163993. PMID: 34439147; PMCID: PMC8391462.

29: Kearns KN, Ironside N, Park MS, Worrall BB, Southerland AM, Chen CJ, Ding D. Neuroprotective Therapies for Spontaneous Intracerebral Hemorrhage. Neurocrit Care. 2021 Dec;35(3):862-886. doi: 10.1007/s12028-021-01311-3. Epub 2021 Aug 2. PMID: 34341912.

30: Jo A, Lee Y, Kam TI, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jiang H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease. Sci Transl Med. 2021 Jul 28;13(604):eaax8891. doi: 10.1126/scitranslmed.aax8891. PMID: 34321320.

31: Pu H, Ma C, Zhao Y, Wang Y, Zhang W, Miao W, Yu F, Hu X, Shi Y, Leak RK, Hitchens TK, Dixon CE, Bennett MV, Chen J. Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury. J Cereb Blood Flow Metab. 2021 Nov;41(11):2870-2886. doi: 10.1177/0271678×211028680. Epub 2021 Jul 14. PMID: 34259069; PMCID: PMC8545055.

32: Li Z, Zhang Y, Zheng Y, Liu W, Zhang X, Li W, Zhang D, Cai Q, Wang S, Meng X, Huang G. Intranasal 15d-PGJ2 ameliorates brain glucose hypometabolism via PPARγ-dependent activation of PGC-1α/GLUT4 signalling in APP/PS1 transgenic mice. Neuropharmacology. 2021 Sep 15;196:108685. doi: 10.1016/j.neuropharm.2021.108685. Epub 2021 Jun 24. PMID: 34175325.

33: Xu C, Chen H, Zhou S, Sun C, Xia X, Peng Y, Zhuang J, Fu X, Zeng H, Zhou H, Cao Y, Yu Q, Li Y, Hu L, Zhou G, Yan F, Chen G, Li J. Pharmacological Activation of RXR-α Promotes Hematoma Absorption via a PPAR-γ-dependent Pathway After Intracerebral Hemorrhage. Neurosci Bull. 2021 Oct;37(10):1412-1426. doi: 10.1007/s12264-021-00735-3. Epub 2021 Jun 17. PMID: 34142331; PMCID: PMC8490551.

34: Liu Z, Meng Y, Miao Y, Yu L, Wei Q, Li Y, Zhang B, Yu Q. Propofol ameliorates renal ischemia/reperfusion injury by enhancing macrophage M2 polarization through PPARγ/STAT3 signaling. Aging (Albany NY). 2021 Jun 10;13(11):15511-15522. doi: 10.18632/aging.203107. Epub 2021 Jun 10. PMID: 34111028; PMCID: PMC8221315.

35: Zhou J, Yang Z, Shen R, Zhong W, Zheng H, Chen Z, Tang J, Zhu J. Resveratrol Improves Mitochondrial Biogenesis Function and Activates PGC-1α Pathway in a Preclinical Model of Early Brain Injury Following Subarachnoid Hemorrhage. Front Mol Biosci. 2021 Apr 22;8:620683. doi: 10.3389/fmolb.2021.620683. PMID: 33968980; PMCID: PMC8100450.

36: Arienti C, Pignatta S, Zanoni M, Zamagni A, Cortesi M, Sarnelli A, Romeo A, Arpa D, Longobardi P, Bartolini D, Tosatto L, Naldini A, Tesei A. High-pressure oxygen rewires glucose metabolism of patient-derived glioblastoma cells and fuels inflammasome response. Cancer Lett. 2021 May 28;506:152-166. doi: 10.1016/j.canlet.2021.02.019. Epub 2021 Feb 27. PMID: 33652086.

37: Zhang T, Li Z, Qin Z, Cao Y, Shan T, Fang Y, Tang L, Jia N, Jia J, Jin Z, Xu T, Li Y. Neuroprotection of Chikusetsu saponin V on transient focal cerebral ischemia/reperfusion and the underlying mechanism. Phytomedicine. 2021 Apr;84:153516. doi: 10.1016/j.phymed.2021.153516. Epub 2021 Feb 17. PMID: 33639592.

38: Fan H, Ding R, Liu W, Zhang X, Li R, Wei B, Su S, Jin F, Wei C, He X, Li X, Duan C. Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats. Redox Biol. 2021 Apr;40:101856. doi: 10.1016/j.redox.2021.101856. Epub 2021 Jan 6. PMID: 33472123; PMCID: PMC7816003.

39: Ye Z, Hu J, Xu H, Sun B, Jin Y, Zhang Y, Zhang J. Serum Exosomal microRNA-27-3p Aggravates Cerebral Injury and Inflammation in Patients with Acute Cerebral Infarction by Targeting PPARγ. Inflammation. 2021 Jun;44(3):1035-1048. doi: 10.1007/s10753-020-01399-3. Epub 2021 Jan 4. Erratum in: Inflammation. 2022 Jul 27;: PMID: 33394189.

40: Xu W, Yan J, Ocak U, Lenahan C, Shao A, Tang J, Zhang J, Zhang JH. Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats. Theranostics. 2021 Jan 1;11(2):522-539. doi: 10.7150/thno.49426. PMID: 33391490; PMCID: PMC7738864.

41: Xie L, Wang Y, Chen Z. LncRNA Blnc1 mediates the permeability and inflammatory response of cerebral hemorrhage by regulating the PPAR-γ/SIRT6/FoxO3 pathway. Life Sci. 2021 Feb 15;267:118942. doi: 10.1016/j.lfs.2020.118942. Epub 2020 Dec 29. PMID: 33359247.

42: Cui W, Wu X, Shi Y, Guo W, Luo J, Liu H, Zheng L, Du Y, Wang P, Wang Q, Feng D, Ge S, Qu Y. 20-HETE synthesis inhibition attenuates traumatic brain injury- induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study. Cell Prolif. 2021 Feb;54(2):e12964. doi: 10.1111/cpr.12964. Epub 2020 Dec 13. PMID: 33314534; PMCID: PMC7848954.

43: Hasegawa H, Yatomi K, Mitome-Mishima Y, Miyamoto N, Tanaka R, Oishi H, Arai H, Hattori N, Urabe T. Pioglitazone Prevents Hemorrhagic Infarction After Transient Focal Ischemia in Type 2 Diabetes. Neurosci Res. 2021 Sep;170:314-321. doi: 10.1016/j.neures.2020.09.004. Epub 2020 Dec 11. PMID: 33309864.

44: Keledjian K, Tsymbalyuk O, Semick S, Moyer M, Negoita S, Kim K, Ivanova S, Gerzanich V, Simard JM. The peroxisome proliferator-activated receptor gamma (PPARγ) agonist, rosiglitazone, ameliorates neurofunctional and neuroinflammatory abnormalities in a rat model of Gulf War Illness. PLoS One. 2020 Nov 13;15(11):e0242427. doi: 10.1371/journal.pone.0242427. PMID: 33186383; PMCID: PMC7665704.

45: Kim H, Lee JE, Yoo HJ, Sung JH, Yang SH. Effect of Pioglitazone on Perihematomal Edema in Intracerebral Hemorrhage Mouse Model by Regulating NLRP3 Expression and Energy Metabolism. J Korean Neurosurg Soc. 2020 Nov;63(6):689-697. doi: 10.3340/jkns.2020.0056. Epub 2020 Oct 27. PMID: 33105536; PMCID: PMC7671775.

46: Wang G, Wu B, Zhang L, Cui Y, Zhang B, Wang H. Laquinimod Prevents Adipogenesis and Obesity by Down-Regulating PPAR-γ and C/EBPα through Activating AMPK. ACS Omega. 2020 Sep 1;5(36):22958-22965. doi: 10.1021/acsomega.0c02525. PMID: 32954145; PMCID: PMC7495734.

47: Zhao JL, Wei C, Xiao X, Dong YH, Tan B, Yu J, Chen G, Yuan Q, Du ZY, Sun YR, Hu J, Xie R. Expression of TNF‑α and IL‑β can be suppressed via the PPAR‑γ/mTOR signaling pathway in BV‑2 microglia: A potential anti‑inflammation mechanism. Mol Med Rep. 2020 Oct;22(4):3559-3565. doi: 10.3892/mmr.2020.11418. Epub 2020 Aug 5. PMID: 32945426.

48: Zhuang J, Peng Y, Gu C, Chen H, Lin Z, Zhou H, Wu X, Li J, Yu X, Cao Y, Zeng H, Fu X, Xu C, Huang P, Cao S, Wang C, Yan F, Chen G. Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage. Transl Stroke Res. 2021 Aug;12(4):660-675. doi: 10.1007/s12975-020-00842-9. Epub 2020 Sep 12. PMID: 32918259.

49: He J, Huang Y, Liu H, Sun X, Wu J, Zhang Z, Liu L, Zhou C, Jiang S, Huang Z, Zhong J, Guo Z, Jiang L, Cheng C. Bexarotene promotes microglia/macrophages - Specific brain - Derived Neurotrophic factor expression and axon sprouting after traumatic brain injury. Exp Neurol. 2020 Dec;334:113462. doi: 10.1016/j.expneurol.2020.113462. Epub 2020 Sep 9. PMID: 32916173.

50: Wang D, Liu F, Zhu L, Lin P, Han F, Wang X, Tan X, Lin L, Xiong Y. FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. J Neuroinflammation. 2020 Aug 31;17(1):257. doi: 10.1186/s12974-020-01921-2. PMID: 32867781; PMCID: PMC7457364.

51: Vogas RS, Pereira MTM, Duarte LS, Carneiro MJ, Farsura AF, Machado JAMM, Costa IF, TomÉ MRN, Milton FA, Neves FAR, Andreo MA, Lopez BG, Sawaya ACHF, Pascoal VDB, Pascoal ACRF. Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity. An Acad Bras Cienc. 2020;92(2):e20191201. doi: 10.1590/0001-3765202020191201. Epub 2020 Aug 12. PMID: 32813866.

52: Gamdzyk M, Lenahan C, Tang J, Zhang JH. Role of peroxisome proliferator- activated receptors in stroke prevention and therapy-The best is yet to come? J Neurosci Res. 2020 Nov;98(11):2275-2289. doi: 10.1002/jnr.24709. Epub 2020 Aug 9. PMID: 32772463.

53: Pu H, Zheng X, Jiang X, Mu H, Xu F, Zhu W, Ye Q, Jizhang Y, Hitchens TK, Shi Y, Hu X, Leak RK, Dixon CE, Bennett MV, Chen J. Interleukin-4 improves white matter integrity and functional recovery after murine traumatic brain injury via oligodendroglial PPARγ. J Cereb Blood Flow Metab. 2021 Mar;41(3):511-529. doi: 10.1177/0271678×20941393. Epub 2020 Aug 5. PMID: 32757740; PMCID: PMC7922743.

54: Tansriratanawong K, Tabei I, Ishikawa H, Ohyama A, Toyomura J, Sato S. Characterization and comparative DNA methylation profiling of four adipogenic genes in adipose-derived stem cells and dedifferentiated fat cells from aging subjects. Hum Cell. 2020 Oct;33(4):974-989. doi: 10.1007/s13577-020-00379-x. Epub 2020 Jun 3. PMID: 32495194; PMCID: PMC7505878.

55: Metzger JM, Lopez MS, Schmidt JK, Murphy ME, Vemuganti R, Emborg ME. Effects of Cardiac Sympathetic Neurodegeneration and PPARγ Activation on Rhesus Macaque Whole Blood MicroRNA and mRNA Expression Profiles. Biomed Res Int. 2020 May 2;2020:9426204. doi: 10.1155/2020/9426204. PMID: 32462037; PMCID: PMC7212295.

56: Zhang K, Cheng H, Song L, Wei W. Inhibition of the Peroxisome Proliferator- Activated Receptor gamma Coactivator 1-alpha (PGC-1α)/Sirtuin 3 (SIRT3) Pathway Aggravates Oxidative Stress After Experimental Subarachnoid Hemorrhage. Med Sci Monit. 2020 May 24;26:e923688. doi: 10.12659/MSM.923688. PMID: 32447338; PMCID: PMC7266085.

57: Meyer Zu Reckendorf S, Brand C, Pedro MT, Hegler J, Schilling CS, Lerner R, Bindila L, Antoniadis G, Knöll B. Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury. Nat Commun. 2020 May 1;11(1):2123. doi: 10.1038/s41467-020-15915-4. PMID: 32358558; PMCID: PMC7195462.

58: Nguyen TTT, Zhang Y, Shang E, Shu C, Torrini C, Zhao J, Bianchetti E, Mela A, Humala N, Mahajan A, Harmanci AO, Lei Z, Maienschein-Cline M, Quinzii CM, Westhoff MA, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models. J Clin Invest. 2020 Jul 1;130(7):3699-3716. doi: 10.1172/JCI129049. PMID: 32315286; PMCID: PMC7324177.

59: Hua TNM, Oh J, Kim S, Antonio JM, Vo VTA, Om J, Choi JW, Kim JY, Jung CW, Park MJ, Jeong Y. Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients. Exp Mol Med. 2020 Apr;52(4):629-642. doi: 10.1038/s12276-020-0413-1. Epub 2020 Apr 13. PMID: 32280134; PMCID: PMC7210935.

60: Sui X, Yoshioka H, Wakai T, Fukumoto Y, Kinouchi H. Neuroprotective effects of peroxisome proliferator-activated receptor γ agonist through activation of Akt and signal transducers and activators of transcription 3 in transient forebrain ischemia. Neuroreport. 2020 Apr 8;31(6):484-489. doi: 10.1097/WNR.0000000000001434. PMID: 32243355.

61: Deng Y, Jiang X, Deng X, Chen H, Xu J, Zhang Z, Liu G, Yong Z, Yuan C, Sun X, Wang C. Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPARγ/NF-κB/IL-6 signaling pathway. Genes Dis. 2019 Jun 6;7(2):253-265. doi: 10.1016/j.gendis.2019.05.002. PMID: 32215295; PMCID: PMC7083749.

62: Castel D, Kergrohen T, Tauziède-Espariat A, Mackay A, Ghermaoui S, Lechapt E, Pfister SM, Kramm CM, Boddaert N, Blauwblomme T, Puget S, Beccaria K, Jones C, Jones DTW, Varlet P, Grill J, Debily MA. Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation. Acta Neuropathol. 2020 Jun;139(6):1109-1113. doi: 10.1007/s00401-020-02142-w. Epub 2020 Mar 19. PMID: 32193787.

63: Zhao JL, Chen YJ, Yu J, Du ZY, Yuan Q, Sun YR, Wu X, Li ZQ, Wu XH, Hu J, Xie R. ISO-alpha-acids improve the hematoma resolution and prevent peri-hematoma inflammations by transforming microglia via PPARgamma-CD36 axis in ICH rats. Int Immunopharmacol. 2020 Jun;83:106396. doi: 10.1016/j.intimp.2020.106396. Epub 2020 Mar 16. PMID: 32193103.

64: Chen D, Wang X, Huang J, Cui S, Zhang L. CDKN1B Mediates Apoptosis of Neuronal Cells and Inflammation Induced by Oxyhemoglobin via miR-502-5p After Subarachnoid Hemorrhage. J Mol Neurosci. 2020 Jul;70(7):1073-1080. doi: 10.1007/s12031-020-01512-z. Epub 2020 Mar 9. PMID: 32152938.

65: Jiang Y, Lin L, Liu N, Wang Q, Yuan J, Li Y, Chung KK, Guo S, Yu Z, Wang X. FGF21 Protects against Aggravated Blood-Brain Barrier Disruption after Ischemic Focal Stroke in Diabetic db/db Male Mice via Cerebrovascular PPARγ Activation. Int J Mol Sci. 2020 Jan 28;21(3):824. doi: 10.3390/ijms21030824. PMID: 32012810; PMCID: PMC7037567.

66: Jiang Q, Chen J, Long X, Yao X, Zou X, Yang Y, Huang G, Zhang H. Phillyrin protects mice from traumatic brain injury by inhibiting the inflammation of microglia via PPARγ signaling pathway. Int Immunopharmacol. 2020 Feb;79:106083. doi: 10.1016/j.intimp.2019.106083. Epub 2020 Jan 7. PMID: 31923823.

67: Wu X, Luo J, Liu H, Cui W, Guo W, Zhao L, Guo H, Bai H, Guo K, Feng D, Qu Y. Recombinant adiponectin peptide promotes neuronal survival after intracerebral haemorrhage by suppressing mitochondrial and ATF4-CHOP apoptosis pathways in diabetic mice via Smad3 signalling inhibition. Cell Prolif. 2020 Feb;53(2):e12759. doi: 10.1111/cpr.12759. Epub 2020 Jan 10. PMID: 31922310; PMCID: PMC7048203.

68: Kao YC, Wei WY, Tsai KJ, Wang LC. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. Int J Mol Sci. 2019 Dec 27;21(1):207. doi: 10.3390/ijms21010207. PMID: 31892244; PMCID: PMC6981702.

69: Jiang B, Wang H, Xu H. Steroid receptor RNA activator affects the development of poststroke depression by regulating the peroxisome proliferator- activated receptor γ signaling pathway. Neuroreport. 2020 Jan 8;31(1):48-56. doi: 10.1097/WNR.0000000000001367. PMID: 31714481; PMCID: PMC6903361.

70: Qu X, Wang N, Chen W, Qi M, Xue Y, Cheng W. RNF34 overexpression exacerbates neurological deficits and brain injury in a mouse model of intracerebral hemorrhage by potentiating mitochondrial dysfunction-mediated oxidative stress. Sci Rep. 2019 Nov 8;9(1):16296. doi: 10.1038/s41598-019-52494-x. PMID: 31704983; PMCID: PMC6841714.

71: Zhang Y, Nguyen TTT, Shang E, Mela A, Humala N, Mahajan A, Zhao J, Shu C, Torrini C, Sanchez-Quintero MJ, Kleiner G, Bianchetti E, Westhoff MA, Quinzii CM, Karpel-Massler G, Bruce JN, Canoll P, Siegelin MD. MET Inhibition Elicits PGC1α-Dependent Metabolic Reprogramming in Glioblastoma. Cancer Res. 2020 Jan 1;80(1):30-43. doi: 10.1158/0008-5472.CAN-19-1389. Epub 2019 Nov 6. PMID: 31694905; PMCID: PMC6942623.

72: Chen TH, Tsai MJ, Fu YS, Weng CF. The Exploration of Natural Compounds for Anti-Diabetes from Distinctive Species Garcinia linii with Comprehensive Review of the Garcinia Family. Biomolecules. 2019 Oct 23;9(11):641. doi: 10.3390/biom9110641. PMID: 31652794; PMCID: PMC6920772.

73: Yu JL, Jin Y, Cao XY, Gu HH. Dexmedetomidine alleviates doxorubicin cardiotoxicity by inhibiting mitochondrial reactive oxygen species generation. Hum Cell. 2020 Jan;33(1):47-56. doi: 10.1007/s13577-019-00282-0. Epub 2019 Oct 23. PMID: 31643023.

74: Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Mol Cell. 2019 Dec 19;76(6):885-895.e7. doi: 10.1016/j.molcel.2019.09.019. Epub 2019 Oct 16. PMID: 31629659.

75: Halstead MR, Geocadin RG. The Medical Management of Cerebral Edema: Past, Present, and Future Therapies. Neurotherapeutics. 2019 Oct;16(4):1133-1148. doi: 10.1007/s13311-019-00779-4. PMID: 31512062; PMCID: PMC6985348.

76: Kim HG, Heo H, Sung MS, Park SW. Carnosine decreases retinal ganglion cell death in a mouse model of optic nerve crushing. Neurosci Lett. 2019 Oct 15;711:134431. doi: 10.1016/j.neulet.2019.134431. Epub 2019 Aug 12. PMID: 31415801.

77: Zhang Q, Lei YH, Zhou JP, Hou YY, Wan Z, Wang HL, Meng H. Role of PGC-1α in Mitochondrial Quality Control in Neurodegenerative Diseases. Neurochem Res. 2019 Sep;44(9):2031-2043. doi: 10.1007/s11064-019-02858-6. Epub 2019 Aug 13. PMID: 31410709.

78: Zhao X, Wei Z, Li D, Yang Z, Tian M, Kang P. Glucocorticoid Enhanced the Expression of Ski in Osteonecrosis of Femoral Head: The Effect on Adipogenesis of Rabbit BMSCs. Calcif Tissue Int. 2019 Nov;105(5):506-517. doi: 10.1007/s00223-019-00592-3. Epub 2019 Jul 30. PMID: 31359074.

79: Chuang YC, Chen SD, Jou SB, Lin TK, Chen SF, Chen NC, Hsu CY. Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus. Int J Mol Sci. 2019 Jul 23;20(14):3588. doi: 10.3390/ijms20143588. PMID: 31340436; PMCID: PMC6678762.

80: Huang J, Liu W, Doycheva DM, Gamdzyk M, Lu W, Tang J, Zhang JH. Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE. Free Radic Biol Med. 2019 Sep;141:322-337. doi: 10.1016/j.freeradbiomed.2019.07.001. Epub 2019 Jul 3. PMID: 31279091; PMCID: PMC6718314.

81: Zhang Z, Zhao G, Liu L, He J, Darwazeh R, Liu H, Chen H, Zhou C, Guo Z, Sun X. Bexarotene Exerts Protective Effects Through Modulation of the Cerebral Vascular Smooth Muscle Cell Phenotypic Transformation by Regulating PPARγ/FLAP/LTB₄ After Subarachnoid Hemorrhage in Rats. Cell Transplant. 2019 Sep-Oct;28(9-10):1161-1172. doi: 10.1177/0963689719842161. Epub 2019 Apr 22. PMID: 31010302; PMCID: PMC6767892.

82: Yu J, Zheng J, Lu J, Sun Z, Wang Z, Zhang J. AdipoRon Protects Against Secondary Brain Injury After Intracerebral Hemorrhage via Alleviating Mitochondrial Dysfunction: Possible Involvement of AdipoR1-AMPK-PGC1α Pathway. Neurochem Res. 2019 Jul;44(7):1678-1689. doi: 10.1007/s11064-019-02794-5. Epub 2019 Apr 13. PMID: 30982205.

83: Zhang WL, Chi CT, Meng XH, Liang SD. MicroRNA‑15a‑5p facilitates the bone marrow stem cell apoptosis of femoral head necrosis through the Wnt/β‑catenin/PPARγ signaling pathway. Mol Med Rep. 2019 Jun;19(6):4779-4787. doi: 10.3892/mmr.2019.10130. Epub 2019 Apr 4. PMID: 30957181; PMCID: PMC6522831.

84: Zuo Y, Huang L, Enkhjargal B, Xu W, Umut O, Travis ZD, Zhang G, Tang J, Liu F, Zhang JH. Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats. J Neuroinflammation. 2019 Feb 21;16(1):47. doi: 10.1186/s12974-019-1432-5. PMID: 30791908; PMCID: PMC6385420.

85: Xu H, Sun L, He Y, Yuan X, Niu J, Su J, Li D. Deficiency in IL-33/ST2 Axis Reshapes Mitochondrial Metabolism in Lipopolysaccharide-Stimulated Macrophages. Front Immunol. 2019 Feb 1;10:127. doi: 10.3389/fimmu.2019.00127. PMID: 30774633; PMCID: PMC6367255.

86: Wang Y, Bao DJ, Xu B, Cheng CD, Dong YF, Wei XP, Niu CS. Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage. Neural Regen Res. 2019 Jun;14(6):1013-1024. doi: 10.4103/1673-5374.250620. PMID: 30762013; PMCID: PMC6404485.

87: Wu Y, Wang L, Hu K, Yu C, Zhu Y, Zhang S, Shao A. Mechanisms and Therapeutic Targets of Depression After Intracerebral Hemorrhage. Front Psychiatry. 2018 Dec 17;9:682. doi: 10.3389/fpsyt.2018.00682. PMID: 30618863; PMCID: PMC6304443.

88: Chen J, Xuan Y, Chen Y, Wu T, Chen L, Guan H, Yang S, He J, Shi D, Wang Y. Netrin-1 alleviates subarachnoid haemorrhage-induced brain injury via the PPARγ/NF-KB signalling pathway. J Cell Mol Med. 2019 Mar;23(3):2256-2262. doi: 10.1111/jcmm.14105. Epub 2019 Jan 7. PMID: 30614619; PMCID: PMC6378208.

89: Yao X, Jiang Q, Ding W, Yue P, Wang J, Zhao K, Zhang H. Interleukin 4 inhibits high mobility group box-1 protein-mediated NLRP3 inflammasome formation by activating peroxisome proliferator-activated receptor-γ in astrocytes. Biochem Biophys Res Commun. 2019 Feb 5;509(2):624-631. doi: 10.1016/j.bbrc.2018.11.145. Epub 2018 Dec 31. PMID: 30606476.

90: Jiang Y, Liu N, Wang Q, Yu Z, Lin L, Yuan J, Guo S, Ahn BJ, Wang XJ, Li X, Lo EH, Sun X, Wang X. Endocrine Regulator rFGF21 (Recombinant Human Fibroblast Growth Factor 21) Improves Neurological Outcomes Following Focal Ischemic Stroke of Type 2 Diabetes Mellitus Male Mice. Stroke. 2018 Dec;49(12):3039-3049. doi: 10.1161/STROKEAHA.118.022119. PMID: 30571410; PMCID: PMC6310061.

91: Wang JS, Xiao WW, Zhong YS, Li XD, Du SX, Xie P, Zheng GZ, Han JM. Galectin-3 deficiency protects lipopolysaccharide-induced chondrocytes injury via regulation of TLR4 and PPAR-γ-mediated NF-κB signaling pathway. J Cell Biochem. 2019 Jun;120(6):10195-10204. doi: 10.1002/jcb.28304. Epub 2018 Dec 19. PMID: 30565728.

92: Zhao Y, Wei X, Song J, Zhang M, Huang T, Qin J. Peroxisome Proliferator- Activated Receptor γ Agonist Rosiglitazone Protects Blood-Brain Barrier Integrity Following Diffuse Axonal Injury by Decreasing the Levels of Inflammatory Mediators Through a Caveolin-1-Dependent Pathway. Inflammation. 2019 Jun;42(3):841-856. doi: 10.1007/s10753-018-0940-2. PMID: 30488141.

93: Li F, Wang X, Deng Z, Zhang X, Gao P, Liu H. Dexmedetomidine reduces oxidative stress and provides neuroprotection in a model of traumatic brain injury via the PGC-1α signaling pathway. Neuropeptides. 2018 Dec;72:58-64. doi: 10.1016/j.npep.2018.10.004. Epub 2018 Nov 2. PMID: 30396595.

94: Ma L, Niu W, Lv J, Jia J, Zhu M, Yang S. PGC-1α-Mediated Mitochondrial Biogenesis is Involved in Cannabinoid Receptor 2 Agonist AM1241-Induced Microglial Phenotype Amelioration. Cell Mol Neurobiol. 2018 Nov;38(8):1529-1537. doi: 10.1007/s10571-018-0628-z. Epub 2018 Oct 12. PMID: 30315387.

95: Liang W, Li X, Li G, Hu L, Ding S, Kang J, Shen J, Li C, Asakawa T. Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats. Evid Based Complement Alternat Med. 2018 Aug 26;2018:9210490. doi: 10.1155/2018/9210490. PMID: 30224934; PMCID: PMC6129318.

96: Chen Z, Tao S, Li X, Yao Q. Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/ NRF1/TFAM signaling pathway. Biochem Biophys Res Commun. 2018 Sep 26;504(1):13-18. doi: 10.1016/j.bbrc.2018.08.027. Epub 2018 Aug 29. PMID: 30172371.

97: Cui J, Wang G, Kandhare AD, Mukherjee-Kandhare AA, Bodhankar SL. Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid- induced neurotoxicity: Possible role of PPAR-γ, Bax/Bcl-2, and caspase-3. Food Chem Toxicol. 2018 Nov;121:95-108. doi: 10.1016/j.fct.2018.08.028. Epub 2018 Aug 18. PMID: 30130594.

98: Perez M, Cartarozzi LP, Chiarotto GB, Oliveira SA, Guimarães FS, Oliveira ALR. Neuronal preservation and reactive gliosis attenuation following neonatal sciatic nerve axotomy by a fluorinated cannabidiol derivative. Neuropharmacology. 2018 Sep 15;140:201-208. doi: 10.1016/j.neuropharm.2018.08.009. Epub 2018 Aug 7. PMID: 30096328.

99: Flück M, Valdivieso P, Ruoss S, von Rechenberg B, Benn MC, Meyer DC, Wieser K, Gerber C. Neurectomy preserves fast fibers when combined with tenotomy of infraspinatus muscle via upregulation of myogenesis. Muscle Nerve. 2019 Jan;59(1):100-107. doi: 10.1002/mus.26316. Epub 2018 Dec 4. PMID: 30073680.

100: Meel MH, de Gooijer MC, Guillén Navarro M, Waranecki P, Breur M, Buil LCM, Wedekind LE, Twisk JWR, Koster J, Hashizume R, Raabe EH, Montero Carcaboso A, Bugiani M, van Tellingen O, van Vuurden DG, Kaspers GJL, Hulleman E. MELK Inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res. 2018 Nov 15;24(22):5645-5657. doi: 10.1158/1078-0432.CCR-18-0924. Epub 2018 Jul 30. PMID: 30061363.

101: Zhong WB, Tsai YC, Chin LH, Tseng JH, Tang LW, Horng S, Fan YC, Hsu SP. A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model. Int J Mol Sci. 2018 Jun 22;19(7):1834. doi: 10.3390/ijms19071834. PMID: 29932104; PMCID: PMC6073567.

102: He J, Liu H, Zhong J, Guo Z, Wu J, Zhang H, Huang Z, Jiang L, Li H, Zhang Z, Liu L, Wu Y, Qi L, Sun X, Cheng C. Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury. Neurobiol Dis. 2018 Sep;117:114-124. doi: 10.1016/j.nbd.2018.06.003. Epub 2018 Jun 7. PMID: 29886067.

103: Qiao H, Zhou Y, Qin X, Cheng J, He Y, Jiang Y. NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation. Stem Cells Int. 2018 May 10;2018:1239143. doi: 10.1155/2018/1239143. PMID: 29861737; PMCID: PMC5971305.

104: Xi Y, Feng D, Tao K, Wang R, Shi Y, Qin H, Murphy MP, Yang Q, Zhao G. MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α. Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2859-2870. doi: 10.1016/j.bbadis.2018.05.018. Epub 2018 May 26. PMID: 29842922.

105: Li Q, Zhu Z, Wang C, Cai L, Lu J, Wang Y, Xu J, Su Z, Zheng W, Chen X. CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells. Int J Mol Med. 2018 Aug;42(2):1054-1063. doi: 10.3892/ijmm.2018.3666. Epub 2018 May 9. PMID: 29749459.

106: Wen L, You W, Wang H, Meng Y, Feng J, Yang X. Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice. J Neurotrauma. 2018 Oct 1;35(19):2330-2340. doi: 10.1089/neu.2017.5540. Epub 2018 Jun 7. PMID: 29649924.

107: Ren T, Yang WS, Lin Y, Liu JF, Li Y, Yang LC, Zeng KY, Peng L, Liu YJ, Ye ZH, Luo XM, Ke YJ, Diao Y, Jin X. A novel PPARα/γ agonist, propane-2-sulfonic acid octadec-9-enyl-amide, ameliorates insulin resistance and gluconeogenesis in vivo and vitro. Eur J Pharmacol. 2018 May 5;826:1-8. doi: 10.1016/j.ejphar.2018.02.029. Epub 2018 Feb 22. PMID: 29476879.

108: Liu Y, Shi L, Liu Y, Li P, Jiang G, Gao X, Zhang Y, Jiang C, Zhu W, Han H, Ju F. Activation of PPARγ mediates icaritin-induced cell cycle arrest and apoptosis in glioblastoma multiforme. Biomed Pharmacother. 2018 Apr;100:358-366. doi: 10.1016/j.biopha.2018.02.006. Epub 2018 Feb 16. PMID: 29453045.

109: Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y. Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. Nat Commun. 2018 Feb 8;9(1):559. doi: 10.1038/s41467-018-03050-0. PMID: 29422647; PMCID: PMC5805734.

110: Liu M, Yang W, Liu S, Hock D, Zhang B, Huo RY, Tong X, Yan H. LXRα is expressed at higher levels in healthy people compared to atherosclerosis patients and its over-expression polarizes macrophages towards an anti- inflammatory MΦ2 phenotype. Clin Exp Hypertens. 2018;40(3):213-217. doi: 10.1080/10641963.2017.1288740. Epub 2018 Feb 8. PMID: 29420090.

111: Li X, Wang H, Wen G, Li L, Gao Y, Zhuang Z, Zhou M, Mao L, Fan Y. Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC-1α pathway as a potential mechanism. J Cell Mol Med. 2018 Feb;22(2):883-891. doi: 10.1111/jcmm.13313. Epub 2017 Dec 4. PMID: 29205806; PMCID: PMC5783850.

112: Xu J, Lv S, Hou Y, Xu K, Sun D, Zheng Y, Zhang Z, Li X, Li Y, Chi G. miR-27b promotes type II collagen expression by targetting peroxisome proliferator-activated receptor-γ2 during rat articular chondrocyte differentiation. Biosci Rep. 2018 Jan 10;38(1):BSR20171109. doi: 10.1042/BSR20171109. PMID: 29187585; PMCID: PMC6435457.

113: Xie Z, Huang L, Enkhjargal B, Reis C, Wan W, Tang J, Cheng Y, Zhang JH. Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. Brain Behav Immun. 2018 Mar;69:190-202. doi: 10.1016/j.bbi.2017.11.012. Epub 2017 Nov 21. PMID: 29162556; PMCID: PMC5894358.

114: Kinouchi T, Kitazato KT, Shimada K, Yagi K, Tada Y, Matsushita N, Kurashiki Y, Satomi J, Sata M, Nagahiro S. Treatment with the PPARγ Agonist Pioglitazone in the Early Post-ischemia Phase Inhibits Pro-inflammatory Responses and Promotes Neurogenesis Via the Activation of Innate- and Bone Marrow-Derived Stem Cells in Rats. Transl Stroke Res. 2018 Jun;9(3):306-316. doi: 10.1007/s12975-017-0577-8. Epub 2017 Nov 6. Erratum in: Transl Stroke Res. 2017 Nov 26;: PMID: 29110250; PMCID: PMC5982463.

115: Stouth DW, Manta A, Ljubicic V. Protein arginine methyltransferase expression, localization, and activity during disuse-induced skeletal muscle plasticity. Am J Physiol Cell Physiol. 2018 Feb 1;314(2):C177-C190. doi: 10.1152/ajpcell.00174.2017. Epub 2017 Nov 1. PMID: 29092819; PMCID: PMC5866438.

116: Wang Y, Chen Q, Tan Q, Feng Z, He Z, Tang J, Feng H, Zhu G, Chen Z. Simvastatin accelerates hematoma resolution after intracerebral hemorrhage in a PPARγ-dependent manner. Neuropharmacology. 2018 Jan;128:244-254. doi: 10.1016/j.neuropharm.2017.10.021. Epub 2017 Oct 17. PMID: 29054366.

117: Jiménez-Maldonado A, Ying Z, Byun HR, Gomez-Pinilla F. Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome. Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):24-33. doi: 10.1016/j.bbadis.2017.10.012. Epub 2017 Oct 7. PMID: 29017895; PMCID: PMC5705281.

118: Fan J, Pi-Anfruns J, Guo M, Im DCS, Cui ZK, Kim S, Wu BM, Aghaloo TL, Lee M. Small molecule-mediated tribbles homolog 3 promotes bone formation induced by bone morphogenetic protein-2. Sci Rep. 2017 Aug 8;7(1):7518. doi: 10.1038/s41598-017-07932-z. PMID: 28790361; PMCID: PMC5548928.

119: Xu J, Sun M, Tan Y, Wang H, Wang H, Li P, Xu Z, Xia Y, Li L, Li Y. Effect of matrix stiffness on the proliferation and differentiation of umbilical cord mesenchymal stem cells. Differentiation. 2017 Jul-Aug;96:30-39. doi: 10.1016/j.diff.2017.07.001. Epub 2017 Jul 21. PMID: 28753444.

120: Li Y, Xu L, Zeng K, Xu Z, Suo D, Peng L, Ren T, Sun Z, Yang W, Jin X, Yang L. Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, protects against ischemia-induced brain damage in mice by inhibiting inflammatory responses. Brain Behav Immun. 2017 Nov;66:289-301. doi: 10.1016/j.bbi.2017.07.015. Epub 2017 Jul 21. PMID: 28736035.

121: Khabbush A, Orford M, Tsai YC, Rutherford T, O'Donnell M, Eaton S, Heales SJR. Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet. Epilepsia. 2017 Aug;58(8):1423-1429. doi: 10.1111/epi.13833. Epub 2017 Jul 6. PMID: 28682459.

122: Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH. Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget. 2017 Jul 25;8(30):48603-48618. doi: 10.18632/oncotarget.18122. PMID: 28611284; PMCID: PMC5564711.

123: Cho SY, Kim SH, Yi MH, Zhang E, Kim E, Park J, Jo EK, Lee YH, Park MS, Kim Y, Park J, Kim DW. Expression of PGC1α in glioblastoma multiforme patients. Oncol Lett. 2017 Jun;13(6):4055-4076. doi: 10.3892/ol.2017.5972. Epub 2017 Apr 3. PMID: 28599408; PMCID: PMC5453058.

124: Kesanakurti D, Maddirela D, Banasavadi-Siddegowda YK, Lai TH, Qamri Z, Jacob NK, Sampath D, Mohanam S, Kaur B, Puduvalli VK. A novel interaction of PAK4 with PPARγ to regulate Nox1 and radiation-induced epithelial-to-mesenchymal transition in glioma. Oncogene. 2017 Sep 14;36(37):5309-5320. doi: 10.1038/onc.2016.261. Epub 2017 May 22. PMID: 28534509; PMCID: PMC5599308.

125: Shih CT, Chang YF, Chen YT, Ma CP, Chen HW, Yang CC, Lu JC, Tsai YS, Chen HC, Tan BC. The PPARγ-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence. Aging Cell. 2017 Aug;16(4):797-813. doi: 10.1111/acel.12607. Epub 2017 May 17. PMID: 28514051; PMCID: PMC5506440.

126: Li P, Wang X, Shan Q, Wu Y, Wang Z. MicroRNA-130b promotes cell migration and invasion by inhibiting peroxisome proliferator-activated receptor-γ in human glioma. Oncol Lett. 2017 Apr;13(4):2615-2622. doi: 10.3892/ol.2017.5760. Epub 2017 Feb 22. PMID: 28454441; PMCID: PMC5403186.

127: Yuan J, Ge H, Liu W, Zhu H, Chen Y, Zhang X, Yang Y, Yin Y, Chen W, Wu W, Yang Y, Lin J. M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway. Oncotarget. 2017 Mar 21;8(12):19855-19865. doi: 10.18632/oncotarget.15774. PMID: 28423639; PMCID: PMC5386728.

128: Li PA, Hou X, Hao S. Mitochondrial biogenesis in neurodegeneration. J Neurosci Res. 2017 Oct;95(10):2025-2029. doi: 10.1002/jnr.24042. Epub 2017 Mar 16. PMID: 28301064.

129: Xing F, Luan Y, Cai J, Wu S, Mai J, Gu J, Zhang H, Li K, Lin Y, Xiao X, Liang J, Li Y, Chen W, Tan Y, Sheng L, Lu B, Lu W, Gao M, Qiu P, Su X, Yin W, Hu J, Chen Z, Sai K, Wang J, Chen F, Chen Y, Zhu S, Liu D, Cheng S, Xie Z, Zhu W, Yan G. The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes. Cell Rep. 2017 Jan 10;18(2):468-481. doi: 10.1016/j.celrep.2016.12.037. Erratum in: Cell Rep. 2018 May 29;23(9):2832-2833. PMID: 28076790; PMCID: PMC5926788.

130: Yue L, Zhao L, Liu H, Li X, Wang B, Guo H, Gao L, Feng D, Qu Y. Adiponectin Protects against Glutamate-Induced Excitotoxicity via Activating SIRT1-Dependent PGC-1α Expression in HT22 Hippocampal Neurons. Oxid Med Cell Longev. 2016;2016:2957354. doi: 10.1155/2016/2957354. Epub 2016 Nov 30. PMID: 28042384; PMCID: PMC5155107.

131: Golko-Perez S, Amit T, Bar-Am O, Youdim MB, Weinreb O. A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1^G93A ALS Mice. Neurotox Res. 2017 Feb;31(2):230-244. doi: 10.1007/s12640-016-9677-6. Epub 2016 Nov 8. PMID: 27826939.

132: de la Monte SM, Tong M, Schiano I, Didsbury J. Improved Brain Insulin/IGF Signaling and Reduced Neuroinflammation with T3D-959 in an Experimental Model of Sporadic Alzheimer's Disease. J Alzheimers Dis. 2017;55(2):849-864. doi: 10.3233/JAD-160656. PMID: 27802237; PMCID: PMC5575806.

133: Müller SH, Girard SL, Hopfner F, Merner ND, Bourassa CV, Lorenz D, Clark LN, Tittmann L, Soto-Ortolaza AI, Klebe S, Hallett M, Schneider SA, Hodgkinson CA, Lieb W, Wszolek ZK, Pendziwiat M, Lorenzo-Betancor O, Poewe W, Ortega-Cubero S, Seppi K, Rajput A, Hussl A, Rajput AH, Berg D, Dion PA, Wurster I, Shulman JM, Srulijes K, Haubenberger D, Pastor P, Vilariño-Güell C, Postuma RB, Bernard G, Ladwig KH, Dupré N, Jankovic J, Strauch K, Panisset M, Winkelmann J, Testa CM, Reischl E, Zeuner KE, Ross OA, Arzberger T, Chouinard S, Deuschl G, Louis ED, Kuhlenbäumer G, Rouleau GA. Genome-wide association study in essential tremor identifies three new loci. Brain. 2016 Dec;139(Pt 12):3163-3169. doi: 10.1093/brain/aww242. Epub 2016 Oct 20. PMID: 27797806; PMCID: PMC5382938.

134: Fan J, Guo M, Im CS, Pi-Anfruns J, Cui ZK, Kim S, Wu BM, Aghaloo TL, Lee M. Enhanced Mandibular Bone Repair by Combined Treatment of Bone Morphogenetic Protein 2 and Small-Molecule Phenamil. Tissue Eng Part A. 2017 Mar;23(5-6):195-207. doi: 10.1089/ten.TEA.2016.0308. Epub 2016 Nov 28. PMID: 27771997; PMCID: PMC5346908.

135: Tong M, Dominguez C, Didsbury J, de la Monte SM. Targeting Alzheimer's Disease Neuro-Metabolic Dysfunction with a Small Molecule Nuclear Receptor Agonist (T3D-959) Reverses Disease Pathologies. J Alzheimers Dis Parkinsonism. 2016 Jun;6(3):238. doi: 10.4172/2161-0460.1000238. Epub 2016 Jun 3. PMID: 27525190; PMCID: PMC4979550.

136: Qu B, Ma Y, Yan M, Gong K, Liang F, Deng S, Jiang K, Ma Z, Pan X. Sirtuin1 promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor γ in MC3T3-E1 cells. Biochem Biophys Res Commun. 2016 Sep 9;478(1):439-445. doi: 10.1016/j.bbrc.2016.06.154. Epub 2016 Jul 1. PMID: 27378422.

137: Elmaci İ, Altinoz MA. A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme. Biochem Genet. 2016 Oct;54(5):573-618. doi: 10.1007/s10528-016-9754-9. Epub 2016 Jul 4. PMID: 27377891.

138: Kim H, Edwards NJ, Choi HA, Chang TR, Jo KW, Lee K. Treatment Strategies to Attenuate Perihematomal Edema in Patients With Intracerebral Hemorrhage. World Neurosurg. 2016 Oct;94:32-41. doi: 10.1016/j.wneu.2016.06.093. Epub 2016 Jun 29. PMID: 27373415.

139: You Y, Hou Y, Zhai X, Li Z, Li L, Zhao Y, Zhao J. Protective effects of PGC-1α via the mitochondrial pathway in rat brains after intracerebral hemorrhage. Brain Res. 2016 Sep 1;1646:34-43. doi: 10.1016/j.brainres.2016.04.076. Epub 2016 May 10. PMID: 27178364.

140: Mukai R, Matsui N, Fujikura Y, Matsumoto N, Hou DX, Kanzaki N, Shibata H, Horikawa M, Iwasa K, Hirasaka K, Nikawa T, Terao J. Preventive effect of dietary quercetin on disuse muscle atrophy by targeting mitochondria in denervated mice. J Nutr Biochem. 2016 May;31:67-76. doi: 10.1016/j.jnutbio.2016.02.001. Epub 2016 Feb 8. PMID: 27133425.

141: Gu JJ, Zhang JH, Chen HJ, Wang SS. MicroRNA-130b promotes cell proliferation and invasion by inhibiting peroxisome proliferator-activated receptor-γ in human glioma cells. Int J Mol Med. 2016 Jun;37(6):1587-93. doi: 10.3892/ijmm.2016.2580. Epub 2016 Apr 27. PMID: 27122306; PMCID: PMC4866956.

142: Huang T, Gao D, Hei Y, Zhang X, Chen X, Fei Z. D-allose protects the blood brain barrier through PPARγ-mediated anti-inflammatory pathway in the mice model of ischemia reperfusion injury. Brain Res. 2016 Jul 1;1642:478-486. doi: 10.1016/j.brainres.2016.04.038. Epub 2016 Apr 19. PMID: 27103568.

143: Kanabus M, Fassone E, Hughes SD, Bilooei SF, Rutherford T, Donnell MO, Heales SJR, Rahman S. The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome. J Inherit Metab Dis. 2016 May;39(3):415-426. doi: 10.1007/s10545-016-9930-4. Epub 2016 Apr 14. PMID: 27080638; PMCID: PMC4851692.

144: Liu H, Rose ME, Culver S, Ma X, Dixon CE, Graham SH. Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats. Biochem Biophys Res Commun. 2016 Apr 15;472(4):648-55. doi: 10.1016/j.bbrc.2016.03.003. Epub 2016 Mar 3. PMID: 26947332.

145: Xu Q, Cai W, Zhang M, Liu Q, Liu X. [The expression and clinopathological significance of miR-130b in human hepatocellular carcinoma]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Mar;32(3):387-92. Chinese. PMID: 26927562.

146: Qiu L, Jiang X, Wen L, Hu Q, Deng Y. [Pioglitazone decreases the levels of inflammatory cytokines in SD rats with traumatic brain injury via up-regulating PPARγ]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Feb;32(2):182-4. Chinese. PMID: 26927377.

147: Liu H, Mao P, Wang J, Wang T, Xie CH. Azilsartan, an angiotensin II type 1 receptor blocker, attenuates tert-butyl hydroperoxide-induced endothelial cell injury through inhibition of mitochondrial dysfunction and anti-inflammatory activity. Neurochem Int. 2016 Mar;94:48-56. doi: 10.1016/j.neuint.2016.02.005. Epub 2016 Feb 12. PMID: 26879328.

148: Wang H, Yan X, Ji LY, Ji XT, Wang P, Guo SW, Li SZ. miR-139 Functions as An Antioncomir to Repress Glioma Progression Through Targeting IGF-1 R, AMY-1, and PGC-1β. Technol Cancer Res Treat. 2017 Aug;16(4):497-511. doi: 10.1177/1533034616630866. Epub 2016 Feb 10. PMID: 26868851; PMCID: PMC5616056.

149: Tong M, Deochand C, Didsbury J, de la Monte SM. T3D-959: A Multi-Faceted Disease Remedial Drug Candidate for the Treatment of Alzheimer's Disease. J Alzheimers Dis. 2016;51(1):123-38. doi: 10.3233/JAD-151013. PMID: 26836193; PMCID: PMC5577391.

150: Flores JJ, Klebe D, Rolland WB, Lekic T, Krafft PR, Zhang JH. PPARγ-induced upregulation of CD36 enhances hematoma resolution and attenuates long-term neurological deficits after germinal matrix hemorrhage in neonatal rats. Neurobiol Dis. 2016 Mar;87:124-33. doi: 10.1016/j.nbd.2015.12.015. Epub 2015 Dec 29. PMID: 26739391; PMCID: PMC4724557.

151: Khan MM, Lustrino D, Silveira WA, Wild F, Straka T, Issop Y, O'Connor E, Cox D, Reischl M, Marquardt T, Labeit D, Labeit S, Benoit E, Molgó J, Lochmüller H, Witzemann V, Kettelhut IC, Navegantes LC, Pozzan T, Rudolf R. Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):746-50. doi: 10.1073/pnas.1524272113. Epub 2016 Jan 5. Erratum in: Proc Natl Acad Sci U S A. 2017 Jun 19;: PMID: 26733679; PMCID: PMC4725522.

152: Agrawal R, Noble E, Vergnes L, Ying Z, Reue K, Gomez-Pinilla F. Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity. J Cereb Blood Flow Metab. 2016 May;36(5):941-53. doi: 10.1177/0271678×15606719. Epub 2015 Oct 1. PMID: 26661172; PMCID: PMC4853835.

153: Sheng X, Chen H, Wang H, Ding Z, Xu G, Zhang J, Lu W, Wu T, Zhao L. MicroRNA-130b promotes cell migration and invasion by targeting peroxisome proliferator-activated receptor gamma in human glioma. Biomed Pharmacother. 2015 Dec;76:121-6. doi: 10.1016/j.biopha.2015.10.003. Epub 2015 Nov 18. PMID: 26653558.

154: Kuo YT, Shih PH, Kao SH, Yeh GC, Lee HM. Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes. PLoS One. 2015 Dec 8;10(12):e0143600. doi: 10.1371/journal.pone.0143600. PMID: 26646764; PMCID: PMC4672922.

155: Lezana JP, Dagan SY, Robinson A, Goldstein RS, Fainzilber M, Bronfman FC, Bronfman M. Axonal PPARγ promotes neuronal regeneration after injury. Dev Neurobiol. 2016 Jun;76(6):688-701. doi: 10.1002/dneu.22353. Epub 2015 Oct 26. PMID: 26446277.

156: Yao J, Zheng K, Zhang X. Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury. Mol Med Rep. 2015 Nov;12(5):6591-7. doi: 10.3892/mmr.2015.4292. Epub 2015 Sep 7. PMID: 26351751; PMCID: PMC4626137.

157: Lin CM, Tsai JT, Chang CK, Cheng JT, Lin JW. Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Drug Des Devel Ther. 2015 Aug 14;9:4709-17. doi: 10.2147/DDDT.S86616. PMID: 26316709; PMCID: PMC4544623.

158: Qi Z, Xu Y, Liang Z, Li S, Wang J, Wei Y, Dong B. Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model. Mol Med Rep. 2015 Nov;12(5):7093-101. doi: 10.3892/mmr.2015.4232. Epub 2015 Aug 20. PMID: 26300349.

159: Zhang L, Wang H. Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin. Mar Drugs. 2015 Jul 14;13(7):4310-30. doi: 10.3390/md13074310. PMID: 26184238; PMCID: PMC4515619.

160: Ching J, Amiridis S, Stylli SS, Bjorksten AR, Kountouri N, Zheng T, Paradiso L, Luwor RB, Morokoff AP, O'Brien TJ, Kaye AH. The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells. Oncotarget. 2015 Aug 28;6(25):21301-14. doi: 10.18632/oncotarget.4019. PMID: 26046374; PMCID: PMC4673266.

161: Ding Z, Yang HW, Xia TS, Wang B, Ding Q. Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction. Int J Mol Med. 2015 Aug;36(2):473-84. doi: 10.3892/ijmm.2015.2237. Epub 2015 Jun 5. PMID: 26046131.

162: Ren H, Gao Z, Wu N, Zeng L, Tang X, Chen X, Liu Z, Zhang W, Wang L, Li Z. Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro. Biochem Biophys Res Commun. 2015 Aug 7;463(4):504-9. doi: 10.1016/j.bbrc.2015.05.058. Epub 2015 May 21. PMID: 26003726.

163: Shimada K, Furukawa H, Wada K, Korai M, Wei Y, Tada Y, Kuwabara A, Shikata F, Kitazato KT, Nagahiro S, Lawton MT, Hashimoto T. Protective Role of Peroxisome Proliferator-Activated Receptor-γ in the Development of Intracranial Aneurysm Rupture. Stroke. 2015 Jun;46(6):1664-72. doi: 10.1161/STROKEAHA.114.007722. Epub 2015 Apr 30. PMID: 25931465; PMCID: PMC4447500.

164: Sumiyoshi M, Satomi J, Kitazato KT, Yagi K, Shimada K, Kurashiki Y, Korai M, Miyamoto T, Suzue R, Kuwayama K, Nagahiro S. PPARγ-Dependent and -Independent Inhibition of the HMGB1/TLR9 Pathway by Eicosapentaenoic Acid Attenuates Ischemic Brain Damage in Ovariectomized Rats. J Stroke Cerebrovasc Dis. 2015 Jun;24(6):1187-95. doi: 10.1016/j.jstrokecerebrovasdis.2015.01.009. Epub 2015 Apr 25. PMID: 25920754.

165: Xiong W, MacColl Garfinkel AE, Li Y, Benowitz LI, Cepko CL. NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Invest. 2015 Apr;125(4):1433-45. doi: 10.1172/JCI79735. Epub 2015 Mar 23. PMID: 25798616; PMCID: PMC4396467.

166: Liu SH, Lee WJ, Lai DW, Wu SM, Liu CY, Tien HR, Chiu CS, Peng YC, Jan YJ, Chao TH, Pan HC, Sheu ML. Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to- mesenchymal transition. Mol Oncol. 2015 Apr;9(4):834-49. doi: 10.1016/j.molonc.2014.12.009. Epub 2015 Jan 6. PMID: 25619450; PMCID: PMC5528772.

167: Conte M, Vasuri F, Bertaggia E, Armani A, Santoro A, Bellavista E, Degiovanni A, D'Errico-Grigioni A, Trisolino G, Capri M, Franchi MV, Narici MV, Sandri M, Franceschi C, Salvioli S. Differential expression of perilipin 2 and 5 in human skeletal muscle during aging and their association with atrophy-related genes. Biogerontology. 2015 Jun;16(3):329-40. doi: 10.1007/s10522-014-9549-5. Epub 2015 Jan 6. Erratum in: Biogerontology. 2015 Jun;16(3):341. PMID: 25559404.

168: Bian H, Hu Q, Liang X, Chen D, Li B, Tang J, Zhang JH. Hyperbaric oxygen preconditioning attenuates hemorrhagic transformation through increasing PPARγ in hyperglycemic MCAO rats. Exp Neurol. 2015 Mar;265:22-9. doi: 10.1016/j.expneurol.2014.12.016. Epub 2014 Dec 24. PMID: 25542160; PMCID: PMC4346496.

169: Distelmaier F, Valsecchi F, Liemburg-Apers DC, Lebiedzinska M, Rodenburg RJ, Heil S, Keijer J, Fransen J, Imamura H, Danhauser K, Seibt A, Viollet B, Gellerich FN, Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ. Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α. Biochim Biophys Acta. 2015 Mar;1852(3):529-40. doi: 10.1016/j.bbadis.2014.12.012. Epub 2014 Dec 20. PMID: 25536029.

170: Payandemehr B, Ebrahimi A, Gholizadeh R, Rahimian R, Varastehmoradi B, Gooshe M, Aghaei HN, Mousavizadeh K, Dehpour AR. Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:140-5. doi: 10.1016/j.pnpbp.2014.11.005. Epub 2014 Nov 13. PMID: 25448777.

171: Ching J, Amiridis S, Stylli SS, Morokoff AP, O'Brien TJ, Kaye AH. A novel treatment strategy for glioblastoma multiforme and glioma associated seizures: increasing glutamate uptake with PPARγ agonists. J Clin Neurosci. 2015 Jan;22(1):21-8. doi: 10.1016/j.jocn.2014.09.001. Epub 2014 Nov 22. PMID: 25439749.

172: Qin H, Tan W, Zhang Z, Bao L, Shen H, Wang F, Xu F, Wang Z. 15d-prostaglandin J2 protects cortical neurons against oxygen-glucose deprivation/reoxygenation injury: involvement of inhibiting autophagy through upregulation of Bcl-2. Cell Mol Neurobiol. 2015 Apr;35(3):303-312. doi: 10.1007/s10571-014-0125-y. Epub 2014 Oct 28. PMID: 25349027.

173: Tyagi E, Zhuang Y, Agrawal R, Ying Z, Gomez-Pinilla F. Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet. Neurobiol Dis. 2015 Jan;73:307-18. doi: 10.1016/j.nbd.2014.09.014. Epub 2014 Oct 2. PMID: 25283985; PMCID: PMC4754354.

174: Mou C, Liu B, Wang M, Jiang M, Han T. PGC-1-related coactivator (PRC) is an important regulator of microglia M2 polarization. J Mol Neurosci. 2015 Jan;55(1):69-75. doi: 10.1007/s12031-014-0315-6. Epub 2014 May 20. PMID: 24838382.

175: Tsai TH, Shih SC, Ho TC, Ma HI, Liu MY, Chen SL, Tsao YP. Pigment epithelium-derived factor 34-mer peptide prevents liver fibrosis and hepatic stellate cell activation through down-regulation of the PDGF receptor. PLoS One. 2014 Apr 24;9(4):e95443. doi: 10.1371/journal.pone.0095443. Erratum in: PLoS One. 2014;9(9): doi/10.1371/journal.pone.0108835. PMID: 24763086; PMCID: PMC3998957.

176: Chen LJ, Cheng MF, Ku PM, Lin JW. Rosiglitazone increases cerebral klotho expression to reverse baroreflex in type 1-like diabetic rats. Biomed Res Int. 2014;2014:309151. doi: 10.1155/2014/309151. Epub 2014 Feb 13. PMID: 24683546; PMCID: PMC3943406.

177: Zhang J, Yang W, Zhao D, Han Y, Liu B, Zhao H, Wang H, Zhang Q, Xu G. Correlation between TSP-1, TGF-β and PPAR-γ expression levels and glioma microvascular density. Oncol Lett. 2014 Jan;7(1):95-100. doi: 10.3892/ol.2013.1650. Epub 2013 Oct 29. PMID: 24348828; PMCID: PMC3861559.

178: Agrawal R, Tyagi E, Vergnes L, Reue K, Gomez-Pinilla F. Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. Biochim Biophys Acta. 2014 Apr;1842(4):535-46. doi: 10.1016/j.bbadis.2013.12.004. Epub 2013 Dec 15. PMID: 24345766.

179: O'Donnell KC, Vargas ME, Sagasti A. WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury. J Neurosci. 2013 Sep 11;33(37):14778-90. doi: 10.1523/JNEUROSCI.1331-13.2013. PMID: 24027278; PMCID: PMC3771034.

180: Pan HC, Yang CN, Hung YW, Lee WJ, Tien HR, Shen CC, Sheehan J, Chou CT, Sheu ML. Reciprocal modulation of C/EBP-α and C/EBP-β by IL-13 in activated microglia prevents neuronal death. Eur J Immunol. 2013 Nov;43(11):2854-65. doi: 10.1002/eji.201343301. Epub 2013 Aug 27. PMID: 23881867.

181: Zhao H, Huang HW, Wu JG, Huang PY. Specialization of mitochondrial and vascular oxidant modulated VEGFR in the denervated skeletal muscle. Cell Signal. 2013 Nov;25(11):2106-14. doi: 10.1016/j.cellsig.2013.06.014. Epub 2013 Jul 2. PMID: 23831211.

182: Xu F, Li J, Ni W, Shen YW, Zhang XP. Peroxisome proliferator-activated receptor-γ agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. PLoS One. 2013;8(1):e55080. doi: 10.1371/journal.pone.0055080. Epub 2013 Jan 25. PMID: 23372817; PMCID: PMC3555818.

183: Tengan CH, Rodrigues GS, Godinho RO. Nitric oxide in skeletal muscle: role on mitochondrial biogenesis and function. Int J Mol Sci. 2012 Dec 14;13(12):17160-84. doi: 10.3390/ijms131217160. PMID: 23242154; PMCID: PMC3546744.

184: Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT. mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats. J Orthop Res. 2013 May;31(5):724-30. doi: 10.1002/jor.22254. Epub 2012 Dec 13. PMID: 23239524; PMCID: PMC4393845.

185: Ostojic O, O'Leary MF, Singh K, Menzies KJ, Vainshtein A, Hood DA. The effects of chronic muscle use and disuse on cardiolipin metabolism. J Appl Physiol (1985). 2013 Feb 15;114(4):444-52. doi: 10.1152/japplphysiol.01312.2012. Epub 2012 Dec 6. PMID: 23221956.

186: Okami N, Narasimhan P, Yoshioka H, Sakata H, Kim GS, Jung JE, Maier CM, Chan PH. Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase. J Cereb Blood Flow Metab. 2013 Jan;33(1):106-14. doi: 10.1038/jcbfm.2012.138. Epub 2012 Oct 3. PMID: 23032483; PMCID: PMC3597369.

187: Wang P, Yu J, Yin Q, Li W, Ren X, Hao X. Rosiglitazone suppresses glioma cell growth and cell cycle by blocking the transforming growth factor-beta mediated pathway. Neurochem Res. 2012 Oct;37(10):2076-84. doi: 10.1007/s11064-012-0828-8. Epub 2012 Jun 16. PMID: 22707243.

188: Ramirez T, Tong M, Ayala CA, Monfils PR, McMillan PN, Zabala V, Wands JR, de la Monte SM. Structural Correlates of PPAR Agonist Rescue of Experimental Chronic Alcohol-Induced Steatohepatitis. J Clin Exp Pathol. 2012 Jun;2(4):114. doi: 10.4172/2161-0681.1000114. PMID: 26339530; PMCID: PMC4554760.

189: Fan YW, Sun KJ, Mao L, Liao H, Wang HD. The expression of PGC-1α in the mice brain after traumatic brain injury. Brain Inj. 2012;26(10):1267-72. doi: 10.3109/02699052.2012.672789. Epub 2012 May 29. PMID: 22642418.

190: Ashabi G, Ramin M, Azizi P, Taslimi Z, Alamdary SZ, Haghparast A, Ansari N, Motamedi F, Khodagholi F. ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats. Behav Brain Res. 2012 Jun 15;232(1):165-73. doi: 10.1016/j.bbr.2012.04.006. Epub 2012 Apr 9. PMID: 22510382.

191: Zhang Q, Wu Y, Sha H, Zhang P, Jia J, Hu Y, Zhu J. Early exercise affects mitochondrial transcription factors expression after cerebral ischemia in rats. Int J Mol Sci. 2012;13(2):1670-1679. doi: 10.3390/ijms13021670. Epub 2012 Feb 6. PMID: 22408416; PMCID: PMC3291985.

192: Cao Y, Wang Q, Zhou Z, Wang Y, Liu Y, Ji Y, Liu F. Changes of peroxisome proliferator-activated receptor-γ on crushed rat sciatic nerves and differentiated primary Schwann cells. J Mol Neurosci. 2012 Jun;47(2):380-8. doi: 10.1007/s12031-011-9662-8. Epub 2011 Nov 18. PMID: 22094441.

193: Kinouchi T, Kitazato KT, Shimada K, Yagi K, Tada Y, Matsushita N, Sumiyoshi M, Satomi J, Kageji T, Nagahiro S. Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats. Stroke. 2012 Feb;43(2):478-83. doi: 10.1161/STROKEAHA.111.618926. Epub 2011 Nov 10. PMID: 22076002.

194: Huang W, András IE, Rha GB, Hennig B, Toborek M. PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling. FASEB J. 2011 Nov;25(11):3979-88. doi: 10.1096/fj.11-188607. Epub 2011 Aug 12. PMID: 21840940; PMCID: PMC3205841.

195: Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Gao J, Kaneko K, Matsusue K, Yamazaki T, Oka Y, Katagiri H. Hepatic peroxisome proliferator-activated receptor-γ-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals. Eur Heart J. 2012 May;33(10):1279-89. doi: 10.1093/eurheartj/ehr265. Epub 2011 Aug 8. PMID: 21825308.

196: Meng B, Zhang Q, Huang C, Zhang HT, Tang T, Yang HL. Effects of a single dose of methylprednisolone versus three doses of rosiglitazone on nerve growth factor levels after spinal cord injury. J Int Med Res. 2011;39(3):805-14. doi: 10.1177/147323001103900313. PMID: 21819712.

197: Wu Y, Tang K, Huang RQ, Zhuang Z, Cheng HL, Yin HX, Shi JX. Therapeutic potential of peroxisome proliferator-activated receptor γ agonist rosiglitazone in cerebral vasospasm after a rat experimental subarachnoid hemorrhage model. J Neurol Sci. 2011 Jun 15;305(1-2):85-91. doi: 10.1016/j.jns.2011.03.006. Epub 2011 Mar 26. PMID: 21440907.

198: Wagatsuma A, Kotake N, Mabuchi K, Yamada S. Expression of nuclear-encoded genes involved in mitochondrial biogenesis and dynamics in experimentally denervated muscle. J Physiol Biochem. 2011 Sep;67(3):359-70. doi: 10.1007/s13105-011-0083-5. Epub 2011 Mar 11. PMID: 21394548.

199: Wan Z, Shi W, Shao B, Shi J, Shen A, Ma Y, Chen J, Lan Q. Peroxisome proliferator-activated receptor γ agonist pioglitazone inhibits β-catenin- mediated glioma cell growth and invasion. Mol Cell Biochem. 2011 Mar;349(1-2):1-10. doi: 10.1007/s11010-010-0637-9. Epub 2011 Jan 9. PMID: 21221726.

200: Tapia-Pérez JH, Kirches E, Mawrin C, Firsching R, Schneider T. Cytotoxic effect of different statins and thiazolidinediones on malignant glioma cells. Cancer Chemother Pharmacol. 2011 May;67(5):1193-201. doi: 10.1007/s00280-010-1535-2. Epub 2010 Dec 1. PMID: 21120479.

201: Nicolakakis N, Hamel E. The Nuclear Receptor PPARgamma as a Therapeutic Target for Cerebrovascular and Brain Dysfunction in Alzheimer's Disease. Front Aging Neurosci. 2010 May 21;2:21. doi: 10.3389/fnagi.2010.00021. PMID: 20725514; PMCID: PMC2912024.

202: Turner C, Schapira AH. Mitochondrial matters of the brain: the role in Huntington's disease. J Bioenerg Biomembr. 2010 Jun;42(3):193-8. doi: 10.1007/s10863-010-9290-y. PMID: 20480217.

203: Wu Y, Zhao XD, Zhuang Z, Xue YJ, Cheng HL, Yin HX, Shi JX. Peroxisome proliferator-activated receptor gamma agonist rosiglitazone attenuates oxyhemoglobin-induced Toll-like receptor 4 expression in vascular smooth muscle cells. Brain Res. 2010 Mar 31;1322:102-8. doi: 10.1016/j.brainres.2010.01.073. Epub 2010 Feb 2. PMID: 20132800.

204: Attia RR, Connnaughton S, Boone LR, Wang F, Elam MB, Ness GC, Cook GA, Park EA. Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha). J Biol Chem. 2010 Jan 22;285(4):2375-85. doi: 10.1074/jbc.M109.039081. Epub 2009 Nov 30. PMID: 19948729; PMCID: PMC2807296.

205: Kreutzer J, Jeske I, Hofmann B, Blumcke I, Fahlbusch R, Buchfelder M, Buslei R. No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson's syndrome and Cushing's disease in vitro and in vivo. Clin Neuropathol. 2009 Nov-Dec;28(6):430-9. PMID: 19919817.

206: Chabi B, Adhihetty PJ, O'Leary MF, Menzies KJ, Hood DA. Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse. J Appl Physiol (1985). 2009 Dec;107(6):1730-5. doi: 10.1152/japplphysiol.91451.2008. Epub 2009 Oct 1. PMID: 19797682.

207: Kobayashi T, Kawamata T, Shibata N, Okada Y, Kobayashi M, Hori T. Angiotensin II type 1 receptor blocker telmisartan reduces cerebral infarct volume and peri-infarct cytosolic phospholipase A(2) level in experimental stroke. J Neurotrauma. 2009 Dec;26(12):2355-64. doi: 10.1089/neu.2009.0965. PMID: 19604102.

208: Huang W, Eum SY, András IE, Hennig B, Toborek M. PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities. FASEB J. 2009 May;23(5):1596-606. doi: 10.1096/fj.08-121624. Epub 2009 Jan 13. PMID: 19141539; PMCID: PMC2669424.

209: Cheng G, Zhang X, Gao D, Jiang X, Dong W. Resveratrol inhibits MMP-9 expression by up-regulating PPAR alpha expression in an oxygen glucose deprivation-exposed neuron model. Neurosci Lett. 2009 Feb 20;451(2):105-8. doi: 10.1016/j.neulet.2008.12.045. Epub 2008 Dec 27. PMID: 19135132.

210: Hu JL, Wang XJ, Zhou PZ, Wang CD, Xu JG, Jiang S. [Apoptosis and differentiation induced with TCLA in rat glioblastoma cells in vitro]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Jul;39(4):570-4. Chinese. PMID: 18798496.

211: Huang W, Rha GB, Han MJ, Eum SY, András IE, Zhong Y, Hennig B, Toborek M. PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells. J Neurochem. 2008 Oct;107(2):497-509. doi: 10.1111/j.1471-4159.2008.05626.x. Epub 2008 Aug 14. PMID: 18710415; PMCID: PMC2597373.

212: Huang CX, Hou YH, Zhao JN, Wang YT, Li JJ, Wen L. [Expression of peroxisome proliferator-activated receptor-gamma in human pituitary neuroendocrine tumors and its correlation to tumor invasiveness]. Ai Zheng. 2008 Jun;27(6):590-4. Chinese. PMID: 18570731.

213: Hyong A, Jadhav V, Lee S, Tong W, Rowe J, Zhang JH, Tang J. Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents. Brain Res. 2008 Jun 18;1215:218-24. doi: 10.1016/j.brainres.2008.04.025. Epub 2008 Apr 22. PMID: 18479673; PMCID: PMC2505191.

214: Lapalombella R, Kern H, Adami N, Biral D, Zampieri S, Scordari A, di Tullio S, Marini M. Persistence of regenerative myogenesis in spite of down-regulation of activity-dependent genes in long-term denervated rat muscle. Neurol Res. 2008 Mar;30(2):197-206. doi: 10.1179/174313208×281091. PMID: 18397613.

215: Heaney AP. Targeting pituitary tumors. Horm Res. 2007;68 Suppl 5:132-6. doi: 10.1159/000110608. Epub 2007 Dec 10. PMID: 18174730.

216: Kang DW, Choi CH, Park JY, Kang SK, Kim YK. Ciglitazone induces caspase- independent apoptosis through down-regulation of XIAP and survivin in human glioma cells. Neurochem Res. 2008 Mar;33(3):551-61. doi: 10.1007/s11064-007-9475-x. Epub 2007 Oct 17. PMID: 17940898.

217: McTigue DM, Tripathi R, Wei P, Lash AT. The PPAR gamma agonist Pioglitazone improves anatomical and locomotor recovery after rodent spinal cord injury. Exp Neurol. 2007 Jun;205(2):396-406. doi: 10.1016/j.expneurol.2007.02.009. Epub 2007 Feb 27. PMID: 17433295; PMCID: PMC1950250.

218: Peptan IA, Hong L, Evans CA. Multiple differentiation potentials of neonatal dura mater-derived cells. Neurosurgery. 2007 Feb;60(2):346-52; discussion 352. doi: 10.1227/01.NEU.0000249278.72063.59. PMID: 17290186.

219: Adhihetty PJ, O'Leary MF, Chabi B, Wicks KL, Hood DA. Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle. J Appl Physiol (1985). 2007 Mar;102(3):1143-51. doi: 10.1152/japplphysiol.00768.2006. Epub 2006 Nov 22. PMID: 17122379.

220: Ma Y, Xia XW, Su CB, Kong YG. [Distribution and expression of peroxisome proliferator activated receptor gamma in human pituitary neuroendocrine tumors]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Jun;28(3):375-7. Chinese. PMID: 16900637.

221: Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y. Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science. 2006 Jun 16;312(5780):1656-9. doi: 10.1126/science.1126010. PMID: 16778057.

222: Wagatsuma A. Upregulation of gene encoding adipogenic transcriptional factors C/EBPalpha and PPARgamma2 in denervated muscle. Exp Physiol. 2006 Jul;91(4):747-53. doi: 10.1113/expphysiol.2006.033662. Epub 2006 May 4. PMID: 16675498.

223: Barberi T, Willis LM, Socci ND, Studer L. Derivation of multipotent mesenchymal precursors from human embryonic stem cells. PLoS Med. 2005 Jun;2(6):e161. doi: 10.1371/journal.pmed.0020161. Epub 2005 Jun 28. PMID: 15971941; PMCID: PMC1160574.

224: Nogueiras R, Barreiro ML, Caminos JE, Gaytán F, Suominen JS, Navarro VM, Casanueva FF, Aguilar E, Toppari J, Diéguez C, Tena-Sempere M. Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. J Cell Sci. 2004 Jul 1;117(Pt 15):3247-57. doi: 10.1242/jcs.01196. PMID: 15226398.

225: Kim HS, Hausman GJ, Hausman DB, Martin RJ, Dean RG. The expression of peroxisome proliferator-activated receptor gamma in pig fetal tissue and primary stromal-vascular cultures. Obes Res. 2000 Jan;8(1):83-8. doi: 10.1038/oby.2000.11. PMID: 10678262.