Perimesencephalic Subarachnoid Hemorrhage Etiology



95% of cases of perimesencephalic subarachnoid hemorrhage have a normal cerebral angiography and the source of bleeding is not identified; the cause is thought to be a venous bleed. This is referred to as non-aneurysmal perimesencephalic subarachnoid hemorrhage.

Rare causes include arteriovenous malformation, dural arteriovenous fistula, trauma and vascular tumours.

The causes of Perimesencephalic Subarachnoid Hemorrhage suggest a venous or capillary rupture at the level of the tentorial notch 1) 2) 3)

The other 5% of cases are due to a vertebrobasilar aneurysm and the prognosis is worse 4) 5) Rare causes include arteriovenous malformation, dural arteriovenous fistula, trauma and vascular tumors 6).

The vast majority of perimesencephalic subarachnoid hemorrhage cases are reported as negative-finding etiologies. Recently, high-resolution images allowed us to overcome the previous difficulty of finding the source of bleeding, which underlies the concept of a “negative finding”.

A venous etiology, hidden behind the tip of the basilar artery; namely, the lateral pontine vein.

Hafez et al highlight this type of aneurysm as a candidate source of perimesencephalic hemorrhage. This case may change our way of dealing with what we have termed a negative finding of subarachnoid hemorrhage 7).


1)
Schwartz TH, Yoon SS, Cutruzzola FW, Goodman RR. Third ventriculostomy: Post-operative ventricular size and outcome. Minim Invasive Neurosurg. 1996;39:122–9.
2)
van Gijn J, van Dongen KJ, Vermeulen M, Hijdra A. Perimesencephalic hemorrhage: A nonaneurysmal and benign form of subarachnoid hemorrhage. Neurology. 1985;35:493–7.
3)
Rinkel GJ, Wijdicks EF, Vermeulen M, Hageman LM, Tans JT, van Gijn J. Outcome in perimesencephalic (nonaneurysmal) subarachnoid hemorrhage: A follow-up study in 37 patients. Neurology. 1990;40:1130–2.
4)
van der Schaaf IC, Velthuis BK, Gouw A, Rinkel GJ. Venous drainage in perimesencephalic hemorrhage. Stroke. 2004 Jul;35(7):1614-8. doi: 10.1161/01.STR.0000131657.08655.ce. Epub 2004 May 27. PMID: 15166390.
5)
Velthuis B, Rinkel G, Ramos L et-al. Stroke. 1999;30 (5): . doi:10.1161/01.STR.30.5.1103
6)
Marder CP, Narla V, Fink JR, Tozer Fink KR. Subarachnoid hemorrhage: beyond aneurysms. AJR Am J Roentgenol. 2014 Jan;202(1):25-37. doi: 10.2214/AJR.12.9749. PMID: 24370126.
7)
Hafez A, Numminen J, Rahul R, Järveläinen J, Niemelä M. Perimesencephalic subarachnoid hemorrhage with a positive angiographic finding: case report and review of the literature. Acta Neurochir (Wien). 2016 Jun;158(6):1045-9. doi: 10.1007/s00701-016-2801-9. Epub 2016 Apr 22. PubMed PMID: 27106848.
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