Notch signaling pathway in glioblastoma

Glioblastoma Stem Cells at the Nexus of Tumor Heterogeneity, Immune Evasion, and Therapeutic Resistance
Notch1 and Major Vault Proteins Modulate Temozolomide Resistance in Glioblastoma
Synapsin III promotes neuronal-like transdifferentiation of glioblastoma stem cells by disrupting JAG1-Notch1 interaction
ARMC10 Drives Glioblastoma Progression Through Activating Notch Pathway
Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma
The role of VANGL2 in glioma oncogenesis and progression: insights into expression profiles and prognostic relevance
Nanoparticle-enhanced delivery of resveratrol for targeted therapy of glioblastoma: Modulating the Akt/GSK-3beta/NF-kB pathway in C6 glioma cells
Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways

Notch signaling pathways and glial cell activation, and other biological processes could play a role in the treatment of PGBM.

HMOX1, AKT1, and EGFR may represent novel therapeutic targets for lomustine in the clinical treatment of PGBM ¹⁾.

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Zhang T, Zhang D, Shi F. Silico analysis of the target and possible mechanism of lomustine in the treatment of primary glioblastoma. J Mol Model. 2022 Dec 8;29(1):3. doi: 10.1007/s00894-022-05405-3. PMID: 36482221.