Notch signaling pathway in glioblastoma

Exploring the Dual Roles of Neural Stem Cells in Glioblastoma: Therapeutic Implications and Opportunities
Importin-alpha transports Norrin to the nucleus to promote proliferation and Notch signaling in glioblastoma stem cells
Glioblastoma Stem Cells at the Nexus of Tumor Heterogeneity, Immune Evasion, and Therapeutic Resistance
Notch1 and Major Vault Proteins Modulate Temozolomide Resistance in Glioblastoma
Synapsin III promotes neuronal-like transdifferentiation of glioblastoma stem cells by disrupting JAG1-Notch1 interaction
ARMC10 Drives Glioblastoma Progression Through Activating Notch Pathway
Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma
The role of VANGL2 in glioma oncogenesis and progression: insights into expression profiles and prognostic relevance

Notch signaling pathways and glial cell activation, and other biological processes could play a role in the treatment of PGBM.

HMOX1, AKT1, and EGFR may represent novel therapeutic targets for lomustine in the clinical treatment of PGBM ¹⁾.

¹⁾

Zhang T, Zhang D, Shi F. Silico analysis of the target and possible mechanism of lomustine in the treatment of primary glioblastoma. J Mol Model. 2022 Dec 8;29(1):3. doi: 10.1007/s00894-022-05405-3. PMID: 36482221.