Molecular fluorescence-guided surgery

1: Kurbegovic S, Juhl K, Sørensen KK, Leth J, Willemoe GL, Christensen A, Adams Y, Jensen AR, von Buchwald C, Skjøth-Rasmussen J, Ploug M, Jensen KJ, Kjaer A. IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts. Theranostics. 2021 May 21;11(15):7159-7174. doi: 10.7150/thno.49787. PMID: 34158842; PMCID: PMC8210614.

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3: Dijkstra BM, de Jong M, Stroet MCM, Andreae F, Dulfer SE, Everts M, Kruijff S, Nonnekens J, den Dunnen WFA, Kruyt FAE, Groen RJM. Correction to: Evaluation of Ac-Lys⁰(IRDye800CW)Tyr³-octreotate as a novel tracer for SSTR₂-targeted molecular fluorescence guided surgery in meningioma. J Neurooncol. 2021 Jun;153(2):223. doi: 10.1007/s11060-021-03769-9. Erratum for: J Neurooncol. 2021 Jun;153(2):211-222. PMID: 34014425; PMCID: PMC8211574.

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7: Dijkstra BM, de Jong M, Stroet MCM, Andreae F, Dulfer SE, Everts M, Kruijff S, Nonnekens J, den Dunnen WFA, Kruyt FAE, Groen RJM. Evaluation of Ac- Lys⁰(IRDye800CW)Tyr³-octreotate as a novel tracer for SSTR₂-targeted molecular fluorescence guided surgery in meningioma. J Neurooncol. 2021 Jun;153(2):211-222. doi: 10.1007/s11060-021-03739-1. Epub 2021 Mar 26. Erratum in: J Neurooncol. 2021 May 20;: PMID: 33768405; PMCID: PMC8211583.

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10: Belykh E, Jubran JH, George LL, Bardonova L, Healey DR, Georges JF, Quarles CC, Eschbacher JM, Mehta S, Scheck AC, Nakaji P, Preul MC. Molecular Imaging of Glucose Metabolism for Intraoperative Fluorescence Guidance During Glioma Surgery. Mol Imaging Biol. 2021 Aug;23(4):586-596. doi: 10.1007/s11307-021-01579-z. Epub 2021 Feb 5. PMID: 33544308.

11: He K, Chi C, Li D, Zhang J, Niu G, Lv F, Wang J, Che W, Zhang L, Ji N, Zhu Z, Tian J, Chen X. Resection and survival data from a clinical trial of glioblastoma multiforme-specific IRDye800-BBN fluorescence-guided surgery. Bioeng Transl Med. 2020 Aug 31;6(1):e10182. doi: 10.1002/btm2.10182. PMID: 33532584; PMCID: PMC7823121.

Intraoperative imaging technologies, specifically 5-ALA and iMRI, may be of benefit in maximising extent of resection in participants with high-grade glioma. However, this is based on low- to very low-certainty evidence. Therefore, the short- and long-term neurological effects are uncertain. Effects of image-guided surgery on overall survival, progression-free survival, and quality of life are unclear. Network and traditional meta-analyses were not possible due to the identified high risk of bias, heterogeneity, and small trials included in this review. A brief economic commentary found limited economic evidence for the equivocal use of iMRI compared with conventional surgery. In terms of costs, one non-systematic review of economic studies suggested that, compared with standard surgery, use of image-guided surgery has an uncertain effect on costs and that 5-ALA was more costly. Further research, including completion of ongoing trials of ultrasound-guided surgery, is needed. ¹⁾.

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