medulloblastoma_shh-activated_and_tp53-mutant

Medulloblastoma, SHH-activated, and TP53-mutant

Typical in childhood. Male:female = 1:1. Predominant histologic variant: large cell/anaplastic. The putative cell of origin: cerebellar granule neuron cell precursors of the external granule cell layer and cochlear nucleus; less likely neural stem cells of the subventricular zone. Frequent genetic mutations: TP53.

▶ Classic morphology. Prognosis: high-risk tumor. Uncommon.

▶ Large cell/anaplastic morphology. Prognosis: high-risk tumor. Prevalent in ages 7–17 years.

▶ Desmoplastic/nodular morphology. Very rare. Uncertain clinical significance.

  • medulloblastoma_shh-activated_and_tp53-mutant.txt
  • Last modified: 2025/04/29 20:24
  • by 127.0.0.1