Intrathecal contrast agents
Inadvertent intrathecal injection of unapproved contrast agents
✖ Caution: serious reactions can occur with inadvertent intrathecal injection (e.g. for myelography, cisternography, ventriculography…) of iodinated contrast media that are not specifically indicated for intrathecal use (including ionic contrast agents as well as some non-ionic agents (e.g. Optiray®, Reno-60…)). This can cause uncontrollable seizures, intracerebral hemorrhage, cerebral edema, coma, paralysis, arachnoiditis, myoclonus (tonic-clonic muscle spasms), rhabdomyolysis with subsequent renal failure, hyperthermia, and respiratory compromise, with a significant fatality rate 1).
1)
Rivera E, Hardjasudarma M, Willis BK, et al. Inadvertent Use of Ionic Contrast Material in Myelography: Case Report and Management Guidelines. Neurosurgery. 1995; 36:413–415