Intervertebral disc degeneration treatment

• Effects of Noise Reduction on the Physical and Mental State of Patients with Lumbar Disc Herniation in an Orthopedic Outpatient Clinic
• Cell-Free Fat Extract for the Treatment of Lumbar Disc Degeneration: A Novel Approach Using Adipose-Derived Biologic
• Apoptotic Pathway in Intervertebral Disc Degeneration: From Molecular Pathways to Clinical Interventions
• A study on the correlation between preoperative vitamin D levels and postoperative pain and quality of life in middle-aged and young patients with lumbar degenerative diseases
• beta-Mangostin Attenuates TET2-Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration
• The impact of fixed segment length on the surgical outcomes of single-segment lumbar burst fractures: shorter segments are more prone to the formation of local stable osteophytes: a retrospective observational study
• Bioactive Therapies for Degenerative Disc Disease: Microenvironmental Foundations of Disease
• A Molecular Chemical Perspective: Mitochondrial Dynamics Is Not a Bystander of Cartilage Diseases

Conservative therapies and surgical treatments for Intervertebral disc degeneration provide only symptomatic pain relief without promoting intervertebral disc regeneration. Therefore, the clinical demand for disc regenerative therapies for intervertebral disc repair is high.

There are several treatment options available, including:

Physical therapy: Physical therapy can help strengthen the muscles that support the spine and improve flexibility. It can also teach patients proper posture and body mechanics to reduce strain on the discs.

Pain medications: Over-the-counter pain medications like ibuprofen or acetaminophen can help manage mild to moderate pain. In some cases, prescription pain medications or muscle relaxants may be necessary.

Steroid injections: Steroid injections can be used to reduce inflammation and pain in the affected area. These injections are typically administered by a pain management specialist.

Surgery: In severe cases where conservative treatments have failed, surgery may be necessary. The most common surgical procedures for intervertebral disc degeneration include discectomy, laminectomy, and spinal fusion.

Alternative therapies: Alternative therapies like chiropractic care, acupuncture, and massage may provide some relief from back pain. However, there is limited scientific evidence to support their effectiveness.

Koo et al. used a rat tail nucleotomy model to develop mechanically stable collagen-cryogel and fibrillated collagen with shape-memory for use in minimally invasive surgery for effective treatment of IVDD. The collagen was loaded with hyaluronic acid (HA) into a rat tail nucleotomy model.

The shape-memory collagen structures exhibited outstanding chondrogenic activities, having completely similar physical properties to those of a typical shape-memory alginate construct in terms of water absorption, compressive properties, and shape-memorability behavior. The treatment of rat tail nucleotomy model with shape-memory collagen-cryogel/HA alleviated mechanical allodynia, maintained a higher concentration of water content, and preserved the disc structure by restoring the matrix proteins.

According to these results, the collagen-based structure could effectively repair and maintain the Intervertebral disc matrix better than the controls, including hyaluronic acid only and shape-memory alginate with hyaluronic acid ¹⁾.

see Discogenic pain treatment.