GBA1

GBA1-associated parkinsonism

It is clear that the immune system and inflammation have a role in Parkinson's disease (PD), including sporadic Parkinson's disease and some genetic forms such as LRRK2-associated Parkinson's disease. One of the most important genes associated with PD is GBA1, as mutations in this gene are found in 5-20% of PD patients in different populations worldwide. Biallelic mutations in GBA1 may cause Gaucher disease, a lysosomal storage disorder with involvement of the immune system, and other lines of evidence link GBA1 to the immune system and inflammation ¹⁾.