Cingulate gyrus function
For an excellent review of data regarding the complex functional role of the cingulate gyrus and the surrounding structures of the frontal lobe, see Rushworth et al. 1).
Functionally, the cingulate gyrus is part of the limbic system with extensive connectivity to different anatomical and functional areas. Many studies were published concerning the cingulate area and neuropsychological findings 2) 3), functional and diffusion tensor imaging 4) 5), lesion studies 6) 7), and electrophysiological stimulation studies with implanted electrodes 8) 9) 10).
1)
Rushworth MF, Buckley MJ, Behrens TE, Walton ME, Bannerman
DM: Functional organization of the medial frontal
cortex. Curr Opin Neurobiol 17:220–227, 2007
2)
di Pellegrino G, Ciaramelli E, Ladavas E: The regulation of
cognitive control following rostral anterior cingulate cortex
lesion in humans. J Cogn Neurosci 19:275–286, 2007
3)
Sumner P, Nachev P, Morris P, Peters AM, Jackson SR, Kennard
C, et al: Human medial frontal cortex mediates unconscious
inhibition of voluntary action. Neuron 54:697–711,
2007
4)
Concha L, Gross DW, Beaulieu C: Diffusion tensor tractography
of the limbic system. AJNR Am J Neuroradiol
26:2267–2274, 2005
5)
Mohamed IS, Otsubo H, Shroff M, Donner E, Drake J, Snead
OC III: Magnetoencephalography and diffusion tensor imaging
in gelastic seizures secondary to a cingula
6)
Hornak J, Bramham J, Rolls ET, Morris RG, O’Doherty J,
Bullock PR, et al: Changes in emotion after circumscribed
surgical lesions of the orbitofrontal and cingulate cortices.
Brain 126:1691–1712, 2003
7)
Nakayama N, Okumura A, Shinoda J, Nakashima T, Iwama
T: Relationship between regional cerebral metabolism and
consciousness disturbance in traumatic diffuse brain injury
without large focal lesions: an FDG-PET study with statistical
parametric mapping analysis. J Neurol Neurosurg Psychiatry
77:856–862, 2006
8)
Kawasaki H, Adolphs R, Oya H, Kovach C, Damasio H, Kaufman
O, et al: Analysis of single-unit responses to emotional
scenes in human ventromedial prefrontal cortex. J Cogn Neurosci
17:1509–1518, 2005
9)
Sperli F, Spinelli L, Pollo C, Seeck M: Contralateral smile and
laughter, but no mirth, induced by electrical stimulation of the
cingulate cortex. Epilepsia 47:440–443, 2006
10)
Tankus A, Yeshurun Y, Flash T, Fried I: Encoding of speed
and direction of movement in the human supplementary motor
area. J Neurosurg 110:685–695, 2009