Chromosome 1

• 1p and/or 19q polysomy is an adverse prognostic factor in oligodendrogliomas, and easy to detect by automated FISH
• Chromosome 1p Loss and 1q Gain for Grading of Meningioma
• Characteristics, outcome, and prognostic factors of young patients with central nervous system World Health Organization grade 3 oligodendrogliomas IDH-mutant and 1p/19q codeleted: A French POLA network study
• The cortical high-flow sign in oligodendroglioma, IDH-mutant and 1p/19q-codeleted is correlated with histological cortical vascular density
• AlkaPhos: a novel fluorescent probe as a potential point-of-care diagnostic tool to estimate recurrence risk of meningiomas
• Oligoastrocytoma: The Vanishing Entity With True Dual Genotype, a Report, its Molecular Profiles and Review of Literature
• Patient-derived glioma organoids real time identification of IDH mutation, 1p/19q-codeletion and CDKN2A/B homozygous deletion with differential ion mobility spectrometry
• Survival Outcomes Associated With First-Line Procarbazine, CCNU, and Vincristine or Temozolomide in Combination With Radiotherapy in IDH-Mutant 1p/19q-Codeleted Grade 3 Oligodendroglioma

The molecular hallmark feature of oligodendroglioma is codeletion of the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) ¹⁾, which is present in about 60–90% of histopathologically diagnosed oligodendroglioma ²⁾.

Complete deletion of both the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) is pathognomonic for oligodendroglioma ^{3) 4)} It is strongly associated with IDH mutation and is mutually exclusive of ATRX & TP53 mutations.

The long arm of Chromosome 1.

NOTCH2NLC is 1 of 3 nearly identical, functional human NOTCH2 (600275)-like genes on chromosome 1q21.1 The NOTCH2L proteins appear to regulate Notch signaling pathway and promote cortical neurogenesis.

1q21.1 microdeletion is a chromosomal change in which a small piece of chromosome 1 is deleted in each cell. The deletion occurs on the long (q) arm of the chromosome in a region designated q21.1. This chromosomal change increases the risk of delayed development, intellectual disability, physical abnormalities, and neurological and psychiatric problems. However, some people with a 1q21.1 microdeletion do not appear to have any associated feature