Aneurysm occlusion
The efficacy of intracranial aneurysm treatment (long-term success or effectiveness of the treatment) is measured by evidence of the aneurysm obliteration (failure to be demonstrated by conventional or noninvasive angiography), without evidence of aneurysm recanalization (any blood flow into the aneurysm) or aneurysm recurrence (reappearance).
Despite advances in embolization devices, coiling of small intracranial aneurysms is still scrutinized. High occlusion rates are achievable, especially in unruptured aneurysms, with coil type and packing density suggesting an association with complete occlusion. Technical complications may be influenced by aneurysm geometry 1).
Compared with pipeline embolization device (PED) alone, PED coiling could improve aneurysm occlusion. However, it could also increase the total complication risk, prolong procedure time, and increase the total cost. Compared with loose packing, dense packing did not enhance the treatment effectiveness but increased the treatment cost.
Clinical relevance statement: The additional treatment effect from coiling embolization declines sharply after a certain point. Specifically, the aneurysm occlusion rate is roughly stable when the coil number is greater than 3 or the total coil length is longer than 150 cm 2).
Aneurysm recanalization
Aneurysm recurrence
Residual aneurysm
De novo aneurysm
de novo aneurysm formation
Evidence of predictors for intracranial aneurysm occlusion after treatment with flow diverters is sparse. Current literature suggests that the absence of branch involvement, younger age, and aneurysm diameter have the highest impact on aneurysm occlusion after treatment with flow diverters. Large studies investigating high-quality data with well-defined inclusion criteria are needed for greater insight into flow diverter effectiveness 3).