Alessandro De Benedictis

https://www.researchgate.net/profile/Alessandro-De-Benedictis

Alessandro De Benedictis et al. from the Bambino Gesù Children's Hospital, IRCCS, Rome described the case of a 17-yr-old patient who underwent resection of an epileptogenic low-grade glioma located within the left-dominant lingual gyrus. Seizures were characterized, as a first symptom, by the right-sided simple visual hallucination that pointed to the left pericalcarine region, corresponding to the lesion location. No signs of primary involvement of anterior temporal-mesial structures (hippocampus/amygdala) were found. As the anatomic-electroclinical correlation was concordant, direct tumor removal was indicated through an infra-occipital supratentorial approach. This route allowed direct access to the target through a safe extra-axial corridor, which limits intraparenchymal dissection until the tumor margin is identified and avoids critical vascular structures, such as the vein of Labbé.

External cerebrospinal fluid drainage was used to facilitate brain relaxation, minimizing brain and venous retraction and, consequently, reducing the risk of postoperative neurological complications, especially for vision. Postoperative magnetic resonance imaging (MRI) demonstrated no surgical complications. Pathological examination revealed a ganglioglioma. At 9-mo follow-up, the neurological examination was normal, antiepileptic therapy was stopped, and the patient was seizure-free. The video describes the main surgical steps, using both intraoperative videos and advanced 3-dimensional modeling of neuroimaging pictures ¹⁾.

1: De Benedictis A, de Palma L, Herur-Raman A, Pepi C, Colafati GS, Carboni A, Randi F, Savioli A, Ricci G, Mastronuzzi A, Carai A, Specchio N, Marras CE. Infra-Occipital Supra-Tentorial Approach for Resection of Low-Grade Tumor of the Left Lingual Gyrus: 2-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2021 May 22:opab172. doi: 10.1093/ons/opab172. Epub ahead of print. PMID: 34022047.

2: Carai A, De Benedictis A, Calloni T, Onorini N, Paternò G, Randi F, Colafati GS, Mastronuzzi A, Marras CE. Intraoperative Ultrasound-Assisted Extent of Resection Assessment in Pediatric Neurosurgical Oncology. Front Oncol. 2021 Apr 21;11:660805. doi: 10.3389/fonc.2021.660805. PMID: 33968768; PMCID: PMC8097032.

3: DE Benedictis A, Marras CE, Petit L, Sarubbo S. The inferior fronto-occipital fascicle: a century of controversies from anatomy theaters to operative neurosurgery. J Neurosurg Sci. 2021 May 3. doi: 10.23736/S0390-5616.21.05360-1. Epub ahead of print. PMID: 33940782.

4: Specchio N, Pepi C, de Palma L, Moavero R, De Benedictis A, Marras CE, Vigevano F, Curatolo P. Surgery for drug-resistant tuberous sclerosis complex- associated epilepsy: who, when, and what. Epileptic Disord. 2021 Feb 1;23(1):53-73. doi: 10.1684/epd.2021.1253. PMID: 33720022.

5: Sarubbo S, Annicchiarico L, Corsini F, Zigiotto L, Herbet G, Moritz-Gasser S, Dalpiaz C, Vitali L, Tate M, De Benedictis A, Amorosino G, Olivetti E, Rozzanigo U, Petralia B, Duffau H, Avesani P. Planning Brain Tumor Resection Using a Probabilistic Atlas of Cortical and Subcortical Structures Critical for Functional Processing: A Proof of Concept. Oper Neurosurg (Hagerstown). 2021 Feb 16;20(3):E175-E183. doi: 10.1093/ons/opaa396. PMID: 33372966.

6: Barba C, Cossu M, Guerrini R, Di Gennaro G, Villani F, De Palma L, Grisotto L, Consales A, Battaglia D, Zamponi N, d'Orio P, Revay M, Rizzi M, Casciato S, Esposito V, Quarato PP, Di Giacomo R, Didato G, Pastori C, Pavia GC, Pellacani S, Matta G, Pacetti M, Tamburrini G, Cesaroni E, Colicchio G, Vatti G, Asioli S, Caulo M; TLE Study Group, Marras CE, Tassi L. Temporal lobe epilepsy surgery in children and adults: A multicenter study. Epilepsia. 2021 Jan;62(1):128-142. doi: 10.1111/epi.16772. Epub 2020 Dec 1. PMID: 33258120.

7: De Palma L, Pepi C, De Benedictis A, Pietrafusa N, Mastronuzzi A, Cacchione A, Carfì-Pavia G, Rossi-Espagnet C, Diomedi-Camassei F, Rossi S, Napolitano A, Carai A, Colafati GS, Longo D, Curatolo P, Vigevano F, Marras CE, Specchio N. Early Onset Epilepsy Caused by Low-Grade Epilepsy-Associated Tumors and Focal Meningeal Involvement. Brain Sci. 2020 Oct 18;10(10):752. doi: 10.3390/brainsci10100752. PMID: 33081051; PMCID: PMC7603244.

8: De Benedictis A, Colafati GS, Carboni A, Carai A, Marras CE. Asymptomatic intrapetrous carotid artery stenosis after a gunshot to the head. Neurology. 2020 Dec 8;95(23):1057-1058. doi: 10.1212/WNL.0000000000011055. Epub 2020 Oct 14. PMID: 33055267.

9: Bertò G, Bullock D, Astolfi P, Hayashi S, Zigiotto L, Annicchiarico L, Corsini F, De Benedictis A, Sarubbo S, Pestilli F, Avesani P, Olivetti E. Classifyber, a robust streamline-based linear classifier for white matter bundle segmentation. Neuroimage. 2021 Jan 1;224:117402. doi: 10.1016/j.neuroimage.2020.117402. Epub 2020 Sep 23. PMID: 32979520.

10: Cossu M, d'Orio P, Barba C, Asioli S, Cardinale F, Casciato S, Caulo M, Colicchio G, Consales A, D'Aniello A, De Benedictis A, De Palma L, Didato G, Di Gennaro G, Di Giacomo R, Esposito V, Guerrini R, Nichelatti M, Revay M, Rizzi M, Vatti G, Villani F, Zamponi N, Tassi L, Marras CE. Focal Cortical Dysplasia IIIa in Hippocampal Sclerosis-Associated Epilepsy: Anatomo-Electro-Clinical Profile and Surgical Results From a Multicentric Retrospective Study. Neurosurgery. 2021 Jan 13;88(2):384-393. doi: 10.1093/neuros/nyaa369. PMID: 32860416.

11: Lodi M, Boccuto L, Carai A, Cacchione A, Miele E, Colafati GS, Diomedi Camassei F, De Palma L, De Benedictis A, Ferretti E, Catanzaro G, Pò A, De Luca A, Rinelli M, Lepri FR, Agolini E, Tartaglia M, Locatelli F, Mastronuzzi A. Low- Grade Gliomas in Patients with Noonan Syndrome: Case-Based Review of the Literature. Diagnostics (Basel). 2020 Aug 12;10(8):582. doi: 10.3390/diagnostics10080582. PMID: 32806529; PMCID: PMC7460327.

12: Specchio N, Ferretti A, Pietrafusa N, Trivisano M, Calabrese C, Carfì Pavia G, De Benedictis A, Marras CE, de Palma L, Vigevano F. Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option? Front Neurol. 2020 Jun 12;11:443. doi: 10.3389/fneur.2020.00443. PMID: 32595584; PMCID: PMC7303322.

13: de Palma L, De Benedictis A, Specchio N, Marras CE. Epileptogenic Network Formation. Neurosurg Clin N Am. 2020 Jul;31(3):335-344. doi: 10.1016/j.nec.2020.03.012. PMID: 32475484.

14: De Benedictis A, Rossi-Espagnet MC, Diomedi-Camassei F, Rossi S, Fontana E, Randi F, Ponzo V, Nucci C, Esposito G, Paternò G, Brunetti C, Savioli A, Carai A, Marras CE. Intraventricular Ectopic Cerebellum. World Neurosurg. 2020 May;137:158-163. doi: 10.1016/j.wneu.2020.01.127. Epub 2020 Jan 26. PMID: 31996339.

15: Rheault F, De Benedictis A, Daducci A, Maffei C, Tax CMW, Romascano D, Caverzasi E, Morency FC, Corrivetti F, Pestilli F, Girard G, Theaud G, Zemmoura I, Hau J, Glavin K, Jordan KM, Pomiecko K, Chamberland M, Barakovic M, Goyette N, Poulin P, Chenot Q, Panesar SS, Sarubbo S, Petit L, Descoteaux M. Tractostorm: The what, why, and how of tractography dissection reproducibility. Hum Brain Mapp. 2020 May;41(7):1859-1874. doi: 10.1002/hbm.24917. Epub 2020 Jan 10. PMID: 31925871; PMCID: PMC7267902.

16: Sarubbo S, Tate M, De Benedictis A, Merler S, Moritz-Gasser S, Herbet G, Duffau H. A normalized dataset of 1821 cortical and subcortical functional responses collected during direct Electrostimulation in patients undergoing awake brain surgery. Data Brief. 2019 Dec 5;28:104892. doi: 10.1016/j.dib.2019.104892. PMID: 31886348; PMCID: PMC6921148.

17: Sarubbo S, Tate M, De Benedictis A, Merler S, Moritz-Gasser S, Herbet G, Duffau H. Mapping critical cortical hubs and white matter pathways by direct Electrostimulation: an original functional atlas of the human brain. Neuroimage. 2020 Jan 15;205:116237. doi: 10.1016/j.neuroimage.2019.116237. Epub 2019 Oct 15. PMID: 31626897; PMCID: PMC7217287.

18: Sarubbo S, Petit L, De Benedictis A, Chioffi F, Ptito M, Dyrby TB. Uncovering the inferior fronto-occipital fascicle and its topological organization in non-human primates: the missing connection for language evolution. Brain Struct Funct. 2019 May;224(4):1553-1567. doi: 10.1007/s00429-019-01856-2. Epub 2019 Mar 7. PMID: 30847641.

19: De Benedictis A, Nocerino E, Menna F, Remondino F, Barbareschi M, Rozzanigo U, Corsini F, Olivetti E, Marras CE, Chioffi F, Avesani P, Sarubbo S. Photogrammetry of the Human Brain: A Novel Method for Three-Dimensional Quantitative Exploration of the Structural Connectivity in Neurosurgery and Neurosciences. World Neurosurg. 2018 Jul;115:e279-e291. doi: 10.1016/j.wneu.2018.04.036. Epub 2018 Apr 13. PMID: 29660551.

20: Sangiorgi S, Benedictis A, Reguzzoni M, Trezza A, Cossu S, Marras CE, Bellocchi S, Manelli A, Protasoni M. Arterial and microvascular supply of cerebral hemispheres in the nude mouse revealed using corrosion casting and scanning electron microscopy. J Anat. 2018 May;232(5):739-746. doi: 10.1111/joa.12791. Epub 2018 Feb 14. PMID: 29441571; PMCID: PMC5879984.

21: Maffei C, Jovicich J, De Benedictis A, Corsini F, Barbareschi M, Chioffi F, Sarubbo S. Topography of the human acoustic radiation as revealed by ex vivo fibers micro-dissection and in vivo diffusion-based tractography. Brain Struct Funct. 2018 Jan;223(1):449-459. doi: 10.1007/s00429-017-1471-6. Epub 2017 Sep 2. PMID: 28866840.

22: Rizzi M, Trezza A, Messina G, De Benedictis A, Franzini A, Marras CE. Exploring the brain through posterior hypothalamus surgery for aggressive behavior. Neurosurg Focus. 2017 Sep;43(3):E14. doi: 10.3171/2017.6.FOCUS17231. PMID: 28859571.

23: De Benedictis A, Trezza A, Carai A, Genovese E, Procaccini E, Messina R, Randi F, Cossu S, Esposito G, Palma P, Amante P, Rizzi M, Marras CE. Robot- assisted procedures in pediatric neurosurgery. Neurosurg Focus. 2017 May;42(5):E7. doi: 10.3171/2017.2.FOCUS16579. PMID: 28463617.

24: Carai A, Mastronuzzi A, De Benedictis A, Messina R, Cacchione A, Miele E, Randi F, Esposito G, Trezza A, Colafati GS, Savioli A, Locatelli F, Marras CE. Robot-Assisted Stereotactic Biopsy of Diffuse Intrinsic Pontine Glioma: A Single-Center Experience. World Neurosurg. 2017 May;101:584-588. doi: 10.1016/j.wneu.2017.02.088. Epub 2017 Feb 27. PMID: 28254596.

25: Esposito G, Messina R, Carai A, Colafati GS, Savioli A, Randi F, De Benedictis A, Cossu S, Fontanella MM, Marras CE. Cochleovestibular Nerve Compression Syndrome Caused by Intrameatal Anterior Inferior Cerebellar Artery Loop: Synthesis of Best Evidence for Clinical Decisions. World Neurosurg. 2016 Dec;96:556-561. doi: 10.1016/j.wneu.2016.09.030. Epub 2016 Sep 16. PMID: 27647022.

26: De Benedictis A, Petit L, Descoteaux M, Marras CE, Barbareschi M, Corsini F, Dallabona M, Chioffi F, Sarubbo S. New insights in the homotopic and heterotopic connectivity of the frontal portion of the human corpus callosum revealed by microdissection and diffusion tractography. Hum Brain Mapp. 2016 Dec;37(12):4718-4735. doi: 10.1002/hbm.23339. Epub 2016 Aug 8. PMID: 27500966; PMCID: PMC6867471.

27: Sarubbo S, De Benedictis A, Merler S, Mandonnet E, Barbareschi M, Dallabona M, Chioffi F, Duffau H. Structural and functional integration between dorsal and ventral language streams as revealed by blunt dissection and direct electrical stimulation. Hum Brain Mapp. 2016 Nov;37(11):3858-3872. doi: 10.1002/hbm.23281. PMID: 27258125; PMCID: PMC6867442.

28: Cacchione A, Mastronuzzi A, Cefalo MG, Colafati GS, Diomedi-Camassei F, Rizzi M, De Benedictis A, Carai A. Pediatric spinal glioblastoma of the conus medullaris: a case report of long survival. Chin J Cancer. 2016 May 9;35:44. doi: 10.1186/s40880-016-0107-1. PMID: 27160742; PMCID: PMC4862181.

29: Pietrafusa N, de Palma L, De Benedictis A, Trivisano M, Marras CE, Vigevano F, Specchio N. Ictal vomiting as a sign of temporal lobe epilepsy confirmed by stereo-EEG and surgical outcome. Epilepsy Behav. 2015 Dec;53:112-6. doi: 10.1016/j.yebeh.2015.10.009. Epub 2015 Nov 8. PMID: 26558713.

30: Rizzi M, De Benedictis A, Messina G, Cordella R, Marchesi D, Messina R, Penner F, Franzini A, Marras CE. Comparative analysis of explanted DBS electrodes. Acta Neurochir (Wien). 2015 Dec;157(12):2135-41. doi: 10.1007/s00701-015-2572-8. Epub 2015 Sep 7. PMID: 26347045.

31: Beretta E, Nessi F, Ferrigno G, Di Meco F, Perin A, Bello L, Casaceli G, Raneri F, De Benedictis A, De Momi E. Enhanced torque-based impedance control to assist brain targeting during open-skull neurosurgery: a feasibility study. Int J Med Robot. 2016 Sep;12(3):326-41. doi: 10.1002/rcs.1690. Epub 2015 Jul 31. PMID: 26230996.

32: Sarubbo S, De Benedictis A, Merler S, Mandonnet E, Balbi S, Granieri E, Duffau H. Towards a functional atlas of human white matter. Hum Brain Mapp. 2015 Aug;36(8):3117-36. doi: 10.1002/hbm.22832. Epub 2015 May 9. PMID: 25959791; PMCID: PMC6869563.

33: De Benedictis A, Duffau H, Paradiso B, Grandi E, Balbi S, Granieri E, Colarusso E, Chioffi F, Marras CE, Sarubbo S. Anatomo-functional study of the temporo-parieto-occipital region: dissection, tractographic and brain mapping evidence from a neurosurgical perspective. J Anat. 2014 Aug;225(2):132-51. doi: 10.1111/joa.12204. Epub 2014 Jun 30. PMID: 24975421; PMCID: PMC4111924.

34: Marras CE, Rizzi M, Cantonetti L, Rebessi E, De Benedictis A, Portaluri F, Randi F, Savioli A, Castelli E, Vigevano F. Pallidotomy for medically refractory status dystonicus in childhood. Dev Med Child Neurol. 2014 Jul;56(7):649-56. doi: 10.1111/dmcn.12420. Epub 2014 Apr 4. PMID: 24697701.

35: De Benedictis A, Freri E, Rizzi M, Franzini A, Ragona F, Specchio N, Rebessi E, Casazza M, Granata T, Marras CE. Vagus nerve stimulation for drug-resistant Epilepsia Partialis Continua: report of four cases. Epilepsy Res. 2013 Nov;107(1-2):163-71. doi: 10.1016/j.eplepsyres.2013.07.010. Epub 2013 Sep 8. PMID: 24074541.

36: Marras CE, Chiesa V, De Benedictis A, Franzini A, Rizzi M, Villani F, Ragona F, Tassi L, Vignoli A, Freri E, Specchio N, Broggi G, Casazza M, Canevini MP. Vagus nerve stimulation in refractory epilepsy: new indications and outcome assessment. Epilepsy Behav. 2013 Sep;28(3):374-8. doi: 10.1016/j.yebeh.2013.05.021. Epub 2013 Jul 6. PMID: 23835092.

37: Marras C, Rizzi M, Ravagnan L, De Benedictis A, Zorzi G, Bongiorno G, Marchesi D, Messina G, Cordella R, Franzini A. Morphological and chemical analysis of a deep brain stimulation electrode explanted from a dystonic patient. J Neural Transm (Vienna). 2013 Oct;120(10):1425-31. doi: 10.1007/s00702-013-1017-x. Epub 2013 Apr 6. PMID: 23563791.

38: De Benedictis A, Sarubbo S, Duffau H. Subcortical surgical anatomy of the lateral frontal region: human white matter dissection and correlations with functional insights provided by intraoperative direct brain stimulation: laboratory investigation. J Neurosurg. 2012 Dec;117(6):1053-69. doi: 10.3171/2012.7.JNS12628. Epub 2012 Sep 21. PMID: 22998058.