Acid-suppressive drug
There are two classes of Acid-suppressive drugs:
Proton‐pump inhibitors (PPIs), which stop acid secretion by inhibiting proton pumps located in the canalicular membrane of the parietal cell; and histamine‐2 receptor antagonists (H2RAs), which target histamine, one of the primary regulators of acid secretion.
Acid-suppressive drugs were significantly associated with all-cause mortality in patients with nonvalvular atrial fibrillation (NVAF) taking oral anticoagulants (OACs) 1).
1)
Arai H, Ueda S, Uchida K, Sakakibara F, Kinjo N, Nezu M, Morimoto T. Association between Acid-Suppressive Drugs and Clinical Outcomes in Patients with Nonvalvular Atrial Fibrillation. Drugs R D. 2022 Jul 19. doi: 10.1007/s40268-022-00392-5. Epub ahead of print. PMID: 35854203.