There are two classes of Acid-suppressive drugs:
Proton‐pump inhibitors (PPIs), which stop acid secretion by inhibiting proton pumps located in the canalicular membrane of the parietal cell; and histamine‐2 receptor antagonists (H2RAs), which target histamine, one of the primary regulators of acid secretion.
Acid-suppressive drugs were significantly associated with all-cause mortality in patients with nonvalvular atrial fibrillation (NVAF) taking oral anticoagulants (OACs) 1).