WHO classification of tumors of hematopoietic and lymphoid tissues
Myeloid neoplasms
myeloproliferative neoplasms
chronic myeloid leukemia, BCR-ABL1-positive
chronic neutrophilic leukemia
primary myelofibrosis essential thrombocythemia chronic eosinophilic leukemia, not otherwise specified myeloproliferative neoplasm, unclassifiable mastocytosis cutaneous mastocytosis systemic mastocytosis indolent systemic mastocytosis smoldering systemic mastocytosis systemic mastocytosis with an associated hematological neoplasm aggressive systemic mastocytosis mast cell leukemia mast cell sarcoma myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement myeloid/lymphoid neoplasms with PDGFRA rearrangement myeloid/lymphoid neoplasms with PDGFRB rearrangement myeloid/lymphoid neoplasms with FGFR1 rearrangement myeloid/lymphoid neoplasms with PCM1-JAK2 (provisional entity) myelodysplastic/myeloproliferative neoplasms chronic myelomonocytic leukemia atypical chronic myeloid leukemia, BCR-ABL1-negative juvenile myelomonocytic leukemia myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis myelodysplastic/myeloproliferative neoplasm, unclassifiable myelodysplastic syndromes myelodysplastic syndrome with single lineage dysplasia myelodysplastic syndrome with multilineage dysplasia myelodysplastic syndrome with ring sideroblasts myelodysplastic syndrome with ring sideroblasts and single lineage dysplasia myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia myelodysplastic syndrome with excess blasts myelodysplastic syndrome with isolated del(5q) myelodysplastic syndrome, unclassifiable refractory cytopenia of childhood (provisional entity) myeloid neoplasms with germline predisposition myeloid neoplasms with germline predisposition without a preexisting disorder or organ dysfunction acute myeloid leukemia with germline CEBPA mutation myeloid neoplasms with germline DDX41 mutation myeloid neoplasms with germline predisposition and preexisting platelet disorders myeloid neoplasms with germline RUNX1 mutation myeloid neoplasms with germline ANKRD26 mutation myeloid neoplasms with germline ETV6 mutation myeloid neoplasms with germline predisposition and other organ dysfunction myeloid neoplasms with germline GATA2 mutation myeloid neoplasms associated with bone marrow failure syndromes myeloid neoplasms associated with telomere biology disorders juvenile myelomonocytic leukemia associated with neurofibromatosis, Noonan syndrome or Noonan syndrome-like disorders myeloid neoplasms associated with Down syndrome acute myeloid leukemia and related neoplasms acute myeloid leukemia with recurrent genetic abnormalities acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1 acute myeloid leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 acute promyelocytic leukemia with PML-RARA acute myeloid leukemia with t(9;11)(p21.3;q23.3); MLLT3-KMT2A acute myeloid leukemia with t(6;9)(p23;q34.1); DEK-NUP214 acute myeloid leukemia with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM acute myeloid leukemia (megakaryoblastic) with t(1;22)(p13.3;q13.3); RBM15-MKL1 acute myeloid leukemia with BCR-ABL1 (provisional entity) acute myeloid leukemia with mutated NPM1 acute myeloid leukemia with biallelic mutations of CEBPA acute myeloid leukemia with mutated RUNX1 (provisional entity) acute myeloid leukemia with myelodysplasia-related changes therapy-related myeloid neoplasms acute myeloid leukemia, not otherwise specified acute myeloid leukemia with minimal differentiation acute myeloid leukemia without maturation acute myeloid leukemia with maturation acute myelomonocytic leukemia acute monoblastic/monocytic leukemia pure erythroid leukemia acute megakaryoblastic leukemia acute basophilic leukemia acute panmyelosis with myelofibrosis myeloid sarcoma myeloid proliferations related to Down syndrome transient abnormal myelopoiesis myeloid leukemia associated with Down syndrome blastic plasmacytoid dendritic cell neoplasm acute leukemias of ambiguous lineage acute undifferentiated leukemia mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1 mixed phenotype acute leukemia with t(v;11q23.3); KMT2A rearranged mixed phenotype acute leukemia, B/myeloid, not otherwise specified mixed phenotype acute leukemia, T/myeloid, not otherwise specified Lymphoid neoplasms precursor lymphoid neoplasms B-lymphoblastic leukemia/lymphoma B-lymphoblastic leukemia/lymphoma, not otherwise specified B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1 B-lymphoblastic leukemia/lymphoma with t(v;11q23.3); KMT2A rearranged B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1 B-lymphoblastic leukemia/lymphoma with hyperdiploidy B-lymphoblastic leukemia/lymphoma with hypodiploidy B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3); IL3-IGH B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1 B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like (provisional entity) B-lymphoblastic leukemia/lymphoma with iAMP21 (provisional entity) T-lymphoblastic leukemia/lymphoma early T-cell precursor lymphoblastic leukemia (provisional entity) natural killer (NK) cell lymphoblastic leukemia/lymphoma (provisional entity) mature B-cell neoplasms chronic lymphocytic leukemia/small lymphocytic lymphoma monoclonal B-cell lymphocytosis B-cell prolymphocytic leukemia splenic marginal zone lymphoma hairy cell leukemia splenic B-cell lymphoma/leukemia, unclassifiable splenic diffuse red pulp small B-cell lymphoma (provisional entity) hairy cell leukemia-variant (provisional entity) lymphoplasmacytic lymphoma Waldenström macroglobulinemia IgM monoclonal gammopathy of undetermined significance heavy-chain diseases μ heavy-chain disease γ heavy-chain disease α heavy-chain disease plasma cell neoplasms non-IgM monoclonal gammopathy of undetermined significance (IgG/A) plasma cell myeloma (a.k.a. multiple myeloma) plasma cell myeloma variants smoldering (asymptomatic) plasma cell myeloma non-secretory myeloma plasma cell leukemia plasmacytoma solitary plasmacytoma of bone extraosseous plasmacytoma monoclonal immunoglobulin deposition diseases primary amyloidosis light chain and heavy chain deposition diseases plasma cell neoplasms with associated paraneoplastic syndrome POEMS syndrome TEMPI syndrome extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) nodal marginal zone lymphoma pediatric nodal marginal zone lymphoma (provisional entity) follicular lymphoma testicular follicular lymphoma in situ follicular neoplasia duodenal-type follicular lymphoma pediatric-type follicular lymphoma large B-cell lymphoma with IRF4 rearrangement (provisional entity) primary cutaneous follicle center lymphoma mantle cell lymphoma leukemic non-nodal mantle cell lymphoma in situ mantle cell neoplasia diffuse large B-cell lymphoma, not otherwise specified germinal center B-cell type activated B-cell type T-cell/histiocyte-rich large B-cell lymphoma primary diffuse large B-cell lymphoma of the central nervous system primary cutaneous diffuse large B-cell lymphoma, leg type EBV-positive diffuse large B-cell lymphoma, not otherwise specified EBV-positive mucocutaneous ulcer (provisional entity) diffuse large B-cell lymphoma associated with chronic inflammation fibrin-associated diffuse large B-cell lymphoma lymphomatoid granulomatosis primary mediastinal (thymic) large B-cell lymphoma intravascular large B-cell lymphoma
ALK-positive large B-cell lymphoma
plasmablastic lymphoma primary effusion lymphoma HHV8-associated lymphoproliferative disorders multicentric Castleman disease HHV8-positive diffuse large B-cell lymphoma, not otherwise specified (provisional entity) HHV8-positive germinotropic lymphoproliferative disorder Burkitt lymphoma Burkitt-like lymphoma with 11q aberration (provisional entity) high-grade B-cell lymphoma high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements high-grade B-cell lymphoma, not otherwise specified B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma mature T- and NK-cell neoplasms T-cell prolymphocytic leukemia T-cell large granular lymphocytic leukemia chronic lymphoproliferative disorder of NK cells (provisional entity) aggressive NK-cell leukemia EBV-positive T-cell and NK-cell lymphoproliferative diseases of childhood systemic EBV-positive T-cell lymphoma of childhood chronic active EBV infection of T- and NK-cell type, systemic form hydroa vacciniforme–like lymphoproliferative disorder severe mosquito bite allergy adult T-cell leukemia/lymphoma extranodal NK-/T-cell lymphoma, nasal type intestinal T-cell lymphoma enteropathy-associated T-cell lymphoma monomorphic epitheliotropic intestinal T-cell lymphoma intestinal T-cell lymphoma, not otherwise specified indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (provisional entity) hepatosplenic T-cell lymphoma subcutaneous panniculitis-like T-cell lymphoma mycosis fungoides Sézary syndrome primary cutaneous CD30+ T-cell lymphoproliferative disorders lymphomatoid papulosis
primary cutaneous anaplastic large cell lymphoma
primary cutanoue peripheral T-cell lymphomas, rare subtypes primary cutaneous γδ T-cell lymphoma primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (provisional entity) primary cutaneous acral CD8+ T-cell lymphoma (provisional entity) primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder (provisional entity) peripheral T-cell lymphoma, not otherwise specified angioimmunoblastic T-cell lymphoma and other nodal lymphomas of T follicular helper cell origin angioimmunoblastic T-cell lymphoma follicular T-cell lymphoma (provisional entity) nodal peripheral T-cell lymphoma with T follicular helper phenotype (provisional entity) anaplastic large-cell lymphoma
anaplastic large cell lymphoma, ALK-positive
anaplastic large cell lymphoma, ALK-negative
breast implant-associated anaplastic large-cell lymphoma (provisional entity) Hodgkin lymphoma nodular lymphocyte predominant Hodgkin lymphoma classical Hodgkin lymphoma nodular sclerosis classical Hodgkin lymphoma lymphocyte-rich classical Hodgkin lymphoma mixed cellularity classical Hodgkin lymphoma lymphocyte-depleted classical Hodgkin lymphoma posttransplant lymphoproliferative disorders (PTLD) plasmacytic hyperplasia PTLD infectious mononucleosis PTLD florid follicular hyperplasia PTLD polymorphic PTLD monomorphic PTLD monomorphic B-cell PTLD monomorphic T/NK-cell PTLD classical Hodgkin lymphoma PTLD Histiocytic and dendritic cell neoplasms histiocytic sarcoma tumors derived from Langerhans cells Langerhans cell histiocytosis Langerhans cell sarcoma indeterminate dendritic cell tumor interdigitating dendritic cell sarcoma follicular dendritic cell sarcoma inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma fibroblastic reticular cell tumor disseminated juvenile xanthogranuloma Erdheim-Chester disease