Waldenstrom macroglobulinemia (WM)
Waldenstrom macroglobulinemia (WM) is a type of non Hodgkin lymphoma (NHL) . The cancer cells make large amounts of an abnormal protein (called a macroglobulin). Another name for WM is lymphoplasmacytic lymphoma. This condition used to be called Waldenstrom’s macroglobulinemia, so some people refer to it as Waldenstrom’s.
To understand WM, it helps to know about the functions of lymphoid tissue in the body.
Bing Neel syndrome is a rare disease manifestation of Waldenstrom macroglobulinemia that results from infiltration of the central nervous system by malignant lymphoplasmacytic cells 1).
1)
Minnema MC, Kimby E, D'Sa S, Fornecker LM, Poulain S, Snijders TJ, Kastritis
E, Kremer S, Fitsiori A, Simon L, Davi F, Lunn M, Castillo JJ, Patterson CJ, Le
Garff-Tavernier M, Costopoulos M, Leblond V, Kersten MJ, Dimopoulos MA, Treon SP.
Guideline for the diagnosis, treatment and response criteria for Bing-Neel
syndrome. Haematologica. 2017 Jan;102(1):43-51. doi:
10.3324/haematol.2016.147728. Epub 2016 Oct 6. PubMed PMID: 27758817; PubMed
Central PMCID: PMC5210231.