Vestibular schwannoma malignant transformation
Vestibular schwannoma to malignant peripheral nerve sheath tumor transformation
From the literature, malignant transformation of a vestibular schwannoma was not a feature of NF2 in the unirradiated patient. NF2 patients should not be told that they have an increased risk of malignant change in a vestibular schwannoma unless they undergo radiation treatment. However, very much larger datasets are required before it can be determined whether there is any association between NF2 and MPNST in the unirradiated patient 1).
1)
King AT, Rutherford SA, Hammerbeck-Ward C, Lloyd SK, Freeman SR, Pathmanaban
ON, Kellett M, Obholzer R, Afridi S, Axon P, Halliday D, Parry A, Thomas OM,
Laitt RD, McCabe MG, Stivaros S, Erridge S, Evans DG; English Specialist NF2
research group. Malignant Peripheral Nerve Sheath Tumors are not a Feature of
Neurofibromatosis Type 2 in the Unirradiated Patient. Neurosurgery. 2017 Jul 20.
doi: 10.1093/neuros/nyx368. [Epub ahead of print] PubMed PMID: 28973692.