Urokinase-type plasminogen activator receptor

The Urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored cell membrane receptor, composed by three homologous domains (DI, DII, DIII). Its main function is focusing of urokinase (uPA) proteolytic activity, responsible for degradation of extracellular matrix (ECM) components, on the cell surface