Tumor-to-tumor metastasis inside a meningioma
Tumor-to-tumor metastasis (TTM) is defined as the hematogenous metastasis within a primary host tumor from a donor neoplasm. Although the precise mechanism of TTM is still unclear, it has been reported in the literature for over a century 1)
There is a difference between Tumor-to-tumor metastasis and collision tumors. The former implies a recipient role of the host tumor, and the latter refers to a co-localization of two different tumors that grow into one another, both being in the same organ. Tumor-to-tumor brain metastasis is a well-described phenomenon but with unclear pathophysiology. Deeper knowledge could be beneficial for its management 2).
lung cancer and breast cancer are the most common donor tumors in TTM 3) 4) 5).