Transcranial magnetic resonance-guided focused ultrasound

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• Plasma glial fibrillary acidic protein as a biomarker of acute focal brain injury after high-intensity focused ultrasound thalamotomy
• Transcranial magnetic resonance-guided focused ultrasound for neurological applications: industry challenges, innovations, and future directions
• Ultrasound Applications in the Treatment of Major Depressive Disorder (MDD): A Systematic Review of Techniques and Efficacy
• Intraprocedural Three-Dimensional Imaging Registration Optimizes Magnetic Resonance Imaging-Guided Focused Ultrasound and Facilitates Novel Applications
• Repeated 5-aminolevulinic acid mediated sonodynamic therapy using magnetic resonance guided focused ultrasound in rat brain tumour models
• Consensus for clinical applications of transcranial magnetic resonance-guided focused ultrasound
• Four-tract tractography: multiparametric direct targeting of the dentatorubrothalamic tract

Transcranial Magnetic Resonance-Guided Focused Ultrasound (tcMRgFUS) typically refers to a therapeutic technique that combines magnetic resonance imaging (MRI) and focused ultrasound to treat certain neurological conditions.

Transcranial: This means the procedure is done through the skull without the need for surgery. The ultrasound waves are targeted at specific brain regions without any incisions.

Magnetic Resonance-Guided (MRg): MRI is used to visualize and guide the procedure in real-time. This provides accurate imaging of the brain and allows for precise targeting of the ultrasound.

Focused Ultrasound (FUS): This involves the use of high-intensity sound waves that are focused on a specific target within the brain. The focused ultrasound can create thermal or mechanical effects, depending on the application.

Transcranial magnetic resonance-guided focused ultrasound at low intensities has been reported to directly evoke responses and reversibly inhibit function in the central nervous system. While some doubt has been cast on the ability of ultrasound to directly evoke neuronal responses, spatially-restricted transcranial ultrasound has demonstrated consistent, inhibitory effects

tFUS predominantly causes neuroinhibition and the primary biophysical mechanism is the thermal effect of focused ultrasound ¹⁾.

see Transcranial magnetic resonance-guided focused ultrasound indications.