Existing tissue adhesives and sealants are far from satisfactory when applied on wet and dynamic tissues.
Li et al. reported a strategy for designing biodegradable super-strong aqueous glue (B-Seal) for surgical uses inspired by an English ivy adhesion strategy and a cement particle packing theory. B-Seal is a fast-gelling, super-strong, and elastic adhesive sealant composed of injectable water-borne biodegradable polyurethane (WPU) nanodispersions with mismatched particle sizes and counterions in its A-B formulation. B-Seal showed 24-fold greater burst pressure than DuraSeal®, 138-fold greater T-pull adhesive strength than fibrin glue, and 16-fold greater lap shear strength than fibrin glue. In vivo evaluation on a rat cerebrospinal fluid (CSF) rhinorrhea model and a porcine craniotomy model validated the safety and efficacy of B-Seal for effective Cerebrospinal fluid fistula prevention and dura repair. The plant-inspired adhesion strategy combined with particle packing theory represents a new direction of designing the next-generation wet tissue adhesives for surgeries 1).
Shah AR, Pearlman AN, O'Grady KM, Bhattacharyya TK, Toriumi DM. Combined use of fibrin tissue adhesive and acellular dermis in dural repair. Am J Rhinol. 2007 Sep-Oct;21(5):619-21. doi: 10.2500/ajr.2007.21.3078. PMID: 17999801.