Thromboxane A2

Thromboxane is a member of the family of lipids known as eicosanoids. The two major thromboxanes are thromboxane A2 and thromboxane B2. The distinguishing feature of thromboxanes is a 6-membered ether-containing ring. Thromboxane is named for its role in clot formation.

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Aspirin irreversibly inhibits cyclooxygenase, preventing synthesis of vascular prostacyclin (a vasodilator and platelet inhibitor) and platelet thromboxane A2 (a vasoconstrictor and platelet activator).

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