Theobromine

Radiomic Analysis of Treatment Effect for Patients with Radiation Necrosis Treated with Pentoxifylline and Vitamin E
Pentoxifylline and Vitamin E Can Restrict Radiation Necrosis via Vascular Pathways, Experimental Study in an Animal Model
Association between dietary theobromine with depression: a population-based study
Pentoxifylline significantly reduces radicular pain secondary to lumbar disc hernia: A prospective, randomized crossover, single-blind controlled pilot study
Resolution of radiation necrosis with bevacizumab following radiation therapy for primary CNS lymphoma
The Preventive Effect of Systemic Honokiol and Systemic Pentoxifylline on Epidural Fibrosis
The effect of pentoxifylline on cerebral vasospasm following experimental subarachnoid hemorrhage
Methylxanthines: Potential Therapeutic Agents for Glioblastoma

A cross-sectional population based study suggests that increased theobromine intake is associated with increased risk for depression. Nevertheless, more investigations are needed to confirm our findings ¹⁾.

¹⁾

Li XY, Liu H, Zhang LY, Yang XT. Association between dietary theobromine with depression: a population-based study. BMC Psychiatry. 2022 Dec 6;22(1):769. doi: 10.1186/s12888-022-04415-y. PMID: 36474233.