SW1573 Cell Line
The SW1573 cell line is derived from a human non-small cell lung carcinoma (NSCLC), specifically an adenocarcinoma. It is commonly used in cancer research to investigate drug resistance, tumor progression, and gene expression profiles.
Origin
- Species: Homo sapiens (Human)
- Tissue: Lung
- Disease: Adenocarcinoma
- Histology: Non-small cell lung cancer (NSCLC)
Characteristics
- Morphology: Epithelial
- Doubling time: ~24–36 hours
- Growth properties: Adherent
- Tumorigenic in mice: Yes (in immunocompromised mice)
- EGFR status: Wild-type (often used in contrast to mutant EGFR models)
Applications
- Study of chemoresistance, especially to cisplatin and paclitaxel
- Research on apoptosis and cell cycle regulation
- Gene expression profiling in NSCLC
- Used as a comparator cell line in targeted therapy studies
Culture Conditions
- Medium: RPMI-1640 supplemented with 10% fetal bovine serum (FBS)
- Temperature: 37°C
- CO₂: 5%