Stem-like cells are a type of cell that has the ability to self-renew and differentiate into different types of cells in the body. In the context of cancer, stem-like cells are thought to be responsible for tumor initiation, growth, and resistance to therapy. Glioblastoma stem-like cells are a subtype of stem-like cells found in glioblastoma.

These cells are thought to be particularly important in glioblastoma because they have a high capacity for self-renewal and can differentiate into other cell types within the tumor.