Stavudine

Neuropathies associated with drugs used to treat HIV

1. nucleoside reverse transcriptase inhibitors

a) zidovudine (Retrovir®) (formerly AZT)

b) didanosine (ddI; Videx®): (formerly dideoxyinosine) can cause a painful dose-related neuropathy ¹⁾

c) stavudine (d4T; Zerit®): can cause sensory neuropathy which usually improves when d4 T is discontinued, and may not recur if restarted at lower dose ²⁾.