🧬 SSTR1 (Somatostatin Receptor 1)
neuropeptide receptor sstr1 somatostatin glioblastoma
SSTR1 is one of five G-protein-coupled somatostatin receptors involved in neurotransmission, hormone regulation, and tumor biology.
🔹 1. Gene and Expression
- Gene:
SSTR1 - Location: Chromosome 14q13
- Expression:
- Brain (especially cortex, hippocampus)
- Pancreas, GI tract, pituitary
- Downregulated in glioblastoma
🔹 2. Function
- Gi/o-coupled receptor → ↓cAMP
- Inhibits hormone secretion (e.g., GH, insulin)
- CNS: modulates synaptic activity, neuroprotection
- Antiproliferative and antiangiogenic effects
🔹 3. Clinical Relevance
- ↓ SSTR1 in glioblastoma = poor prognosis
- Correlates with:
- IDH1-wildtype
- EGFR amplification
- G-CIMP-negative subtype
- May serve as a prognostic biomarker
💊 4. Therapeutic Implications
- Agonists: octreotide, pasireotide
- ↓ proliferation in GBM cell lines
- Potential strategies:
- Targeted therapy with SSTR1 agonists
- Combined molecular profiling + treatment
🔬 5. Ligands and Pathways
| Type | Example | Function |
|---|---|---|
| Agonist | Octreotide | ↓ tumor cell growth |
| Agonist | Pasireotide | Broader affinity (SSTR1/2/5) |
| Antagonist | (under study) | Not clinically available |
Signaling Pathways Affected:
- ↓ Adenylyl cyclase → ↓ cAMP
- CDKN1A-B upregulation
- Modulation of JAK/STAT, NF-κB, TGF-β pathways