Somatostatin
(also known as growth hormone-inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF)) or somatotropin release-inhibiting hormone is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits insulin and glucagon secretion.
Somatostatin treatment can induce extensive fibrosis in GH secreting pituitary neuroendocrine tumor 1).
Somatostatin receptor
Somatostatin analogs
1)
Kerschbaumer J, Pinggera D, Moser P, Hofmann A, Thomé C, Freyschlag CF.
Somatostatin treatment can induce extensive fibrosis in growth hormone-producing
adenoma. Acta Neurochir (Wien). 2016 Mar;158(3):441-3. doi:
10.1007/s00701-016-2714-7. Epub 2016 Jan 23. PubMed PMID: 26801514.