SNCA gene

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the Parkinson's disease pathogenesis. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively, spliced transcripts encoding different isoforms have been identified for this gene

A study demonstrated the importance of the SNCA locus for the etiology of Parkinson's disease in Latinos. By leveraging the demographic history of a cohort via admixture mapping, they identified two potential PD risk loci that merit further study ¹⁾.

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