or squash preparation. A small portion of specimen is smeared or compressed with moderate pressure between two glass slides, rapidly fixed, stained, and dehydrated for examination. This technique can be particularly useful for: multiple sclerosis (identifying histiocytes), visualizing long cell processes in gliomas, and identifying cytoplasmic inclusions or intranuclear pseudoinclusions) ¹⁾.

The cohesive nature often seen in tumors such as metastases and meningiomas is apparent, as are areas of necrosis. Σ: Smears are good for cytology, but do not show architecture. Preserve more tissue for perma- nent pathology than frozen section.