Long-term anti-seizure drug therapy with zonisamide, sultiam, lacosamide, clobazam, and rufinamide from prepubertal to adulthood causes apoptosis and disruption of folliculogenesis in the ovarian follicles of nonepileptic rats 1)
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Kart PÖ, Gürgen SG, Esenülkü G, Dilber B, Yıldız N, Yazar U, Sarsmaz HY, Topsakal AS, Kamaşak T, Arslan EA, Şahin S, Cansu A. An Investigation of the Effects of Chronic Zonisamide, Sultiam, Lacosamide, Clobazam, and Rufinamide Antiseizure Drugs on Foliculogenesis in Ovarian Tissue in Prepubertal Non-Epileptic Rats. Int J Dev Neurosci. 2022 Jun 9. doi: 10.1002/jdn.10200. Epub ahead of print. PMID: 35680420.