rs11558961 might influence the chemoresistance and progression of GBM cells via promoting the binding of miR 139, ultimately decrease the susceptibility of GBM. This investigation will shed light on the optimizing for clinical trial design and individualizing of therapeutic plans 1).
1)
Wang J, Wang ML, Wang CH, Sun SY, Zhang HB, Jiang YY, Xu QW, Wang Y, Gu SX. A
novel functional polymorphism of GFAP decrease glioblastoma susceptibility
through inhibiting the binding of miR-139. Aging (Albany NY). 2018 May 10. doi:
10.18632/aging.101442. [Epub ahead of print] PubMed PMID: 29746255.