R. Loch Macdonald

Dr. Macdonald completed his Neurosurgery residency at the University of Toronto, after obtaining his MD degree at the University of British Columbia and PhD in Experimental Surgery at the University of Alberta. Following a clinical fellowship in Toronto, Dr. Macdonald was recruited to the University of Chicago Medical Center in 1993 as an Assistant Professor. He assumed the role of Neurosurgery Residency Program Director from 2000-2003 and was appointed as a Full Professor of Surgery (Neurosurgery) and of Radiation and Cellular Oncology in 2003. In 2007, Dr. Macdonald was recruited back to Toronto as the Head of the Division of Neurosurgery at St. Michael's Hospital, where he holds the Keenan Endowed Chair in Surgery.

Dr. Macdonald's clinical expertise includes cerebrovascular surgery, intracranial aneurysms and malformations, cerebral arterial bypass surgery, carotid artery disease, brain tumors, neurooncology, spinal vascular malformations and spinal tumors. He maintains an active research program focused on the basic mechanisms of contraction of vascular smooth muscle by blood and hemoglobin, cerebral vasospasm after subarachnoid hemorrhage, mechanisms of intimal proliferation and thrombosis of arteriovenous fistulas. Dr. Macdonald is currently a Full Professor of Surgery and Member of the Institute of Medical Science at the University of Toronto and a Scientist at the Li Ka Shing Knowledge Institute and Keenan Research Center, St. Michael's Hospital. He is married to Sheilah and has three children, Iain, Robyn and Erin.

1: Macdonald RL. Age and outcome after aneurysmal subarachnoid hemorrhage. Journal of Neurology, Neurosurgery, and Psychiatry. 2021 Jun 29:jnnp-2021-326920. doi: 10.1136/jnnp-2021-326920. Epub ahead of print. PMID: 34187868.

2: Hernandez CC, Tian X, Hu N, Shen W, Catron MA, Yang Y, Chen J, Jiang Y, Zhang Y, Macdonald RL. Dravet syndrome-associated mutations in <i>GABRA1</i>, <i>GABRB2</i> and <i>GABRG2</i> define the genetic landscape of defects of GABA_A receptors. Brain Commun. 2021 Mar 11;3(2):fcab033. doi: 10.1093/braincomms/fcab033. PMID: 34095830; PMCID: PMC8176149.

3: Sadan O, Waddel H, Moore R, Feng C, Mei Y, Pearce D, Kraft J, Pimentel C, Mathew S, Akbik F, Ameli P, Taylor A, Danyluk L, Martin KS, Garner K, Kolenda J, Pujari A, Asbury W, Jaja BNR, Macdonald RL, Cawley CM, Barrow DL, Samuels O. Does intrathecal nicardipine for cerebral vasospasm following subarachnoid hemorrhage correlate with reduced delayed cerebral ischemia? A retrospective propensity score-based analysis. J Neurosurg. 2021 Jun 4:1-10. doi: 10.3171/2020.12.JNS203673. Epub ahead of print. PMID: 34087804.

4: Tso MK, Turgeon P, Bosche B, Lee CK, Nie T, D'Abbondanza J, Ai J, Marsden PA, Macdonald RL. Gene expression profiling of brain endothelial cells after experimental subarachnoid haemorrhage. Sci Rep. 2021 Apr 9;11(1):7818. doi: 10.1038/s41598-021-87301-z. PMID: 33837224; PMCID: PMC8035152.

5: Qu S, Zhou C, Howe R, Shen W, Huang X, Catron M, Hu N, Macdonald RL. The K328M substitution in the human GABA_A receptor gamma2 subunit causes GEFS+ and premature sudden death in knock-in mice. Neurobiol Dis. 2021 May;152:105296. doi: 10.1016/j.nbd.2021.105296. Epub 2021 Feb 11. PMID: 33582225.

6: Shen D, Chen J, Liu D, Shen M, Wang X, Wu Y, Ke S, Macdonald RL, Zhang Q. The <i>GABRG2</i> F343L allele causes spontaneous seizures in a novel transgenic zebrafish model that can be treated with suberanilohydroxamic acid (SAHA). Ann Transl Med. 2020 Dec;8(23):1560. doi: 10.21037/atm-20-3745. PMID: 33437759; PMCID: PMC7791267.

7: Wan H, Brathwaite S, Ai J, Hynynen K, Macdonald RL. Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2021 Jan 14:271678×20980296. doi: 10.1177/0271678×20980296. Epub ahead of print. PMID: 33444089.

8: Macdonald RL. Commentary: Low-Dose Intravenous Heparin Infusion After Aneurysmal Subarachnoid Hemorrhage Is Associated With Decreased Risk of Delayed Neurological Deficit and Cerebral Infarction. Neurosurgery. 2021 Feb 16;88(3):E234-E235. doi: 10.1093/neuros/nyaa476. PMID: 33289512.

9: Etminan N, Macdonald RL. Neurovascular disease, diagnosis, and therapy: Subarachnoid hemorrhage and cerebral vasospasm. Handb Clin Neurol. 2021;176:135-169. doi: 10.1016/B978-0-444-64034-5.00009-2. PMID: 33272393.

10: Neifert SN, Chapman EK, Martini ML, Shuman WH, Schupper AJ, Oermann EK, Mocco J, Macdonald RL. Aneurysmal Subarachnoid Hemorrhage: the Last Decade. Transl Stroke Res. 2021 Jun;12(3):428-446. doi: 10.1007/s12975-020-00867-0. Epub 2020 Oct 19. PMID: 33078345.

11: Macdonald RL, Hänggi D, Ko NU, Darsaut TE, Carlson AP, Wong GK, Etminan N, Mayer SA, Aldrich EF, Diringer MN, Ng D, Strange P, Bleck T, Grubb R, Suarez JI. NEWTON-2 Cisternal (Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage): A Phase 2, Multicenter, Randomized, Open-Label Safety Study of Intracisternal EG-1962 in Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2020 Dec 15;88(1):E13-E26. doi: 10.1093/neuros/nyaa430. PMID: 32985652.

12: Eagles ME, Tso MK, Ayling OGS, Wong JH, MacDonald RL. Unfavorable Outcome After Good Grade Aneurysmal Subarachnoid Hemorrhage: Exploratory Analysis. World Neurosurg. 2020 Dec;144:e842-e848. doi: 10.1016/j.wneu.2020.09.079. Epub 2020 Sep 18. PMID: 32956894.

13: Shen W, Poliquin S, Macdonald RL, Dong M, Kang JQ. Endoplasmic reticulum stress increases inflammatory cytokines in an epilepsy mouse model Gabrg2^+/Q390X knockin: A link between genetic and acquired epilepsy? Epilepsia. 2020 Oct;61(10):2301-2312. doi: 10.1111/epi.16670. Epub 2020 Sep 17. PMID: 32944937; PMCID: PMC7918935.

14: Schupper AJ, Eagles ME, Neifert SN, Mocco J, Macdonald RL. Lessons from the CONSCIOUS-1 Study. J Clin Med. 2020 Sep 14;9(9):2970. doi: 10.3390/jcm9092970. PMID: 32937959; PMCID: PMC7564635.

15: Zhang CQ, Catron MA, Ding L, Hanna CM, Gallagher MJ, Macdonald RL, Zhou C. Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model. Cereb Cortex. 2021 Jan 5;31(2):768-784. doi: 10.1093/cercor/bhaa256. PMID: 32930324; PMCID: PMC7906787.

16: Macdonald RL, Torres E, Schwartzentruber TE, Panesi M. State-to-State Master Equation and Direct Molecular Simulation Study of Energy Transfer and Dissociation for the N₂-N System. J Phys Chem A. 2020 Sep 3;124(35):6986-7000. doi: 10.1021/acs.jpca.0c04029. Epub 2020 Aug 19. PMID: 32786989.

17: Neifert SN, Martini ML, Hardigan T, Ladner TR, MacDonald RL, Oermann EK. Trends in Incidence and Mortality by Hospital Teaching Status and Location in Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2020 Oct;142:e253-e259. doi: 10.1016/j.wneu.2020.06.180. Epub 2020 Jun 27. PMID: 32599190.

18: Qu S, Catron M, Zhou C, Janve V, Shen W, Howe RK, Macdonald RL. GABA_A receptor β3 subunit mutation D120N causes Lennox-Gastaut syndrome in knock-in mice. Brain Commun. 2020;2(1):fcaa028. doi: 10.1093/braincomms/fcaa028. Epub 2020 Mar 10. PMID: 32467926; PMCID: PMC7238755.

19: Aldrich EF, Higashida R, Hmissi A, Le EJ, Macdonald RL, Marr A, Mayer SA, Roux S, Bruder N. Thick and diffuse cisternal clot independently predicts vasospasm-related morbidity and poor outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2020 May 22:1-9. doi: 10.3171/2020.3.JNS193400. Epub ahead of print. PMID: 32442971.

20: Martini ML, Neifert SN, Yaeger KA, Hardigan T, Ladner TR, Nistal DA, Lamb C, Kellner CP, Macdonald RL, Mocco J, Oermann EK. Increased Risk of Transient Cerebral Ischemia After Subarachnoid Hemorrhage in Patients with Premorbid Opioid Use Disorders: A Nationwide Analysis of Outcomes. World Neurosurg. 2020 Sep;141:e195-e203. doi: 10.1016/j.wneu.2020.05.075. Epub 2020 May 17. PMID: 32434033.

21: Chai CL, Pyeong Jeon J, Tsai YH, Whittaker P, Macdonald RL, Lindgren AE, Ayling OGS, Acioly MA, Cohen-Gadol A, Huang YH. Endovascular Intervention Versus Surgery in Ruptured Intracranial Aneurysms in Equipoise: A Systematic Review. Stroke. 2020 Jun;51(6):1703-1711. doi: 10.1161/STROKEAHA.120.028798. Epub 2020 May 13. PMID: 32397934.

22: Hackenberg KAM, Rajabzadeh-Oghaz H, Dreier R, Buchholz BA, Navid A, Rocke DM, Abdulazim A, Hänggi D, Siddiqui A, Macdonald RL, Meng H, Etminan N. Collagen Turnover in Relation to Risk Factors and Hemodynamics in Human Intracranial Aneurysms. Stroke. 2020 May;51(5):1624-1628. doi: 10.1161/STROKEAHA.120.029335. Epub 2020 Mar 20. Erratum in: Stroke. 2020 May;51(5):e102. PMID: 32192404; PMCID: PMC7340076.

23: Carlson AP, Hänggi D, Wong GK, Etminan N, Mayer SA, Aldrich F, Diringer MN, Schmutzhard E, Faleck HJ, Ng D, Saville BR, Bleck T, Grubb R Jr, Miller M, Suarez JI, Proskin HM, Macdonald RL; NEWTON Investigators. Single-Dose Intraventricular Nimodipine Microparticles Versus Oral Nimodipine for Aneurysmal Subarachnoid Hemorrhage. Stroke. 2020 Apr;51(4):1142-1149. doi: 10.1161/STROKEAHA.119.027396. Epub 2020 Mar 6. PMID: 32138631.

24: Carlson AP, Alchbli A, Hänggi D, Macdonald RL, Shuttleworth CW. Effect of Locally Delivered Nimodipine Microparticles on Spreading Depolarization in Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2021 Feb;34(1):345-349. doi: 10.1007/s12028-020-00935-1. PMID: 32103439.

25: Maher M, Schweizer TA, Macdonald RL. Treatment of Spontaneous Subarachnoid Hemorrhage: Guidelines and Gaps. Stroke. 2020 Apr;51(4):1326-1332. doi: 10.1161/STROKEAHA.119.025997. Epub 2020 Jan 22. PMID: 31964292.

26: Lidington D, Fares JC, Uhl FE, Dinh DD, Kroetsch JT, Sauvé M, Malik FA, Matthes F, Vanherle L, Adel A, Momen A, Zhang H, Aschar-Sobbi R, Foltz WD, Wan H, Sumiyoshi M, Macdonald RL, Husain M, Backx PH, Heximer SP, Meissner A, Bolz SS. CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage. JACC Basic Transl Sci. 2019 Nov 27;4(8):940-958. doi: 10.1016/j.jacbts.2019.07.004. PMID: 31909302; PMCID: PMC6939007.

27: Macdonald RL, Hänggi D, Strange P, Steiger HJ, Mocco J, Miller M, Mayer SA, Hoh BL, Faleck HJ, Etminan N, Diringer MN, Carlson AP, Aldrich F; NEWTON Investigators. Nimodipine pharmacokinetics after intraventricular injection of sustained-release nimodipine for subarachnoid hemorrhage. J Neurosurg. 2019 Dec 6:1-7. doi: 10.3171/2019.9.JNS191366. Epub ahead of print. PMID: 31812149.

28: MacDonald RL, Syme A, Little B, Ward L, Thomas CG. Toward the combined optimization of dynamic axes (CODA) for stereotactic radiotherapy and radiosurgery using fixed couch trajectories. Med Phys. 2020 Feb;47(2):307-316. doi: 10.1002/mp.13887. Epub 2019 Dec 3. PMID: 31659750.

29: MacDonald RL, Lee Y, Schasfoort J, Soliman H, Sahgal A, Ruschin M. Real-Time Infrared Motion Tracking Analysis for Patients Treated With Gated Frameless Image Guided Stereotactic Radiosurgery. Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):413-421. doi: 10.1016/j.ijrobp.2019.10.030. Epub 2019 Oct 23. PMID: 31655198.

30: Carlson AP, Hänggi D, Macdonald RL, Shuttleworth CW. Nimodipine Reappraised: An Old Drug With a Future. Curr Neuropharmacol. 2020;18(1):65-82. doi: 10.2174/1570159×17666190927113021. PMID: 31560289; PMCID: PMC7327937.

31: Dijkland SA, Jaja BNR, van der Jagt M, Roozenbeek B, Vergouwen MDI, Suarez JI, Torner JC, Todd MM, van den Bergh WM, Saposnik G, Zumofen DW, Cusimano MD, Mayer SA, Lo BWY, Steyerberg EW, Dippel DWJ, Schweizer TA, Macdonald RL, Lingsma HF; Members of the SAHIT Collaboration. Between-center and between-country differences in outcome after aneurysmal subarachnoid hemorrhage in the Subarachnoid Hemorrhage International Trialists (SAHIT) repository. J Neurosurg. 2019 Aug 23:1-9. doi: 10.3171/2019.5.JNS19483. Epub ahead of print. PMID: 31443072.

32: Shi YW, Zhang Q, Cai K, Poliquin S, Shen W, Winters N, Yi YH, Wang J, Hu N, Macdonald RL, Liao WP, Kang JQ. Synaptic clustering differences due to different GABRB3 mutations cause variable epilepsy syndromes. Brain. 2019 Oct 1;142(10):3028-3044. doi: 10.1093/brain/awz250. PMID: 31435640; PMCID: PMC6776116.

33: Hoogmoed J, de Oliveira Manoel AL, Coert BA, Marotta TR, Macdonald RL, Vandertop WP, Verbaan D, Germans MR. Why Do Patients with Poor-Grade Subarachnoid Hemorrhage Die? World Neurosurg. 2019 Nov;131:e508-e513. doi: 10.1016/j.wneu.2019.07.221. Epub 2019 Aug 6. PMID: 31398522.

34: Mayer SA, Aldrich EF, Bruder N, Hmissi A, Macdonald RL, Viarasilpa T, Marr A, Roux S, Higashida RT. Thick and Diffuse Subarachnoid Blood as a Treatment Effect Modifier of Clazosentan After Subarachnoid Hemorrhage. Stroke. 2019 Oct;50(10):2738-2744. doi: 10.1161/STROKEAHA.119.025682. Epub 2019 Aug 9. PMID: 31394993.

35: Eagles ME, Powell MF, Ayling OGS, Tso MK, Macdonald RL. Acute kidney injury after aneurysmal subarachnoid hemorrhage and its effect on patient outcome: an exploratory analysis. J Neurosurg. 2019 Jul 12:1-8. doi: 10.3171/2019.4.JNS19103. Epub ahead of print. PMID: 31299650.

36: Suarez JI, Macdonald RL. The End of the Tower of Babel in Subarachnoid Hemorrhage: Common Data Elements at Last. Neurocrit Care. 2019 Jun;30(Suppl 1):1-3. doi: 10.1007/s12028-019-00751-2. PMID: 31152313.

37: Chou SH, Macdonald RL, Keller E; Unruptured Intracranial Aneurysms and SAH CDE Project Investigators. Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations. Neurocrit Care. 2019 Jun;30(Suppl 1):46-59. doi: 10.1007/s12028-019-00725-4. PMID: 31144274; PMCID: PMC7888262.

38: Stienen MN, Visser-Meily JM, Schweizer TA, Hänggi D, Macdonald RL, Vergouwen MDI; Unruptured Intracranial Aneurysms and SAH CDE Project Investigators. Prioritization and Timing of Outcomes and Endpoints After Aneurysmal Subarachnoid Hemorrhage in Clinical Trials and Observational Studies: Proposal of a Multidisciplinary Research Group. Neurocrit Care. 2019 Jun;30(Suppl 1):102-113. doi: 10.1007/s12028-019-00737-0. PMID: 31123994.

39: de Oliveira Manoel AL, van der Jagt M, Amin-Hanjani S, Bambakidis NC, Brophy GM, Bulsara K, Claassen J, Connolly ES, Hoffer SA, Hoh BL, Holloway RG, Kelly AG, Mayer SA, Nakaji P, Rabinstein AA, Vajkoczy P, Vergouwen MDI, Woo H, Zipfel GJ, Suarez JI; Unruptured Aneurysms and SAH − CDE Project Investigators. Common Data Elements for Unruptured Intracranial Aneurysms and Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Working Group on Hospital Course and Acute Therapies-Proposal of a Multidisciplinary Research Group. Neurocrit Care. 2019 Jun;30(Suppl 1):36-45. doi: 10.1007/s12028-019-00726-3. PMID: 31119687.

40: Hackenberg KAM, Etminan N, Wintermark M, Meyers PM, Lanzino G, Rüfenacht D, Krings T, Huston J 3rd, Rinkel G, Derdeyn C; Unruptured Intracranial Aneurysms and SAH CDE Project Investigators. Common Data Elements for Radiological Imaging of Patients with Subarachnoid Hemorrhage: Proposal of a Multidisciplinary Research Group. Neurocrit Care. 2019 Jun;30(Suppl 1):60-78. doi: 10.1007/s12028-019-00728-1. PMID: 31115823.

41: Hackenberg KAM, Algra A, Salman RA, Frösen J, Hasan D, Juvela S, Langer D, Meyers P, Morita A, Rinkel G, Etminan N; Unruptured Aneurysms and SAH CDE Project Investigators. Definition and Prioritization of Data Elements for Cohort Studies and Clinical Trials on Patients with Unruptured Intracranial Aneurysms: Proposal of a Multidisciplinary Research Group. Neurocrit Care. 2019 Jun;30(Suppl 1):87-101. doi: 10.1007/s12028-019-00729-0. PMID: 31102238.

42: Damani R, Mayer S, Dhar R, Martin RH, Nyquist P, Olson DM, Mejia-Mantilla JH, Muehlschlegel S, Jauch EC, Mocco J, Mutoh T, Suarez JI; Unruptured Intracranial Aneurysms and SAH CDE Project Investigators. Common Data Element for Unruptured Intracranial Aneurysm and Subarachnoid Hemorrhage: Recommendations from Assessments and Clinical Examination Workgroup/Subcommittee. Neurocrit Care. 2019 Jun;30(Suppl 1):28-35. doi: 10.1007/s12028-019-00736-1. PMID: 31090013.

43: Zhang CQ, McMahon B, Dong H, Warner T, Shen W, Gallagher M, Macdonald RL, Kang JQ. Molecular basis for and chemogenetic modulation of comorbidities in GABRG2-deficient epilepsies. Epilepsia. 2019 Jun;60(6):1137-1149. doi: 10.1111/epi.15160. Epub 2019 May 14. PMID: 31087664; PMCID: PMC6880653.

44: Suarez JI, Sheikh MK, Macdonald RL, Amin-Hanjani S, Brown RD Jr, de Oliveira Manoel AL, Derdeyn CP, Etminan N, Keller E, Leroux PD, Mayer SA, Morita A, Rinkel G, Rufennacht D, Stienen MN, Torner J, Vergouwen MDI, Wong GKC; Unruptured Intracranial Aneurysms and SAH CDE Project Investigators. Common Data Elements for Unruptured Intracranial Aneurysms and Subarachnoid Hemorrhage Clinical Research: A National Institute for Neurological Disorders and Stroke and National Library of Medicine Project. Neurocrit Care. 2019 Jun;30(Suppl 1):4-19. doi: 10.1007/s12028-019-00723-6. PMID: 31087257.

45: Hernandez CC, XiangWei W, Hu N, Shen D, Shen W, Lagrange AH, Zhang Y, Dai L, Ding C, Sun Z, Hu J, Zhu H, Jiang Y, Macdonald RL. Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies. Brain. 2019 Jul 1;142(7):1938-1954. doi: 10.1093/brain/awz123. PMID: 31056671; PMCID: PMC6598634.

46: Macdonald RL, Katan M. Haptoglobin and hemoglobin in subarachnoid hemorrhage: A tale of 2 globins. Neurology. 2019 Apr 30;92(18):831-832. doi: 10.1212/WNL.0000000000007399. Epub 2019 Apr 5. PMID: 30952791.

47: Mikhail M, Ayling OGS, Eagles ME, Ibrahim GM, Macdonald RL. Association between weekend admissions and mortality after aneurysmal subarachnoid hemorrhage: the “weekend effect” revisited. J Neurosurg. 2019 Mar 29;132(4):1167-1173. doi: 10.3171/2019.1.JNS183185. PMID: 30925472.

48: Taslimi S, Ku JC, Modabbernia A, Macdonald RL. Hemorrhage, Seizures, and Dynamic Changes of Familial versus Nonfamilial Cavernous Malformation: Systematic Review and Meta-analysis. World Neurosurg. 2019 Jun;126:241-246. doi: 10.1016/j.wneu.2019.02.115. Epub 2019 Mar 7. PMID: 30851471.

49: Hernandez CC, Macdonald RL. A structural look at GABA_A receptor mutations linked to epilepsy syndromes. Brain Res. 2019 Jul 1;1714:234-247. doi: 10.1016/j.brainres.2019.03.004. Epub 2019 Mar 7. PMID: 30851244.

50: Eagles ME, Tso MK, Macdonald RL. Cognitive Impairment, Functional Outcome, and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2019 Jan 10:S1878-8750(19)30020-8. doi: 10.1016/j.wneu.2018.12.152. Epub ahead of print. PMID: 30639483.

51: Macdonald RL. Letter to the Editor. Limited data? J Neurosurg. 2018 Dec 14;130(2):670-671. doi: 10.3171/2018.9.JNS182618. PMID: 30554185.

52: Murphy A, Lee TY, Marotta TR, Spears J, Macdonald RL, Aviv RI, Baker A, Bharatha A. Prospective Multicenter Study of Changes in MTT after Aneurysmal SAH and Relationship to Delayed Cerebral Ischemia in Patients with Good- and Poor- Grade Admission Status. AJNR Am J Neuroradiol. 2018 Nov;39(11):2027-2033. doi: 10.3174/ajnr.A5844. Epub 2018 Oct 18. PMID: 30337436; PMCID: PMC7655376.

53: MacDonald RL, Thomas CG, Ward L, Syme A. Intra-arc binary collimation algorithm for the optimization of stereotactic radiotherapy treatment of multiple metastases with multiple prescriptions. Med Phys. 2018 Dec;45(12):5597-5607. doi: 10.1002/mp.13224. Epub 2018 Oct 24. PMID: 30288758.

54: Macdonald RL. Management of Intracranial Hemorrhage in the Anticoagulated Patient. Neurosurg Clin N Am. 2018 Oct;29(4):605-613. doi: 10.1016/j.nec.2018.06.013. Epub 2018 Aug 14. PMID: 30223973.

55: Eagles ME, Tso MK, Macdonald RL. Significance of fluctuations in serum sodium levels following aneurysmal subarachnoid hemorrhage: an exploratory analysis. J Neurosurg. 2018 Aug 17;131(2):420-425. doi: 10.3171/2018.3.JNS173068. PMID: 30117765.

56: Lagrange AH, Hu N, Macdonald RL. GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABA_A receptors. J Physiol. 2018 Sep;596(18):4475-4495. doi: 10.1113/JP276187. Epub 2018 Aug 12. PMID: 30019335; PMCID: PMC6138284.

57: Hänggi D, Etminan N, Mayer SA, Aldrich EF, Diringer MN, Schmutzhard E, Faleck HJ, Ng D, Saville BR, Macdonald RL; NEWTON Investigators. Clinical Trial Protocol: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage [NEWTON-2 (Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After SubarachNoid Hemorrhage)]. Neurocrit Care. 2019 Feb;30(1):88-97. doi: 10.1007/s12028-018-0575-z. PMID: 30014184.

58: Darsaut TE, Fahed R, Macdonald RL, Arthur AS, Kalani MYS, Arikan F, Roy D, Weill A, Bilocq A, Rempel JL, Chow MM, Ashforth RA, Findlay JM, Castro-Afonso LH, Chagnon M, Gevry G, Raymond J. Surgical or endovascular management of ruptured intracranial aneurysms: an agreement study. J Neurosurg. 2018 Jul 13;131(1):25-31. doi: 10.3171/2018.1.JNS172645. PMID: 30004285.

59: Lin H, Hu N, Zhang Y, Wang Y, Macdonald RL. Whole exome sequencing reveals novel NOV and DCAF13 variants in a Chinese pedigree with familial cortical myoclonic tremor with epilepsy. Neurosci Lett. 2018 Sep 25;684:115-120. doi: 10.1016/j.neulet.2018.07.014. Epub 2018 Jul 9. PMID: 30003937.

60: Ayling OGS, Ibrahim GM, Alotaibi NM, Gooderham PA, Macdonald RL. Anemia After Aneurysmal Subarachnoid Hemorrhage Is Associated With Poor Outcome and Death. Stroke. 2018 Aug;49(8):1859-1865. doi: 10.1161/STROKEAHA.117.020260. PMID: 29946013.

61: Bailey DM, Catron MA, Kovtun O, Macdonald RL, Zhang Q, Rosenthal SJ. Single Quantum Dot Tracking Reveals Serotonin Transporter Diffusion Dynamics are Correlated with Cholesterol-Sensitive Threonine 276 Phosphorylation Status in Primary Midbrain Neurons. ACS Chem Neurosci. 2018 Nov 21;9(11):2534-2541. doi: 10.1021/acschemneuro.8b00214. Epub 2018 May 24. PMID: 29787674.

62: de Oliveira Manoel AL, Macdonald RL. Neuroinflammation as a Target for Intervention in Subarachnoid Hemorrhage. Front Neurol. 2018 May 2;9:292. doi: 10.3389/fneur.2018.00292. PMID: 29770118; PMCID: PMC5941982.

63: Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald RL, Hol EM, Meijers JCM, Vergouwen MDI. Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage. J Thromb Haemost. 2018 Jul;16(7):1413-1422. doi: 10.1111/jth.14136. Epub 2018 Jun 8. PMID: 29729651; PMCID: PMC6055612.

64: Hird MA, Vesely KA, Tasneem T, Saposnik G, Macdonald RL, Schweizer TA. A Case-Control Study Investigating Simulated Driving Errors in Ischemic Stroke and Subarachnoid Hemorrhage. Front Neurol. 2018 Feb 13;9:54. doi: 10.3389/fneur.2018.00054. PMID: 29487561; PMCID: PMC5816745.

65: Robar JL, Moran K, Allan J, Clancey J, Joseph T, Chytyk-Praznik K, MacDonald RL, Lincoln J, Sadeghi P, Rutledge R. Intrapatient study comparing 3D printed bolus versus standard vinyl gel sheet bolus for postmastectomy chest wall radiation therapy. Pract Radiat Oncol. 2018 Jul-Aug;8(4):221-229. doi: 10.1016/j.prro.2017.12.008. Epub 2017 Dec 24. PMID: 29452866.

66: Wang CH, Hernandez CC, Wu J, Zhou N, Hsu HY, Shen ML, Wang YC, Macdonald RL, Wu DC. A Missense Mutation A384P Associated with Human Hyperekplexia Reveals a Desensitization Site of Glycine Receptors. J Neurosci. 2018 Mar 14;38(11):2818-2831. doi: 10.1523/JNEUROSCI.0674-16.2018. Epub 2018 Feb 13. PMID: 29440552; PMCID: PMC5852660.

67: Macdonald RL, Jaffe RL, Schwenke DW, Panesi M. Construction of a coarse- grain quasi-classical trajectory method. I. Theory and application to N₂-N₂ system. J Chem Phys. 2018 Feb 7;148(5):054309. doi: 10.1063/1.5011331. PMID: 29421898.

68: Macdonald RL, Grover MS, Schwartzentruber TE, Panesi M. Construction of a coarse-grain quasi-classical trajectory method. II. Comparison against the direct molecular simulation method. J Chem Phys. 2018 Feb 7;148(5):054310. doi: 10.1063/1.5011332. PMID: 29421878.

69: Alotaibi NM, Samuel N, Mansouri A, Nejad R, Macdonald RL. Glioblastoma Following Ischemic Stroke. Can J Neurol Sci. 2017 Nov;44(6):732-733. doi: 10.1017/cjn.2017.220. PMID: 29391081.

70: Jaja BNR, Saposnik G, Lingsma HF, Macdonald E, Thorpe KE, Mamdani M, Steyerberg EW, Molyneux A, Manoel ALO, Schatlo B, Hanggi D, Hasan D, Wong GKC, Etminan N, Fukuda H, Torner J, Schaller KL, Suarez JI, Stienen MN, Vergouwen MDI, Rinkel GJE, Spears J, Cusimano MD, Todd M, Le Roux P, Kirkpatrick P, Pickard J, van den Bergh WM, Murray G, Johnston SC, Yamagata S, Mayer S, Schweizer TA, Macdonald RL; SAHIT collaboration. Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study. BMJ. 2018 Jan 18;360:j5745. doi: 10.1136/bmj.j5745. Erratum in: BMJ. 2018 Sep 26;362:k4079. PMID: 29348138.

71: Hernandez CC, Zhang Y, Hu N, Shen D, Shen W, Liu X, Kong W, Jiang Y, Macdonald RL. GABA _A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy. Sci Rep. 2017 Nov 21;7(1):15903. doi: 10.1038/s41598-017-16010-3. PMID: 29162865; PMCID: PMC5698489.

72: Ayling OGS, Alotaibi NM, Wang JZ, Fatehi M, Ibrahim GM, Benavente O, Field TS, Gooderham PA, Macdonald RL. Suboccipital Decompressive Craniectomy for cerebellar infarction: A Systematic Review and Meta-Analysis. World Neurosurg. 2018 Feb;110:450-459.e5. doi: 10.1016/j.wneu.2017.10.144. Epub 2017 Dec 2. PMID: 29104155.

73: MacDonald RL, Thomas CG, Syme A. Dynamic collimator trajectory algorithm for multiple metastases dynamic conformal arc treatment planning. Med Phys. 2018 Jan;45(1):5-17. doi: 10.1002/mp.12648. Epub 2017 Nov 27. PMID: 29094419.

74: Alotaibi NM, Wang JZ, Pasarikovski CR, Guha D, Al-Mufti F, Mamdani M, Saposnik G, Schweizer TA, Macdonald RL. Management of raised intracranial pressure in aneurysmal subarachnoid hemorrhage: time for a consensus? Neurosurg Focus. 2017 Nov;43(5):E13. doi: 10.3171/2017.7.FOCUS17426. PMID: 29088956.

75: Jaja BNR, Schweizer TA, Claassen J, Le Roux P, Mayer SA, Macdonald RL; SAHIT Collaborators. The SAFARI Score to Assess the Risk of Convulsive Seizure During Admission for Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2018 Jun 1;82(6):887-893. doi: 10.1093/neuros/nyx334. PMID: 28973169.

76: Germans MR, Jaja BNR, de Oliviera Manoel AL, Cohen AH, Macdonald RL. Sex differences in delayed cerebral ischemia after subarachnoid hemorrhage. J Neurosurg. 2018 Aug;129(2):458-464. doi: 10.3171/2017.3.JNS162808. Epub 2017 Sep 1. PMID: 28862545.

77: Alotaibi NM, Ibrahim GM, Wang J, Guha D, Mamdani M, Schweizer TA, Macdonald RL. Neurosurgeon academic impact is associated with clinical outcomes after clipping of ruptured intracranial aneurysms. PLoS One. 2017 Jul 20;12(7):e0181521. doi: 10.1371/journal.pone.0181521. PMID: 28727832; PMCID: PMC5519166.

78: Huang X, Zhou C, Tian M, Kang JQ, Shen W, Verdier K, Pimenta A, MacDonald RL. Overexpressing wild-type γ2 subunits rescued the seizure phenotype in Gabrg2^+/Q390X Dravet syndrome mice. Epilepsia. 2017 Aug;58(8):1451-1461. doi: 10.1111/epi.13810. Epub 2017 Jun 6. PMID: 28586508; PMCID: PMC5554098.

79: Pasarikovski CR, Alotaibi NM, Al-Mufti F, Macdonald RL. Hypertonic Saline for Increased Intracranial Pressure After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review. World Neurosurg. 2017 Sep;105:1-6. doi: 10.1016/j.wneu.2017.05.085. Epub 2017 May 23. PMID: 28549643.

80: Warner TA, Liu Z, Macdonald RL, Kang JQ. Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2^+/Q390X mice. Epilepsy Res. 2017 Aug;134:1-8. doi: 10.1016/j.eplepsyres.2017.04.020. Epub 2017 Apr 30. PMID: 28505490; PMCID: PMC5512282.

81: Eagles ME, Jaja BNR, Macdonald RL. Incorporating a Modified Graeb Score to the Modified Fisher Scale for Improved Risk Prediction of Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2018 Mar 1;82(3):299-305. doi: 10.1093/neuros/nyx165. PMID: 28419304.

82: Ku JC, Alotaibi NM, Wang J, Ibrahim GM, Schweizer TA, Macdonald RL. Internet search volumes in brain aneurysms and subarachnoid hemorrhage: Is there evidence of seasonality? Clin Neurol Neurosurg. 2017 Jul;158:1-4. doi: 10.1016/j.clineuro.2017.04.008. Epub 2017 Apr 6. PMID: 28412503.

83: Guha D, Macdonald RL. Perioperative Management of Anticoagulation. Neurosurg Clin N Am. 2017 Apr;28(2):287-295. doi: 10.1016/j.nec.2016.11.011. Epub 2017 Feb 1. PMID: 28325463.

84: Hänggi D, Macdonald RL. Response by Hänggi and Macdonald to Letter Regarding Article, “Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])”. Stroke. 2017 Apr;48(4):e114. doi: 10.1161/STROKEAHA.117.016603. Epub 2017 Mar 10. PMID: 28283608.

85: Murphy A, de Oliveira Manoel AL, Macdonald RL, Baker A, Lee TY, Marotta T, Montanera W, Aviv R, Bharatha A. Changes in Cerebral Perfusion with Induced Hypertension in Aneurysmal Subarachnoid Hemorrhage: A Pilot and Feasibility Study. Neurocrit Care. 2017 Aug;27(1):3-10. doi: 10.1007/s12028-017-0379-6. PMID: 28244000.

86: Grasso G, Alafaci C, Macdonald RL. Management of aneurysmal subarachnoid hemorrhage: State of the art and future perspectives. Surg Neurol Int. 2017 Jan 19;8:11. doi: 10.4103/2152-7806.198738. Erratum in: Surg Neurol Int. 2017 Apr 26;8:71. PMID: 28217390; PMCID: PMC5288992.

87: Hernandez CC, Kong W, Hu N, Zhang Y, Shen W, Jackson L, Liu X, Jiang Y, Macdonald RL. Altered Channel Conductance States and Gating of GABA_A Receptors by a Pore Mutation Linked to Dravet Syndrome. eNeuro. 2017 Feb 10;4(1):ENEURO.0251-16.2017. doi: 10.1523/ENEURO.0251-16.2017. PMID: 28197552; PMCID: PMC5301078.

88: Etminan N, Macdonald RL. Management of aneurysmal subarachnoid hemorrhage. Handb Clin Neurol. 2017;140:195-228. doi: 10.1016/B978-0-444-63600-3.00012-X. PMID: 28187800.

89: Alotaibi NM, Guha D, Ahuja CS, Spears J, Muller PJ, Tucker WS, Hudson AR, Macdonald RL. History of neurosurgery at University of Toronto: the St. Michael's story. J Neurosurg. 2017 Dec;127(6):1417-1425. doi: 10.3171/2016.9.JNS161119. Epub 2017 Jan 27. PMID: 28128690.

90: Rawal S, Alcaide-Leon P, Macdonald RL, Rinkel GJ, Victor JC, Krings T, Kapral MK, Laupacis A. Meta-analysis of timing of endovascular aneurysm treatment in subarachnoid haemorrhage: inconsistent results of early treatment within 1 day. J Neurol Neurosurg Psychiatry. 2017 Mar;88(3):241-248. doi: 10.1136/jnnp-2016-314596. Epub 2017 Jan 18. PMID: 28100721.

91: Alotaibi NM, Elkarim GA, Samuel N, Ayling OGS, Guha D, Fallah A, Aldakkan A, Jaja BNR, de Oliveira Manoel AL, Ibrahim GM, Macdonald RL. Effects of decompressive craniectomy on functional outcomes and death in poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Neurosurg. 2017 Dec;127(6):1315-1325. doi: 10.3171/2016.9.JNS161383. Epub 2017 Jan 6. PMID: 28059660.

92: MacDonald RL, Robar JL, Thomas CG. Overlap-guided fixed-patient support positioning optimization for cranial SRT. Med Phys. 2017 Jan;44(1):17-27. doi: 10.1002/mp.12008. Epub 2017 Jan 3. PMID: 28044324.

93: Delahanty RJ, Zhang Y, Bichell TJ, Shen W, Verdier K, Macdonald RL, Xu L, Boyd K, Williams J, Kang JQ. Beyond Epilepsy and Autism: Disruption of GABRB3 Causes Ocular Hypopigmentation. Cell Rep. 2016 Dec 20;17(12):3115-3124. doi: 10.1016/j.celrep.2016.11.067. PMID: 28009282; PMCID: PMC5240804.

94: Bell JD, Rhind SG, Di Battista AP, Macdonald RL, Baker AJ. Biomarkers of Glycocalyx Injury are Associated with Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage: A Case Series Supporting a New Hypothesis. Neurocrit Care. 2017 Jun;26(3):339-347. doi: 10.1007/s12028-016-0357-4. PMID: 28000132.

95: Bosche B, Molcanyi M, Rej S, Doeppner TR, Obermann M, Müller DJ, Das A, Hescheler J, Macdonald RL, Noll T, Härtel FV. Low-Dose Lithium Stabilizes Human Endothelial Barrier by Decreasing MLC Phosphorylation and Universally Augments Cholinergic Vasorelaxation Capacity in a Direct Manner. Front Physiol. 2016 Dec 6;7:593. doi: 10.3389/fphys.2016.00593. Erratum in: Front Physiol. 2019 May 22;10:648. PMID: 27999548; PMCID: PMC5138228.

96: Hänggi D, Etminan N, Aldrich F, Steiger HJ, Mayer SA, Diringer MN, Hoh BL, Mocco J, Faleck HJ, Macdonald RL; NEWTON Investigators. Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]). Stroke. 2017 Jan;48(1):145-151. doi: 10.1161/STROKEAHA.116.014250. Epub 2016 Dec 8. PMID: 27932607; PMCID: PMC5176000.

97: Germans MR, Boogaarts HD, Macdonald RL. Neuroprotection in Critical Care Neurology. Semin Neurol. 2016 Dec;36(6):642-648. doi: 10.1055/s-0036-1592359. Epub 2016 Dec 1. PMID: 27907969.

98: Alotaibi NM, Samuel N, Wang J, Ahuja CS, Guha D, Ibrahim GM, Schweizer TA, Saposnik G, Macdonald RL. The Use of Social Media Communications in Brain Aneurysms and Subarachnoid Hemorrhage: A Mixed-Method Analysis. World Neurosurg. 2017 Feb;98:456-462. doi: 10.1016/j.wneu.2016.11.085. Epub 2016 Nov 24. PMID: 27890750.

99: Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL. Correction: Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population. PLoS One. 2016 Nov 21;11(11):e0167264. doi: 10.1371/journal.pone.0167264. Erratum for: PLoS One. 2016 Sep 13;11(9):e0162883. PMID: 27870904; PMCID: PMC5117773.

100: Shen D, Hernandez CC, Shen W, Hu N, Poduri A, Shiedley B, Rotenberg A, Datta AN, Leiz S, Patzer S, Boor R, Ramsey K, Goldberg E, Helbig I, Ortiz- Gonzalez XR, Lemke JR, Marsh ED, Macdonald RL. De novo GABRG2 mutations associated with epileptic encephalopathies. Brain. 2017 Jan;140(1):49-67. doi: 10.1093/brain/aww272. Epub 2016 Nov 17. PMID: 27864268; PMCID: PMC5226060.

101: Ayling OG, Ibrahim GM, Alotaibi NM, Gooderham PA, Macdonald RL. Dissociation of Early and Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage. Stroke. 2016 Dec;47(12):2945-2951. doi: 10.1161/STROKEAHA.116.014794. Epub 2016 Nov 8. PMID: 27827324.

102: Wang J, Alotaibi NM, Akbar MA, Ayling OG, Ibrahim GM, Macdonald RL; SAHIT collaborators. Loss of Consciousness at Onset of Aneurysmal Subarachnoid Hemorrhage is Associated with Functional Outcomes in Good-Grade Patients. World Neurosurg. 2017 Feb;98:308-313. doi: 10.1016/j.wneu.2016.10.099. Epub 2016 Nov 3. PMID: 27818312.

103: D'Abbondanza JA, Ai J, Lass E, Wan H, Brathwaite S, Tso MK, Lee C, Marsden PA, Macdonald RL. Robust effects of genetic background on responses to subarachnoid hemorrhage in mice. J Cereb Blood Flow Metab. 2016 Nov;36(11):1942-1954. doi: 10.1177/0271678×15612489. Epub 2015 Oct 26. PMID: 26661216; PMCID: PMC5094306.

104: Ishii A, Kang JQ, Schornak CC, Hernandez CC, Shen W, Watkins JC, Macdonald RL, Hirose S. A <i>de novo</i> missense mutation of <i>GABRB2</i> causes early myoclonic encephalopathy. J Med Genet. 2017 Mar;54(3):202-211. doi: 10.1136/jmedgenet-2016-104083. Epub 2016 Oct 27. PMID: 27789573; PMCID: PMC5384423.

105: Wang J, Shen D, Xia G, Shen W, Macdonald RL, Xu D, Kang JQ. Differential protein structural disturbances and suppression of assembly partners produced by nonsense GABRG2 epilepsy mutations: implications for disease phenotypic heterogeneity. Sci Rep. 2016 Oct 20;6:35294. doi: 10.1038/srep35294. PMID: 27762395; PMCID: PMC5071880.

106: Aldakkan A, Mansouri A, Jaja BN, Alotaibi NM, Macdonald RL; Subarachnoid Hemorrhage International Trialists Collaborators. Predictors of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage with Asymptomatic Angiographic Vasospasm on Admission. World Neurosurg. 2017 Jan;97:199-204. doi: 10.1016/j.wneu.2016.09.096. Epub 2016 Oct 4. PMID: 27717776.

107: de Oliveira Manoel AL, Mansur A, Silva GS, Germans MR, Jaja BN, Kouzmina E, Marotta TR, Abrahamson S, Schweizer TA, Spears J, Macdonald RL. Functional Outcome After Poor-Grade Subarachnoid Hemorrhage: A Single-Center Study and Systematic Literature Review. Neurocrit Care. 2016 Dec;25(3):338-350. doi: 10.1007/s12028-016-0305-3. PMID: 27651379.

108: de Oliveira Manoel AL, Goffi A, Zampieri FG, Turkel-Parrella D, Duggal A, Marotta TR, Macdonald RL, Abrahamson S. The critical care management of spontaneous intracranial hemorrhage: a contemporary review. Crit Care. 2016 Sep 18;20:272. doi: 10.1186/s13054-016-1432-0. PMID: 27640182; PMCID: PMC5027096.

109: Macdonald RL, Schweizer TA. Spontaneous subarachnoid haemorrhage. Lancet. 2017 Feb 11;389(10069):655-666. doi: 10.1016/S0140-6736(16)30668-7. Epub 2016 Sep 13. PMID: 27637674.

110: Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL. Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population. PLoS One. 2016 Sep 13;11(9):e0162883. doi: 10.1371/journal.pone.0162883. Erratum in: PLoS One. 2016 Nov 21;11(11):e0167264. PMID: 27622563; PMCID: PMC5021343.

111: Lo BW, Fukuda H, Angle M, Teitelbaum J, Macdonald RL, Farrokhyar F, Thabane L, Levine MA. Clinical outcome prediction in aneurysmal subarachnoid hemorrhage - Alterations in brain-body interface. Surg Neurol Int. 2016 Aug 1;7(Suppl 18):S527-37. doi: 10.4103/2152-7806.187496. PMID: 27583179; PMCID: PMC4982352.

112: Lo BW, Fukuda H, Angle M, Teitelbaum J, Macdonald RL, Farrokhyar F, Thabane L, Levine MA. Aneurysmal subarachnoid hemorrhage prognostic decision-making algorithm using classification and regression tree analysis. Surg Neurol Int. 2016 Jul 7;7:73. doi: 10.4103/2152-7806.185786. PMID: 27512607; PMCID: PMC4964664.

113: Botzolakis EJ, Gurba KN, Lagrange AH, Feng HJ, Stanic AK, Hu N, Macdonald RL. Comparison of γ-Aminobutyric Acid, Type A (GABAA), Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS. J Biol Chem. 2016 Sep 23;291(39):20440-61. doi: 10.1074/jbc.M115.698860. Epub 2016 Aug 4. PMID: 27493204; PMCID: PMC5034041.

114: Macdonald RL. Response. J Neurosurg. 2016 Apr;124(4):1132-3. PMID: 27482577.

115: Alotaibi NM, Samuel N, Guha D, Nassiri F, Badhiwala JH, Tam J, Shamji MF, Kulkarni AV, Macdonald RL, Lozano AM. Social Media for Academic Neurosurgical Programs: The University of Toronto Experience. World Neurosurg. 2016 Sep;93:449-57. doi: 10.1016/j.wneu.2016.06.134. Epub 2016 Jul 14. PMID: 27423202.

116: Kang JQ, Macdonald RL. Molecular Pathogenic Basis for GABRG2 Mutations Associated With a Spectrum of Epilepsy Syndromes, From Generalized Absence Epilepsy to Dravet Syndrome. JAMA Neurol. 2016 Aug 1;73(8):1009-16. doi: 10.1001/jamaneurol.2016.0449. PMID: 27367160; PMCID: PMC5426359.

117: Warner TA, Shen W, Huang X, Liu Z, Macdonald RL, Kang JQ. Differential molecular and behavioural alterations in mouse models of GABRG2 haploinsufficiency versus dominant negative mutations associated with human epilepsy. Hum Mol Genet. 2016 Aug 1;25(15):3192-3207. doi: 10.1093/hmg/ddw168. Epub 2016 Jun 23. PMID: 27340224; PMCID: PMC5179921.

118: Janve VS, Hernandez CC, Verdier KM, Hu N, Macdonald RL. Reply. Ann Neurol. 2016 Aug;80(2):312-3. doi: 10.1002/ana.24701. Epub 2016 Jun 24. PMID: 27270493.

119: Taslimi S, Modabbernia A, Amin-Hanjani S, Barker FG 2nd, Macdonald RL. Natural history of cavernous malformation: Systematic review and meta-analysis of 25 studies. Neurology. 2016 May 24;86(21):1984-91. doi: 10.1212/WNL.0000000000002701. Epub 2016 Apr 22. PMID: 27164680; PMCID: PMC4887121.

120: Witsch J, Frey HP, Patel S, Park S, Lahiri S, Schmidt JM, Agarwal S, Falo MC, Velazquez A, Jaja B, Macdonald RL, Connolly ES, Claassen J. Prognostication of long-term outcomes after subarachnoid hemorrhage: The FRESH score. Ann Neurol. 2016 Jul;80(1):46-58. doi: 10.1002/ana.24675. Epub 2016 May 25. PMID: 27129898.

121: Alharbi BM, Tso MK, Macdonald RL. Animal models of spontaneous intracerebral hemorrhage. Neurol Res. 2016 May;38(5):448-55. doi: 10.1080/01616412.2016.1144671. Epub 2016 Apr 21. PMID: 27098341.

122: Nassiri F, Ibrahim GM, Badhiwala JH, Witiw CD, Mansouri A, Alotaibi NM, Macdonald RL. A Propensity Score-Matched Study of the Use of Non-steroidal Anti- inflammatory Agents Following Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care. 2016 Dec;25(3):351-358. doi: 10.1007/s12028-016-0266-6. PMID: 27000643.

123: Janve VS, Hernandez CC, Verdier KM, Hu N, Macdonald RL. Epileptic encephalopathy de novo GABRB mutations impair γ-aminobutyric acid type A receptor function. Ann Neurol. 2016 May;79(5):806-825. doi: 10.1002/ana.24631. PMID: 26950270; PMCID: PMC5014730.

124: Hänggi D, Etminan N, Steiger HJ, Johnson M, Peet MM, Tice T, Burton K, Hudson B, Turner M, Stella A, Heshmati P, Davis C, Faleck HJ, Macdonald RL. A Site-Specific, Sustained-Release Drug Delivery System for Aneurysmal Subarachnoid Hemorrhage. Neurotherapeutics. 2016 Apr;13(2):439-49. doi: 10.1007/s13311-016-0424-8. PMID: 26935204; PMCID: PMC4824023.

125: Wan A, Jaja BN, Schweizer TA, Macdonald RL; , on behalf of the SAHIT collaboration. Clinical characteristics and outcome of aneurysmal subarachnoid hemorrhage with intracerebral hematoma. J Neurosurg. 2016 Dec;125(6):1344-1351. doi: 10.3171/2015.10.JNS151036. Epub 2016 Feb 26. PMID: 26918469.

126: Bosche B, Molcanyi M, Noll T, Rej S, Zatschler B, Doeppner TR, Hescheler J, Müller DJ, Macdonald RL, Härtel FV. A differential impact of lithium on endothelium-dependent but not on endothelium-independent vessel relaxation. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jun 3;67:98-106. doi: 10.1016/j.pnpbp.2016.02.004. Epub 2016 Feb 10. PMID: 26875501.

127: Alotaibi NM, Guha D, Fallah A, Aldakkan A, Nassiri F, Badhiwala JH, Ibrahim GM, Shamji MF, Macdonald RL, Lozano AM. Social Media Metrics and Bibliometric Profiles of Neurosurgical Departments and Journals: Is There a Relationship? World Neurosurg. 2016 Jun;90:574-579.e7. doi: 10.1016/j.wneu.2016.01.087. Epub 2016 Feb 6. PMID: 26855310.

128: de Oliveira Manoel AL, Goffi A, Marotta TR, Schweizer TA, Abrahamson S, Macdonald RL. The critical care management of poor-grade subarachnoid haemorrhage. Crit Care. 2016 Jan 23;20:21. doi: 10.1186/s13054-016-1193-9. PMID: 26801901; PMCID: PMC4724088.

129: Alotaibi NM, Nassiri F, Badhiwala JH, Witiw CD, Ibrahim GM, Macdonald RL, Lozano AM. The Most Cited Works in Aneurysmal Subarachnoid Hemorrhage: A Bibliometric Analysis of the 100 Most Cited Articles. World Neurosurg. 2016 May;89:587-592.e6. doi: 10.1016/j.wneu.2015.11.072. Epub 2015 Dec 23. PMID: 26723285.

130: Martinez JL, Macdonald RL. Surgical Strategies for Acutely Ruptured Arteriovenous Malformations. Front Neurol Neurosci. 2015;37:166-81. doi: 10.1159/000437121. Epub 2015 Nov 12. PMID: 26587641.

131: Ayling OG, Ibrahim GM, Macdonald RL. Response. J Neurosurg. 2015 Sep;123(3):619-20. PMID: 26561672.

132: Macdonald RL. Subarachnoid Hemorrhage and Loss of Consciousness. JAMA Neurol. 2016 Jan;73(1):17-8. doi: 10.1001/jamaneurol.2015.3485. PMID: 26551437.

133: Jaja BN, Lingsma H, Steyerberg EW, Schweizer TA, Thorpe KE, Macdonald RL;  on behalf of SAHIT investigators. Neuroimaging characteristics of ruptured aneurysm as predictors of outcome after aneurysmal subarachnoid hemorrhage: pooled analyses of the SAHIT cohort. J Neurosurg. 2016 Jun;124(6):1703-11. doi: 10.3171/2015.4.JNS142753. Epub 2015 Oct 23. PMID: 26495952.

134: Tso MK, Ibrahim GM, Macdonald RL. Predictors of Shunt-Dependent Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2016 Feb;86:226-32. doi: 10.1016/j.wneu.2015.09.056. Epub 2015 Sep 30. PMID: 26428322.

135: Bonares MJ, Egeto P, de Oliveira Manoel AL, Vesely KA, Macdonald RL, Schweizer TA. Unruptured intracranial aneurysm treatment effects on cognitive function: a meta-analysis. J Neurosurg. 2016 Mar;124(3):784-90. doi: 10.3171/2014.12.JNS141625. Epub 2015 Sep 18. PMID: 26381251.

136: Guha D, Coyne S, Macdonald RL. Timing of the resumption of antithrombotic agents following surgical evacuation of chronic subdural hematomas: a retrospective cohort study. J Neurosurg. 2016 Mar;124(3):750-9. doi: 10.3171/2015.2.JNS141889. Epub 2015 Sep 11. PMID: 26361283.

137: Macdonald RL. Origins of the Concept of Vasospasm. Stroke. 2016 Jan;47(1):e11-5. doi: 10.1161/STROKEAHA.114.006498. Epub 2015 Sep 3. PMID: 26337970.

138: Lo BW, Fukuda H, Nishimura Y, Macdonald RL, Farrokhyar F, Thabane L, Levine MA. Pathophysiologic mechanisms of brain-body associations in ruptured brain aneurysms: A systematic review. Surg Neurol Int. 2015 Aug 11;6:136. doi: 10.4103/2152-7806.162677. PMID: 26322246; PMCID: PMC4544125.

139: Etminan N, Brown RD Jr, Beseoglu K, Juvela S, Raymond J, Morita A, Torner JC, Derdeyn CP, Raabe A, Mocco J, Korja M, Abdulazim A, Amin-Hanjani S, Al-Shahi Salman R, Barrow DL, Bederson J, Bonafe A, Dumont AS, Fiorella DJ, Gruber A, Hankey GJ, Hasan DM, Hoh BL, Jabbour P, Kasuya H, Kelly ME, Kirkpatrick PJ, Knuckey N, Koivisto T, Krings T, Lawton MT, Marotta TR, Mayer SA, Mee E, Pereira VM, Molyneux A, Morgan MK, Mori K, Murayama Y, Nagahiro S, Nakayama N, Niemelä M, Ogilvy CS, Pierot L, Rabinstein AA, Roos YB, Rinne J, Rosenwasser RH, Ronkainen A, Schaller K, Seifert V, Solomon RA, Spears J, Steiger HJ, Vergouwen MD, Wanke I, Wermer MJ, Wong GK, Wong JH, Zipfel GJ, Connolly ES Jr, Steinmetz H, Lanzino G, Pasqualin A, Rüfenacht D, Vajkoczy P, McDougall C, Hänggi D, LeRoux P, Rinkel GJ, Macdonald RL. The unruptured intracranial aneurysm treatment score: a multidisciplinary consensus. Neurology. 2015 Sep 8;85(10):881-9. doi: 10.1212/WNL.0000000000001891. Epub 2015 Aug 14. PMID: 26276380; PMCID: PMC4560059.

140: Young JM, Morgan BR, Mišić B, Schweizer TA, Ibrahim GM, Macdonald RL. A Partial Least-Squares Analysis of Health-Related Quality-of-Life Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2015 Dec;77(6):908-15; discussion 915. doi: 10.1227/NEU.0000000000000928. PMID: 26248048.

141: Macdonald RL. Nanoparticles and Microparticles. Neurosurgery. 2015 Aug;62 Suppl 1:152-9. doi: 10.1227/NEU.0000000000000810. PMID: 26181936.

142: Maher M, Churchill NW, de Oliveira Manoel AL, Graham SJ, Macdonald RL, Schweizer TA. Altered Resting-State Connectivity within Executive Networks after Aneurysmal Subarachnoid Hemorrhage. PLoS One. 2015 Jul 14;10(7):e0130483. doi: 10.1371/journal.pone.0130483. PMID: 26172281; PMCID: PMC4501762.

143: Yagi K, Lidington D, Wan H, Fares JC, Meissner A, Sumiyoshi M, Ai J, Foltz WD, Nedospasov SA, Offermanns S, Nagahiro S, Macdonald RL, Bolz SS. Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage. Stroke. 2015 Aug;46(8):2260-70. doi: 10.1161/STROKEAHA.114.006365. Epub 2015 Jul 2. PMID: 26138121.

144: Macdonald RL. Editorial: Clip or coil? Six years of follow-up in BRAT. J Neurosurg. 2015 Sep;123(3):605-7. doi: 10.3171/2014.11.JNS142261. Epub 2015 Jun 26. PMID: 26115466.

145: Macdonald RL. Flow diverters: one device does not fit all. J Neurosurg. 2015 Oct;123(4):829-30. doi: 10.3171/2014.12.JNS142537. Epub 2015 Jun 19. PMID: 26090837.

146: Ayling OG, Ibrahim GM, Drake B, Torner JC, Macdonald RL. Operative complications and differences in outcome after clipping and coiling of ruptured intracranial aneurysms. J Neurosurg. 2015 Sep;123(3):621-8. doi: 10.3171/2014.11.JNS141607. Epub 2015 Jun 5. PMID: 26047409.

147: Hemphill JC 3rd, Greenberg SM, Anderson CS, Becker K, Bendok BR, Cushman M, Fung GL, Goldstein JN, Macdonald RL, Mitchell PH, Scott PA, Selim MH, Woo D; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology. Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2015 Jul;46(7):2032-60. doi: 10.1161/STR.0000000000000069. Epub 2015 May 28. PMID: 26022637.

148: Kang JQ, Shen W, Zhou C, Xu D, Macdonald RL. The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration. Nat Neurosci. 2015 Jul;18(7):988-96. doi: 10.1038/nn.4024. Epub 2015 May 25. PMID: 26005849; PMCID: PMC4482801.

149: Macdonald RL. When in Rome, do as the Romans do? World Neurosurg. 2015 Sep;84(3):638-9. doi: 10.1016/j.wneu.2015.05.006. Epub 2015 May 14. PMID: 25982685.

150: MacDonald RL, Thomas CG. Dynamic trajectory-based couch motion for improvement of radiation therapy trajectories in cranial SRT. Med Phys. 2015 May;42(5):2317-25. doi: 10.1118/1.4917165. PMID: 25979026.

151: de Oliveira Manoel AL, Jaja BN, Germans MR, Yan H, Qian W, Kouzmina E, Marotta TR, Turkel-Parrella D, Schweizer TA, Macdonald RL; SAHIT collaborators. The VASOGRADE: A Simple Grading Scale for Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Stroke. 2015 Jul;46(7):1826-31. doi: 10.1161/STROKEAHA.115.008728. Epub 2015 May 14. PMID: 25977276.

152: Macdonald RL. Support for Obamacare? J Neurosurg. 2015 Aug;123(2):402-4. doi: 10.3171/2014.10.JNS142006. Epub 2015 May 8. PMID: 25955876.

153: Bosche B, Macdonald RL. Letter by Bosche and Macdonald regarding article, “relevance of blood-brain barrier disruption after endovascular treatment of ischemic stroke: dual-energy computed tomographic study”. Stroke. 2015 May;46(5):e126-7. doi: 10.1161/STROKEAHA.115.009131. Epub 2015 Apr 14. PMID: 25873599.

154: Murphy A, Manoel AL, Burgers K, Kouzmina E, Lee T, Macdonald RL, Bharatha A. Early CT perfusion changes and blood-brain barrier permeability after aneurysmal subarachnoid hemorrhage. Neuroradiology. 2015 Aug;57(8):767-73. doi: 10.1007/s00234-015-1529-1. Epub 2015 Apr 14. PMID: 25868518.

155: Germans MR, Macdonald RL. Preoperative Angiography of Middle Cerebral Artery Bifurcation Aneurysms. World Neurosurg. 2015 Aug;84(2):222-3. doi: 10.1016/j.wneu.2015.04.003. Epub 2015 Apr 8. PMID: 25862109.

156: Tso MK, Macdonald RL. Neuro-ophthalmic Assessment in Unruptured Intracranial Aneurysms. World Neurosurg. 2015 Jul;84(1):12-4. doi: 10.1016/j.wneu.2015.02.040. Epub 2015 Mar 6. PMID: 25753235.

157: Etminan N, Macdonald RL. Computational Fluid Dynamics and Intracranial Aneurysms: Higher Mathematics Meets Complex Biology. World Neurosurg. 2015 Jun;83(6):1017-9. doi: 10.1016/j.wneu.2015.02.015. Epub 2015 Feb 28. PMID: 25731798.

158: Hänggi D, Etminan N, Macdonald RL, Steiger HJ, Mayer SA, Aldrich F, Diringer MN, Hoh BL, Mocco J, Strange P, Faleck HJ, Miller M. NEWTON: Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage. Neurocrit Care. 2015 Oct;23(2):274-84. doi: 10.1007/s12028-015-0112-2. PMID: 25678453.

159: de Oliveira Manoel AL, Mansur A, Murphy A, Turkel-Parrella D, Macdonald M, Macdonald RL, Montanera W, Marotta TR, Bharatha A, Effendi K, Schweizer TA. Aneurysmal subarachnoid haemorrhage from a neuroimaging perspective. Crit Care. 2014 Nov 13;18(6):557. doi: 10.1186/s13054-014-0557-2. PMID: 25673429; PMCID: PMC4331293.

160: Jaja BN, Lingsma H, Schweizer TA, Thorpe KE, Steyerberg EW, Macdonald RL; SAHIT collaboration. Prognostic value of premorbid hypertension and neurological status in aneurysmal subarachnoid hemorrhage: pooled analyses of individual patient data in the SAHIT repository. J Neurosurg. 2015 Mar;122(3):644-52. doi: 10.3171/2014.10.JNS132694. Epub 2015 Jan 2. PMID: 25554825.

161: Etminan N, Macdonald RL, Davis C, Burton K, Steiger HJ, Hänggi D. Intrathecal application of the nimodipine slow-release microparticle system eg-1962 for prevention of delayed cerebral ischemia and improvement of outcome after aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl. 2015;120:281-6. doi: 10.1007/978-3-319-04981-6_47. PMID: 25366637.

162: Bonares MJ, de Oliveira Manoel AL, Macdonald RL, Schweizer TA. Behavioral profile of unruptured intracranial aneurysms: a systematic review. Ann Clin Transl Neurol. 2014 Mar;1(3):220-32. doi: 10.1002/acn3.41. Epub 2014 Feb 25. PMID: 25356400; PMCID: PMC4184552.

163: Ibrahim GM, Macdonald RL. The network topology of aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 2015 Aug;86(8):895-901. doi: 10.1136/jnnp-2014-308992. Epub 2014 Oct 3. PMID: 25280913.

164: Macdonald RL. Occlusion of the M2: confusion about reperfusion. J Neurosurg. 2014 Dec;121(6):1351-2. doi: 10.3171/2013.12.JNS132245. Epub 2014 Sep 26. PMID: 25259567.

165: Macdonald RL, Diringer MN, Citerio G. Understanding the disease: aneurysmal subarachnoid hemorrhage. Intensive Care Med. 2014 Dec;40(12):1940-3. doi: 10.1007/s00134-014-3483-5. Epub 2014 Sep 16. PMID: 25223854.

166: Lakovic K, Ai J, D'Abbondanza J, Tariq A, Sabri M, Alarfaj AK, Vasdev P, Macdonald RL. Bilirubin and its oxidation products damage brain white matter. J Cereb Blood Flow Metab. 2014 Nov;34(11):1837-47. doi: 10.1038/jcbfm.2014.154. Epub 2014 Aug 27. PMID: 25160671; PMCID: PMC4269762.

167: Guha D, Ibrahim GM, Kertzer JD, Macdonald RL. National socioeconomic indicators are associated with outcomes after aneurysmal subarachnoid hemorrhage: a hierarchical mixed-effects analysis. J Neurosurg. 2014 Nov;121(5):1039-47. doi: 10.3171/2014.7.JNS132141. Epub 2014 Aug 15. PMID: 25127417.

168: Macdonald RL. When you are old. Stroke. 2014 Sep;45(9):2830-2. doi: 10.1161/STROKEAHA.114.006666. Epub 2014 Aug 12. PMID: 25116871.

169: Fukuda H, Iwasaki K, Murao K, Yamagata S, Lo BW, Macdonald RL. Risk factors and consequences of unexpected trapping for ruptured anterior communicating artery aneurysms. Surg Neurol Int. 2014 Jul 11;5:106. doi: 10.4103/2152-7806.136701. PMID: 25101201; PMCID: PMC4123263.

170: Alotaibi NM, Witiw CD, Germans MR, Macdonald RL. Spontaneous subdural fluid collection following aneurysmal subarachnoid hemorrhage: subdural hygroma or external hydrocephalus? Neurocrit Care. 2014 Oct;21(2):312-5. doi: 10.1007/s12028-014-0017-5. PMID: 25030709.

171: Eisa-Beygi S, Macdonald RL, Wen XY. Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics: insights from zebrafish (Danio rerio). J Cereb Blood Flow Metab. 2014 Sep;34(9):1430-3. doi: 10.1038/jcbfm.2014.128. Epub 2014 Jul 16. PMID: 25027310; PMCID: PMC4158677.

172: Kapadia A, Schweizer TA, Spears J, Cusimano M, Macdonald RL. Nonaneurysmal perimesencephalic subarachnoid hemorrhage: diagnosis, pathophysiology, clinical characteristics, and long-term outcome. World Neurosurg. 2014 Dec;82(6):1131-43. doi: 10.1016/j.wneu.2014.07.006. Epub 2014 Jul 5. PMID: 25003696.

173: Etminan N, Macdonald RL. Medical complications after aneurysmal subarachnoid hemorrhage: an emerging contributor to poor outcome. World Neurosurg. 2015 Mar;83(3):303-4. doi: 10.1016/j.wneu.2014.06.031. Epub 2014 Jun 18. PMID: 24954260.

174: Macdonald RL. Editorial: see one, simulate fifty, then do one? J Neurosurg. 2014 Aug;121(2):225-7; discussion 226-7. doi: 10.3171/2014.3.JNS132591. Epub 2014 Jun 20. PMID: 24949673.

175: Todd E, Gurba KN, Botzolakis EJ, Stanic AK, Macdonald RL. GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G). Neurobiol Dis. 2014 Sep;69:215-24. doi: 10.1016/j.nbd.2014.05.013. Epub 2014 May 27. PMID: 24874541.

176: Jaja BN, Attalla D, Macdonald RL, Schweizer TA, Cusimano MD, Etminan N, Hanggi D, Hasan D, Johnston SC, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Noble A, Quinn A, Schenk T, Spears J, Singh J, Todd M, Torner J, Tseng M, van den Bergh W, Vergouwen MD, Wong GK. The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage. Neurocrit Care. 2014 Dec;21(3):551-9. doi: 10.1007/s12028-014-9990-y. PMID: 24865271.

177: Macdonald RL. Are statins to be STASHed in subarachnoid haemorrhage? Lancet Neurol. 2014 Jul;13(7):639-41. doi: 10.1016/S1474-4422(14)70095-X. Epub 2014 May 15. PMID: 24837689.

178: Ladowski D, Qian W, Kapadia AN, Macdonald RL, Schweizer TA. Effect of aneurysmal subarachnoid hemorrhage on word generation. Behav Neurol. 2014;2014:610868. doi: 10.1155/2014/610868. Epub 2014 Mar 2. PMID: 24803729; PMCID: PMC4006618.

179: Eisa-Beygi S, Wen XY, Macdonald RL. A call for rigorous study of statins in resolution of cerebral cavernous malformation pathology. Stroke. 2014 Jun;45(6):1859-61. doi: 10.1161/STROKEAHA.114.005132. Epub 2014 May 6. PMID: 24803598.

180: Huang X, Hernandez CC, Hu N, Macdonald RL. Three epilepsy-associated GABRG2 missense mutations at the γ+/β- interface disrupt GABAA receptor assembly and trafficking by similar mechanisms but to different extents. Neurobiol Dis. 2014 Aug;68:167-79. doi: 10.1016/j.nbd.2014.04.015. Epub 2014 May 4. PMID: 24798517; PMCID: PMC4169075.

181: Etminan N, Dreier R, Buchholz BA, Beseoglu K, Bruckner P, Matzenauer C, Torner JC, Brown RD Jr, Steiger HJ, Hänggi D, Macdonald RL. Age of collagen in intracranial saccular aneurysms. Stroke. 2014 Jun;45(6):1757-63. doi: 10.1161/STROKEAHA.114.005461. Epub 2014 Apr 29. PMID: 24781080; PMCID: PMC4380291.

182: Bell JD, Thomas TC, Lass E, Ai J, Wan H, Lifshitz J, Baker AJ, Macdonald RL. Platelet-mediated changes to neuronal glutamate receptor expression at sites of microthrombosis following experimental subarachnoid hemorrhage. J Neurosurg. 2014 Dec;121(6):1424-31. doi: 10.3171/2014.3.JNS132130. Epub 2014 Apr 18. PMID: 24745710.

183: Eisa-Beygi S, Ekker M, Moon TW, Macdonald RL, Wen XY. Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway: highlights from animal studies. Reprod Toxicol. 2014 Jul;46:115-20. doi: 10.1016/j.reprotox.2014.04.001. Epub 2014 Apr 13. PMID: 24732207.

184: Etminan N, Beseoglu K, Barrow DL, Bederson J, Brown RD Jr, Connolly ES Jr, Derdeyn CP, Hänggi D, Hasan D, Juvela S, Kasuya H, Kirkpatrick PJ, Knuckey N, Koivisto T, Lanzino G, Lawton MT, LeRoux P, McDougall CG, Mee E, Mocco J, Molyneux A, Morgan MK, Mori K, Morita A, Murayama Y, Nagahiro S, Pasqualin A, Raabe A, Raymond J, Rinkel GJ, Rüfenacht D, Seifert V, Spears J, Steiger HJ, Steinmetz H, Torner JC, Vajkoczy P, Wanke I, Wong GK, Wong JH, Macdonald RL. Multidisciplinary consensus on assessment of unruptured intracranial aneurysms: proposal of an international research group. Stroke. 2014 May;45(5):1523-30. doi: 10.1161/STROKEAHA.114.004519. Epub 2014 Mar 25. PMID: 24668202.

185: Kassardjian CD, Macdonald RL, Munoz DG. Hemangioblastomas in the elderly: epidemiology and clinical characteristics. J Clin Neurosci. 2014 Jul;21(7):1205-8. doi: 10.1016/j.jocn.2013.10.023. Epub 2013 Dec 29. PMID: 24629394.

186: Reddy D, Fallah A, Petropoulos JA, Farrokhyar F, Macdonald RL, Jichici D. Prophylactic magnesium sulfate for aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Neurocrit Care. 2014 Oct;21(2):356-64. doi: 10.1007/s12028-014-9964-0. PMID: 24619389.

187: Tso MK, Macdonald RL. Subarachnoid hemorrhage: a review of experimental studies on the microcirculation and the neurovascular unit. Transl Stroke Res. 2014 Apr;5(2):174-89. doi: 10.1007/s12975-014-0323-4. Epub 2014 Feb 11. PMID: 24510780.

188: Ibrahim GM, Morgan BR, Macdonald RL. Patient phenotypes associated with outcomes after aneurysmal subarachnoid hemorrhage: a principal component analysis. Stroke. 2014 Mar;45(3):670-6. doi: 10.1161/STROKEAHA.113.003078. Epub 2014 Jan 14. PMID: 24425125.

189: Johnston AJ, Kang JQ, Shen W, Pickrell WO, Cushion TD, Davies JS, Baer K, Mullins JGL, Hammond CL, Chung SK, Thomas RH, White C, Smith PEM, Macdonald RL, Rees MI. A novel GABRG2 mutation, p.R136*, in a family with GEFS+ and extended phenotypes. Neurobiol Dis. 2014 Apr;64:131-141. doi: 10.1016/j.nbd.2013.12.013. Epub 2014 Jan 7. PMID: 24407264; PMCID: PMC4222744.

190: Mathieu E, Gupta N, Macdonald RL, Ai J, Yücel YH. In vivo imaging of lymphatic drainage of cerebrospinal fluid in mouse. Fluids Barriers CNS. 2013 Dec 21;10(1):35. doi: 10.1186/2045-8118-10-35. PMID: 24360130; PMCID: PMC3879644.

191: Brathwaite S, Macdonald RL. Current management of delayed cerebral ischemia: update from results of recent clinical trials. Transl Stroke Res. 2014 Apr;5(2):207-26. doi: 10.1007/s12975-013-0316-8. Epub 2013 Dec 13. PMID: 24338266.

192: Sehba FA, Pluta RM, Macdonald RL. Brain injury after transient global cerebral ischemia and subarachnoid hemorrhage. Stroke Res Treat. 2013;2013:827154. doi: 10.1155/2013/827154. Epub 2013 Nov 12. PMID: 24327930; PMCID: PMC3845861.

193: Etminan N, Buchholz BA, Dreier R, Bruckner P, Torner JC, Steiger HJ, Hänggi D, Macdonald RL. Cerebral aneurysms: formation, progression, and developmental chronology. Transl Stroke Res. 2014 Apr;5(2):167-73. doi: 10.1007/s12975-013-0294-x. Epub 2013 Oct 30. PMID: 24323717; PMCID: PMC4399795.

194: Macdonald RL, Jaja B, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK, Singh J; SAHIT Collaboration. SAHIT Investigators–on the outcome of some subarachnoid hemorrhage clinical trials. Transl Stroke Res. 2013 Jun;4(3):286-96. doi: 10.1007/s12975-012-0242-1. Epub 2013 Jan 7. PMID: 24323299.

195: Macdonald RL. Delayed neurological deterioration after subarachnoid haemorrhage. Nat Rev Neurol. 2014 Jan;10(1):44-58. doi: 10.1038/nrneurol.2013.246. Epub 2013 Dec 10. PMID: 24323051.

196: Macdonald RL. Haptoglobin genotype. J Neurosurg. 2014 Feb;120(2):382-4. doi: 10.3171/2013.7.JNS131178. Epub 2013 Nov 29. PMID: 24286149.

197: Wan H, AlHarbi BM, Macdonald RL. Mechanisms, treatment and prevention of cellular injury and death from delayed events after aneurysmal subarachnoid hemorrhage. Expert Opin Pharmacother. 2014 Feb;15(2):231-43. doi: 10.1517/14656566.2014.865724. Epub 2013 Nov 27. PMID: 24283706.

198: Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL. Co-expression of γ2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor β2 subunits. Neurochem Res. 2014 Jun;39(6):1088-103. doi: 10.1007/s11064-013-1187-9. Epub 2013 Nov 12. PMID: 24213971; PMCID: PMC4018433.

199: Macdonald RL. Aneurysm wall inflammation. J Neurosurg. 2014 Jan;120(1):70-2. doi: 10.3171/2013.5.JNS13824. Epub 2013 Oct 25. PMID: 24160480.

200: Tso M, Macdonald RL. Carotid endarterectomy: minimizing unplanned readmissions. World Neurosurg. 2014 Dec;82(6):e701-3. doi: 10.1016/j.wneu.2013.10.049. Epub 2013 Oct 21. PMID: 24157917.

201: Saleem MA, Macdonald RL. Cerebral aneurysm presenting with aseptic meningitis: a case report. J Med Case Rep. 2013 Oct 18;7:244. doi: 10.1186/1752-1947-7-244. PMID: 24139091; PMCID: PMC4016604.

202: Tso M, Macdonald RL. Lateral canthotomy: part of a neurosurgeon's toolkit? World Neurosurg. 2014 Jul-Aug;82(1-2):e189-90. doi: 10.1016/j.wneu.2013.10.004. Epub 2013 Oct 6. PMID: 24103550.

203: Witiw CD, Citow JS, Ginsberg HJ, Spears J, Perrin RG, Cusimano MD, Macdonald RL. A novel device to simplify intraoperative radiographic visualization of the cervical spine by producing transient caudal shoulder displacement: a 2-center case series of 80 patients. J Neurosurg Spine. 2013 Dec;19(6):697-700. doi: 10.3171/2013.9.SPINE11998. Epub 2013 Oct 4. PMID: 24093467.

204: Germans MR, Macdonald RL. Is a sylvian fissure hematoma caused by leaking vessels? World Neurosurg. 2014 Dec;82(6):e689-91. doi: 10.1016/j.wneu.2013.09.047. Epub 2013 Sep 26. PMID: 24076213.

205: Germans MR, Macdonald RL. Clip or coil-is some of the effect on outcome related to the risk of delayed cerebral ischemia? World Neurosurg. 2014 Dec;82(6):e679-81. doi: 10.1016/j.wneu.2013.09.030. Epub 2013 Sep 25. PMID: 24076058.

206: Han SM, Wan H, Kudo G, Foltz WD, Vines DC, Green DE, Zoerle T, Tariq A, Brathwaite S, D'Abbondanza J, Ai J, Macdonald RL. Molecular alterations in the hippocampus after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2014 Jan;34(1):108-17. doi: 10.1038/jcbfm.2013.170. Epub 2013 Sep 25. PMID: 24064494; PMCID: PMC3887350.

207: Al-Khindi T, Macdonald RL, Schweizer TA. Decision-making deficits persist after aneurysmal subarachnoid hemorrhage. Neuropsychology. 2014 Jan;28(1):68-74. doi: 10.1037/neu0000003. Epub 2013 Sep 16. PMID: 24040927.

208: Jaja BN, Saposnik G, Nisenbaum R, Lo BW, Schweizer TA, Thorpe KE, Macdonald RL. Racial/ethnic differences in inpatient mortality and use of institutional postacute care following subarachnoid hemorrhage. J Neurosurg. 2013 Dec;119(6):1627-32. doi: 10.3171/2013.7.JNS13544. Epub 2013 Sep 10. PMID: 24015781.

209: Macdonald RL. Seizures after craniectomy: an under-recognised complication? J Neurol Neurosurg Psychiatry. 2014 Jul;85(7):714. doi: 10.1136/jnnp-2013-306102. Epub 2013 Aug 20. PMID: 23962620.

210: Tso M, Macdonald RL. Temporary artery occlusion in aneurysm surgery: patients with subarachnoid hemorrhage. World Neurosurg. 2014 Jul- Aug;82(1-2):e55-7. doi: 10.1016/j.wneu.2013.07.124. Epub 2013 Aug 4. PMID: 23924971.

211: Tso M, Macdonald RL. Temporary artery occlusion in aneurysm surgery: patients with unruptured aneurysms. World Neurosurg. 2014 Sep-Oct;82(3-4):312-3. doi: 10.1016/j.wneu.2013.07.123. Epub 2013 Aug 4. PMID: 23924963.

212: Jaja BN, Saposnik G, Nisenbaum R, Schweizer TA, Reddy D, Thorpe KE, Macdonald RL. Effect of socioeconomic status on inpatient mortality and use of postacute care after subarachnoid hemorrhage. Stroke. 2013 Oct;44(10):2842-7. doi: 10.1161/STROKEAHA.113.001368. Epub 2013 Jul 30. PMID: 23899917.

213: Sheldon S, Macdonald RL, Cusimano M, Spears J, Schweizer TA. Long-term consequences of subarachnoid hemorrhage: examining working memory. J Neurol Sci. 2013 Sep 15;332(1-2):145-7. doi: 10.1016/j.jns.2013.06.021. Epub 2013 Jul 18. PMID: 23871092.

214: Macdonald RL. Does prevention of vasospasm in subarachnoid hemorrhage improve clinical outcome? Yes. Stroke. 2013 Jun;44(6 Suppl 1):S31-3. doi: 10.1161/STROKEAHA.112.679142. PMID: 23709722.

215: Macdonald RL. Subarachnoid hemorrhage and outcome. J Neurosurg. 2013 Sep;119(3):603-4. doi: 10.3171/2013.1.JNS122368. Epub 2013 May 31. PMID: 23724982.

216: Kang JQ, Shen W, Macdonald RL. Trafficking-deficient mutant GABRG2 subunit amount may modify epilepsy phenotype. Ann Neurol. 2013 Oct;74(4):547-59. doi: 10.1002/ana.23947. Epub 2013 Sep 16. PMID: 23720301; PMCID: PMC3839255.

217: Ibrahim GM, Macdonald RL. The effects of fluid balance and colloid administration on outcomes in patients with aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis. Neurocrit Care. 2013 Oct;19(2):140-9. doi: 10.1007/s12028-013-9860-z. PMID: 23715669.

218: Lo BW, Macdonald RL, Baker A, Levine MA. Clinical outcome prediction in aneurysmal subarachnoid hemorrhage using Bayesian neural networks with fuzzy logic inferences. Comput Math Methods Med. 2013;2013:904860. doi: 10.1155/2013/904860. Epub 2013 Apr 10. PMID: 23690884; PMCID: PMC3639630.

219: Tam AK, Kapadia A, Ilodigwe D, Li Z, Schweizer TA, Macdonald RL. Impact of global cerebral atrophy on clinical outcome after subarachnoid hemorrhage. J Neurosurg. 2013 Jul;119(1):198-206. doi: 10.3171/2013.3.JNS121950. Epub 2013 May 10. PMID: 23662822.

220: Alahmadi H, Cusimano MD, Woo K, Mohammed AA, Goguen J, Smyth HS, Macdonald RL, Muller PJ, Horvath E, Kovacs K. Impact of technique on cushing disease outcome using strict remission criteria. Can J Neurol Sci. 2013 May;40(3):334-41. doi: 10.1017/s031716710001427x. PMID: 23603168.

221: Tso MK, Macdonald RL. Acute microvascular changes after subarachnoid hemorrhage and transient global cerebral ischemia. Stroke Res Treat. 2013;2013:425281. doi: 10.1155/2013/425281. Epub 2013 Mar 25. PMID: 23589781; PMCID: PMC3621372.

222: Ibrahim GM, Fallah A, Macdonald RL. Clinical, laboratory, and radiographic predictors of the occurrence of seizures following aneurysmal subarachnoid hemorrhage. J Neurosurg. 2013 Aug;119(2):347-52. doi: 10.3171/2013.3.JNS122097. Epub 2013 Apr 12. PMID: 23581590.

223: Sabri M, Ai J, Lass E, D'abbondanza J, Macdonald RL. Genetic elimination of eNOS reduces secondary complications of experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2013 Jul;33(7):1008-14. doi: 10.1038/jcbfm.2013.49. Epub 2013 Apr 3. PMID: 23549379; PMCID: PMC3705434.

224: Macdonald RL. Commentary. J Neurosci Rural Pract. 2013 Jan;4(1):47-9. PMID: 23546350; PMCID: PMC3579045.

225: Sabri M, Lass E, Macdonald RL. Early brain injury: a common mechanism in subarachnoid hemorrhage and global cerebral ischemia. Stroke Res Treat. 2013;2013:394036. doi: 10.1155/2013/394036. Epub 2013 Feb 28. PMID: 23533958; PMCID: PMC3603523.

226: Tso M, Macdonald RL. A need for a standardized cognitive outcome measure in subarachnoid hemorrhage clinical studies. World Neurosurg. 2014 Feb;81(2):252-4. doi: 10.1016/j.wneu.2013.03.020. Epub 2013 Mar 15. PMID: 23507296.

227: Macdonald RL. Reversing rat poison-is faster better? World Neurosurg. 2014 Jan;81(1):43-5. doi: 10.1016/j.wneu.2013.03.013. Epub 2013 Mar 14. PMID: 23500125.

228: Summerfield TC, Crawford TS, Young RD, Chua JP, Macdonald RL, Sherman LA, Eaton-Rye JJ. Environmental pH affects photoautotrophic growth of Synechocystis sp. PCC 6803 strains carrying mutations in the lumenal proteins of PSII. Plant Cell Physiol. 2013 Jun;54(6):859-74. doi: 10.1093/pcp/pct036. Epub 2013 Feb 26. PMID: 23444302.

229: Fukuda H, Munoz D, Macdonald RL. Spontaneous thalamic hemorrhage from a lateral posterior choroidal artery aneurysm. World Neurosurg. 2013 Dec;80(6):900.e1-6. doi: 10.1016/j.wneu.2013.02.006. Epub 2013 Feb 8. PMID: 23396071.

230: Witiw CD, Ibrahim GM, Fallah A, Macdonald RL. Early predictors of prolonged stay in a critical care unit following aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2013 Jun;18(3):291-7. doi: 10.1007/s12028-013-9815-4. PMID: 23371849.

231: Etminan N, Dreier R, Buchholz BA, Bruckner P, Steiger HJ, Hänggi D, Macdonald RL. Exploring the age of intracranial aneurysms using carbon birth dating: preliminary results. Stroke. 2013 Mar;44(3):799-802. doi: 10.1161/STROKEAHA.112.673806. Epub 2013 Jan 17. PMID: 23329209; PMCID: PMC3591482.

232: Macdonald RL, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Jaja B, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK; SAHIT Collaboration. Subarachnoid Hemorrhage International Trialists data repository (SAHIT). World Neurosurg. 2013 Mar-Apr;79(3-4):418-22. doi: 10.1016/j.wneu.2013.01.006. Epub 2013 Jan 4. PMID: 23295631.

233: Lo B, Macdonald RL. Health-related quality of life after aneurysmal subarachnoid hemorrhage: new data from a large series in Germany. World Neurosurg. 2013 Feb;79(2):243-4. doi: 10.1016/j.wneu.2012.12.025. Epub 2012 Dec 24. PMID: 23270709.

234: Macdonald RL, Kang JQ. mRNA surveillance and endoplasmic reticulum quality control processes alter biogenesis of mutant GABAA receptor subunits associated with genetic epilepsies. Epilepsia. 2012 Dec;53 Suppl 9(0 9):59-70. doi: 10.1111/epi.12035. PMID: 23216579; PMCID: PMC3762703.

235: Macdonald RL. Fish oil for subarachnoid hemorrhage–this is not snake oil. World Neurosurg. 2014 Feb;81(2):250-1. doi: 10.1016/j.wneu.2012.11.020. Epub 2012 Nov 14. PMID: 23159655.

236: Macdonald RL. Endothelin antagonists in subarachnoid hemorrhage: what next? Crit Care. 2012 Nov 9;16(6):171. doi: 10.1186/cc11822. PMID: 23146320; PMCID: PMC3672573.

237: Jaja BN, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK, Singh J, Macdonald RL. Clinical prediction models for aneurysmal subarachnoid hemorrhage: a systematic review. Neurocrit Care. 2013 Feb;18(1):143-53. doi: 10.1007/s12028-012-9792-z. PMID: 23138544.

238: Macdonald RL. Whether subarachnoid hemorrhage depends on the weather? World Neurosurg. 2013 Jan;79(1):64-5. doi: 10.1016/j.wneu.2012.10.028. Epub 2012 Oct 24. PMID: 23103265.

239: Tian M, Mei D, Freri E, Hernandez CC, Granata T, Shen W, Macdonald RL, Guerrini R. Impaired surface αβγ GABA(A) receptor expression in familial epilepsy due to a GABRG2 frameshift mutation. Neurobiol Dis. 2013 Feb;50:135-41. doi: 10.1016/j.nbd.2012.10.008. Epub 2012 Oct 13. PMID: 23069679; PMCID: PMC3762699.

240: Hill MD, Martin RH, Mikulis D, Wong JH, Silver FL, Terbrugge KG, Milot G, Clark WM, Macdonald RL, Kelly ME, Boulton M, Fleetwood I, McDougall C, Gunnarsson T, Chow M, Lum C, Dodd R, Poublanc J, Krings T, Demchuk AM, Goyal M, Anderson R, Bishop J, Garman D, Tymianski M; ENACT trial investigators. Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2012 Nov;11(11):942-50. doi: 10.1016/S1474-4422(12)70225-9. Epub 2012 Oct 8. PMID: 23051991.

241: Macdonald RL. Cavernous malformation. J Neurosurg. 2013 Jan;118(1):47-8; discussion 48-9. doi: 10.3171/2012.4.JNS12592. Epub 2012 Oct 5. PMID: 23039147.

242: Ilodigwe D, Murray GD, Kassell NF, Torner J, Kerr RS, Molyneux AJ, Macdonald RL. Sliding dichotomy compared with fixed dichotomization of ordinal outcome scales in subarachnoid hemorrhage trials. J Neurosurg. 2013 Jan;118(1):3-12. doi: 10.3171/2012.9.JNS111383. Epub 2012 Oct 5. PMID: 23039145.

243: Porter RJ, Dhir A, Macdonald RL, Rogawski MA. Mechanisms of action of antiseizure drugs. Handb Clin Neurol. 2012;108:663-81. doi: 10.1016/B978-0-444-52899-5.00021-6. PMID: 22939059.

244: Macdonald RL. Editorial: venous thrombosis. J Neurosurg. 2012 Oct;117(4):735-7. doi: 10.3171/2011.11.JNS111709. Epub 2012 Aug 24. PMID: 22920961.

245: Macdonald RL. Editorial: I am become misery, the spoiler of lives? I think not. J Neurosurg. 2012 Oct;117(4):745-8. doi: 10.3171/2011.11.JNS111710. Epub 2012 Aug 24. PMID: 22920958.

246: Sabri M, Ai J, Lakovic K, D'abbondanza J, Ilodigwe D, Macdonald RL. Mechanisms of microthrombi formation after experimental subarachnoid hemorrhage. Neuroscience. 2012 Nov 8;224:26-37. doi: 10.1016/j.neuroscience.2012.08.002. Epub 2012 Aug 16. PMID: 22902542.

247: Zoerle T, Ilodigwe D, Wan H, Lakovic K, Sabri M, Ai J, Macdonald RL. Pharmacologic reduction of angiographic vasospasm in experimental subarachnoid hemorrhage: systematic review. Acta Neurochir Suppl. 2013;115:247-51. doi: 10.1007/978-3-7091-1192-5_44. PMID: 22890676.

248: Sabri M, Ai J, Lakovic K, Macdonald RL. Mechanisms of microthrombosis and microcirculatory constriction after experimental subarachnoid hemorrhage. Acta Neurochir Suppl. 2013;115:185-92. doi: 10.1007/978-3-7091-1192-5_35. PMID: 22890667.

249: Etminan N, Vergouwen MD, Macdonald RL. Angiographic vasospasm versus cerebral infarction as outcome measures after aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl. 2013;115:33-40. doi: 10.1007/978-3-7091-1192-5_8. PMID: 22890640.

250: Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey A, Marr A, Roux S, Kassell N. Randomised trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2). Acta Neurochir Suppl. 2013;115:27-31. doi: 10.1007/978-3-7091-1192-5_7. PMID: 22890639.

251: Tam AK, Ilodigwe D, Li Z, Schweizer TA, Macdonald RL. Global cerebral atrophy after subarachnoid hemorrhage: a possible marker of acute brain injury and assessment of its impact on outcome. Acta Neurochir Suppl. 2013;115:17-21. doi: 10.1007/978-3-7091-1192-5_5. PMID: 22890637.

252: Macdonald RL. History and definition of delayed cerebral ischemia. Acta Neurochir Suppl. 2013;115:3-7. doi: 10.1007/978-3-7091-1192-5_2. PMID: 22890634.

253: Macdonald RL, Leung M, Tice T. Intracranial drug delivery for subarachnoid hemorrhage. Ther Deliv. 2012 Jan;3(1):91-103. doi: 10.4155/tde.11.124. PMID: 22833935.

254: Macdonald RL. Stroke: new guidelines for subarachnoid haemorrhage-required reading. Nat Rev Neurol. 2012 Aug;8(8):418-9. doi: 10.1038/nrneurol.2012.137. Epub 2012 Jul 3. PMID: 22751531.

255: Huang X, Tian M, Hernandez CC, Hu N, Macdonald RL. The GABRG2 nonsense mutation, Q40X, associated with Dravet syndrome activated NMD and generated a truncated subunit that was partially rescued by aminoglycoside-induced stop codon read-through. Neurobiol Dis. 2012 Oct;48(1):115-23. doi: 10.1016/j.nbd.2012.06.013. Epub 2012 Jun 30. PMID: 22750526; PMCID: PMC3762464.

256: Schweizer TA, Macdonald RL. Ten years after SAH: would they “love to change the world?”. World Neurosurg. 2013 Jan;79(1):60-1. doi: 10.1016/j.wneu.2012.06.037. Epub 2012 Jun 25. PMID: 22743199.

257: Wu X, Wu Z, Ning G, Guo Y, Ali R, Macdonald RL, De Blas AL, Luscher B, Chen G. γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting. J Biol Chem. 2012 Aug 10;287(33):27417-30. doi: 10.1074/jbc.M112.360461. Epub 2012 Jun 18. PMID: 22711532; PMCID: PMC3431651.

258: Rotondo F, Kovacs K, Macdonald RL, Prud'homme GJ, Latta E, Munoz D. Non- small cell bronchial carcinoma metastasizing into a prolactin-producing pituitary neuroendocrine tumor. Int J Surg Pathol. 2013 Feb;21(1):68-71. doi: 10.1177/1066896912449478. Epub 2012 Jun 10. PMID: 22689615.

259: Ibrahim GM, Macdonald RL. Electrocardiographic changes predict angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2012 Aug;43(8):2102-7. doi: 10.1161/STROKEAHA.112.658153. Epub 2012 Jun 7. PMID: 22678087.

260: Kapadia AN, Naik NP, Macdonald R, Schweizer TA. Cognitive and mood profile of Sturge-Weber Syndrome affecting the thalamus. Can J Neurol Sci. 2012 May;39(3):402-4. doi: 10.1017/s031716710002223x. PMID: 22666901.

261: Hasan D, Hashimoto T, Kung D, Macdonald RL, Winn HR, Heistad D. Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results. Stroke. 2012 Jul;43(7):1964-7. doi: 10.1161/STROKEAHA.112.655829. Epub 2012 May 15. PMID: 22588264; PMCID: PMC3383865.

262: Macdonald RL. Outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2012 Jul;117(1):12-4; discussion 14. doi: 10.3171/2012.1.JNS112105. Epub 2012 Apr 27. PMID: 22540401.

263: Tian M, Macdonald RL. The intronic GABRG2 mutation, IVS6+2T→G, associated with childhood absence epilepsy altered subunit mRNA intron splicing, activated nonsense-mediated decay, and produced a stable truncated γ2 subunit. J Neurosci. 2012 Apr 25;32(17):5937-52. doi: 10.1523/JNEUROSCI.5332-11.2012. PMID: 22539854; PMCID: PMC3357398.

264: Zoerle T, Ilodigwe DC, Wan H, Lakovic K, Sabri M, Ai J, Macdonald RL. Pharmacologic reduction of angiographic vasospasm in experimental subarachnoid hemorrhage: systematic review and meta-analysis. J Cereb Blood Flow Metab. 2012 Sep;32(9):1645-58. doi: 10.1038/jcbfm.2012.57. Epub 2012 Apr 25. PMID: 22534672; PMCID: PMC3437599.

265: Cook DJ, Kan S, Ai J, Kasuya H, Macdonald RL. Cisternal sustained release dihydropyridines for subarachnoid hemorrhage. Curr Neurovasc Res. 2012 May;9(2):139-48. doi: 10.2174/156720212800410894. PMID: 22475399.

266: Macdonald RL. Mirror aneurysms. J Neurosurg. 2012 Jun;116(6):1235-6; discussion 1236-7. doi: 10.3171/2011.11.JNS111919. Epub 2012 Mar 9. PMID: 22404674.

267: Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey A, Nowbakht P, Roux S, Kassell N. Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling. Stroke. 2012 Jun;43(6):1463-9. doi: 10.1161/STROKEAHA.111.648980. Epub 2012 Mar 8. Erratum in: Stroke. 2012 Jul;43(7):e68. PMID: 22403047.

268: Fine B, Singh N, Aviv R, Macdonald RL. Decisions: does a patient with a thunderclap headache need a lumbar puncture? CMAJ. 2012 Mar 20;184(5):555-6. doi: 10.1503/cmaj.110517. Epub 2012 Mar 5. PMID: 22392938; PMCID: PMC3307560.

269: Macdonald RL, Hunsche E, Schüler R, Wlodarczyk J, Mayer SA. Quality of life and healthcare resource use associated with angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2012 Apr;43(4):1082-8. doi: 10.1161/STROKEAHA.111.634071. Epub 2012 Feb 9. PMID: 22328549.

270: Sheldon S, Macdonald RL, Schweizer TA. Free recall memory performance after aneurysmal subarachnoid hemorrhage. J Int Neuropsychol Soc. 2012 Mar;18(2):334-42. doi: 10.1017/S1355617711001780. Epub 2012 Feb 13. PMID: 22325677.

271: Gurba KN, Hernandez CC, Hu N, Macdonald RL. GABRB3 mutation, G32R, associated with childhood absence epilepsy alters α1β3γ2L γ-aminobutyric acid type A (GABAA) receptor expression and channel gating. J Biol Chem. 2012 Apr 6;287(15):12083-97. doi: 10.1074/jbc.M111.332528. Epub 2012 Feb 2. PMID: 22303015; PMCID: PMC3320954.

272: Schweizer TA, Al-Khindi T, Macdonald RL. Mini-Mental State Examination versus Montreal Cognitive Assessment: rapid assessment tools for cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. J Neurol Sci. 2012 May 15;316(1-2):137-40. doi: 10.1016/j.jns.2012.01.003. Epub 2012 Jan 26. PMID: 22280947.

273: Suarez JI, Martin RH, Calvillo E, Dillon C, Bershad EM, Macdonald RL, Wong J, Harbaugh R; ALISAH Investigators. The Albumin in Subarachnoid Hemorrhage (ALISAH) multicenter pilot clinical trial: safety and neurologic outcomes. Stroke. 2012 Mar;43(3):683-90. doi: 10.1161/STROKEAHA.111.633958. Epub 2012 Jan 19. PMID: 22267829; PMCID: PMC3288646.

274: Macdonald RL. Shunts and aneurysms. World Neurosurg. 2011 Dec;76(6):520-1. doi: 10.1016/j.wneu.2011.07.030. PMID: 22251495.

275: Macdonald RL. Editorial: on the persisting difficulty of making predictions, especially about the future. J Neurosurg. 2012 Apr;116(4):866-9; discussion 869-70. doi: 10.3171/2011.9.JNS111393. Epub 2012 Jan 13. PMID: 22242673.

276: Macdonald RL, Kang JQ, Gallagher MJ. GABA_A Receptor Subunit Mutations and Genetic Epilepsies. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th ed. Bethesda (MD): National Center for Biotechnology Information (US); 2012. PMID: 22787601.

277: Strong AJ, Macdonald RL. Cortical spreading ischemia in the absence of proximal vasospasm after aneurysmal subarachnoid hemorrhage: evidence for a dual mechanism of delayed cerebral ischemia. J Cereb Blood Flow Metab. 2012 Feb;32(2):201-2. doi: 10.1038/jcbfm.2011.170. Epub 2011 Dec 7. PMID: 22146191; PMCID: PMC3272614.

278: Macdonald RL. Dissecting the complexities of aneurysm hemodynamics. World Neurosurg. 2012 Nov;78(5):418-21. doi: 10.1016/j.wneu.2011.10.006. Epub 2011 Nov 1. PMID: 22120234.

279: Macdonald RL. Nimodipine–oral or intravenous? No–subarachnoid. World Neurosurg. 2012 Jul;78(1-2):50-2. doi: 10.1016/j.wneu.2011.10.024. Epub 2011 Nov 1. PMID: 22120216.

280: Macdonald RL. Ischemia. J Neurosurg. 2012 Mar;116(3):643-6; discussion 646-7. doi: 10.3171/2011.8.JNS111226. Epub 2011 Nov 18. PMID: 22098197.

281: Ibrahim GM, Weidauer S, Vatter H, Raabe A, Macdonald RL. Attributing hypodensities on CT to angiographic vasospasm is not sensitive and unreliable. Stroke. 2012 Jan;43(1):109-12. doi: 10.1161/STROKEAHA.111.632745. Epub 2011 Oct 13. PMID: 21998061.

282: Hernandez CC, Gurba KN, Hu N, Macdonald RL. The GABRA6 mutation, R46W, associated with childhood absence epilepsy, alters 6β22 and 6β2 GABA(A) receptor channel gating and expression. J Physiol. 2011 Dec 1;589(Pt 23):5857-78. doi: 10.1113/jphysiol.2011.218883. Epub 2011 Sep 19. PMID: 21930603; PMCID: PMC3249055.

283: Crowley RW, Macdonald RL. Is vasospasm actually bad for you? World Neurosurg. 2011 Jul-Aug;76(1-2):6. doi: 10.1016/j.wneu.2011.05.040. PMID: 21839927.

284: Ibrahim GM, Weidauer S, Macdonald RL. Interobserver variability in the interpretation of computed tomography following aneurysmal subarachnoid hemorrhage. J Neurosurg. 2011 Dec;115(6):1191-6. doi: 10.3171/2011.7.JNS11725. Epub 2011 Aug 5. PMID: 21819195.

285: Wijman CA, Smirnakis SM, Vespa P, Szigeti K, Ziai WC, Ning MM, Rosand J, Hanley DF, Geocadin R, Hall C, Le Roux PD, Suarez JI, Zaidat OO; First Neurocritical Care Research Conference Investigators. Research and technology in neurocritical care. Neurocrit Care. 2012 Feb;16(1):42-54. doi: 10.1007/s12028-011-9609-5. PMID: 21796494; PMCID: PMC3790471.

286: Hall CE, Mirski M, Palesch YY, Diringer MN, Qureshi AI, Robertson CS, Geocadin R, Wijman CA, Le Roux PD, Suarez JI; First Neurocritical Care Research Conference Investigators. Clinical trial design in the neurocritical care unit. Neurocrit Care. 2012 Feb;16(1):6-19. doi: 10.1007/s12028-011-9608-6. PMID: 21792753.

287: Ibrahim GM, Vachhrajani S, Ilodigwe D, Kassell NF, Mayer SA, Ruefenacht D, Schmiedek P, Weidauer S, Pasqualin A, Macdonald RL. Method of aneurysm treatment does not affect clot clearance after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2012 Jan;70(1):102-9; discussion 109. doi: 10.1227/NEU.0b013e31822e5a8e. PMID: 21788917.

288: Tang J, Ai J, Macdonald RL. Developing a model of chronic subdural hematoma. Acta Neurochir Suppl. 2011;111:25-9. doi: 10.1007/978-3-7091-0693-8_5. PMID: 21725727.

289: Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Bach D, Frey A, Marr A, Roux S, Kassell N. Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo- controlled phase 3 trial (CONSCIOUS-2). Lancet Neurol. 2011 Jul;10(7):618-25. doi: 10.1016/S1474-4422(11)70108-9. Epub 2011 Jun 2. PMID: 21640651.

290: Vergouwen MD, Etminan N, Ilodigwe D, Macdonald RL. Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2011 Jul;31(7):1545-53. doi: 10.1038/jcbfm.2011.56. Epub 2011 Apr 20. PMID: 21505477; PMCID: PMC3137476.

291: Macdonald RL. Optimal antiepileptic drug use for patients with subarachnoid hemorrhage. World Neurosurg. 2011 Feb;75(2):211-3. doi: 10.1016/j.wneu.2010.10.050. PMID: 21492716.

292: Chen G, Tariq A, Ai J, Sabri M, Jeon HJ, Tang EJ, Lakovic K, Wan H, Macdonald RL. Different effects of clazosentan on consequences of subarachnoid hemorrhage in rats. Brain Res. 2011 May 25;1392:132-9. doi: 10.1016/j.brainres.2011.03.068. Epub 2011 Apr 3. PMID: 21466789.

293: Sabri M, Ai J, Macdonald RL. Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan. Stroke. 2011 May;42(5):1454-60. doi: 10.1161/STROKEAHA.110.604728. Epub 2011 Mar 31. PMID: 21454820.

294: Sabri M, Ai J, Marsden PA, Macdonald RL. Simvastatin re-couples dysfunctional endothelial nitric oxide synthase in experimental subarachnoid hemorrhage. PLoS One. 2011 Feb 23;6(2):e17062. doi: 10.1371/journal.pone.0017062. PMID: 21373645; PMCID: PMC3044158.

295: Crowley RW, Medel R, Dumont AS, Ilodigwe D, Kassell NF, Mayer SA, Ruefenacht D, Schmiedek P, Weidauer S, Pasqualin A, Macdonald RL. Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage. Stroke. 2011 Apr;42(4):919-23. doi: 10.1161/STROKEAHA.110.597005. Epub 2011 Feb 24. PMID: 21350201.

296: Vergouwen MD, Ilodigwe D, Macdonald RL. Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects. Stroke. 2011 Apr;42(4):924-9. doi: 10.1161/STROKEAHA.110.597914. Epub 2011 Feb 10. PMID: 21311062.

297: Etminan N, Vergouwen MD, Ilodigwe D, Macdonald RL. Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta- analysis. J Cereb Blood Flow Metab. 2011 Jun;31(6):1443-51. doi: 10.1038/jcbfm.2011.7. Epub 2011 Feb 2. PMID: 21285966; PMCID: PMC3130329.

298: Sabri M, Ai J, Macdonald RL. Nitric oxide related pathophysiological changes following subarachnoid haemorrhage. Acta Neurochir Suppl. 2011;110(Pt 1):105-9. doi: 10.1007/978-3-7091-0353-1_19. PMID: 21116924.

299: Kang JQ, Shen W, Lee M, Gallagher MJ, Macdonald RL. Slow degradation and aggregation in vitro of mutant GABAA receptor gamma2(Q351X) subunits associated with epilepsy. J Neurosci. 2010 Oct 13;30(41):13895-905. doi: 10.1523/JNEUROSCI.2320-10.2010. PMID: 20943930; PMCID: PMC2976503.

300: Sabri M, Macdonald RL. Statins: a potential therapeutic addition to treatment for aneurysmal subarachnoid hemorrhage? World Neurosurg. 2010 Jun;73(6):646-53. doi: 10.1016/j.wneu.2010.03.032. PMID: 20934152.

301: Macdonald RL. Optimizing subarachnoid fibrinolytic therapy for aneurysmal subarachnoid hemorrhage. World Neurosurg. 2010 Jun;73(6):622-3. doi: 10.1016/j.wneu.2010.05.046. PMID: 20934139.

302: Macdonald RL. Erythropoietin: will it improve outcome after subarachnoid hemorrhage? World Neurosurg. 2010 May;73(5):463-4. doi: 10.1016/j.wneu.2010.03.041. PMID: 20920924.

303: Ryttlefors M, Enblad P, Ronne-Engström E, Persson L, Ilodigwe D, Macdonald RL. Patient age and vasospasm after subarachnoid hemorrhage. Neurosurgery. 2010 Oct;67(4):911-7. doi: 10.1227/NEU.0b013e3181ed11ab. PMID: 20881555.

304: Ferguson SD, Rosen DS, Bardo D, Macdonald RL. Arterial diameters on catheter and computed tomographic angiography. World Neurosurg. 2010 Mar;73(3):165-73; discussion e25. doi: 10.1016/j.surneu.2008.12.017. Epub 2009 Jul 15. PMID: 20860954.

305: Macdonald RL, Higashida RT, Keller E, Mayer SA, Molyneux A, Raabe A, Vajkoczy P, Wanke I, Frey A, Marr A, Roux S, Kassell NF. Preventing vasospasm improves outcome after aneurysmal subarachnoid hemorrhage: rationale and design of CONSCIOUS-2 and CONSCIOUS-3 trials. Neurocrit Care. 2010 Dec;13(3):416-24. doi: 10.1007/s12028-010-9433-3. PMID: 20838933.

306: Botzolakis EJ, Zhao J, Gurba KN, Macdonald RL, Hedera P. The effect of HSP- causing mutations in SPG3A and NIPA1 on the assembly, trafficking, and interaction between atlastin-1 and NIPA1. Mol Cell Neurosci. 2011 Jan;46(1):122-35. doi: 10.1016/j.mcn.2010.08.012. Epub 2010 Sep 21. PMID: 20816793; PMCID: PMC3010260.

307: Dumont AS, Crowley RW, Monteith SJ, Ilodigwe D, Kassell NF, Mayer S, Ruefenacht D, Weidauer S, Pasqualin A, Macdonald RL. Endovascular treatment or neurosurgical clipping of ruptured intracranial aneurysms: effect on angiographic vasospasm, delayed ischemic neurological deficit, cerebral infarction, and clinical outcome. Stroke. 2010 Nov;41(11):2519-24. doi: 10.1161/STROKEAHA.110.579383. Epub 2010 Sep 2. PMID: 20813994.

308: Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, Mendelow AD, Juvela S, Yonas H, Terbrugge KG, Macdonald RL, Diringer MN, Broderick JP, Dreier JP, Roos YB. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010 Oct;41(10):2391-5. doi: 10.1161/STROKEAHA.110.589275. Epub 2010 Aug 26. PMID: 20798370.

309: Schweizer TA, Macdonald RL. Brain hemorrhage: assessing outcome after subarachnoid hemorrhage. Nat Rev Neurol. 2010 Aug;6(8):427-8. doi: 10.1038/nrneurol.2010.94. PMID: 20689567.

310: Feng HJ, Kao C, Gallagher MJ, Jansen ED, Mahadevan-Jansen A, Konrad PE, Macdonald RL. Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation. J Neurosci Methods. 2010 Sep 30;192(1):110-4. doi: 10.1016/j.jneumeth.2010.07.014. Epub 2010 Jul 21. PMID: 20654645; PMCID: PMC3096872.

311: Morgenstern LB, Hemphill JC 3rd, Anderson C, Becker K, Broderick JP, Connolly ES Jr, Greenberg SM, Huang JN, MacDonald RL, Messé SR, Mitchell PH, Selim M, Tamargo RJ; American Heart Association Stroke Council and Council on Cardiovascular Nursing. Guidelines for the management of spontaneous intracerebral hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2010 Sep;41(9):2108-29. doi: 10.1161/STR.0b013e3181ec611b. Epub 2010 Jul 22. PMID: 20651276; PMCID: PMC4462131.

312: Lo WY, Lagrange AH, Hernandez CC, Harrison R, Dell A, Haslam SM, Sheehan JH, Macdonald RL. Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating. J Biol Chem. 2010 Oct 8;285(41):31348-61. doi: 10.1074/jbc.M110.151449. Epub 2010 Jul 16. PMID: 20639197; PMCID: PMC2951209.

313: Jeon H, Ai J, Sabri M, Tariq A, Macdonald RL. Learning deficits after experimental subarachnoid hemorrhage in rats. Neuroscience. 2010 Sep 15;169(4):1805-14. doi: 10.1016/j.neuroscience.2010.06.039. Epub 2010 Jun 23. PMID: 20600651.

314: Takahashi M, Zhang ZD, Macdonald RL. Sphenopalatine ganglion stimulation for vasospasm after experimental subarachnoid hemorrhage. J Neurosurg. 2011 Apr;114(4):1104-9. doi: 10.3171/2010.6.JNS091525. Epub 2010 Jul 2. PMID: 20597600.

315: Al-Khindi T, Macdonald RL, Schweizer TA. Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. Stroke. 2010 Aug;41(8):e519-36. doi: 10.1161/STROKEAHA.110.581975. Epub 2010 Jul 1. PMID: 20595669.

316: Tam AK, Ilodigwe D, Mocco J, Mayer S, Kassell N, Ruefenacht D, Schmiedek P, Weidauer S, Pasqualin A, Macdonald RL. Impact of systemic inflammatory response syndrome on vasospasm, cerebral infarction, and outcome after subarachnoid hemorrhage: exploratory analysis of CONSCIOUS-1 database. Neurocrit Care. 2010 Oct;13(2):182-9. doi: 10.1007/s12028-010-9402-x. PMID: 20593247.

317: Ding L, Feng HJ, Macdonald RL, Botzolakis EJ, Hu N, Gallagher MJ. GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors. J Biol Chem. 2010 Aug 20;285(34):26390-405. doi: 10.1074/jbc.M110.142299. Epub 2010 Jun 15. PMID: 20551311; PMCID: PMC2924069.

318: Feng HJ, Macdonald RL. Barbiturates require the N terminus and first transmembrane domain of the delta subunit for enhancement of alpha1beta3delta GABAA receptor currents. J Biol Chem. 2010 Jul 30;285(31):23614-21. doi: 10.1074/jbc.M110.122564. Epub 2010 Jun 4. PMID: 20525684; PMCID: PMC2911329.

319: Sacher A, Wollmann R, Kalokhe U, Munoz D, Guiot MC, Macdonald RL. Long-term survival of a patient with glioblastoma. Can J Neurol Sci. 2010 Mar;37(2):289-92. doi: 10.1017/s0317167100010118. PMID: 20437948.

320: Macdonald RL. Concerns regarding the recent report of simvastatin inhibition of microthrombosis after subarachnoid hemorrhage in rats. Ann Clin Lab Sci. 2010 Spring;40(2):182-3; author reply 183. PMID: 20421632.

321: Macdonald RL, Kang JQ, Gallagher MJ. Mutations in GABAA receptor subunits associated with genetic epilepsies. J Physiol. 2010 Jun 1;588(Pt 11):1861-9. doi: 10.1113/jphysiol.2010.186999. Epub 2010 Mar 22. PMID: 20308251; PMCID: PMC2901974.

322: Nikitina E, Kawashima A, Takahashi M, Zhang ZD, Shang X, Ai J, Macdonald RL. Alteration in voltage-dependent calcium channels in dog basilar artery after subarachnoid hemorrhage. Laboratory investigation. J Neurosurg. 2010 Oct;113(4):870-80. doi: 10.3171/2010.2.JNS091038. PMID: 20225918.

323: Tang X, Hernandez CC, Macdonald RL. Modulation of spontaneous and GABA- evoked tonic alpha4beta3delta and alpha4beta3gamma2L GABAA receptor currents by protein kinase A. J Neurophysiol. 2010 Feb;103(2):1007-19. doi: 10.1152/jn.00801.2009. Epub 2009 Nov 25. PMID: 19939957; PMCID: PMC2822691.

324: Delahanty RJ, Kang JQ, Brune CW, Kistner EO, Courchesne E, Cox NJ, Cook EH Jr, Macdonald RL, Sutcliffe JS. Maternal transmission of a rare GABRB3 signal peptide variant is associated with autism. Mol Psychiatry. 2011 Jan;16(1):86-96. doi: 10.1038/mp.2009.118. Epub 2009 Nov 24. PMID: 19935738; PMCID: PMC3428055.

325: Tariq A, Ai J, Chen G, Sabri M, Jeon H, Shang X, Macdonald RL. Loss of long-term potentiation in the hippocampus after experimental subarachnoid hemorrhage in rats. Neuroscience. 2010 Jan 20;165(2):418-26. doi: 10.1016/j.neuroscience.2009.10.040. PMID: 19854243.

326: Belelli D, Harrison NL, Maguire J, Macdonald RL, Walker MC, Cope DW. Extrasynaptic GABAA receptors: form, pharmacology, and function. J Neurosci. 2009 Oct 14;29(41):12757-63. doi: 10.1523/JNEUROSCI.3340-09.2009. PMID: 19828786; PMCID: PMC2784229.

327: Kang JQ, Macdonald RL. Making sense of nonsense GABA(A) receptor mutations associated with genetic epilepsies. Trends Mol Med. 2009 Sep;15(9):430-8. doi: 10.1016/j.molmed.2009.07.003. Epub 2009 Aug 31. PMID: 19717338; PMCID: PMC3076198.

328: Jeon H, Ai J, Sabri M, Tariq A, Shang X, Chen G, Macdonald RL. Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage. BMC Neurosci. 2009 Aug 25;10:103. doi: 10.1186/1471-2202-10-103. PMID: 19706182; PMCID: PMC2749856.

329: Sabri M, Jeon H, Ai J, Tariq A, Shang X, Chen G, Macdonald RL. Anterior circulation mouse model of subarachnoid hemorrhage. Brain Res. 2009 Oct 27;1295:179-85. doi: 10.1016/j.brainres.2009.08.021. Epub 2009 Aug 15. PMID: 19686712.

330: Macdonald RL. Soluble endoglin linking eclamptic women and brain vascular malformations? Ann Neurol. 2009 Jul;66(1):2-4. doi: 10.1002/ana.21763. PMID: 19670430.

331: Kreiter KT, Mayer SA, Howard G, Knappertz V, Ilodigwe D, Sloan MA, Macdonald RL. Sample size estimates for clinical trials of vasospasm in subarachnoid hemorrhage. Stroke. 2009 Jul;40(7):2362-7. doi: 10.1161/STROKEAHA.109.547331. Epub 2009 May 21. PMID: 19461029.

332: Bianchi MT, Botzolakis EJ, Lagrange AH, Macdonald RL. Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study. Epilepsy Res. 2009 Aug;85(2-3):212-20. doi: 10.1016/j.eplepsyres.2009.03.007. Epub 2009 May 15. PMID: 19447010; PMCID: PMC2834588.

333: Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM. Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. J Neurosci. 2009 May 13;29(19):6250-65. doi: 10.1523/JNEUROSCI.0856-09.2009. PMID: 19439603; PMCID: PMC2730639.

334: Macdonald RL. Subarachnoid hemorrhage and microdialysis. J Neurosurg. 2009 Nov;111(5):907-8. doi: 10.3171/2009.3.JNS09275. PMID: 19425894.

335: Macdonald RL, Kang JQ. Molecular pathology of genetic epilepsies associated with GABAA receptor subunit mutations. Epilepsy Curr. 2009 Jan-Feb;9(1):18-23. doi: 10.1111/j.1535-7511.2008.01278.x. PMID: 19396344; PMCID: PMC2668111.

336: Lipsman N, Tolentino J, Macdonald RL. Effect of country or continent of treatment on outcome after aneurysmal subarachnoid hemorrhage. Clinical article. J Neurosurg. 2009 Jul;111(1):67-74. doi: 10.3171/2008.10.JNS08184. PMID: 19326980.

337: Pluta RM, Hansen-Schwartz J, Dreier J, Vajkoczy P, Macdonald RL, Nishizawa S, Kasuya H, Wellman G, Keller E, Zauner A, Dorsch N, Clark J, Ono S, Kiris T, Leroux P, Zhang JH. Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought. Neurol Res. 2009 Mar;31(2):151-8. doi: 10.1179/174313209×393564. PMID: 19298755; PMCID: PMC2706525.

338: Kang JQ, Shen W, Macdonald RL. The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression. J Neurosci. 2009 Mar 4;29(9):2845-56. doi: 10.1523/JNEUROSCI.4772-08.2009. PMID: 19261880; PMCID: PMC2754234.

339: Kang JQ, Shen W, Macdonald RL. Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X. J Neurosci. 2009 Mar 4;29(9):2833-44. doi: 10.1523/JNEUROSCI.4512-08.2009. PMID: 19261879; PMCID: PMC2687144.

340: Schultheiss KE, Jang YG, Yanowitch RN, Tolentino J, Curry DJ, Lüders J, Asgarzadie-Gadim F, Macdonald RL. Fat and neurosurgery: does obesity affect outcome after intracranial surgery? Neurosurgery. 2009 Feb;64(2):316-26; discussion 326-7. doi: 10.1227/01.NEU.0000336329.90648.17. PMID: 19190459.

341: Zhao J, Matthies DS, Botzolakis EJ, Macdonald RL, Blakely RD, Hedera P. Hereditary spastic paraplegia-associated mutations in the NIPA1 gene and its Caenorhabditis elegans homolog trigger neural degeneration in vitro and in vivo through a gain-of-function mechanism. J Neurosci. 2008 Dec 17;28(51):13938-51. doi: 10.1523/JNEUROSCI.4668-08.2008. PMID: 19091982; PMCID: PMC2660329.

342: Pearl JD, Macdonald RL. Vasospasm after aneurysmal subarachnoid hemorrhage: need for further study. Acta Neurochir Suppl. 2008;105:207-10. doi: 10.1007/978-3-211-09469-3_39. PMID: 19066110.

343: Botzolakis EJ, Maheshwari A, Feng HJ, Lagrange AH, Shaver JH, Kassebaum NJ, Venkataraman R, Baudenbacher F, Macdonald RL. Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics. J Neurosci Methods. 2009 Mar 15;177(2):294-302. doi: 10.1016/j.jneumeth.2008.10.014. Epub 2008 Oct 21. PMID: 19013195; PMCID: PMC3786708.

344: Macdonald RL. Clazosentan: an endothelin receptor antagonist for treatment of vasospasm after subarachnoid hemorrhage. Expert Opin Investig Drugs. 2008 Nov;17(11):1761-7. doi: 10.1517/13543784.17.11.1761. PMID: 18922111.

345: Jang YG, Ilodigwe D, Macdonald RL. Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2009;10(1):141-7. doi: 10.1007/s12028-008-9147-y. Epub 2008 Sep 23. PMID: 18810661.

346: Sabri M, Kawashima A, Ai J, Macdonald RL. Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: a possible cause for poor prognosis. Brain Res. 2008 Oct 31;1238:163-71. doi: 10.1016/j.brainres.2008.08.031. Epub 2008 Aug 23. PMID: 18786513; PMCID: PMC2585051.

347: Feng HJ, Botzolakis EJ, Macdonald RL. Context-dependent modulation of alphabetagamma and alphabetadelta GABA A receptors by penicillin: implications for phasic and tonic inhibition. Neuropharmacology. 2009 Jan;56(1):161-73. doi: 10.1016/j.neuropharm.2008.08.010. Epub 2008 Aug 19. PMID: 18775733; PMCID: PMC2661208.

348: Lo WY, Botzolakis EJ, Tang X, Macdonald RL. A conserved Cys-loop receptor aspartate residue in the M3-M4 cytoplasmic loop is required for GABAA receptor assembly. J Biol Chem. 2008 Oct 31;283(44):29740-52. doi: 10.1074/jbc.M802856200. Epub 2008 Aug 21. PMID: 18723504; PMCID: PMC2573071.

349: Macdonald RL, Kassell NF, Mayer S, Ruefenacht D, Schmiedek P, Weidauer S, Frey A, Roux S, Pasqualin A; CONSCIOUS-1 Investigators. Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial. Stroke. 2008 Nov;39(11):3015-21. doi: 10.1161/STROKEAHA.108.519942. Epub 2008 Aug 7. PMID: 18688013.

350: Rula EY, Lagrange AH, Jacobs MM, Hu N, Macdonald RL, Emeson RB. Developmental modulation of GABA(A) receptor function by RNA editing. J Neurosci. 2008 Jun 11;28(24):6196-201. doi: 10.1523/JNEUROSCI.0443-08.2008. PMID: 18550761; PMCID: PMC2746000.

351: Jahromi BS, Aihara Y, Ai J, Zhang ZD, Weyer G, Nikitina E, Yassari R, Houamed KM, Macdonald RL. Temporal profile of potassium channel dysfunction in cerebrovascular smooth muscle after experimental subarachnoid haemorrhage. Neurosci Lett. 2008 Jul 25;440(1):81-6. doi: 10.1016/j.neulet.2008.05.015. Epub 2008 May 10. PMID: 18547725; PMCID: PMC2518203.

352: Tanaka M, Olsen RW, Medina MT, Schwartz E, Alonso ME, Duron RM, Castro- Ortega R, Martinez-Juarez IE, Pascual-Castroviejo I, Machado-Salas J, Silva R, Bailey JN, Bai D, Ochoa A, Jara-Prado A, Pineda G, Macdonald RL, Delgado-Escueta AV. Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy. Am J Hum Genet. 2008 Jun;82(6):1249-61. doi: 10.1016/j.ajhg.2008.04.020. PMID: 18514161; PMCID: PMC2427288.

353: Aihara Y, Jahromi BS, Yassari R, Takahashi M, Macdonald RL. Induction of housekeeping gene expression after subarachnoid hemorrhage in dogs. J Neurosci Methods. 2008 Jul 15;172(1):1-7. doi: 10.1016/j.jneumeth.2008.03.020. Epub 2008 Apr 10. PMID: 18490059; PMCID: PMC2478696.

354: O'Kelly C, Macdonald RL. Coiling and aneurysm rerupture: incomplete treatment is a causal intermediate not a confounder. Stroke. 2008 Jul;39(7):e121; author reply e122. doi: 10.1161/STROKEAHA.107.519561. Epub 2008 May 15. PMID: 18483416.

355: Jahromi BS, Aihara Y, Ai J, Zhang ZD, Weyer G, Nikitina E, Yassari R, Houamed KM, Macdonald RL. Preserved BK channel function in vasospastic myocytes from a dog model of subarachnoid hemorrhage. J Vasc Res. 2008;45(5):402-15. doi: 10.1159/000124864. Epub 2008 Apr 10. PMID: 18401179.

356: Feng HJ, Mathews GC, Kao C, Macdonald RL. Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus. J Neurophysiol. 2008 Mar;99(3):1285-93. doi: 10.1152/jn.01180.2007. Epub 2008 Jan 23. PMID: 18216225.

357: Jahromi BS, Aihara Y, Ai J, Zhang ZD, Nikitina E, Macdonald RL. Voltage- gated K+ channel dysfunction in myocytes from a dog model of subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2008 Apr;28(4):797-811. doi: 10.1038/sj.jcbfm.9600577. Epub 2007 Nov 7. PMID: 17987046.

358: Toth G, Rubeiz H, Macdonald RL. Polytetrafluoroethylene-induced granuloma and brainstem cyst after microvascular decompression for trigeminal neuralgia: case report. Neurosurgery. 2007 Oct;61(4):E875-7; discussion E877. doi: 10.1227/01.NEU.0000298919.62742.EB. PMID: 17986923.

359: Bianchi MT, Botzolakis EJ, Haas KF, Fisher JL, Macdonald RL. Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation. J Physiol. 2007 Nov 1;584(Pt 3):769-87. doi: 10.1113/jphysiol.2007.142364. Epub 2007 Sep 20. PMID: 17884921; PMCID: PMC2276985.

360: Rosen DS, Macdonald RL, Huo D, Goldenberg FD, Novakovic RL, Frank JI, Rosengart AJ. Intraventricular hemorrhage from ruptured aneurysm: clinical characteristics, complications, and outcomes in a large, prospective, multicenter study population. J Neurosurg. 2007 Aug;107(2):261-5. doi: 10.3171/JNS-07/08/0261. PMID: 17695378.

361: Rosengart AJ, Huo JD, Tolentino J, Novakovic RL, Frank JI, Goldenberg FD, Macdonald RL. Outcome in patients with subarachnoid hemorrhage treated with antiepileptic drugs. J Neurosurg. 2007 Aug;107(2):253-60. doi: 10.3171/JNS-07/08/0253. PMID: 17695377.

362: Gallagher MJ, Ding L, Maheshwari A, Macdonald RL. The GABAA receptor alpha1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradation. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12999-3004. doi: 10.1073/pnas.0700163104. Epub 2007 Aug 1. PMID: 17670950; PMCID: PMC1941799.

363: Macdonald RL. lumbar drainage after subarachnoid hemorrhage: does it reduce vasospasm and delayed hydrocephalus? Neurocrit Care. 2007;7(1):1-2. doi: 10.1007/s12028-007-0046-4. PMID: 17657651.

364: Rosengart AJ, Schultheiss KE, Tolentino J, Macdonald RL. Prognostic factors for outcome in patients with aneurysmal subarachnoid hemorrhage. Stroke. 2007 Aug;38(8):2315-21. doi: 10.1161/STROKEAHA.107.484360. Epub 2007 Jun 14. PMID: 17569871.

365: Macdonald RL, Pluta RM, Zhang JH. Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution. Nat Clin Pract Neurol. 2007 May;3(5):256-63. doi: 10.1038/ncpneuro0490. PMID: 17479073.

366: Hansen-Schwartz J, Vajkoczy P, Macdonald RL, Pluta RM, Zhang JH. Cerebral vasospasm: looking beyond vasoconstriction. Trends Pharmacol Sci. 2007 Jun;28(6):252-6. doi: 10.1016/j.tips.2007.04.002. Epub 2007 Apr 26. PMID: 17466386.

367: Ferguson S, Macdonald RL. Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhage. Neurosurgery. 2007 Apr;60(4):658-67; discussion 667. doi: 10.1227/01.NEU.0000255396.23280.31. PMID: 17415202.

368: Xie A, Aihara Y, Bouryi VA, Nikitina E, Jahromi BS, Zhang ZD, Takahashi M, Macdonald RL. Novel mechanism of endothelin-1-induced vasospasm after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2007 Oct;27(10):1692-701. doi: 10.1038/sj.jcbfm.9600471. Epub 2007 Mar 28. PMID: 17392694.

369: MacDonald RL. Evidence-based treatment of subarachnoid hemorrhage: current status and future possibilities. Clin Neurosurg. 2006;53:257-66. PMID: 17380760.

370: Rosen DS, Amidei C, Tolentino J, Reilly C, Macdonald RL. Subarachnoid clot volume correlates with age, neurological grade, and blood pressure. Neurosurgery. 2007 Feb;60(2):259-66; discussion 266-7. doi: 10.1227/01.NEU.0000249271.56816.03. PMID: 17290176.

371: Nikitina E, Zhang ZD, Kawashima A, Jahromi BS, Bouryi VA, Takahashi M, Xie A, Macdonald RL. Voltage-dependent calcium channels of dog basilar artery. J Physiol. 2007 Apr 15;580(Pt. 2):523-41. doi: 10.1113/jphysiol.2006.126128. Epub 2006 Dec 21. PMID: 17185332; PMCID: PMC2075556.

372: Macdonald RL, Kang JQ, Gallagher MJ, Feng HJ. GABA(A) receptor mutations associated with generalized epilepsies. Adv Pharmacol. 2006;54:147-69. doi: 10.1016/s1054-3589(06)54007-4. PMID: 17175814.

373: Zhang ZD, Macdonald RL. Contribution of the remodeling response to cerebral vasospasm. Neurol Res. 2006 Oct;28(7):713-20. doi: 10.1179/016164106×151990. PMID: 17164034.

374: Lagrange AH, Botzolakis EJ, Macdonald RL. Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA. J Physiol. 2007 Feb 1;578(Pt 3):655-76. doi: 10.1113/jphysiol.2006.122135. Epub 2006 Nov 23. PMID: 17124266; PMCID: PMC2151343.

375: Weyer GW, Nolan CP, Macdonald RL. Evidence-based cerebral vasospasm management. Neurosurg Focus. 2006 Sep 15;21(3):E8. doi: 10.3171/foc.2006.21.3.8. PMID: 17029347.

376: Nolan CP, Macdonald RL. Can angiographic vasospasm be used as a surrogate marker in evaluating therapeutic interventions for cerebral vasospasm? Neurosurg Focus. 2006 Sep 15;21(3):E1. doi: 10.3171/foc.2006.21.3.1. PMID: 17029333.

377: Audenaert D, Schwartz E, Claeys KG, Claes L, Deprez L, Suls A, Van Dyck T, Lagae L, Van Broeckhoven C, Macdonald RL, De Jonghe P. A novel GABRG2 mutation associated with febrile seizures. Neurology. 2006 Aug 22;67(4):687-90. doi: 10.1212/01.wnl.0000230145.73496.a2. PMID: 16924025.

378: Frontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, Connolly ES Jr, MacDonald RL, Mayer SA. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale. Neurosurgery. 2006 Jul;59(1):21-7; discussion 21-7. doi: 10.1227/01.NEU.0000218821.34014.1B. PMID: 16823296.

379: Das S, Bendok BR, Novakovic RL, Parkinson RJ, Rosengart AJ, Macdonald RL, Frank JI. Return of vision after transarterial coiling of a carotid cavernous sinus fistula: case report. Surg Neurol. 2006 Jul;66(1):82-5; discussion 85. doi: 10.1016/j.surneu.2005.10.008. PMID: 16793452.

380: Young JB, Jahromi BS, Zhang ZD, Macdonald RL. A novel device for in vitro isometric tension recordings of cylindrical artery segments. Med Eng Phys. 2007 Jan;29(1):169-74. doi: 10.1016/j.medengphy.2006.02.003. Epub 2006 Mar 10. PMID: 16529973.

381: Kang JQ, Shen W, Macdonald RL. Why does fever trigger febrile seizures? GABAA receptor gamma2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent trafficking deficiencies. J Neurosci. 2006 Mar 1;26(9):2590-7. doi: 10.1523/JNEUROSCI.4243-05.2006. PMID: 16510738; PMCID: PMC6793669.

382: Feng HJ, Kang JQ, Song L, Dibbens L, Mulley J, Macdonald RL. Delta subunit susceptibility variants E177A and R220H associated with complex epilepsy alter channel gating and surface expression of alpha4beta2delta GABAA receptors. J Neurosci. 2006 Feb 1;26(5):1499-506. doi: 10.1523/JNEUROSCI.2913-05.2006. PMID: 16452673; PMCID: PMC6675478.

383: Macdonald RL, Zhang ZD, Takahashi M, Nikitina E, Young J, Xie A, Larkin L. Calcium sensitivity of vasospastic basilar artery after experimental subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2329-36. doi: 10.1152/ajpheart.00911.2005. Epub 2006 Jan 6. PMID: 16399868.

384: Alexander JJ, Jacob A, Bao L, Macdonald RL, Quigg RJ. Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. J Immunol. 2005 Dec 15;175(12):8312-9. doi: 10.4049/jimmunol.175.12.8312. PMID: 16339572.

385: Boco T, Macdonald RL. Absence of acute cerebral vasoconstriction after cocaine-associated subarachnoid hemorrhage. Neurocrit Care. 2004;1(4):449-54. doi: 10.1385/NCC:1:4:449. PMID: 16174948.

386: Lo SE, Rosengart AJ, Novakovic RL, Kang UJ, Shah DN, Khan MA, Dalvi A, Goldenberg FD, Macdonald RL, Frank JI. Identification and treatment of cervical and oromandibular dystonia in acutely brain-injured patients. Neurocrit Care. 2005;3(2):139-45. doi: 10.1385/NCC:3:2:139. PMID: 16174883.

387: Rosen DS, Macdonald RL. Subarachnoid hemorrhage grading scales: a systematic review. Neurocrit Care. 2005;2(2):110-8. doi: 10.1385/NCC:2:2:110. PMID: 16159052.

388: Macdonald RL. Routine cerebral angiography after surgery for saccular aneurysms: is it worth it? Neurosurgery. 2005 Sep;57(3):E601; author reply E601. doi: 10.1227/01.neu.0000181085.07914.39. PMID: 16145517.

389: Jones-Davis DM, Song L, Gallagher MJ, Macdonald RL. Structural determinants of benzodiazepine allosteric regulation of GABA(A) receptor currents. J Neurosci. 2005 Aug 31;25(35):8056-65. doi: 10.1523/JNEUROSCI.0348-05.2005. PMID: 16135763; PMCID: PMC6725463.

390: Gallagher MJ, Shen W, Song L, Macdonald RL. Endoplasmic reticulum retention and associated degradation of a GABAA receptor epilepsy mutation that inserts an aspartate in the M3 transmembrane segment of the alpha1 subunit. J Biol Chem. 2005 Nov 11;280(45):37995-8004. doi: 10.1074/jbc.M508305200. Epub 2005 Aug 25. PMID: 16123039.

391: Rosen D, Novakovic R, Goldenberg FD, Huo D, Baldwin ME, Frank JI, Rosengart AJ, Macdonald RL. Racial differences in demographics, acute complications, and outcomes in patients with subarachnoid hemorrhage: a large patient series. J Neurosurg. 2005 Jul;103(1):18-24. doi: 10.3171/jns.2005.103.1.0018. PMID: 16121968.

392: Weyer GW, Jahromi BS, Aihara Y, Agbaje-Williams M, Nikitina E, Zhang ZD, Macdonald RL. Expression and function of inwardly rectifying potassium channels after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2006 Mar;26(3):382-91. doi: 10.1038/sj.jcbfm.9600193. PMID: 16079788.

393: Yarnitsky D, Lorian A, Shalev A, Zhang ZD, Takahashi M, Agbaje-Williams M, Macdonald RL. Reversal of cerebral vasospasm by sphenopalatine ganglion stimulation in a dog model of subarachnoid hemorrhage. Surg Neurol. 2005 Jul;64(1):5-11; discussion 11. doi: 10.1016/j.surneu.2004.09.029. PMID: 15993169.

394: Schomas DA, Roeske JC, MacDonald RL, Sweeney PJ, Mehta N, Mundt AJ. Predictors of tumor control in patients treated with linac-based stereotactic radiosurgery for metastatic disease to the brain. Am J Clin Oncol. 2005 Apr;28(2):180-7. doi: 10.1097/01.coc.0000143017.69880.04. PMID: 15803014.

395: Takahashi M, Macdonald RL. Vascular aspects of neuroprotection. Neurol Res. 2004 Dec;26(8):862-9. doi: 10.1179/016164104×3815. PMID: 15727270.

396: Karadsheh MS, Shah MS, Tang X, Macdonald RL, Stitzel JA. Functional characterization of mouse alpha4beta2 nicotinic acetylcholine receptors stably expressed in HEK293T cells. J Neurochem. 2004 Dec;91(5):1138-50. doi: 10.1111/j.1471-4159.2004.02801.x. PMID: 15569257.

397: Baldwin ME, Macdonald RL, Huo D, Novakovic RL, Goldenberg FD, Frank JI, Rosengart AJ. Early vasospasm on admission angiography in patients with aneurysmal subarachnoid hemorrhage is a predictor for in-hospital complications and poor outcome. Stroke. 2004 Nov;35(11):2506-11. doi: 10.1161/01.STR.0000144654.79393.cf. Epub 2004 Oct 7. Erratum in: Stroke. 2005 Jan;36(1):175. Novakovia, Roberta L [corrected to Novakovic, Roberta L]. PMID: 15472099.

398: Kang JQ, Macdonald RL. The GABAA receptor gamma2 subunit R43Q mutation linked to childhood absence epilepsy and febrile seizures causes retention of alpha1beta2gamma2S receptors in the endoplasmic reticulum. J Neurosci. 2004 Oct 6;24(40):8672-7. doi: 10.1523/JNEUROSCI.2717-04.2004. Erratum in: J Neurosci. 2004 Oct 13;24(41):1p following 9126. Kang, Jingqiong [corrected to Kang, Jing- Qiong]. PMID: 15470132; PMCID: PMC6729953.

399: Macdonald RL, Gallagher MJ, Feng HJ, Kang J. GABA(A) receptor epilepsy mutations. Biochem Pharmacol. 2004 Oct 15;68(8):1497-506. doi: 10.1016/j.bcp.2004.07.029. PMID: 15451392.

400: Feng HJ, Macdonald RL. Multiple actions of propofol on alphabetagamma and alphabetadelta GABAA receptors. Mol Pharmacol. 2004 Dec;66(6):1517-24. doi: 10.1124/mol.104.003426. Epub 2004 Aug 26. PMID: 15331770.

401: Reilly C, Amidei C, Tolentino J, Jahromi BS, Macdonald RL. Clot volume and clearance rate as independent predictors of vasospasm after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2004 Aug;101(2):255-61. doi: 10.3171/jns.2004.101.2.0255. PMID: 15309916.

402: Macdonald RL. GABAA Receptor Defects Can Cause Epilepsy. Epilepsy Curr. 2001 Nov;1(2):74. doi: 10.1046/j.1535-7597.2001.00018.x. PMID: 15309196; PMCID: PMC320826.

403: Feng HJ, Bianchi MT, Macdonald RL. Pentobarbital differentially modulates alpha1beta3delta and alpha1beta3gamma2L GABAA receptor currents. Mol Pharmacol. 2004 Oct;66(4):988-1003. doi: 10.1124/mol.104.002543. Epub 2004 Jul 9. PMID: 15247320.

404: Gallagher MJ, Song L, Arain F, Macdonald RL. The juvenile myoclonic epilepsy GABA(A) receptor alpha1 subunit mutation A322D produces asymmetrical, subunit position-dependent reduction of heterozygous receptor currents and alpha1 subunit protein expression. J Neurosci. 2004 Jun 16;24(24):5570-8. doi: 10.1523/JNEUROSCI.1301-04.2004. PMID: 15201329; PMCID: PMC6729321.

405: Macdonald RL, Marton LS, Andrus PK, Hall ED, Johns L, Sajdak M. Time course of production of hydroxyl free radical after subarachnoid hemorrhage in dogs. Life Sci. 2004 Jul 9;75(8):979-89. doi: 10.1016/j.lfs.2004.02.010. PMID: 15193958.

406: Feng HJ, Macdonald RL. Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. J Neurophysiol. 2004 Sep;92(3):1577-85. doi: 10.1152/jn.00285.2004. Epub 2004 May 19. PMID: 15152020.

407: Yassari R, Sayama T, Jahromi BS, Aihara Y, Stoodley M, Macdonald RL. Angiographic, hemodynamic and histological characterization of an arteriovenous fistula in rats. Acta Neurochir (Wien). 2004 May;146(5):495-504. doi: 10.1007/s00701-004-0248-x. Epub 2004 Mar 25. PMID: 15118887.

408: Dibbens LM, Feng HJ, Richards MC, Harkin LA, Hodgson BL, Scott D, Jenkins M, Petrou S, Sutherland GR, Scheffer IE, Berkovic SF, Macdonald RL, Mulley JC. GABRD encoding a protein for extra- or peri-synaptic GABAA receptors is a susceptibility locus for generalized epilepsies. Hum Mol Genet. 2004 Jul 1;13(13):1315-9. doi: 10.1093/hmg/ddh146. Epub 2004 Apr 28. PMID: 15115768.

409: Macdonald RL, Weir B, Zhang J, Marton LS, Sajdak M, Johns LM. Adenosine triphosphate and hemoglobin in vasospastic monkeys. Neurosurg Focus. 1997 Oct 15;3(4):e3. doi: 10.3171/foc.1997.3.4.6. PMID: 15104409.

410: Rosen DS, Macdonald RL. Grading of subarachnoid hemorrhage: modification of the world World Federation of Neurosurgical Societies scale on the basis of data for a large series of patients. Neurosurgery. 2004 Mar;54(3):566-75; discussion 575-6. PMID: 15028129.

411: Rosen DS, Macdonald RL. Grading of Subarachnoid Hemorrhage: Modification of the World Federation of Neurosurgical Societies Scale on the Basis of Data for a Large Series of Patients. Neurosurgery. 2004 Mar 1;54(3):566-576. doi: 10.1227/01.NEU.0000108862.32404.A5. PMID: 28173116.

412: Macdonald RL. Advances in vascular surgery. Stroke. 2004 Feb;35(2):375-80. doi: 10.1161/01.STR.0000115167.83107.66. PMID: 14757885.

413: Macdonald RL, Curry DJ, Aihara Y, Zhang ZD, Jahromi BS, Yassari R. Magnesium and experimental vasospasm. J Neurosurg. 2004 Jan;100(1):106-10. doi: 10.3171/jns.2004.100.1.0106. PMID: 14743919.

414: Aihara Y, Jahromi BS, Yassari R, Nikitina E, Agbaje-Williams M, Macdonald RL. Molecular profile of vascular ion channels after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2004 Jan;24(1):75-83. doi: 10.1097/01.WCB.0000095803.98378.D8. PMID: 14688619.

415: Hinkle DJ, Macdonald RL. Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents. J Neurosci. 2003 Dec 17;23(37):11698-710. doi: 10.1523/JNEUROSCI.23-37-11698.2003. PMID: 14684872; PMCID: PMC6740942.

416: Bianchi MT, Macdonald RL. Neurosteroids shift partial agonist activation of GABA(A) receptor channels from low- to high-efficacy gating patterns. J Neurosci. 2003 Nov 26;23(34):10934-43. doi: 10.1523/JNEUROSCI.23-34-10934.2003. PMID: 14645489; PMCID: PMC6740972.

417: Macdonald RL, Bianchi MT, Feng H. Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current. Exp Neurol. 2003 Nov;184 Suppl 1:S58-67. doi: 10.1016/j.expneurol.2003.08.011. Erratum in: Exp Neurol. 2005 Jan;191(1):223. Bianch, Matt T [corrected to Bianchi, Matt T]. PMID: 14597328.

418: Lee MC, Macdonald RL. Intraoperative cerebral angiography: superficial temporal artery method and results. Neurosurgery. 2003 Nov;53(5):1067-74; discussion 1074-5. doi: 10.1227/01.neu.0000088739.89056.04. PMID: 14580273.

419: Kim H, Macdonald RL. An N-terminal histidine is the primary determinant of alpha subunit-dependent Cu2+ sensitivity of alphabeta3gamma2L GABA(A) receptors. Mol Pharmacol. 2003 Nov;64(5):1145-52. doi: 10.1124/mol.64.5.1145. PMID: 14573764.

420: Macdonald RL, Rosengart A, Huo D, Karrison T. Factors associated with the development of vasospasm after planned surgical treatment of aneurysmal subarachnoid hemorrhage. J Neurosurg. 2003 Oct;99(4):644-52. doi: 10.3171/jns.2003.99.4.0644. PMID: 14567598.

421: Hinkle DJ, Bianchi MT, Macdonald RL. Modifications of a commercial perfusion system for use in ultrafast solution exchange during patch clamp recording. Biotechniques. 2003 Sep;35(3):472-4, 476. PMID: 14513550.

422: Kim H, Flanagin BA, Qin C, Macdonald RL, Stitzel JA. The mouse Chrna4 A529T polymorphism alters the ratio of high to low affinity alpha 4 beta 2 nAChRs. Neuropharmacology. 2003 Sep;45(3):345-54. doi: 10.1016/s0028-3908(03)00167-9. PMID: 12871652.

423: Macdonald RL, Amidei C, Baron J, Weir B, Brown F, Erickson RK, Hekmatpanah J, Frim D. Randomized, pilot study of intermittent pneumatic compression devices plus dalteparin versus intermittent pneumatic compression devices plus heparin for prevention of venous thromboembolism in patients undergoing craniotomy. Surg Neurol. 2003 May;59(5):363-72; discussion 372-4. doi: 10.1016/s0090-3019(03)00111-3. PMID: 12765806.

424: Torres IJ, Mundt AJ, Sweeney PJ, Llanes-Macy S, Dunaway L, Castillo M, Macdonald RL. A longitudinal neuropsychological study of partial brain radiation in adults with brain tumors. Neurology. 2003 Apr 8;60(7):1113-8. doi: 10.1212/01.wnl.0000055862.20003.4a. PMID: 12682316.

425: Aihara Y, Jahromi BS, Yassari R, Sayama T, Macdonald RL. Effects of a nitric oxide donor on and correlation of changes in cyclic nucleotide levels with experimental vasospasm. Neurosurgery. 2003 Mar;52(3):661-7; discussion 666-7. doi: 10.1227/01.neu.0000048188.88980.86. PMID: 12590692.

426: Jones-Davis DM, Macdonald RL. GABA(A) receptor function and pharmacology in epilepsy and status epilepticus. Curr Opin Pharmacol. 2003 Feb;3(1):12-8. doi: 10.1016/s1471-4892(02)00015-2. PMID: 12550736.

427: Chen C, Bharucha V, Chen Y, Westenbroek RE, Brown A, Malhotra JD, Jones D, Avery C, Gillespie PJ 3rd, Kazen-Gillespie KA, Kazarinova-Noyes K, Shrager P, Saunders TL, Macdonald RL, Ransom BR, Scheuer T, Catterall WA, Isom LL. Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17072-7. doi: 10.1073/pnas.212638099. Epub 2002 Dec 12. PMID: 12481039; PMCID: PMC139271.

428: Bianchi MT, Haas KF, Macdonald RL. Alpha1 and alpha6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABA(A) receptors containing the delta subunit. Neuropharmacology. 2002 Sep;43(4):492-502. doi: 10.1016/s0028-3908(02)00163-6. PMID: 12367596.

429: Bianchi MT, Macdonald RL. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. J Physiol. 2002 Oct 1;544(Pt 1):3-18. doi: 10.1113/jphysiol.2002.020255. PMID: 12356876; PMCID: PMC2290568.

430: Jones DM, Esmaeil N, Maren S, Macdonald RL. Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. Epilepsy Res. 2002 Aug;50(3):301-12. doi: 10.1016/s0920-1211(02)00085-2. PMID: 12200221.

431: Buhr A, Bianchi MT, Baur R, Courtet P, Pignay V, Boulenger JP, Gallati S, Hinkle DJ, Macdonald RL, Sigel E. Functional characterization of the new human GABA(A) receptor mutation beta3(R192H). Hum Genet. 2002 Aug;111(2):154-60. doi: 10.1007/s00439-002-0766-7. Epub 2002 Jul 16. PMID: 12189488.

432: Macdonald RL, Zhang ZD, Curry D, Elas M, Aihara Y, Halpern H, Jahromi BS, Johns L. Intracisternal sodium nitroprusside fails to prevent vasospasm in nonhuman primates. Neurosurgery. 2002 Sep;51(3):761-8; discussion 768-70. PMID: 12188956.

433: Bianchi MT, Song L, Zhang H, Macdonald RL. Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans. J Neurosci. 2002 Jul 1;22(13):5321-7. doi: 10.1523/JNEUROSCI.22-13-05321.2002. PMID: 12097483; PMCID: PMC6758211.

434: Ono S, Komuro T, Macdonald RL. Heme oxygenase-1 gene therapy for prevention of vasospasm in rats. J Neurosurg. 2002 Jun;96(6):1094-102. doi: 10.3171/jns.2002.96.6.1094. PMID: 12066912.

435: Greenfield LJ Jr, Zaman SH, Sutherland ML, Lummis SC, Niemeyer MI, Barnard EA, Macdonald RL. Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. Neuropharmacology. 2002 Mar;42(4):502-21. doi: 10.1016/s0028-3908(01)00196-4. PMID: 11955521.

436: Macdonald RL, Zhang ZD, Ono S, Komuro T. Up-regulation of parathyroid hormone receptor in cerebral arteries after subarachnoid hemorrhage in monkeys. Neurosurgery. 2002 May;50(5):1083-91; discussion 1091-3. doi: 10.1097/00006123-200205000-00025. PMID: 11950412.

437: Wohlfarth KM, Bianchi MT, Macdonald RL. Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit. J Neurosci. 2002 Mar 1;22(5):1541-9. doi: 10.1523/JNEUROSCI.22-05-01541.2002. PMID: 11880484; PMCID: PMC6758857.

438: Bianchi MT, Macdonald RL. Agonist Trapping by GABAA Receptor Channels. J Neurosci. 2001 Dec 1;21(23):9083-91. doi: 10.1523/JNEUROSCI.21-23-09083.2001. PMID: 11717341; PMCID: PMC6763914.

439: Bianchi MT, Macdonald RL. Mutation of the 9' leucine in the GABA(A) receptor gamma2L subunit produces an apparent decrease in desensitization by stabilizing open states without altering desensitized states. Neuropharmacology. 2001 Nov;41(6):737-44. doi: 10.1016/s0028-3908(01)00132-0. PMID: 11640928.

440: Le H, Munshi I, Macdonald RL, Wollmann R, Frank J. Traumatic aneurysm resulting from insertion of an intracranial pressure monitor. Case illustration. J Neurosurg. 2001 Oct;95(4):720. doi: 10.3171/jns.2001.95.4.0720. PMID: 11596971.

441: Komuro T, Borsody MK, Ono S, Marton LS, Weir BK, Zhang ZD, Paik E, Macdonald RL. The vasorelaxation of cerebral arteries by carbon monoxide. Exp Biol Med (Maywood). 2001 Oct;226(9):860-5. doi: 10.1177/153537020122600909. PMID: 11568310.

442: Ono S, Komuro T, Macdonald RL. Adenovirus-mediated heme oxygenase-1 gene transfection prevents hemoglobin-induced contraction of rat basilar artery. Acta Neurochir Suppl. 2001;77:93-6. doi: 10.1007/978-3-7091-6232-3_20. PMID: 11563317.

443: Macdonald RL. Pathophysiology and molecular genetics of vasospasm. Acta Neurochir Suppl. 2001;77:7-11. doi: 10.1007/978-3-7091-6232-3_2. PMID: 11563312.

444: Jahromi BS, Komuro T, Macdonald RL, Marton LS, Weir BK. Phosphatidylcholine peroxidized by hemoglobin increases intracellular calcium in dog basilar artery smooth muscle cells. Acta Neurochir Suppl. 2001;77:45-7. doi: 10.1007/978-3-7091-6232-3_11. PMID: 11563307.

445: Zhang ZD, Yamini B, Komuro T, Ono S, Johns L, Marton LS, Weir B, Macdonald RL. Delayed clot removal and experimental vasospasm. Acta Neurochir Suppl. 2001;77:33-5. doi: 10.1007/978-3-7091-6232-3_8. PMID: 11563304.

446: Zhang ZD, Marton LS, Ono S, Komuro T, Weir B, Macdonald RL. Complimentary deoxyribonucleic acid array analysis of cerebral arteries after experimental subarachnoid hemorrhage. Acta Neurochir Suppl. 2001;77:17-9. doi: 10.1007/978-3-7091-6232-3_4. PMID: 11563279.

447: Macdonald RL, Ono S, Johns L, Marton LS, Weir B, Zhang ZD, Yamini B, Komuro T, Ahmed I, Stoodley M. Molecular weight interactions in experimental vasospasm. Acta Neurochir Suppl. 2001;77:115-7. doi: 10.1007/978-3-7091-6232-3_25. PMID: 11563267.

448: Citow JS, Rini B, Wollmann R, Macdonald RL. Isolated, primary extranodal Hodgkin's disease of the spine: case report. Neurosurgery. 2001 Aug;49(2):453-6; discussion 456-7. doi: 10.1097/00006123-200108000-00037. PMID: 11504124.

449: Zhang ZD, Yamini B, Komuro T, Ono S, Johns L, Marton LS, Weir B, Macdonald RL. Vasospasm in monkeys resolves because of loss of and encasement of subarachnoid blood clot. Stroke. 2001 Aug;32(8):1868-74. doi: 10.1161/01.str.32.8.1868. PMID: 11486119.

450: Macdonald RL, Weir BK, Marton LS, Zhang ZD, Sajdak M, Johns LM, Kowalczuk A, Borsody M. Role of adenosine 5'-triphosphate in vasospasm after subarachnoid hemorrhage: human investigations. Neurosurgery. 2001 Apr;48(4):854-62; discussion 862-3. doi: 10.1097/00006123-200104000-00033. PMID: 11322446.

451: Nagaya N, Macdonald RL. Two gamma2L subunit domains confer low Zn2+ sensitivity to ternary GABA(A) receptors. J Physiol. 2001 Apr 1;532(Pt 1):17-30. doi: 10.1111/j.1469-7793.2001.0017g.x. PMID: 11283222; PMCID: PMC2278531.

452: Kelly KM, Kume A, Albin RL, Macdonald RL. Autoradiography of L-type and N-type calcium channels in aged rat hippocampus, entorhinal cortex, and neocortex. Neurobiol Aging. 2001 Jan-Feb;22(1):17-23. doi: 10.1016/s0197-4580(00)00178-0. PMID: 11164272.

453: Lin G, Macdonald RL, Marton LS, Kowalczuk A, Solenski NJ, Weir BK. Hemoglobin increases endothelin-1 in endothelial cells by decreasing nitric oxide. Biochem Biophys Res Commun. 2001 Jan 26;280(3):824-30. doi: 10.1006/bbrc.2000.4167. PMID: 11162595.

454: Bianchi MT, Haas KF, Macdonald RL. Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors. J Neurosci. 2001 Feb 15;21(4):1127-36. doi: 10.1523/JNEUROSCI.21-04-01127.2001. PMID: 11160383; PMCID: PMC6762234.

455: Foroohar M, Macdonald RL, Roth S, Stoodley M, Weir B. Intraoperative variables and early outcome after aneurysm surgery. Surg Neurol. 2000 Oct;54(4):304-15. doi: 10.1016/s0090-3019(00)00294-9. PMID: 11136985.

456: Neelands TR, King AP, Macdonald RL. Functional expression of L-, N-, P/Q-, and R-type calcium channels in the human NT2-N cell line. J Neurophysiol. 2000 Dec;84(6):2933-44. doi: 10.1152/jn.2000.84.6.2933. PMID: 11110822.

457: Lüders JC, Weihl CC, Lin G, Ghadge G, Stoodley M, Roos RP, Macdonald RL. Adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats. Neurosurgery. 2000 Nov;47(5):1206-14; discussion 1214-5. doi: 10.1097/00006123-200011000-00039. PMID: 11063115.

458: Marton LS, Wang X, Kowalczuk A, Zhang ZD, Windmeyer E, Macdonald RL. Effects of hemoglobin on heme oxygenase gene expression and viability of cultured smooth muscle cells. Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2405-13. doi: 10.1152/ajpheart.2000.279.5.H2405. PMID: 11045978.

459: Borsody MK, DeGiovanni GM, Marton LS, Macdonald RL, Weir B. Thrombin reduces cerebral arterial contractions caused by cerebrospinal fluid from patients with subarachnoid hemorrhage. Stroke. 2000 Sep;31(9):2149-56. doi: 10.1161/01.str.31.9.2149. PMID: 10978044.

460: Stoodley M, MacDonald RL, Weir B, Marton LS, Johns L, Du Zhang Z, Kowalczuk A. Subarachnoid hemorrhage as a cause of an adaptive response in cerebral arteries. J Neurosurg. 2000 Sep;93(3):463-70. doi: 10.3171/jns.2000.93.3.0463. PMID: 10969945.

461: Stoodley MA, Foroohar M, Macdonald RL, Weir BK. Multimedia computer database for neurosurgery. Neurosurgery. 2000 Jul;47(1):178-86; discussion 186-8. doi: 10.1097/00006123-200007000-00037. PMID: 10917361.

462: Ono S, Zhang ZD, Marton LS, Yamini B, Windmeyer E, Johns L, Kowalczuk A, Lin G, Macdonald RL. Heme oxygenase-1 and ferritin are increased in cerebral arteries after subarachnoid hemorrhage in monkeys. J Cereb Blood Flow Metab. 2000 Jul;20(7):1066-76. doi: 10.1097/00004647-200007000-00006. PMID: 10908040.

463: Stoodley M, Weihl CC, Zhang ZD, Lin G, Johns LM, Kowalczuk A, Ghadge G, Roos RP, Macdonald RL. Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Neurosurgery. 2000 May;46(5):1193-202; discussion 1202-3. doi: 10.1097/00006123-200005000-00034. PMID: 10807252.

464: Zaroff JG, Rordorf GA, Titus JS, Newell JB, Nowak NJ, Torchiana DF, Aretz HT, Picard MH, Macdonald RL. Regional myocardial perfusion after experimental subarachnoid hemorrhage. Stroke. 2000 May;31(5):1136-43. doi: 10.1161/01.str.31.5.1136. PMID: 10797178.

465: Baldwin ZK, Meyerson SL, Skelly CL, McKinsey JF, Bassiouny HS, MacDonald RL, Gewertz BL, Schwartz LB. Estimating the contemporary in-hospital costs of carotid endarterectomy. Ann Vasc Surg. 2000 May;14(3):210-5. doi: 10.1007/s100169910037. PMID: 10796951.

466: Jani AB, Pelizzari CA, Chen GT, Roeske J, Hamilton RJ, Macdonald RL, Bova F, Hoffmann KR, Sweeney PA. Volume rendering quantification algorithm for reconstruction of CT volume-rendered structures: Part I. Cerebral arteriovenous malformations. IEEE Trans Med Imaging. 2000 Jan;19(1):12-24. doi: 10.1109/42.832956. PMID: 10782615.

467: Fisher JL, Hinkle DJ, Macdonald RL. Loreclezole inhibition of recombinant alpha1beta1gamma2L GABA(A) receptor single channel currents. Neuropharmacology. 2000 Jan 4;39(2):235-45. doi: 10.1016/s0028-3908(99)00108-2. PMID: 10670419.

468: Lyden P, Shin C, Jackson-Friedman C, Hassid S, Chong A, Macdonald RL. Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke. 2000 Jan;31(1):169-75. doi: 10.1161/01.str.31.1.169. PMID: 10625734.

469: Burgard EC, Haas KF, Macdonald RL. Channel properties determine the transient activation kinetics of recombinant GABA(A) receptors. Brain Res Mol Brain Res. 1999 Nov 10;73(1-2):28-36. doi: 10.1016/s0169-328x(99)00230-2. PMID: 10581395.

470: Citow JS, Macdonald RL, Ferguson MK. Combined laminectomy and thoracoscopic resection of a dumbbell neurofibroma: technical case report. Neurosurgery. 1999 Nov;45(5):1263-5; discussion 1265-6. doi: 10.1097/00006123-199911000-00057. PMID: 10549949.

471: MacDonald RL, Kapur J. Pharmacological properties of recombinant and hippocampal dentate granule cell GABAA receptors. Adv Neurol. 1999;79:979-90. PMID: 10514880.

472: Munshi I, Macdonald RL, Weir BK. Intraoperative angiography of brain arteriovenous malformations. Neurosurgery. 1999 Sep;45(3):491-7; discussion 497-9. doi: 10.1097/00006123-199909000-00016. PMID: 10493371.

473: Neelands TR, Macdonald RL. Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors. Mol Pharmacol. 1999 Sep;56(3):598-610. doi: 10.1124/mol.56.3.598. PMID: 10462548.

474: Macdonald RL, Amidei C, Lin G, Munshi I, Baron J, Weir BK, Brown F, Erickson RK, Hekmatpanah J. Safety of perioperative subcutaneous heparin for prophylaxis of venous thromboembolism in patients undergoing craniotomy. Neurosurgery. 1999 Aug;45(2):245-51; discussion 251-2. doi: 10.1097/00006123-199908000-00008. PMID: 10449068.

475: Neelands TR, Zhang J, Macdonald RL. GABA(A) receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells. J Neurosci. 1999 Aug 15;19(16):7057-65. doi: 10.1523/JNEUROSCI.19-16-07057.1999. PMID: 10436060; PMCID: PMC6782845.

476: Macdonald RL, Kapur J. Acute cellular alterations in the hippocampus after status epilepticus. Epilepsia. 1999;40 Suppl 1:S9-20; discussion S21-2. doi: 10.1111/j.1528-1157.1999.tb00873.x. PMID: 10421557.

477: Alexander JJ, Lim A, He C, MacDonald RL, Holers VM, Quigg RJ. Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury. Immunopharmacology. 1999 May;42(1-3):245-54. doi: 10.1016/s0162-3109(99)00010-7. PMID: 10408385.

478: Connell PP, Macdonald RL, Mansur DB, Nicholas MK, Mundt AJ. Tumor size predicts control of benign meningiomas treated with radiotherapy. Neurosurgery. 1999 Jun;44(6):1194-9; discussion 1199-200. PMID: 10371618.

479: Wang X, Marton LS, Weir BK, Macdonald RL. Immediate early gene expression in vascular smooth-muscle cells synergistically induced by hemolysate components. J Neurosurg. 1999 Jun;90(6):1083-90. doi: 10.3171/jns.1999.90.6.1083. PMID: 10350256.

480: Weir B, Macdonald RL, Stoodley M. Etiology of cerebral vasospasm. Acta Neurochir Suppl. 1999;72:27-46. doi: 10.1007/978-3-7091-6377-1_3. PMID: 10337411.

481: Kapur J, Haas KF, Macdonald RL. Physiological properties of GABAA receptors from acutely dissociated rat dentate granule cells. J Neurophysiol. 1999 May;81(5):2464-71. doi: 10.1152/jn.1999.81.5.2464. PMID: 10322081.

482: Citow JS, Macdonald RL. Posterior decompression of the vertebral artery narrowed by cervical osteophyte: case report. Surg Neurol. 1999 May;51(5):495-8; discussion 498-9. doi: 10.1016/s0090-3019(98)00121-9. PMID: 10321878.

483: Macdonald RL, Johns L, Lin G, Marton LS, Hallak H, Marcoux F, Kowalczuk A. Prevention of vasospasm after subarachnoid hemorrhage in dogs by continuous intravenous infusion of PD-156707. Neurol Med Chir (Tokyo). 1998;38 Suppl:138-45. doi: 10.2176/nmc.38.suppl_138. PMID: 10234996.

484: Tietz EI, Kapur J, Macdonald RL. Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. J Neurophysiol. 1999 Apr;81(4):1575-86. doi: 10.1152/jn.1999.81.4.1575. PMID: 10200193.

485: King AP, Hall KE, Macdonald RL. kappa- and mu-Opioid inhibition of N-type calcium currents is attenuated by 4beta-phorbol 12-myristate 13-acetate and protein kinase C in rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 1999 Apr;289(1):312-20. PMID: 10087019.

486: Sawada M, Yanamoto H, Nagata I, Hashimoto N, Nakahara I, Akiyama Y, Kikuchi H, Macdonald RL. Prevention of neointimal formation by a serine protease inhibitor, FUT-175, after carotid balloon injury in rats. Stroke. 1999 Mar;30(3):644-50. doi: 10.1161/01.str.30.3.644. PMID: 10066865.

487: Kapur J, Macdonald RL. Postnatal development of hippocampal dentate granule cell gamma-aminobutyric acidA receptor pharmacological properties. Mol Pharmacol. 1999 Mar;55(3):444-52. PMID: 10051527.

488: Macdonald RL, Zhang J, Marton LS, Weir B. Effects of cell-permeant calcium chelators on contractility in monkey basilar artery. J Neurotrauma. 1999 Jan;16(1):37-47. doi: 10.1089/neu.1999.16.37. PMID: 9989465.

489: Weihl C, Macdonald RL, Stoodley M, Lüders J, Lin G. Gene therapy for cerebrovascular disease. Neurosurgery. 1999 Feb;44(2):239-52; discussion 253. doi: 10.1097/00006123-199902000-00001. PMID: 9932877.

490: Lowenstein DH, Bleck T, Macdonald RL. It's time to revise the definition of status epilepticus. Epilepsia. 1999 Jan;40(1):120-2. doi: 10.1111/j.1528-1157.1999.tb02000.x. PMID: 9924914.

491: Neelands TR, Fisher JL, Bianchi M, Macdonald RL. Spontaneous and gamma- aminobutyric acid (GABA)-activated GABA(A) receptor channels formed by epsilon subunit-containing isoforms. Mol Pharmacol. 1999 Jan;55(1):168-78. doi: 10.1124/mol.55.1.168. PMID: 9882711.

492: Guan YY, Weir BK, Marton LS, Macdonald RL, Zhang H. Effects of erythrocyte lysate of different incubation times on intracellular free calcium in rat basilar artery smooth-muscle cells. J Neurosurg. 1998 Dec;89(6):1007-14. doi: 10.3171/jns.1998.89.6.1007. PMID: 9833828.

493: Haas KF, Macdonald RL. GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts. J Physiol. 1999 Jan 1;514 ( Pt 1)(Pt 1):27-45. doi: 10.1111/j.1469-7793.1999.027af.x. Erratum in: J Physiol. 2004 Aug 1;558(Pt 3):1013. PMID: 9831714; PMCID: PMC2269054.

494: Stoodley MA, Macdonald RL, Weir BK. Surgical treatment of middle cerebral artery aneurysms. Neurosurg Clin N Am. 1998 Oct;9(4):823-34. PMID: 9738109.

495: Stoodley MA, Macdonald RL, Weir BK. Pregnancy and intracranial aneurysms. Neurosurg Clin N Am. 1998 Jul;9(3):549-56. PMID: 9668186.

496: Neelands TR, Greenfield LJ Jr, Zhang J, Turner RS, Macdonald RL. GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells. J Neurosci. 1998 Jul 1;18(13):4993-5007. doi: 10.1523/JNEUROSCI.18-13-04993.1998. PMID: 9634565; PMCID: PMC6792560.

497: Macdonald RL, Bassiouny M, Johns L, Sajdak M, Marton LS, Weir BK, Hall ED, Andrus PK. U74389G prevents vasospasm after subarachnoid hemorrhage in dogs. Neurosurgery. 1998 Jun;42(6):1339-45; discussion 1345-6. doi: 10.1097/00006123-199806000-00089. PMID: 9632194.

498: Macdonald RL, Zhang J, Weir B, Marton LS, Wollman R. Adenosine triphosphate causes vasospasm of the rat femoral artery. Neurosurgery. 1998 Apr;42(4):825-32; discussion 832-3. doi: 10.1097/00006123-199804000-00082. PMID: 9574647.

499: Fisher JL, Macdonald RL. The role of an alpha subtype M2-M3 His in regulating inhibition of GABAA receptor current by zinc and other divalent cations. J Neurosci. 1998 Apr 15;18(8):2944-53. doi: 10.1523/JNEUROSCI.18-08-02944.1998. PMID: 9526011; PMCID: PMC6792601.

500: Macdonald RL, Stoodley M. Pathophysiology of cerebral ischemia. Neurol Med Chir (Tokyo). 1998 Jan;38(1):1-11. doi: 10.2176/nmc.38.1. PMID: 9540326.

501: Fisher JL, Macdonald RL. Functional properties of recombinant GABA(A) receptors composed of single or multiple beta subunit subtypes. Neuropharmacology. 1997 Nov-Dec;36(11-12):1601-10. doi: 10.1016/s0028-3908(97)00133-0. PMID: 9517431.

502: Macdonald RL, Mojtahedi S, Johns L, Kowalczuk A. Randomized comparison of Guglielmi detachable coils and cellulose acetate polymer for treatment of aneurysms in dogs. Stroke. 1998 Feb;29(2):478-85; discussion 485-6. doi: 10.1161/01.str.29.2.478. PMID: 9472893.

503: Kim CJ, Weir BK, Macdonald RL, Zhang H. Erythrocyte lysate releases Ca2+ from IP3-sensitive stores and activates Ca(2+)-dependent K+ channels in rat basilar smooth muscle cells. Neurol Res. 1998 Jan;20(1):23-30. doi: 10.1080/01616412.1998.11740480. PMID: 9471099.

504: Zhang H, Weir BK, Marton LS, Lee KS, Macdonald RL. P2 purinoceptors in cultured bovine middle cerebral artery endothelial cells. J Cardiovasc Pharmacol. 1997 Dec;30(6):767-74. doi: 10.1097/00005344-199712000-00011. PMID: 9436816.

505: Fisher JL, Macdonald RL. Single channel properties of recombinant GABAA receptors containing gamma 2 or delta subtypes expressed with alpha 1 and beta 3 subtypes in mouse L929 cells. J Physiol. 1997 Dec 1;505 ( Pt 2)(Pt 2):283-97. doi: 10.1111/j.1469-7793.1997.283bb.x. PMID: 9423172; PMCID: PMC1160063.

506: Kowalczuk A, Macdonald RL, Amidei C, Dohrmann G 3rd, Erickson RK, Hekmatpanah J, Krauss S, Krishnasamy S, Masters G, Mullan SF, Mundt AJ, Sweeney P, Vokes EE, Weir BK, Wollman RL. Quantitative imaging study of extent of surgical resection and prognosis of malignant astrocytomas. Neurosurgery. 1997 Nov;41(5):1028-36; discussion 1036-8. doi: 10.1097/00006123-199711000-00004. PMID: 9361056.

507: Kane J, Macdonald RL, Zhang J, Sima B. HEPES inhibits contractile responses of canine basilar artery. Neurol Res. 1997 Oct;19(5):527-33. doi: 10.1080/01616412.1997.11740852. PMID: 9329031.

508: Sima B, Weir BK, Macdonald RL, Zhang H. Extracellular nucleotide-induced [Ca2+]i elevation in rat basilar smooth muscle cells. Stroke. 1997 Oct;28(10):2053-8; discussion 2059. doi: 10.1161/01.str.28.10.2053. PMID: 9341718.

509: Fisher JL, Zhang J, Macdonald RL. The role of alpha1 and alpha6 subtype amino-terminal domains in allosteric regulation of gamma-aminobutyric acida receptors. Mol Pharmacol. 1997 Oct;52(4):714-24. doi: 10.1124/mol.52.4.714. PMID: 9380035.

510: Kapur J, Macdonald RL. Rapid seizure-induced reduction of benzodiazepine and Zn2+ sensitivity of hippocampal dentate granule cell GABAA receptors. J Neurosci. 1997 Oct 1;17(19):7532-40. doi: 10.1523/JNEUROSCI.17-19-07532.1997. PMID: 9295398; PMCID: PMC2892718.

511: Macdonald RL, Hoffman HJ. Subarachnoid hemorrhage and vasospasm following removal of craniopharyngioma. J Clin Neurosci. 1997 Jul;4(3):348-52. doi: 10.1016/s0967-5868(97)90104-1. PMID: 18638982.

512: Macdonald RL, Fehlings MG, Tator CH, Lozano A, Fleming JR, Gentili F, Bernstein M, Wallace MC, Tasker RR. Multilevel anterior cervical corpectomy and fibular allograft fusion for cervical myelopathy. J Neurosurg. 1997 Jun;86(6):990-7. doi: 10.3171/jns.1997.86.6.0990. PMID: 9171178.

513: Macdonald RL, Greenfield LJ Jr. Mechanisms of action of new antiepileptic drugs. Curr Opin Neurol. 1997 Apr;10(2):121-8. doi: 10.1097/00019052-199704000-00009. PMID: 9147003.

514: Wiley JW, Moises HC, Gross RA, MacDonald RL. Dynorphin A-mediated reduction in multiple calcium currents involves a G(o) alpha-subtype G protein in rat primary afferent neurons. J Neurophysiol. 1997 Mar;77(3):1338-48. doi: 10.1152/jn.1997.77.3.1338. PMID: 9084601.

515: Saxena NC, Neelands TR, MacDonald RL. Contrasting actions of lanthanum on different recombinant gamma-aminobutyric acid receptor isoforms expressed in L929 fibroblasts. Mol Pharmacol. 1997 Feb;51(2):328-35. doi: 10.1124/mol.51.2.328. PMID: 9203639.

516: Greenfield LJ Jr, Sun F, Neelands TR, Burgard EC, Donnelly JL, MacDonald RL. Expression of functional GABAA receptors in transfected L929 cells isolated by immunomagnetic bead separation. Neuropharmacology. 1997 Jan;36(1):63-73. doi: 10.1016/s0028-3908(96)00150-5. PMID: 9144642.

517: Cagen SZ, MacDonald RL, Van Gelder G. Review of risk assessments on 1,3-butadiene (1985-1991). Toxicology. 1996 Oct 28;113(1-3):215-20. doi: 10.1016/0300-483x(96)03447-6. PMID: 8901900.

518: Kapur J, Macdonald RL. Cyclic AMP-dependent protein kinase enhances hippocampal dentate granule cell GABAA receptor currents. J Neurophysiol. 1996 Oct;76(4):2626-34. doi: 10.1152/jn.1996.76.4.2626. PMID: 8899633.

519: Greenfield LJ Jr, Macdonald RL. Whole-cell and single-channel alpha1 beta1 gamma2S GABAA receptor currents elicited by a “multipuffer” drug application device. Pflugers Arch. 1996 Oct;432(6):1080-90. doi: 10.1007/s004240050238. PMID: 8781204.

520: Hino A, Tokuyama Y, Weir B, Takeda J, Yano H, Bell GI, Macdonald RL. Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys. Neurosurgery. 1996 Sep;39(3):562-7; discussion 567-8. doi: 10.1097/00006123-199609000-00026. PMID: 8875487.

521: Kapur J, Macdonald RL. Pharmacological properties of gamma-aminobutyric acidA receptors from acutely dissociated rat dentate granule cells. Mol Pharmacol. 1996 Sep;50(3):458-66. PMID: 8794882.

522: Kim CJ, Bassiouny M, Macdonald RL, Weir B, Johns LM. Effect of BQ-123 and tissue plasminogen activator on vasospasm after subarachnoid hemorrhage in monkeys. Stroke. 1996 Sep;27(9):1629-33. doi: 10.1161/01.str.27.9.1629. PMID: 8784140.

523: Ryan MJ, Erickson RK, Levin DN, Pelizzari CA, Macdonald RL, Dohrmann GJ. Frameless stereotaxy with real-time tracking of patient head movement and retrospective patient-image registration. J Neurosurg. 1996 Aug;85(2):287-92. doi: 10.3171/jns.1996.85.2.0287. PMID: 8755758.

524: Hino A, Tokuyama Y, Kobayashi M, Yano M, Weir B, Takeda J, Wang X, Bell GI, Macdonald RL. Increased expression of endothelin B receptor mRNA following subarachnoid hemorrhage in monkeys. J Cereb Blood Flow Metab. 1996 Jul;16(4):688-97. doi: 10.1097/00004647-199607000-00020. PMID: 8964809.

525: Alexander TD, Macdonald RL, Weir B, Kowalczuk A. Intraoperative angiography in cerebral aneurysm surgery: a prospective study of 100 craniotomies. Neurosurgery. 1996 Jul;39(1):10-7; discussion 17-8. doi: 10.1097/00006123-199607000-00004. PMID: 8805135.

526: Lin YF, Angelotti TP, Dudek EM, Browning MD, Macdonald RL. Enhancement of recombinant alpha 1 beta 1 gamma 2L gamma-aminobutyric acidA receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both beta 1 and gamma 2L subunits. Mol Pharmacol. 1996 Jul;50(1):185-95. PMID: 8700112.

527: Burgard EC, Tietz EI, Neelands TR, Macdonald RL. Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype. Mol Pharmacol. 1996 Jul;50(1):119-27. PMID: 8700104.

528: Mullan S, Mojtahedi S, Johnson DL, Macdonald RL. Cerebral venous malformation-arteriovenous malformation transition forms. J Neurosurg. 1996 Jul;85(1):9-13. doi: 10.3171/jns.1996.85.1.0009. PMID: 8683287.

529: Mullan S, Mojtahedi S, Johnson DL, Macdonald RL. Embryological basis of some aspects of cerebral vascular fistulas and malformations. J Neurosurg. 1996 Jul;85(1):1-8. doi: 10.3171/jns.1996.85.1.0001. PMID: 8683257.

530: Zhang J, Sima B, Johns LM, Macdonald RL. Time course of changes in arterial relaxation following subarachnoid hemorrhage in dogs. Neurol Res. 1996 Jun;18(3):227-32. doi: 10.1080/01616412.1996.11740409. PMID: 8837057.

531: Kume A, Greenfield LJ Jr, Macdonald RL, Albin RL. Felbamate inhibits [3H]t-butylbicycloorthobenzoate (TBOB) binding and enhances Cl- current at the gamma-aminobutyric AcidA (GABAA) receptor. J Pharmacol Exp Ther. 1996 Jun;277(3):1784-92. PMID: 8667250.

532: Zhang H, Weir BK, Macdonald RL, Marton LS, Solenski NJ, Kwan AL, Lee KS. Mechanisms of [Ca++]i elevation induced by erythrocyte components in endothelial cells. J Pharmacol Exp Ther. 1996 Jun;277(3):1501-9. PMID: 8667216.

533: Kim CJ, Weir B, Macdonald RL, Marton LS, Zhang H. Hemolysate inhibits L-type Ca2+ channels in rat basilar smooth muscle cells. J Vasc Res. 1996 May- Jun;33(3):258-64. doi: 10.1159/000159153. PMID: 8924523.

534: Macdonald RL. Controversies in the management of carotid stenosis. J Neurosci Nurs. 1996 Apr;28(2):93-8. doi: 10.1097/01376517-199604000-00005. PMID: 8718756.

535: Saxena NC, Macdonald RL. Properties of putative cerebellar gamma- aminobutyric acid A receptor isoforms. Mol Pharmacol. 1996 Mar;49(3):567-79. PMID: 8643098.

536: Macdonald RL, Saxena NC, Angelotti TP. Functional expression of recombinant GABAA receptor channels in L929 fibroblasts. Epilepsy Res Suppl. 1996;12:177-85. PMID: 9302516.

537: Macdonald RL. Is there a mechanistic basis for rational polypharmacy? Epilepsy Res Suppl. 1996;11:79-93. PMID: 9294730.

538: Donnelly JL, MacDonald RL. Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents. Neuropharmacology. 1996;35(9-10):1233-41. doi: 10.1016/s0028-3908(96)00053-6. PMID: 9014138.

539: Zhang H, Weir B, Marton LS, Macdonald RL, Bindokas V, Miller RJ, Brorson JR. Mechanisms of hemolysate-induced [Ca2+]i elevation in cerebral smooth muscle cells. Am J Physiol. 1995 Dec;269(6 Pt 2):H1874-90. doi: 10.1152/ajpheart.1995.269.6.H1874. PMID: 8594895.

540: Macdonald RL, Zhang J, Sima B, Johns L. Papaverine-sensitive vasospasm and arterial contractility and compliance after subarachnoid hemorrhage in dogs. Neurosurgery. 1995 Nov;37(5):962-7; discussion 967-8. doi: 10.1227/00006123-199511000-00016. PMID: 8559346.

541: Hino A, Weir BK, Macdonald RL, Thisted RA, Kim CJ, Johns LM. Prospective, randomized, double-blind trial of BQ-123 and bosentan for prevention of vasospasm following subarachnoid hemorrhage in monkeys. J Neurosurg. 1995 Sep;83(3):503-9. doi: 10.3171/jns.1995.83.3.0503. PMID: 7666230.

542: Hall KE, Browning MD, Dudek EM, Macdonald RL. Enhancement of high threshold calcium currents in rat primary afferent neurons by constitutively active protein kinase C. J Neurosci. 1995 Sep;15(9):6069-76. doi: 10.1523/JNEUROSCI.15-09-06069.1995. PMID: 7666190; PMCID: PMC6577655.

543: Macdonald RL, Wallace MC, Montanera WJ, Glen JA. Pathological effects of angioplasty on vasospastic carotid arteries in a rabbit model. J Neurosurg. 1995 Jul;83(1):111-7. doi: 10.3171/jns.1995.83.1.0111. PMID: 7782825.

544: Macdonald RL, Kowalczuk A, Johns L. Emboli enter penetrating arteries of monkey brain in relation to their size. Stroke. 1995 Jul;26(7):1247-50; discussion 1250-1. doi: 10.1161/01.str.26.7.1247. PMID: 7604423.

545: Macdonald RL, Linke RA, Devlin GE, Mizuta M. Confirmation of the local nature of the plasma grating photorefractive effect. Opt Lett. 1995 Jun 1;20(11):1322-4. doi: 10.1364/ol.20.001322. PMID: 19859513.

546: Macdonald RL, Zhang J, Han H. Angioplasty reduces pharmacologically mediated vasoconstriction in rabbit carotid arteries with and without vasospasm. Stroke. 1995 Jun;26(6):1053-9; discussion 1059-60. doi: 10.1161/01.str.26.6.1053. PMID: 7762023.

547: Macdonald RL. Ethanol, gamma-aminobutyrate type A receptors, and protein kinase C phosphorylation. Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3633-5. doi: 10.1073/pnas.92.9.3633. PMID: 7731956; PMCID: PMC42016.

548: Massa E, Kelly KM, Yule DI, MacDonald RL, Uhler MD. Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms. Mol Pharmacol. 1995 Apr;47(4):707-16. PMID: 7723731.

549: Pennell PB, Ogaily MS, Macdonald RL. Aplastic anemia in a patient receiving felbamate for complex partial seizures. Neurology. 1995 Mar;45(3 Pt 1):456-60. doi: 10.1212/wnl.45.3.456. PMID: 7898696.

550: Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia. 1995;36 Suppl 2:S2-12. doi: 10.1111/j.1528-1157.1995.tb05996.x. PMID: 8784210.

551: Rock DM, Macdonald RL. Polyamine regulation of N-methyl-D-aspartate receptor channels. Annu Rev Pharmacol Toxicol. 1995;35:463-82. doi: 10.1146/annurev.pa.35.040195.002335. PMID: 7598503.

552: Macdonald RL, Linke RA, Chadi JD, Thio T, Devlin GE, Becla P. Thick plasma gratings using a local photorefractive effect in CdZnTe:In. Opt Lett. 1994 Dec 15;19(24):2131-3. doi: 10.1364/ol.19.002131. PMID: 19855763.

553: Lin YF, Browning MD, Dudek EM, Macdonald RL. Protein kinase C enhances recombinant bovine alpha 1 beta 1 gamma 2L GABAA receptor whole-cell currents expressed in L929 fibroblasts. Neuron. 1994 Dec;13(6):1421-31. doi: 10.1016/0896-6273(94)90427-8. PMID: 7993633.

554: Saxena NC, Macdonald RL. Assembly of GABAA receptor subunits: role of the delta subunit. J Neurosci. 1994 Nov;14(11 Pt 2):7077-86. doi: 10.1523/JNEUROSCI.14-11-07077.1994. PMID: 7525894; PMCID: PMC6577243.

555: Moises HC, Rusin KI, Macdonald RL. Mu- and kappa-opioid receptors selectively reduce the same transient components of high-threshold calcium current in rat dorsal root ganglion sensory neurons. J Neurosci. 1994 Oct;14(10):5903-16. doi: 10.1523/JNEUROSCI.14-10-05903.1994. PMID: 7931552; PMCID: PMC6577010.

556: Coyne TJ, Montanera WJ, Macdonald RL, Wallace MC. Percutaneous transluminal angioplasty for cerebral vasospasm after subarachnoid hemorrhage. Can J Surg. 1994 Oct;37(5):391-6. PMID: 7922900.

557: Moises HC, Rusin KI, Macdonald RL. mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein. J Neurosci. 1994 Jun;14(6):3842-51. doi: 10.1523/JNEUROSCI.14-06-03842.1994. PMID: 8207492; PMCID: PMC6576957.

558: Macdonald RL, Weir BK. Cerebral vasospasm and free radicals. Free Radic Biol Med. 1994 May;16(5):633-43. doi: 10.1016/0891-5849(94)90064-7. PMID: 8026807.

559: Macdonald RL, Wallace MC, Coyne TJ. The effect of surgery on the severity of vasospasm. J Neurosurg. 1994 Mar;80(3):433-9. doi: 10.3171/jns.1994.80.3.0433. PMID: 8113855.

560: Rogers CJ, Twyman RE, Macdonald RL. Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture. J Physiol. 1994 Feb 15;475(1):69-82. doi: 10.1113/jphysiol.1994.sp020050. PMID: 7514665; PMCID: PMC1160356.

561: Vollrath BA, Weir BK, Macdonald RL, Cook DA. Intracellular mechanisms involved in the responses of cerebrovascular smooth-muscle cells to hemoglobin. J Neurosurg. 1994 Feb;80(2):261-8. doi: 10.3171/jns.1994.80.2.0261. PMID: 8283265.

562: Macdonald RL, Humphreys RP, Rutka JT, Kestle JR. Colloid cysts in children. Pediatr Neurosurg. 1994;20(3):169-77. doi: 10.1159/000120782. PMID: 8204490.

563: Macdonald RL, Hoffman HJ, Kestle JR, Rutka JT, Weinstein G. Needle aspiration of acute subdural hematomas in infancy. Pediatr Neurosurg. 1994;20(1):73-6; discussion 77. doi: 10.1159/000120768. PMID: 8142286.

564: Macdonald RL, Olsen RW. GABAA receptor channels. Annu Rev Neurosci. 1994;17:569-602. doi: 10.1146/annurev.ne.17.030194.003033. PMID: 7516126.

565: Macdonald RL, Kelly KM. Mechanisms of action of currently prescribed and newly developed antiepileptic drugs. Epilepsia. 1994;35 Suppl 4:S41-50. doi: 10.1111/j.1528-1157.1994.tb05955.x. PMID: 7513639.

566: Angelotti TP, Uhler MD, Macdonald RL. Enhancement of recombinant gamma- aminobutyric acid type A receptor currents by chronic activation of cAMP- dependent protein kinase. Mol Pharmacol. 1993 Dec;44(6):1202-10. PMID: 8264557.

567: Macdonald RL, Wallace MC, Kestle JR. Role of angiography following aneurysm surgery. J Neurosurg. 1993 Dec;79(6):826-32. doi: 10.3171/jns.1993.79.6.0826. PMID: 8246049.

568: Driscoll TJ, MacDonald RL, Lawandy NM. Helicity dependence of optically encoded second-harmonic generation in glasses. Phys Rev A. 1993 Oct;48(4):3278-3285. doi: 10.1103/physreva.48.3278. PMID: 9909983.

569: Rock DM, Kelly KM, Macdonald RL. Gabapentin actions on ligand- and voltage- gated responses in cultured rodent neurons. Epilepsy Res. 1993 Oct;16(2):89-98. doi: 10.1016/0920-1211(93)90023-z. PMID: 7505742.

570: MacDonald RL, Lawandy NM, Khurgin JB. Saturation of near-resonant chi (3)(0;2 omega,- omega,- omega ) in quantum-confined semiconductors. Phys Rev B Condens Matter. 1993 Jul 15;48(3):1607-1611. doi: 10.1103/physrevb.48.1607. PMID: 10008521.

571: Wiley JW, Gross RA, MacDonald RL. Agonists for neuropeptide Y receptor subtypes NPY-1 and NPY-2 have opposite actions on rat nodose neuron calcium currents. J Neurophysiol. 1993 Jul;70(1):324-30. doi: 10.1152/jn.1993.70.1.324. PMID: 8395583.

572: Macdonald RL, Lawandy NM. Efficient second-harmonic generation into the UV by using optically encoded silicate glasses. Opt Lett. 1993 Apr 15;18(8):595. doi: 10.1364/ol.18.000595. PMID: 19802211.

573: Angelotti TP, Macdonald RL. Assembly of GABAA receptor subunits: alpha 1 beta 1 and alpha 1 beta 1 gamma 2S subunits produce unique ion channels with dissimilar single-channel properties. J Neurosci. 1993 Apr;13(4):1429-40. doi: 10.1523/JNEUROSCI.13-04-01429.1993. PMID: 7681870; PMCID: PMC6576715.

574: Angelotti TP, Uhler MD, Macdonald RL. Assembly of GABAA receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene technique. J Neurosci. 1993 Apr;13(4):1418-28. doi: 10.1523/JNEUROSCI.13-04-01418.1993. PMID: 7681869; PMCID: PMC6576728.

575: MacDonald RL, Lawandy NM. Observation of charge screening in semiconductor nanocrystals. Phys Rev B Condens Matter. 1993 Jan 15;47(4):1961-1966. doi: 10.1103/physrevb.47.1961. PMID: 10006232.

576: Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia. 1993;34 Suppl 5:S1-8. doi: 10.1111/j.1528-1157.1993.tb05918.x. PMID: 7687957.

577: Macdonald RL, Weir BK, Grace MG, Chen MH, Martin TP, Young JD. Mechanism of cerebral vasospasm following subarachnoid hemorrhage in monkeys. Can J Neurol Sci. 1992 Nov;19(4):419-27. PMID: 1423039.

578: Porter NM, Angelotti TP, Twyman RE, MacDonald RL. Kinetic properties of alpha 1 beta 1 gamma-aminobutyric acidA receptor channels expressed in Chinese hamster ovary cells: regulation by pentobarbital and picrotoxin. Mol Pharmacol. 1992 Nov;42(5):872-81. PMID: 1331767.

579: Angelotti TP, Tan F, Chahine KG, Macdonald RL. Molecular and electrophysiological characterization of a allelic variant of the rat alpha 6 GABAA receptor subunit. Brain Res Mol Brain Res. 1992 Nov;16(1-2):173-8. doi: 10.1016/0169-328x(92)90209-t. PMID: 1281255.

580: Twyman RE, Macdonald RL. Neurosteroid regulation of GABAA receptor single- channel kinetic properties of mouse spinal cord neurons in culture. J Physiol. 1992 Oct;456:215-45. doi: 10.1113/jphysiol.1992.sp019334. PMID: 1338096; PMCID: PMC1175679.

581: Rock DM, Macdonald RL. The polyamine diaminodecane (DA-10) produces a voltage-dependent flickery block of single NMDA receptor channels. Neurosci Lett. 1992 Sep 14;144(1-2):111-5. doi: 10.1016/0304-3940(92)90728-p. PMID: 1279482.

582: Wiley JW, Gross RA, MacDonald RL. The peptide CGRP increases a high- threshold Ca2+ current in rat nodose neurones via a pertussis toxin-sensitive pathway. J Physiol. 1992 Sep;455:367-81. doi: 10.1113/jphysiol.1992.sp019306. PMID: 1336552; PMCID: PMC1175649.

583: Macdonald RL, Weir BK, Runzer TD, Grace MG. Malondialdehyde, glutathione peroxidase, and superoxide dismutase in cerebrospinal fluid during cerebral vasospasm in monkeys. Can J Neurol Sci. 1992 Aug;19(3):326-32. PMID: 1393841.

584: Rock DM, MacDonald RL. Spermine and related polyamines produce a voltage- dependent reduction of N-methyl-D-aspartate receptor single-channel conductance. Mol Pharmacol. 1992 Jul;42(1):157-64. PMID: 1378923.

585: Macdonald RL, Weir BK, Runzer TD, Grace MG, Poznansky MJ. Effect of intrathecal superoxide dismutase and catalase on oxyhemoglobin-induced vasospasm in monkeys. Neurosurgery. 1992 Apr;30(4):529-39. doi: 10.1227/00006123-199204000-00010. PMID: 1584351.

586: Takanashi Y, Weir BK, Vollrath B, Kasuya H, Macdonald RL, Cook D. Time course of changes in concentration of intracellular free calcium in cultured cerebrovascular smooth muscle cells exposed to oxyhemoglobin. Neurosurgery. 1992 Mar;30(3):346-50. doi: 10.1227/00006123-199203000-00006. PMID: 1620296.

587: Macdonald RL, Weir BK, Young JD, Grace MG. Cytoskeletal and extracellular matrix proteins in cerebral arteries following subarachnoid hemorrhage in monkeys. J Neurosurg. 1992 Jan;76(1):81-90. doi: 10.3171/jns.1992.76.1.0081. PMID: 1727173.

588: MacDonald RL, Twyman RE. Kinetic properties and regulation of GABAA receptor channels. Ion Channels. 1992;3:315-43. doi: 10.1007/978-1-4615-3328-3_10. PMID: 1384760.

589: Rock DM, Macdonald RL. The polyamine spermine has multiple actions on N-methyl-D-aspartate receptor single-channel currents in cultured cortical neurons. Mol Pharmacol. 1992 Jan;41(1):83-8. PMID: 1370709.

590: Macdonald RL, Twyman RE, Ryan-Jastrow T, Angelotti TP. Regulation of GABAA receptor channels by anticonvulsant and convulsant drugs and by phosphorylation. Epilepsy Res Suppl. 1992;9:265-77. PMID: 1337441.

591: Twyman RE, Green RM, MacDonald RL. Kinetics of open channel block by penicillin of single GABAA receptor channels from mouse spinal cord neurones in culture. J Physiol. 1992 Jan;445:97-127. doi: 10.1113/jphysiol.1992.sp018914. PMID: 1323672; PMCID: PMC1179972.

592: Kelly KM, Gross RA, Macdonald RL. Tetrahydroaminoacridine (THA) reduces voltage-dependent calcium currents in rat sensory neurons. Neurosci Lett. 1991 Nov 11;132(2):247-50. doi: 10.1016/0304-3940(91)90312-h. PMID: 1784428.

593: Macdonald RL, Weir BK, Chen MH, Grace MG. Scanning electron microscopy of normal and vasospastic monkey cerebrovascular smooth muscle cells. Neurosurgery. 1991 Oct;29(4):544-50. doi: 10.1097/00006123-199110000-00010. PMID: 1944834.

594: Findlay JM, Macdonald RL, Weir BK, Grace MG. Surgical manipulation of primate cerebral arteries in established vasospasm. J Neurosurg. 1991 Sep;75(3):425-32. doi: 10.3171/jns.1991.75.3.0425. PMID: 1869944.

595: Macdonald RL, Weir BK, Runzer TD, Grace MG, Findlay JM, Saito K, Cook DA, Mielke BW, Kanamaru K. Etiology of cerebral vasospasm in primates. J Neurosurg. 1991 Sep;75(3):415-24. doi: 10.3171/jns.1991.75.3.0415. PMID: 1869943.

596: Klimek EH, Macdonald RL, Deck JH. Pneumocephalus following treatment of esthesioneuroblastoma. Can J Neurol Sci. 1991 Aug;18(3):358-60. doi: 10.1017/s0317167100031966. PMID: 1913375.

597: Macdonald RL, Weir BK. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke. 1991 Aug;22(8):971-82. doi: 10.1161/01.str.22.8.971. PMID: 1866764.

598: Macdonald RL, Schwartz ML, Lewis AJ. Neurenteric cyst located dorsal to the cervical spine: case report. Neurosurgery. 1991 Apr;28(4):583-7; discussion 587-8. doi: 10.1097/00006123-199104000-00017. PMID: 2034355.

599: Twyman RE, Macdonald RL. Kinetic properties of the glycine receptor main- and sub-conductance states of mouse spinal cord neurones in culture. J Physiol. 1991 Apr;435:303-31. doi: 10.1113/jphysiol.1991.sp018512. PMID: 1722820; PMCID: PMC1181464.

600: Rock DM, McLean MJ, Macdonald RL, Catterall WA, Taylor CP. Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha- benzoate binding in vitro. Epilepsy Res. 1991 Apr;8(3):197-203. doi: 10.1016/0920-1211(91)90064-m. PMID: 1651226.

601: Fields CG, Lloyd DH, Macdonald RL, Otteson KM, Noble RL. HBTU activation for automated Fmoc solid-phase peptide synthesis. Pept Res. 1991 Mar- Apr;4(2):95-101. PMID: 1815783.

602: De Deyn PP, Marescau B, Macdonald RL. Guanidino compounds that are increased in hyperargininemia inhibit GABA and glycine responses on mouse neurons in cell culture. Epilepsy Res. 1991 Mar;8(2):134-41. doi: 10.1016/0920-1211(91)90081-p. PMID: 1712285.

603: Macdonald RL, Weir BK, Grace MG, Martin TP, Doi M, Cook DA. Morphometric analysis of monkey cerebral arteries exposed in vivo to whole blood, oxyhemoglobin, methemoglobin, and bilirubin. Blood Vessels. 1991;28(6):498-510. doi: 10.1159/000158896. PMID: 1782405.

604: Findlay JM, Macdonald RL, Weir BK. Current concepts of pathophysiology and management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage. Cerebrovasc Brain Metab Rev. 1991 Winter;3(4):336-61. PMID: 1772740.

605: Gross RA, Uhler MD, Macdonald RL. The reduction of neuronal calcium currents by ATP-gamma-S is mediated by a G protein and occurs independently of cyclic AMP-dependent protein kinase. Brain Res. 1990 Dec 10;535(2):214-20. doi: 10.1016/0006-8993(90)91603-e. PMID: 1963568.

606: Porter NM, Twyman RE, Uhler MD, Macdonald RL. Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons. Neuron. 1990 Dec;5(6):789-96. doi: 10.1016/0896-6273(90)90338-g. PMID: 2176510.

607: Macdonald RL, Muller PJ, Tucker WS, Moulton RJ, Hudson AR. Petrous meningiomas: a review of seventeen cases. Can J Neurol Sci. 1990 Nov;17(4):399-403. doi: 10.1017/s0317167100030961. PMID: 2276098.

608: De Deyn PP, Macdonald RL. Guanidino compounds that are increased in cerebrospinal fluid and brain of uremic patients inhibit GABA and glycine responses on mouse neurons in cell culture. Ann Neurol. 1990 Nov;28(5):627-33. doi: 10.1002/ana.410280505. PMID: 2135950.

609: Macdonald RL, Deck JH. Immunohistochemistry of ecchordosis physaliphora and chordoma. Can J Neurol Sci. 1990 Nov;17(4):420-3. doi: 10.1017/s0317167100031000. PMID: 1703453.

610: Gross RA, Uhler MD, Macdonald RL. The cyclic AMP-dependent protein kinase catalytic subunit selectively enhances calcium currents in rat nodose neurones. J Physiol. 1990 Oct;429:483-96. doi: 10.1113/jphysiol.1990.sp018268. PMID: 2177506; PMCID: PMC1181711.

611: Gross RA, Moises HC, Uhler MD, Macdonald RL. Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents. Proc Natl Acad Sci U S A. 1990 Sep;87(18):7025-9. doi: 10.1073/pnas.87.18.7025. PMID: 1976250; PMCID: PMC54675.

612: Kelly KM, Gross RA, Macdonald RL. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neurosci Lett. 1990 Aug 14;116(1-2):233-8. doi: 10.1016/0304-3940(90)90416-7. PMID: 2175404.

613: Moss SJ, Smart TG, Porter NM, Nayeem N, Devine J, Stephenson FA, Macdonald RL, Barnard EA. Cloned GABA receptors are maintained in a stable cell line: allosteric and channel properties. Eur J Pharmacol. 1990 Jul 31;189(1):77-88. doi: 10.1016/0922-4106(90)90232-m. PMID: 2171964.

614: Kanamaru K, Weir BK, Findlay JM, Grace M, Macdonald RL. A dosage study of the effect of the 21-aminosteroid U74006F on chronic cerebral vasospasm in a primate model. Neurosurgery. 1990 Jul;27(1):29-38. doi: 10.1097/00006123-199007000-00004. PMID: 2377279.

615: Wiley JW, Gross RA, Lu YX, Macdonald RL. Neuropeptide Y reduces calcium current and inhibits acetylcholine release in nodose neurons via a pertussis toxin-sensitive mechanism. J Neurophysiol. 1990 Jun;63(6):1499-507. doi: 10.1152/jn.1990.63.6.1499. PMID: 2358888.

616: MacDonald RL, Schwartz ML, Mirich D, Sharkey PW, Nelson WR. Diagnosis of cervical spine injury in motor vehicle crash victims: how many X-rays are enough? J Trauma. 1990 Apr;30(4):392-7. PMID: 2182894.

617: Twyman RE, Rogers CJ, Macdonald RL. Intraburst kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture. J Physiol. 1990 Apr;423:193-220. doi: 10.1113/jphysiol.1990.sp018018. PMID: 2167362; PMCID: PMC1189753.

618: Gross RA, Wiley JW, Ryan-Jastrow T, Macdonald RL. Regulation by GTP and its stable thiol derivatives of calcium current components in rat nodose ganglion neurons. Mol Pharmacol. 1990 Apr;37(4):546-53. PMID: 2157961.

619: Macdonald RL, Cusimano MD, Deck JH, Gullane PJ, Dolan EJ. Cerebrospinal fluid fistula secondary to ecchordosis physaliphora. Neurosurgery. 1990 Mar;26(3):515-8; discussion 518-9. doi: 10.1097/00006123-199003000-00022. PMID: 2320221.

620: De Deyn PP, Marescau B, MacDonald RL. Epilepsy and the GABA-hypothesis a brief review and some examples. Acta Neurol Belg. 1990;90(2):65-81. PMID: 2164316.

621: MacDonald RL, Rogers CJ, Twyman RE. Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture. J Physiol. 1989 Oct;417:483-500. doi: 10.1113/jphysiol.1989.sp017814. PMID: 2482885; PMCID: PMC1189279.

622: Gross RA, MacDonald RL. Activators of protein kinase C selectively enhance inactivation of a calcium current component of cultured sensory neurons in a pertussis toxin-sensitive manner. J Neurophysiol. 1989 Jun;61(6):1259-69. doi: 10.1152/jn.1989.61.6.1259. PMID: 2746325.

623: Macdonald RL, Bernstein M. Emergency lumbar puncture in adults. Can Fam Physician. 1989 May;35:1183-6. PMID: 21248954; PMCID: PMC2280348.

624: Gross RA, Macdonald RL, Ryan-Jastrow T. 2-Chloroadenosine reduces the N calcium current of cultured mouse sensory neurones in a pertussis toxin- sensitive manner. J Physiol. 1989 Apr;411:585-95. doi: 10.1113/jphysiol.1989.sp017592. PMID: 2614735; PMCID: PMC1190543.

625: Rock DM, Macdonald RL, Taylor CP. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant. Epilepsy Res. 1989 Mar-Apr;3(2):138-43. doi: 10.1016/0920-1211(89)90041-7. PMID: 2565229.

626: Macdonald RL, Rogers CJ, Twyman RE. Kinetic properties of the GABAA receptor main conductance state of mouse spinal cord neurones in culture. J Physiol. 1989 Mar;410:479-99. doi: 10.1113/jphysiol.1989.sp017545. PMID: 2477526; PMCID: PMC1190491.

627: Twyman RE, Rogers CJ, Macdonald RL. Differential regulation of gamma- aminobutyric acid receptor channels by diazepam and phenobarbital. Ann Neurol. 1989 Mar;25(3):213-20. doi: 10.1002/ana.410250302. PMID: 2471436.

628: Twyman RE, Rogers CJ, Macdonald RL. Pentobarbital and picrotoxin have reciprocal actions on single GABAA receptor channels. Neurosci Lett. 1989 Jan 2;96(1):89-95. doi: 10.1016/0304-3940(89)90248-6. PMID: 2467232.

629: De Deyn PP, Macdonald RL. Effects of antiepileptic drugs on GABA responses and on reduction of GABA responses by PTZ and DMCM on mouse neurons in cell culture. Epilepsia. 1989 Jan-Feb;30(1):17-25. doi: 10.1111/j.1528-1157.1989.tb05275.x. PMID: 2912714.

630: Macdonald RL. Antiepileptic drug actions. Epilepsia. 1989;30 Suppl 1:S19-28; discussion S64-8. doi: 10.1111/j.1528-1157.1989.tb05810.x. PMID: 2550216.

631: Gross RA, Macdonald RL. Cyclic AMP selectively reduces the N-type calcium current component of mouse sensory neurons in culture by enhancing inactivation. J Neurophysiol. 1989 Jan;61(1):97-105. doi: 10.1152/jn.1989.61.1.97. PMID: 2537387.

632: Gross RA, Macdonald RL. Differential actions of pentobarbitone on calcium current components of mouse sensory neurones in culture. J Physiol. 1988 Nov;405:187-203. doi: 10.1113/jphysiol.1988.sp017328. PMID: 2855640; PMCID: PMC1190971.

633: De Deyn PP, Macdonald RL. Effects of non-sedative anxiolytic drugs on responses to GABA and on diazepam-induced enhancement of these responses on mouse neurones in cell culture. Br J Pharmacol. 1988 Sep;95(1):109-20. doi: 10.1111/j.1476-5381.1988.tb16554.x. PMID: 2905900; PMCID: PMC1854132.

634: Macdonald RL, Findlay JM, Tator CH. Sphenoethmoidal sinusitis complicated by cavernous sinus thrombosis and pontocerebellar infarction. Can J Neurol Sci. 1988 Aug;15(3):310-3. doi: 10.1017/s0317167100027803. PMID: 3208216.

635: De Deyn PP, Marescau B, Macdonald RL. Effects of alpha-keto-delta- guanidinovaleric acid on inhibitory amino acid responses on mouse neurons in cell culture. Brain Res. 1988 May 24;449(1-2):54-60. doi: 10.1016/0006-8993(88)91023-2. PMID: 3395858.

636: Gross RA, Macdonald RL. Reduction of the same calcium current component by A and C kinases: differential pertussis toxin sensitivity. Neurosci Lett. 1988 May 16;88(1):50-6. doi: 10.1016/0304-3940(88)90314-x. PMID: 2456492.

637: MacDonald RL, Findlay JM, Tator CH. Microcystic spinal cord degeneration causing posttraumatic myelopathy. Report of two cases. J Neurosurg. 1988 Mar;68(3):466-71. doi: 10.3171/jns.1988.68.3.0466. PMID: 3343618.

638: Gross RA, Macdonald RL. Barbiturates and nifedipine have different and selective effects on calcium currents of mouse DRG neurons in culture: a possible basis for differing clinical actions. The 1987 S. Weir Mitchell award. Neurology. 1988 Mar;38(3):443-51. doi: 10.1212/wnl.38.3.443. PMID: 2450304.

639: McLean MJ, Macdonald RL. Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture. J Pharmacol Exp Ther. 1988 Feb;244(2):789-95. PMID: 2450203.

640: Macdonald RL. Anticonvulsant drug actions on neurons in cell culture. J Neural Transm. 1988;72(3):173-83. doi: 10.1007/BF01243417. PMID: 3047314.

641: MacDonald RL, Hughes BL, Aarnaes SL, Peterson EM, de la Maza LM. Evaluation of a shell vial centrifugation method for the detection of herpes simplex virus. Diagn Microbiol Infect Dis. 1988 Jan;9(1):51-4. doi: 10.1016/0732-8893(88)90061-2. PMID: 2836124.

642: Macdonald RL, Twyman RE, Rogers CJ, Weddle MG. Pentobarbital regulation of the kinetic properties of GABA receptor chloride channels. Adv Biochem Psychopharmacol. 1988;45:61-71. PMID: 2459926.

643: Werz MA, Grega DS, MacDonald RL. Actions of mu, delta and kappa opioid agonists and antagonists on mouse primary afferent neurons in culture. J Pharmacol Exp Ther. 1987 Oct;243(1):258-63. PMID: 2822900.

644: Gross RA, Macdonald RL. Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5469-73. doi: 10.1073/pnas.84.15.5469. PMID: 2440050; PMCID: PMC298879.

645: Werz MA, Macdonald RL. Dual actions of phorbol esters to decrease calcium and potassium conductances of mouse neurons. Neurosci Lett. 1987 Jul 9;78(1):101-6. doi: 10.1016/0304-3940(87)90569-6. PMID: 2441331.

646: De Deyn PP, Macdonald RL. CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture. J Pharmacol Exp Ther. 1987 Jul;242(1):48-55. PMID: 3039114.

647: Werz MA, Macdonald RL. Phorbol esters: voltage-dependent effects on calcium-dependent action potentials of mouse central and peripheral neurons in cell culture. J Neurosci. 1987 Jun;7(6):1639-47. doi: 10.1523/JNEUROSCI.07-06-01639.1987. PMID: 3598639; PMCID: PMC6568866.

648: Grega DS, Macdonald RL. Activators of adenylate cyclase and cyclic AMP prolong calcium-dependent action potentials of mouse sensory neurons in culture by reducing a voltage-dependent potassium conductance. J Neurosci. 1987 Mar;7(3):700-7. doi: 10.1523/JNEUROSCI.07-03-00700.1987. PMID: 3031236; PMCID: PMC6569065.

649: Grega DS, Werz MA, Macdonald RL. Forskolin and phorbol esters reduce the same potassium conductance of mouse neurons in culture. Science. 1987 Jan 16;235(4786):345-8. doi: 10.1126/science.2432663. PMID: 2432663.

650: Macdonald RL, McLean MJ. Mechanisms of anticonvulsant drug action. Electroencephalogr Clin Neurophysiol Suppl. 1987;39:200-8. PMID: 2888643.

651: McLean MJ, Macdonald RL. Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther. 1986 Aug;238(2):727-38. PMID: 2874218.

652: Macdonald RL, Werz MA. Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones. J Physiol. 1986 Aug;377:237-49. doi: 10.1113/jphysiol.1986.sp016184. PMID: 2432242; PMCID: PMC1182830.

653: McLean MJ, Macdonald RL. Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture. J Pharmacol Exp Ther. 1986 Jun;237(3):1001-11. PMID: 3086538.

654: Macdonald RL, Weddle MG, Gross RA. Benzodiazepine, beta-carboline, and barbiturate actions on GABA responses. Adv Biochem Psychopharmacol. 1986;41:67-78. PMID: 2874695.

655: Macdonald RL, McLean MJ. Anticonvulsant drugs: mechanisms of action. Adv Neurol. 1986;44:713-36. PMID: 2871724.

656: MacDonald RL, Skerritt JH, Werz MA. Adenosine agonists reduce voltage- dependent calcium conductance of mouse sensory neurones in cell culture. J Physiol. 1986 Jan;370:75-90. doi: 10.1113/jphysiol.1986.sp015923. PMID: 2420981; PMCID: PMC1192669.

657: Werz MA, Macdonald RL. Barbiturates decrease voltage-dependent calcium conductance of mouse neurons in dissociated cell culture. Mol Pharmacol. 1985 Sep;28(3):269-77. PMID: 2412101.

658: Werz MA, Macdonald RL. Dynorphin and neoendorphin peptides decrease dorsal root ganglion neuron calcium-dependent action potential duration. J Pharmacol Exp Ther. 1985 Jul;234(1):49-56. PMID: 2409273.

659: Macdonald RL, McLean MJ, Skerritt JH. Anticonvulsant drug mechanisms of action. Fed Proc. 1985 Jul;44(10):2634-9. PMID: 2408925.

660: Skerritt JH, Johnston GA, Chow SC, MacDonald RL, Prager RH, Ward AD. Differential modulation of gamma-aminobutyric acid receptors by caprolactam derivatives with central nervous system depressant or convulsant activity. Brain Res. 1985 Apr 8;331(2):225-33. doi: 10.1016/0006-8993(85)91548-3. PMID: 2985202.

661: McLean MJ, MacDonald RL. Cellular mechanistic bases for classification of clinically useful anticonvulsant drugs. Ann Acad Med Singap. 1985 Jan;14(1):128-36. PMID: 4004118.

662: Werz MA, Macdonald RL. Dynorphin reduces voltage-dependent calcium conductance of mouse dorsal root ganglion neurons. Neuropeptides. 1984 Dec;5(1-3):253-6. doi: 10.1016/0143-4179(84)90075-1. PMID: 6152324.

663: Skerritt JH, Werz MA, McLean MJ, Macdonald RL. Diazepam and its anomalous p-chloro-derivative Ro 5-4864: comparative effects on mouse neurons in cell culture. Brain Res. 1984 Sep 17;310(1):99-105. doi: 10.1016/0006-8993(84)90013-1. PMID: 6478244.

664: Skerritt JH, Macdonald RL. Multiple actions of convulsant barbiturates on mouse neurons in cell culture. J Pharmacol Exp Ther. 1984 Jul;230(1):82-8. PMID: 6747834.

665: Skerritt JH, Macdonald RL. Benzodiazepine receptor ligand actions on GABA responses. Beta-carbolines, purines. Eur J Pharmacol. 1984 May 18;101(1-2):135-41. doi: 10.1016/0014-2999(84)90039-6. PMID: 6086358.

666: Skerritt JH, Macdonald RL. Benzodiazepine receptor ligand actions on GABA responses. Benzodiazepines, CL 218872, zopiclone. Eur J Pharmacol. 1984 May 18;101(1-2):127-34. doi: 10.1016/0014-2999(84)90038-4. PMID: 6086357.

667: Werz MA, Macdonald RL. Dynorphin reduces calcium-dependent action potential duration by decreasing voltage-dependent calcium conductance. Neurosci Lett. 1984 May 4;46(2):185-90. doi: 10.1016/0304-3940(84)90439-7. PMID: 6146120.

668: Skerritt JH, Macdonald RL. Diazepam enhances the action but not the binding of the GABA analog, THIP. Brain Res. 1984 Apr 9;297(1):181-6. doi: 10.1016/0006-8993(84)90557-2. PMID: 6722533.

669: Skerritt JH, Macdonald RL. Benzodiazepine Ro 15-1788: electrophysiological evidence for partial agonist activity. Neurosci Lett. 1983 Dec 30;43(2-3):321-6. doi: 10.1016/0304-3940(83)90208-2. PMID: 6143288.

670: Werz MA, MacDonald RL. Opioid peptides selective for mu- and delta-opiate receptors reduce calcium-dependent action potential duration by increasing potassium conductance. Neurosci Lett. 1983 Dec 2;42(2):173-8. doi: 10.1016/0304-3940(83)90402-0. PMID: 6320066.

671: McLean MJ, Macdonald RL. Multiple actions of phenytoin on mouse spinal cord neurons in cell culture. J Pharmacol Exp Ther. 1983 Dec;227(3):779-89. PMID: 6317847.

672: Bergey GK, MacDonald RL, Habig WH, Hardegree MC, Nelson PG. Tetanus toxin: convulsant action on mouse spinal cord neurons in culture. J Neurosci. 1983 Nov;3(11):2310-23. doi: 10.1523/JNEUROSCI.03-11-02310.1983. PMID: 6631482; PMCID: PMC6564628.

673: Werz MA, Macdonald RL. Opioid peptides with differential affinity for mu and delta receptors decrease sensory neuron calcium-dependent action potentials. J Pharmacol Exp Ther. 1983 Nov;227(2):394-402. PMID: 6313900.

674: Nelson PG, Marshall KC, Pun RY, Christian CN, Sheriff WH Jr, Macdonald RL, Neale EA. Synaptic interactions between mammalian central neurons in cell culture. II. Quantal Analysis of EPSPs. J Neurophysiol. 1983 Jun;49(6):1442-58. doi: 10.1152/jn.1983.49.6.1442. PMID: 6875632.

675: Macdonald RL, Pun RY, Neale EA, Nelson PG. Synaptic interactions between mammalian central neurons in cell culture. I. Reversal potential for excitatory postsynaptic potentials. J Neurophysiol. 1983 Jun;49(6):1428-41. doi: 10.1152/jn.1983.49.6.1428. PMID: 6875631.

676: Neale EA, Nelson PG, Macdonald RL, Christian CN, Bowers LM. Synaptic interactions between mammalian central neurons in cell culture. III. Morphophysiological correlates of quantal synaptic transmission. J Neurophysiol. 1983 Jun;49(6):1459-68. doi: 10.1152/jn.1983.49.6.1459. PMID: 6308178.

677: Nowak LM, Macdonald RL. Ionic mechanism of muscarinic cholinergic depolarization of mouse spinal cord neurons in cell culture. J Neurophysiol. 1983 Mar;49(3):792-803. doi: 10.1152/jn.1983.49.3.792. PMID: 6834099.

678: Nowak LM, Macdonald RL. Muscarine-sensitive voltage-dependent potassium current in cultured murine spinal cord neurons. Neurosci Lett. 1983 Jan 31;35(1):85-91. doi: 10.1016/0304-3940(83)90531-1. PMID: 6843894.

679: Werz MA, Macdonald RL. Heterogeneous sensitivity of cultured dorsal root ganglion neurones to opioid peptides selective for mu- and delta-opiate receptors. Nature. 1982 Oct 21;299(5885):730-3. doi: 10.1038/299730a0. PMID: 6289131.

680: Moonen G, Neale EA, Macdonald RL, Gibbs W, Nelson PG. Cerebellar macroneurons in microexplant cell culture. Methodology, basic electrophysiology, and morphology after horseradish peroxidase injection. Brain Res. 1982 Sep;281(1):59-73. doi: 10.1016/0165-3806(82)90113-4. PMID: 6291726.

681: Macdonald RL, Moonen G, Neale EA, Nelson PG. Cerebellar macroneurons in microexplant cell culture. Postsynaptic amino acid pharmacology. Brain Res. 1982 Sep;281(1):75-88. doi: 10.1016/0165-3806(82)90114-6. PMID: 6128065.

682: Nowak LM, Macdonald RL. Substance P: ionic basis for depolarizing responses of mouse spinal cord neurons in cell culture. J Neurosci. 1982 Aug;2(8):1119-28. doi: 10.1523/JNEUROSCI.02-08-01119.1982. PMID: 6180151; PMCID: PMC6564281.

683: Nowak LM, Young AB, Macdonald RL. GABA and bicuculline actions on mouse spinal cord and cortical neurons in cell culture. Brain Res. 1982 Jul 22;244(1):155-64. doi: 10.1016/0006-8993(82)90913-1. PMID: 6288177.

684: Frere RC, Macdonald RL, Young AB. GABA binding and bicuculline in spinal cord and cortical membranes from adult rat and from mouse neurons in cell culture. Brain Res. 1982 Jul 22;244(1):145-53. doi: 10.1016/0006-8993(82)90912-x. PMID: 6288176.

685: Werz MA, Macdonald RL. Opioid peptides decrease calcium-dependent action potential duration of mouse dorsal root ganglion neurons in cell culture. Brain Res. 1982 May 6;239(1):315-21. doi: 10.1016/0006-8993(82)90859-9. PMID: 7093688.

686: Heyer EJ, Macdonald RL. Calcium- and sodium-dependent action potentials of mouse spinal cord and dorsal root ganglion neurons in cell culture. J Neurophysiol. 1982 Apr;47(4):641-55. doi: 10.1152/jn.1982.47.4.641. PMID: 7069458.

687: Werz MA, Macdonald RL. Opiate alkaloids antagonize postsynaptic glycine and GABA responses: correlation with convulsant action. Brain Res. 1982 Mar 18;236(1):107-19. doi: 10.1016/0006-8993(82)90038-5. PMID: 7066678.

688: Heyer EJ, Macdonald RL. Barbiturate reduction of calcium-dependent action potentials: correlation with anesthetic action. Brain Res. 1982 Mar 18;236(1):157-71. doi: 10.1016/0006-8993(82)90042-7. PMID: 6279233.

689: Heyer EJ, Nowak LM, Macdonald RL. Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: bicuculline and penicillin. Brain Res. 1982 Jan 28;232(1):41-56. doi: 10.1016/0006-8993(82)90609-6. PMID: 7055710.

690: Macdonald RL, McLean MJ. Cellular bases of barbiturate and phenytoin anticonvulsant drug action. Epilepsia. 1982;23 Suppl 1:S7-18. doi: 10.1111/j.1528-1157.1982.tb06093.x. PMID: 7140671.

691: Neale EA, Moonen G, Macdonald RL, Nelson PG. Cerebellar macroneurons in microexplant cell culture: ultrastructural morphology. Neuroscience. 1982;7(8):1879-90. doi: 10.1016/0306-4522(82)90004-5. PMID: 7133404.

692: Heyer EJ, Nowak LM, Macdonald RL. Bicuculline: a convulsant with synaptic and nonsynaptic actions. Neurology. 1981 Nov;31(11):1381-90. doi: 10.1212/wnl.31.11.1381. PMID: 7198187.

693: Heyer EJ, MacDonald RL, Bergey GK, Nelson PG. Calcium-dependent action potentials in mouse spinal cord neurons in cell culture. Brain Res. 1981 Sep 14;220(2):408-15. doi: 10.1016/0006-8993(81)91234-8. PMID: 7284766.

694: Macdonald RL, Young AB. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture. Mol Cell Biochem. 1981 Aug 11;38 Spec No(Pt 1):147-62. doi: 10.1007/BF00235693. PMID: 6270545.

695: Nowak LM, MacDonald RL. Substance P decreases a potassium conductance of spinal cord neurons in cell culture. Brain Res. 1981 Jun 15;214(2):416-23. doi: 10.1016/0006-8993(81)91205-1. PMID: 6165445.

696: Schulz DW, Macdonald RL. Barbiturate enhancement of GABA-mediated inhibition and activation of chloride ion conductance: correlation with anticonvulsant and anesthetic actions. Brain Res. 1981 Mar 23;209(1):177-88. doi: 10.1016/0006-8993(81)91179-3. PMID: 6260300.

697: Macdonald RL, Nowak LM. Substance P and somatostatin actions on spinal cord neurons in primary dissociated cell culture. Adv Biochem Psychopharmacol. 1981;28:159-73. PMID: 6163331.

698: Neale EA, MacDonald RL, Nelson PG. An inhibitory spinal cord neuron. JAMA. 1980 Dec 5;244(22):2555. PMID: 7431596.

699: Zimmerman EA, MacDonald RL, Vale W, Faden AI. Symposium on neuropeptides. Trans Am Neurol Assoc. 1980;105:504-27. PMID: 6758286.

700: Macdonald RL, Nowak LM. Somatostatin actions in primary dissociated cell cultures of mammalian spinal cord neurons. Int J Neurol. 1980;14(2-4):221-32. PMID: 6152909.

701: Macdonald RL, Bergey GK. Valproic acid augments GABA-mediated postsynaptic inhibition in cultured mammalian neurons. Brain Res. 1979 Jul 20;170(3):558-62. doi: 10.1016/0006-8993(79)90975-2. PMID: 380778.

702: MacDonald RL, Barker JL. Enhancement of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of anticonvulsant action. Brain Res. 1979 May 11;167(2):323-36. doi: 10.1016/0006-8993(79)90826-6. PMID: 445132.

703: Macdonald RL, Barker JL. Anticonvulsant and anesthetic barbiturates: different postsynaptic actions in cultured mammalian neurons. Neurology. 1979 Apr;29(4):432-47. doi: 10.1212/wnl.29.4.432. PMID: 220560.

704: Neale EA, Macdonald RL, Nelson PG. Intracellular horseradish peroxidase injection for correlation of light and electron microscopic anatomy with synaptic physiology of cultured mouse spinal cord neurons. Brain Res. 1978 Aug 25;152(2):265-82. doi: 10.1016/0006-8993(78)90255-x. PMID: 209872.

705: Macdonald RL, Barker JL. Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons. Science. 1978 May 19;200(4343):775-7. doi: 10.1126/science.205953. PMID: 205953.

706: Nelson PG, Neale EA, Macdonald RL. Formation and modification of synapses in central nervous system cell cultures. Fed Proc. 1978 May 15;37(7):2010-5. PMID: 565301.

707: Macdonald RL, Barker JL. Specific antagonism of GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons: a common mode of convulsant action. Neurology. 1978 Apr;28(4):325-30. doi: 10.1212/wnl.28.4.325. PMID: 565020.

708: Barker JL, Neale JH, Smith TG Jr, Macdonald RL. Opiate peptide modulation of amino acid responses suggests novel form of neuronal communication. Science. 1978 Mar 31;199(4336):1451-3. doi: 10.1126/science.204016. PMID: 204016.

709: Macdonald RL, Nelson PG. Specific-opiate-induced depression of transmitter release from dorsal root ganglion cells in culture. Science. 1978 Mar 31;199(4336):1449-51. doi: 10.1126/science.204015. PMID: 204015.

710: Bergey GK, Macdonald RL. The porphyrin precursor delta aminolevulinic acid diminishes amino acid responses in cultured murine spinal cord neurons. Trans Am Neurol Assoc. 1978;103:87-91. PMID: 574676.

711: Macdonald RL, Bergey GK. Valproic acid: effect on GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons. Trans Am Neurol Assoc. 1978;103:254-6. PMID: 390834.

712: Macdonald RL, Barker JL. Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurones. Nature. 1977 Jun 23;267(5613):720-1. doi: 10.1038/267720a0. PMID: 195224.

713: Macdonald RL, Barker JL. Phenobarbital enhances GABA-mediated postsynaptic inhibition in cultured mammalian neurons. Trans Am Neurol Assoc. 1977;102:139-40. PMID: 616093.

714: Cohen DH, MacDonald RL. Involvement of the avian hypothalamus in defensively conditioned heart rate change. J Comp Neurol. 1976 Jun 15;167(4):465-80. doi: 10.1002/cne.901670405. PMID: 1270630.

715: MacDonald RL, Hsu D, Mann JE Jr, Sperelakis N. An analysis of the problem of K-+ accumulation in the intercalated disk clefts of cardiac muscle. J Theor Biol. 1975 Jun;51(2):455-73. doi: 10.1016/0022-5193(75)90074-0. PMID: 1142797.

716: Sperelakis N, Macdonald RL. Ratio of transverse to longitudinal resistivities of isolated cardiac muscle fiber bundles. J Electrocardiol. 1974 Oct;7(4):301-14. doi: 10.1016/s0022-0736(74)80061-0. PMID: 4462694.

717: Macdonald RL, Mann JE Jr, Sperelakis N. Derivation of general equations describing tracer diffusion in any two-compartment tissue with application to ionic diffusion in cylindrical muscle bundles. J Theor Biol. 1974 May;45(1):107-30. doi: 10.1016/0022-5193(74)90046-0. PMID: 4836883.

718: Macdonald RL, Cohen DH. Heart rate and blood pressure responses to Electrostimulation of the central nervous system in the pigeon (Columba livia). J Comp Neurol. 1973 Jul 15;150(2):109-36. doi: 10.1002/cne.901500202. PMID: 4579121.

719: Cohen DH, Macdonald RL. Some variables affecting orienting and conditioned heart-rate responses in the pigeon. J Comp Physiol Psychol. 1971 Jan;74(1):123-33. doi: 10.1037/h0030326. PMID: 5163697.

720: Macdonald RL, Cohen DH. Cells of origin of sympathetic pre- and postganglionic cardioacceleratory fibers in the pigeon. J Comp Neurol. 1970 Nov;140(3):343-58. doi: 10.1002/cne.901400307. PMID: 5476888.

721: Cohen DH, Schnall AM, Macdonald RL, Pitts LH. Medullary cells of origin of vagal cardioinhibitory fibers in the pigeon. I. Anatomical studies of peripheral vagus nerve and the dorsal motor nucleus. J Comp Neurol. 1970 Nov;140(3):299-320. doi: 10.1002/cne.901400305. PMID: 5476886.