PICOT

(Patient, Intervention, Comparative, Outcome, Timing, and Type of study), complemented with a verification of regulatory approval, examination of sample size, quality of patient allocation, maintenance of treatment, and presence of masking techniques

The systematic review suggested in the methods section is: patients (P), regulatory approval, sample size calculation, allocation, intervention group (I), control group (C), maintenance, outcome (O), blinding techniques, time of study (T), and type of study (T).