A phagosome is a membrane-bound vesicle formed around a particle engulfed by a phagocytic cell through the process of phagocytosis. Once internalized, the phagosome fuses with lysosomes to form a phagolysosome, where the contents are degraded by enzymes.

Phagosomes play a crucial role in the innate immune response, particularly in the clearance of pathogens and apoptotic cells. In the context of glioblastoma (GB), changes in phagosome-related protein expression may reflect alterations in immune surveillance, tumour-associated macrophage activity, and neuroinflammatory mechanisms.

Recent studies, such as those by Liu et al. have linked phagosome pathways to potential biomarker candidates in GB, suggesting a role in disease progression and tumour-host interactions ¹⁾