Peripheral nerve hyperexcitability

Peripheral nerve hyperexcitability (PNH) is a syndrome of spontaneous and continuous muscle fiber activity, cramps, and slow relaxation of muscles of peripheral nerve origin. The electrophysiologic basis consists of spontaneous burst

Raja SN, Ringkamp M, Guan Y, Campbell JN. John J. Bonica Award Lecture: Peripheral neuronal hyperexcitability: the “low-hanging” target for safe therapeutic strategies in neuropathic pain. Pain. 2020 Sep;161 Suppl 1:S14-S26. doi: 10.1097/j.pain.0000000000001838. PMID: 33090736.s of single motor unit discharges with a high intraburst frequency.