The term “pathological hallmark” typically refers to a characteristic feature or sign that is distinctive and indicative of a particular disease or pathological condition. In medical and scientific contexts, researchers often identify specific markers, changes, or patterns that are considered hallmarks of a particular disease.

For example:

Beta-amyloid plaques and neurofibrillary tangles are pathological hallmarks of Alzheimer's disease. Lewy bodies are a pathological hallmark of Parkinson's disease and Lewy body dementia. Hemorrhagic lesions are a pathological hallmark of some types of strokes. These hallmarks are crucial for diagnosis, understanding the underlying mechanisms of diseases, and developing potential treatments. They serve as recognizable features that help distinguish one condition from another.