Nimodipine for Cerebral Vasospasm Prevention
Nimodipine is the only approved prophylactic medication. In addition to its anticoagulant properties, heparin also has a pleiotropic and anti-inflammatory effect that could be beneficial in vasospasm.
Administration of intravenous UFH for more than 48 hours reduced the rate of cerebral infarction with a good safety profile. This result supports the ongoing clinical trial 1).
Removal of subarachnoid hemorrhage as soon as possible.
Installation of thrombolytic agents (e.g. urokinase).
Antiinflammatory agents (steroids or NSAIDs).
Nimodipine for subarachnoid hemorrhage
1)
Lukito PP, Lie H, Helsa K, July J. Heparin in the treatment of aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Neurosurg Focus. 2022 Mar;52(3):E9. doi: 10.3171/2021.12.FOCUS21419. PMID: 35231899.