Neurogenic region (NR)
New neurons are continually born throughout adulthood predominantly in several regions of the brain:
The subventricular zone (SVZ)
The subgranular zone (SGZ), part of the dentate gyrus of hippocampus.
The nucleus accumbens, specifically medium spiny neurons
Glioblastoma GBM contrast-enhancing recurrence is significantly associated with proximity to NRs. NR-contacting initial tumors were more likely to recur out of radiation treatment fields 1).
1)
Chen L, Chaichana KL, Kleinberg L, Ye X, Quinones-Hinojosa A, Redmond K.
Glioblastoma recurrence patterns near neural stem cell regions. Radiother Oncol.
2015 Aug 11. pii: S0167-8140(15)00392-8. doi: 10.1016/j.radonc.2015.07.032. [Epub
ahead of print] PubMed PMID: 26276527.