Tumors with hypothalamic neuronal differentiation are classified as gangliocytomas or neurocytomas based on large and small cell sizes, respectively 1)

A 56-year-old male patient with bitemporal hemianopsia. Computed tomography and magnetic resonance imaging revealed a tumor in the sellar region. The tumor was totally excised. Postoperative histological examination of the tumor demonstrated that synaptophysin, chromogranin-A and neuron-specific enolase were positive, while luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, adrenocorticotropic hormone, thyroid-stimulating hormone, glial fibrillary acidic protein, S-100, nestin and epithelial membrane antigen were negative, which were the main pathological features of neurocytomas. This is the fourth case of EVN located in the sellar region reported 2).


1)
Asa SL, Mete O, Perry A, Osamura RY. Overview of the 2022 WHO Classification of Pituitary Tumors. Endocr Pathol. 2022 Mar;33(1):6-26. doi: 10.1007/s12022-022-09703-7. Epub 2022 Mar 15. PMID: 35291028.
2)
Peng P, Chen F, Zhou D, Liu H, Li J. Neurocytoma of the pituitary gland: A case report and literature review. Biomed Rep. 2015 May;3(3):301-303. Epub 2015 Feb 16. PubMed PMID: 26137226.
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