Nasopharyngeal carcinoma

Nasopharyngeal carcinomas: may be related to Epstein-Barr Virus (EBV) infection.

Epstein-Barr virus DNA level is significantly correlated to the outcomes of patients with Nasopharyngeal carcinoma (NPC) ¹⁾.

The fossa of Rosenmüller, also known as the posterolateral recess, is the most common site of origin for nasopharyngeal carcinoma

Juvenile angiofibroma.

It is critical to understand the factors associated with nasopharyngeal carcinoma (NPC) metastasis. To track the evolutionary route of metastasis, here we perform an integrative genomic analysis of 163 matched blood and primary, regional lymph node metastasis and distant metastasis tumor samples, combined with single-cell RNA-seq on 11 samples from two patients. The mutation burden, gene mutation frequency, mutation signature, and copy number frequency are similar between metastatic tumors and primary and regional lymph node tumors. There are two distinct evolutionary routes of metastasis, including metastases, which evolved from regional lymph nodes (lymphatic route, 61.5%, 8/13) and from primary tumors (hematogenous route, 38.5%, 5/13). The hematogenous route is characterized by higher IFN-γ response gene expression and a higher fraction of exhausted CD8+ T cells. Based on a radiomics model, we find that the hematogenous group has significantly better progression-free survival and PD-1 immunotherapy response, while the lymphatic group has a better response to locoregional radiotherapy ²⁾.

A nasopharyngeal carcinoma arose in a 52-year-old patient and occupied the right middle skull base extending to the ICA. We first identified and dissected the ICA from the posterolateral part of the tumor using a transcervical approach. Then, the tumor was approached and removed by an orbitozygomatic technique with hemifacial dismasking. The surgical defect was filled using a temporal muscle flap, which was divided into two parts according to the blood supply from either the anterior or the posterior deep temporal artery.

The postoperative course was uneventful and favorable cosmetic results were obtained. The patient has been free of carcinoma for more than 40 months after the surgery.

This new combined approach might be a good option for selected patients with nasopharyngeal tumors ³⁾.