Modic Type III changes
Modic changes Type III MRI appearance: hypointense on T1, hypointense on T2
(low SI on T1W and T2W images) are believed to be associated with subchondral bone sclerosis on plain radiographs. In recent years, MCs have been extensively used to identify the causes of non-specific low back pain (LBP) 1) 2) 3) 4), and in particular, Modic type I change has been reported to be associated with LBP 5) 6).
1)
Braithwaite I, White J, Saifuddin A, Renton P, Taylor BA. Vertebral end-plate (Modic) changes on lumbar spine MRI : correlation with pain reproduction at lumbar discography. Eur Spine J. 1998;7:363–368.
2)
Jensen RK, Leboeuf-Yde C, Wedderkopp N, Sorensen JS, Jensen TS, Manniche C. Is the development of Modic changes associated with clinical symptoms? A 14-month cohort study with MRI. Eur Spine J. 2012;21:2271–2279.
3)
Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C. Vertebral endplate signal changes (Modic change) : a systematic literature review of prevalence and association with non-specific low back pain. Eur Spine J. 2008;17:1407–1422.
4)
Luoma K, Vehmas T, Grönblad M, Kerttula L, Kääpä E. MRI follow-up of subchondral signal abnormalities in a selected group of chronic low back pain patients. Eur Spine J. 2008;17:1300–1308.
5)
Mitra D, Cassar-Pullicino VN, McCall IW. Longitudinal study of vertebral type-1 end-plate changes on MR of the lumbar spine. Eur Radiol. 2004;14:1574–1581.
6)
Toyone T, Takahashi K, Kitahara H, Yamagata M, Murakami M, Moriya H. Vertebral bone-marrow changes in degenerative lumbar disc disease. An MRI study of 74 patients with low back pain. J Bone Joint Surg Br. 1994;76:757–764.