In a work, Li et al. measured the expression of miR-378 in glioma tissues and non-neoplastic brain tissues was measured using real-time polymerase chain reaction (PCR), and found that MicroRNA-378 expression level was significantly lower in glioma tissues compared with non-neoplastic brain tissues.

Patients with lower miR-378 expression level had significantly poorer overall survival. Multivariate Cox regression analysis showed that miR-378 expression was an independent prognostic factor for 5-year overall survival. Over-expression of miR-378 inhibits glioma cell migration and invasion. In conclusion, the results indicated that miR-378 may serve as a tumor suppressor and play an important role in inhibiting tumor migration and invasion. The work implicates the potential effect of miR-378 on the prognosis of glioma ¹⁾.