miR-505-5p

• Identification and Experimental Validation of Prognostic miRNA Signature and Ferroptosis-Related Key Genes in Cervical Squamous Cell Carcinoma
• MicroRNA-505-5p/-3p Regulates the Proliferation, Invasion, Apoptosis, and Temozolomide Resistance in Mesenchymal Glioma Stem Cells by Targeting AUF1
• Circulating MiR-505-5p as a Diagnostic Marker for Acute Cerebral Infarction and Its Predictive Value for Clinical Outcomes after Endovascular Mechanical Thrombectomy
• Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food
• Uncovering miRNA-mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of <em>BRCA2</em>^MUT Ovarian Cancer PEO1-OR Cells with the ATR/CHK1 Pathway Inhibitors
• Drug metabolism and inflammation related distinct miRNA signature of colchicine resistant familial Mediterranean fever patients
• Alterations in Abundance and Compartmentalization of miRNAs in Blood Plasma Extracellular Vesicles and Extracellular Condensates during HIV/SIV Infection and Its Modulation by Antiretroviral Therapy (ART) and Delta-9-Tetrahydrocannabinol (Δ⁹-THC)
• Intradermal miR-16-5p targets Akt3 and reduces RTX-induced postherpetic neuralgia-mimic pain in mice

miR-505-5p is a microRNA (miRNA) that has been studied for its potential roles in various biological processes and diseases. miR-505-5p has been implicated in several areas of research:

Cancer: It has been shown to have potential roles in different types of cancer, where it may function as either a tumor suppressor or an oncogene, depending on the context.

Cardiovascular Disease: miR-505-5p may be involved in regulating cardiac function and could be a potential biomarker for cardiovascular diseases.

Neurodegenerative Diseases: Some studies suggest that miR-505-5p might be involved in neurodegenerative processes, potentially influencing disease progression or serving as a diagnostic marker.

Development and Differentiation: It might play a role in developmental processes and cellular differentiation.

The precise functions and mechanisms of miR-505-5p are still being explored, and ongoing research aims to clarify its roles and potential therapeutic applications.

Dearden et al. identified programmed overexpression of hypothalamic miR-505-5p that is established in the fetus, lasts to adulthood and is maintained in hypothalamic neural progenitor cells cultured in vitro. Metabolic hormones and long-chain fatty acids associated with obesity increase miR-505-5p expression in hypothalamic neurons in vitro. They demonstrated that targets of miR-505-5p are enriched in fatty acid metabolism pathways and overexpression of miR-505-5p decreased neuronal fatty acid metabolism in vitro. miR-505-5p targets are associated with increased BMI in human genetic studies. Intra-cerebroventricular injection of miR-505-5p in wild-type mice increased HFD intake, mimicking the phenotype observed in offspring exposed to maternal obesity. Conversely, maternal exercise intervention in an obese mouse pregnancy rescued the programmed increase of hypothalamic miR-505-5p in offspring of obese dams and reduced high-fat diet (HFD) intake to control offspring levels. This study identifies a novel mechanism by which maternal obesity programs obesity in offspring via increased intake of high-fat foods ¹⁾.

Diagnostic Marker for Acute Cerebral Infarction and Its Predictive Value for Clinical Outcomes after Endovascular Mechanical Thrombectomy ²⁾.