MIMIC-III database

MIMIC-III is a large, freely available database comprising de-identification of health data associated with over forty thousand patients who stayed in critical care units of the Beth Israel Deaconess Medical Center between 2001 and 2012. The database includes information such as demographics, vital sign measurements made at the bedside (~1 data point per hour), laboratory test results, procedures, medications, caregiver notes, imaging reports, and mortality (including post-hospital discharge).

MIMIC supports a diverse range of analytic studies spanning epidemiology, clinical decision-rule improvement, and electronic tool development. It is notable for three factors: it is freely available to researchers worldwide; it encompasses a diverse and very large population of ICU patients; and it contains highly granular data, including vital signs, laboratory results, and medications.

Based on the MIMIC-III database, Yi et al. firstly described the dissimilarities in survival probability, mortality, and neurological recovery among mainstream treatments for intracerebral hemorrhage; secondly, patient classification was determined by important clinical features; and outcome variations among treatment groups were compared. The 28-day, 90-day, and in-hospital mortality in the craniotomy group were significantly lower than minimally invasive surgery (MIS) and non-surgical group patients; and, the medium/long-term mortality in the MIS group was significantly lower than the non-surgical group. The craniotomy group positively correlated with short-term GCS recovery compared with the MIS group; no difference existed between the non-surgical and MIS groups. The craniotomy group's 90-day survival probability and short-term GCS recovery were superior to the other two treatments in the subgroups of first GCS 3-12; this tendency also presented in the MIS group over the non-surgical group. For milder patients (first GCS > 12), the three treatment regimens had a minimal effect on patient survival, but the non-surgical group showed an advantage in short-term GCS recovery. Craniotomy patients have lower mortality and a better short-term neurological recovery in an ICH population, especially in short-to-medium term mortality and short-term neurological recovery over MIS patients. In addition, surgical treatment is recommendable for patients with a GCS ≤ 12. ¹⁾.

2: Kim HB, Nguyen HT, Jin Q, Tamby S, Gelaf Romer T, Sung E, Liu R, Greenstein JL, Suarez JI, Storm C, Winslow RL, Stevens RD. Computational signatures for post-cardiac arrest trajectory prediction: Importance of early physiological time series. Anaesth Crit Care Pain Med. 2022 Feb;41(1):101015. doi: 10.1016/j.accpm.2021.101015. Epub 2021 Dec 27. PMID: 34968747.

3: Liu D, Tang Y, Zhang Q. Admission Hyperglycemia Predicts Long-Term Mortality in Critically Ill Patients With Subarachnoid Hemorrhage: A Retrospective Analysis of the MIMIC-III Database. Front Neurol. 2021 Oct 5;12:678998. doi: 10.3389/fneur.2021.678998. PMID: 34675863; PMCID: PMC8525327.

4: Sarkar R, Martin C, Mattie H, Gichoya JW, Stone DJ, Celi LA. Performance of intensive care unit severity scoring systems across different ethnicities in the USA: a retrospective observational study. Lancet Digit Health. 2021 Apr;3(4):e241-e249. doi: 10.1016/S2589-7500(21)00022-4. PMID: 33766288; PMCID: PMC8063502.

5: Ge X, Zhu L, Li W, Sun J, Chen F, Li Y, Lei P, Zhang J. Red Cell Distribution Width to Platelet Count Ratio: A Promising Routinely Available Indicator of Mortality for Acute Traumatic Brain Injury. J Neurotrauma. 2022 Jan;39(1-2):159-171. doi: 10.1089/neu.2020.7481. Epub 2021 May 3. Erratum in: J Neurotrauma. 2021 Sep 1;38(17):2487. PMID: 33719580.

6: Yang Y, Liang S, Geng J, Wang Q, Wang P, Cao Y, Li R, Gao G, Li L. Development of a nomogram to predict 30-day mortality of patients with sepsis- associated encephalopathy: a retrospective cohort study. J Intensive Care. 2020 Jul 2;8:45. doi: 10.1186/s40560-020-00459-y. PMID: 32637121; PMCID: PMC7331133.

7: Feng M, McSparron JI, Kien DT, Stone DJ, Roberts DH, Schwartzstein RM, Vieillard-Baron A, Celi LA. Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database. Intensive Care Med. 2018 Jun;44(6):884-892. doi: 10.1007/s00134-018-5208-7. Epub 2018 May 28. PMID: 29806057.