meningioma_histological_subtype

Meningioma histological subtype

WHO classification

World Health Organization Classification of Tumors of the Central Nervous System 2016 describes 15 subtypes of meningioma. Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. Grading is based solely on histology, with an absence of molecular markers. Although the existing classification and grading approach is of prognostic value, it harbours shortcomings such as ill-defined parameters for subtypes and grading criteria prone to arbitrary judgment 1).

Meningothelial meningioma 9531/0

Fibrous meningioma (fibroblastic) 9532/0

Transitional meningioma (mixed) 9537/0

Psammomatous meningioma 9533/0

Angiomatous meningioma 9534/0

Microcystic meningioma 9530/0

Secretory meningioma 9530/0

Lymphoplasmacyte rich meningioma 9530/0

Metaplastic meningioma 9530/0

Chordoid meningioma 9538/1

Clear cell meningioma 9538/1

Atypical meningioma 9539/1

Papillary meningioma 9538/3

Rhabdoid meningioma 9538/3

Anaplastic meningioma (malignant) 9530/3

1)
Sahm F, Schrimpf D, Stichel D, Jones DTW, Hielscher T, Schefzyk S, Okonechnikov K, Koelsche C, Reuss DE, Capper D, Sturm D, Wirsching HG, Berghoff AS, Baumgarten P, Kratz A, Huang K, Wefers AK, Hovestadt V, Sill M, Ellis HP, Kurian KM, Okuducu AF, Jungk C, Drueschler K, Schick M, Bewerunge-Hudler M, Mawrin C, Seiz-Rosenhagen M, Ketter R, Simon M, Westphal M, Lamszus K, Becker A, Koch A, Schittenhelm J, Rushing EJ, Collins VP, Brehmer S, Chavez L, Platten M, Hänggi D, Unterberg A, Paulus W, Wick W, Pfister SM, Mittelbronn M, Preusser M, Herold-Mende C, Weller M, von Deimling A. DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis. Lancet Oncol. 2017 May;18(5):682-694. doi: 10.1016/S1470-2045(17)30155-9. Epub 2017 Mar 15. PubMed PMID: 28314689.
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