Medulloblastoma clinical features

Clinical history is typically brief (6–12 weeks). The predilection for posterior fossa predisposes to early obstructive hydrocephalus. Usual presenting symptoms: H/A, N/V, and ataxia. Infants with hydrocephalus may present with irritability, lethargy, or progressive macrocrania ¹⁾.

Spinal drop metastases may produce back pain, urinary retention, or leg weakness.

Common signs: papilledema, truncal & appendicular ataxia, nystagmus, EOM palsies. Macrocrania in infants and young children.

Medulloblastoma may also cause nuclear facial palsy (from the involvement of facial colliculus on the floor of the fourth ventricle).