Meaningful refers to research results, innovations, or interventions that have clear biological, clinical, or translational significance beyond mere technical success.

• Demonstrates functional or therapeutic impact
• Solves a defined clinical or scientific problem
• Offers improvement over existing alternatives
• Relevance is supported by context and application

• Delivery of fluorescent proteins without therapeutic intent
• Engineering complexity without biological justification
• In vivo “proofs” that lack disease relevance

A gene therapy that restores motor function in a Parkinson’s model is meaningful. Delivering Cas9 to random brain cells without editing or phenotype data is not.